| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Coptis Chinensis | Acute Liver Failure | 1 | PM | 29253766 | 📋 | Protective effect of Coptisine from Rhizoma Coptidis on LPS/D-GalN-induced acute liver failure in mice through up-regulating expression of miR-122 |
| Coptis Chinensis | Acute Liver Injury | 1 | PM | 23871807 | 📋 | Inhibitory effect of Coptis chinensis on inflammation in LPS-induced endotoxemia |
| Coptis Chinensis | Colon Cancer | 2 | PM | 38759074 | 📋 | Exploring active ingredients and mechanisms of Coptidis Rhizoma-ginger against colon cancer using network pharmacology and molecular docking |
| Coptis Chinensis | Colon Cancer | 1 | PM | 20707080 | 📋 | [Effects of Coptis chinensis and Evodia rutaecarpa water extract on DMH-induced precancerous lesion of colon] |
| Coptis Chinensis | Colorectal Cancer | 2 | PM | 37404762 | 📋 | Liquid chromatography-tandem mass spectrometry analysis of a ratio-optimized drug pair of Sophora flavescens Aiton and Coptis chinensis Franch and study on the mechanism of anti-colorectal cancer effect of two alkaloids thereof |
| Coptis Chinensis | Colorectal Cancer | 1 | PM | 35783510 | 📋 | Characterizing the Antitumor Effect of Coptis chinensis and Mume Fructus against Colorectal Cancer Based on Pharmacological Analysis |
| Coptis Chinensis | Colorectal Cancer | 3 | PM | 33806077 | 📋 | Coptidis Rhizoma Extract Reverses 5-Fluorouracil Resistance in HCT116 Human Colorectal Cancer Cells via Modulation of Thymidylate Synthase |
| Coptis Chinensis | Colorectal Cancer | 4 | PM | 28165459 | 📋 | Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo |
| Coptis Chinensis | Dysbiosis | 1 | PM | 33152428 | 📋 | Coptis chinensis Franch polysaccharides provide a dynamically regulation on intestinal microenvironment, based on the intestinal flora and mucosal immunity |
| Coptis Chinensis | Gastric Cancer | 2 | PM | 36142236 | 📋 | Isoquinoline Alkaloids from Coptis chinensis Franch: Focus on Coptisine as a Potential Therapeutic Candidate against Gastric Cancer Cells |
| Coptis Chinensis | Gastric Cancer | 1 | PM | 34737010 | 📋 | Coptis chinensis and dried ginger herb combination inhibits gastric tumor growth by interfering with glucose metabolism via LDHA and SLC2A1 |
| Coptis Chinensis | Gastric Ulcer | 1 | PM | 32132292 | 📋 | Preventive effects of Rhizoma Coptidis and Atractylodes on mice with gastric-ulcer |
| Coptis Chinensis | Gastritis | 2 | PM | 37393026 | 📋 | Identification of the therapeutic effect and molecular mechanism of Coptis chinensis Franch. and Magnolia officinalis var. biloba on chronic gastritis |
| Coptis Chinensis | Gastritis | 1 | PM | 34745289 | 📋 | Unveiling the Mechanism of Principal Drugs of Lianpu Drink on Chronic Gastritis by Network Pharmacology |
| Coptis Chinensis | Hepatic Fibrosis | 1 | PM | 23190573 | 📋 | A comparative study on the hepatoprotective action of bear bile and Coptidis Rhizoma aqueous extract on experimental liver fibrosis in rats |
| Coptis Chinensis | Hepatitis C | 1 | PM | 30486350 | 📋 | Methanolic Extract of Rhizoma Coptidis Inhibits the Early Viral Entry Steps of Hepatitis C Virus Infection |
| Coptis Chinensis | Inflammatory Bowel Disease | 1 | PM | 33181286 | 📋 | Tracking evidences of Coptis chinensis for the treatment of inflammatory bowel disease from pharmacological, pharmacokinetic to clinical studies |
| Coptis Chinensis | Intestinal Injury | 1 | PM | 35340213 | 📋 | Sanguinarine-Chelerythrine Fraction of Coptis chinensis Exerts Anti-inflammatory Activity in Carrageenan Paw Oedema Test in Rats and Reveals Reduced Gastrotoxicity |
| Coptis Chinensis | Intestinal Metaplasia | 1 | PM | 38837097 | 📋 | Exploring the therapeutic mechanisms of Coptidis Rhizoma in gastric precancerous lesions: a network pharmacology approach |
| Coptis Chinensis | Intestinal Permeability | 1 | PM | 33224253 | 📋 | The Herbal Medicine Scutellaria-Coptis Alleviates Intestinal Mucosal Barrier Damage in Diabetic Rats by Inhibiting Inflammation and Modulating the Gut Microbiota |
| Coptis Chinensis | Irritable Bowel Syndrome | 1 | PM | 21511022 | 📋 | Analgesic effect of Coptis chinensis rhizomes (Coptidis Rhizoma) extract on rat model of irritable bowel syndrome |
| Coptis Chinensis | Liver Cancer | 2 | PM | 33946527 | 📋 | ROS-Mediated Anti-Tumor Effect of Coptidis Rhizoma against Human Hepatocellular Carcinoma Hep3B Cells and Xenografts |
| Coptis Chinensis | Liver Cancer | 6 | PM | 29867512 | 📋 | Coptisine Induces Apoptosis in Human Hepatoma Cells Through Activating 67-kDa Laminin Receptor/cGMP Signaling |
| Coptis Chinensis | Liver Cancer | 5 | PM | 29710498 | 📋 | Coptisine from Rhizoma coptidis exerts an anti-cancer effect on hepatocellular carcinoma by up-regulating miR-122 |
| Coptis Chinensis | Liver Cancer | 3 | PM | 24363282 | 📋 | Suppression of vascular endothelial growth factor via inactivation of eukaryotic elongation factor 2 by alkaloids in Coptidis rhizome in hepatocellular carcinoma |
| Coptis Chinensis | Liver Cancer | 4 | PM | 21106616 | 📋 | F-actin reorganization and inactivation of rho signaling pathway involved in the inhibitory effect of Coptidis Rhizoma on hepatoma cell migration |
| Coptis Chinensis | Liver Cancer | 1 | PM | 19724899 | 📋 | Coptis Chinensis Inhibits Hepatocellular Carcinoma Cell Growth Through Nonsteroidal Anti-Inflammatory Drug-Activated Gene Activation |
| Coptis Chinensis | Non-Alcoholic Steatohepatitis | 2 | PM | 38103844 | 📋 | Integrating transcriptomics and network pharmacology to reveal the mechanisms of total Rhizoma Coptidis alkaloids against nonalcoholic steatohepatitis |
| Coptis Chinensis | Non-Alcoholic Steatohepatitis | 1 | PM | 37482263 | 📋 | Protective effects of scutellaria-coptis herb couple against non-alcoholic steatohepatitis via activating NRF2 and FXR pathways in vivo and in vitro |
| Coptis Chinensis | Oral Cancer | 1 | PM | 34674717 | 📋 | Huanglianjiedu Decoction as an effective treatment for oral squamous cell carcinoma based on network pharmacology and experimental validation |
| Coptis Chinensis | Oral Candidiasis | 1 | PM | 38729536 | 📋 | Coptidis rhizoma extract alleviates oropharyngeal candidiasis by gC1qR-EGFR/ERK/c-fos axis-induced endocytosis of oral epithelial cells |
| Coptis Chinensis | Ulcerative Colitis | 3 | PM | 37595814 | 📋 | Combination of Coptis chinensis polysaccharides and berberine ameliorates ulcerative colitis by regulating gut microbiota and activating AhR/IL-22 pathway |
| Coptis Chinensis | Ulcerative Colitis | 2 | PM | 36532769 | 📋 | Therapeutic targets and pharmacological mechanisms of Coptidis Rhizoma against ulcerative colitis: Findings of system pharmacology and bioinformatics analysis |
| Coptis Chinensis | Ulcerative Colitis | 1 | PM | 35030387 | 📋 | Effect of Coptis chinensis franch and Magnolia officinalis on intestinal flora and intestinal barrier in a TNBS-induced ulcerative colitis rats model |
