Substance | Condition | Seq | Src | PMID | Dtl | Title |
Berberine | Acute Liver Failure | 1 | PM | 29191769 | 📋 | Berberine protects acute liver failure in mice through inhibiting inflammation and mitochondria-dependent apoptosis |
Berberine | Acute Liver Injury | 1 | PM | 31432116 | 📋 | Berberine Ameliorates CCl4‑induced Liver Injury in Rats Through Regulation of the Nrf2‑Keap1‑ARE and p53 Signaling Pathways |
Berberine | Acute Pancreatitis | 1 | PM | 30066867 | 📋 | Cognitive Impairments Induced by Severe Acute Pancreatitis Are Attenuated by Berberine Treatment in Rats |
Berberine | Acute Pancreatitis | 2 | PM | 28797013 | 📋 | Effects of Berberine on Acute Necrotizing Pancreatitis and Associated Lung Injury |
Berberine | Acute Pancreatitis | 3 | PM | 27148818 | 📋 | Berberine Inhibits Inflammatory Mediators and Attenuates Acute Pancreatitis Through Deactivation of JNK Signaling Pathways |
Berberine | Atrophic Gastritis | 1 | PM | 34265298 | 📋 | Therapeutic effect of berberine on chronic atrophic gastritis based on plasma and urine metabolisms |
Berberine | Atrophic Gastritis | 2 | PM | 33841162 | 📋 | Berberine Attenuates Chronic Atrophic Gastritis Induced by MNNG and Its Potential Mechanism |
Berberine | Atrophic Gastritis | 3 | PM | 33340526 | 📋 | Berberine regulates macrophage polarization through IL-4-STAT6 signaling pathway in Helicobacter pylori-induced chronic atrophic gastritis |
Berberine | Atrophic Gastritis | 4 | PM | 32097666 | 📋 | Mechanism of Berberine in Treating Helicobacter Pylori Induced Chronic Atrophic Gastritis Through IRF8-IFN-γ Signaling Axis Suppressing |
Berberine | Autoimmune Hepatitis | 2 | PM | 38466881 | 📋 | Berberine alleviates concanavalin A-induced autoimmune hepatitis in mice by modulating the gut microbiota |
Berberine | Autoimmune Hepatitis | 1 | PM | 29283990 | 📋 | The Effects of Berberine on Concanavalin A-Induced Autoimmune Hepatitis (AIH) in Mice and the Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase (AMPK) Pathway |
Berberine | Biliary Tract Cancer | 2 | PM | 36308362 | 📋 | Low Dose Berberine Suppresses Cholangiocarcinoma Cell Progression as a Multi-Kinase Inhibitor |
Berberine | Biliary Tract Cancer | 1 | PM | 28566619 | 📋 | Berberine Induces Cell Cycle Arrest in Cholangiocarcinoma Cell Lines via Inhibition of NF-κB and STAT3 Pathways |
Berberine | Colitis | 16 | PM | 36528592 | 📋 | Berberine increases stromal production of Wnt molecules and activates Lgr5+ stem cells to promote epithelial restitution in experimental colitis |
Berberine | Colitis | 15 | PM | 35980327 | 📋 | A Combination of Baicalin and Berberine Hydrochloride Ameliorates Dextran Sulfate Sodium-Induced Colitis by Modulating Colon Gut Microbiota |
Berberine | Colitis | 14 | PM | 35259053 | 📋 | Berberine represses Wnt/β-catenin pathway activation via modulating the microRNA-103a-3p/Bromodomain-containing protein 4 axis, thereby refraining pyroptosis and reducing the intestinal mucosal barrier defect induced via colitis |
Berberine | Colitis | 10 | PM | 33285228 | 📋 | Berberine improves colitis by triggering AhR activation by microbial tryptophan catabolites |
Berberine | Colitis | 9 | PM | 33061833 | 📋 | Anticolitic Effect of Berberine in Rat Experimental Model: Impact of PGE2/p38 MAPK Pathways |
Berberine | Colitis | 8 | PM | 32800336 | 📋 | Regulation of MFN2 by berberine alleviates obesity exacerbated colitis |
Berberine | Colitis | 13 | PM | 32564751 | 📋 | Berberine Administration in Treatment of Colitis: A Review |
Berberine | Colitis | 7 | PM | 32483416 | 📋 | Rescuing Dicer Expression in Inflamed Colon Tissues Alleviates Colitis and Prevents Colitis-Associated Tumorigenesis |
Berberine | Colitis | 18 | PM | 31866303 | 📋 | Circadian pharmacological effects of berberine on chronic colitis in mice: Role of the clock component Rev-erbα |
Berberine | Colitis | 6 | PM | 31417110 | 📋 | Berberine Improved Experimental Chronic Colitis by Regulating Interferon-γ- And IL-17A-producing Lamina Propria CD4 + T Cells Through AMPK Activation |
Berberine | Colitis | 4 | PM | 31354497 | 📋 | Berberine Protects Mice Against Dextran Sulfate Sodium-Induced Colitis by Activating mTORC1 Pathway |
Berberine | Colitis | 5 | PM | 29891588 | 📋 | Berberine Upregulates P-Glycoprotein in Human Caco-2 Cells and in an Experimental Model of Colitis in the Rat via Activation of Nrf2-Dependent Mechanisms |
Berberine | Colitis | 3 | PM | 29482156 | 📋 | Berberine Inhibits Macrophage M1 Polarization via AKT1/SOCS1/NF-κB Signaling Pathway to Protect Against DSS-induced Colitis |
Berberine | Colitis | 2 | PM | 28759012 | 📋 | Berberine Inhibits Colitis-Associated Tumorigenesis via Suppressing Inflammatory Responses and the Consequent EGFR Signaling-Involved Tumor Cell Growth |
Berberine | Colitis | 1 | PM | 28587416 | 📋 | Berberine Alleviates Dextran Sodium Sulfate-Induced Colitis by Improving Intestinal Barrier Function and Reducing Inflammation and Oxidative Stress |
Berberine | Colitis | 12 | PM | 24363687 | 📋 | Comparative Study of Berberis vulgaris Fruit Extract and Berberine Chloride Effects on Acetic Acid-Induced Colitis in Rats |
Berberine | Colitis | 17 | PM | 22173918 | 📋 | Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice |
Berberine | Colitis | 11 | PM | 20828550 | 📋 | Berberine ameliorates TNBS-induced colitis by inhibiting lipid peroxidation, enterobacterial growth and NF-κB activation |
Berberine | Colon Cancer | 24 | PM | 38312643 | 📋 | Berberine improved the microbiota in lung tissue of colon cancer and reversed the bronchial epithelial cell changes caused by cancer cells |
Berberine | Colon Cancer | 23 | PM | 38020547 | 📋 | Study on the mechanism of action of effective monomeric, berberine of Xianglian Pill in inhibiting human colon cancer cells based on fatty acid synthase target |
Berberine | Colon Cancer | 22 | PM | 37639199 | 📋 | Suppression of colon cancer growth by berberine mediated by the intestinal microbiota and the suppression of DNA methyltransferases (DNMTs) |
Berberine | Colon Cancer | 17 | PM | 37175233 | 📋 | Berberine Inhibited Growth and Migration of Human Colon Cancer Cell Lines by Increasing Phosphatase and Tensin and Inhibiting Aquaporins 1, 3 and 5 Expressions |
Berberine | Colon Cancer | 16 | PM | 35837174 | 📋 | c-MYC and HIF1α promoter G-quadruplexes dependent metabolic regulation mechanism of berberine in colon cancer |
Berberine | Colon Cancer | 15 | PM | 35641094 | 📋 | Berberine suppresses the migration and invasion of colon cancer cells by inhibition of lipogenesis through modulation of promyelocytic leukemia zinc finger-mediated sterol-regulatory element binding proteins cleavage-activating protein ubiquitination |
Berberine | Colon Cancer | 14 | PM | 35572672 | 📋 | Suppression of Berberine and Probiotics ( in vitro and in vivo) on the Growth of Colon Cancer With Modulation of Gut Microbiota and Butyrate Production |
Berberine | Colon Cancer | 13 | PM | 35063579 | 📋 | β-catenin correlates with the progression of colon cancers and berberine inhibits the proliferation of colon cancer cells by regulating the β-catenin signaling pathway |
Berberine | Colon Cancer | 12 | PM | 34028068 | 📋 | Demethyleneberberine promotes apoptosis and suppresses TGF-β/Smads induced EMT in the colon cancer cells HCT-116 |
Berberine | Colon Cancer | 11 | PM | 33806918 | 📋 | Quantitative Proteomics Analysis of Berberine-Treated Colon Cancer Cells Reveals Potential Therapy Targets |
Berberine | Colon Cancer | 10 | PM | 33417512 | 📋 | Berberine regulates the Notch1/PTEN/PI3K/AKT/mTOR pathway and acts synergistically with 17-AAG and SAHA in SW480 colon cancer cells |
Berberine | Colon Cancer | 9 | PM | 32483416 | 📋 | Rescuing Dicer Expression in Inflamed Colon Tissues Alleviates Colitis and Prevents Colitis-Associated Tumorigenesis |
Berberine | Colon Cancer | 2 | PM | 31874145 | 📋 | Berberine Suppresses Colon Cancer Cell Proliferation by Inhibiting the SCAP/SREBP-1 Signaling Pathway-Mediated Lipogenesis |
Berberine | Colon Cancer | 4 | PM | 31663444 | 📋 | Berberine and Tinospora cordifolia Exert a Potential Anticancer Effect on Colon Cancer Cells by Acting on Specific Pathways |
Berberine | Colon Cancer | 6 | PM | 30536375 | 📋 | Berberine Reversed the Epithelial-Mesenchymal Transition of Normal Colonic Epithelial Cells Induced by SW480 Cells Through Regulating the Important Components in the TGF-β Pathway |
Berberine | Colon Cancer | 20 | PM | 30195873 | 📋 | Coptisine-induced apoptosis in human colon cancer cells (HCT-116) is mediated by PI3K/Akt and mitochondrial-associated apoptotic pathway |
Berberine | Colon Cancer | 8 | PM | 29938466 | 📋 | Potential Prophylactic Effect of Berberine Against Rat Colon Carcinoma Induce by 1,2-Dimethyl Hydrazine |
Berberine | Colon Cancer | 5 | PM | 29565467 | 📋 | Berberine Decelerates Glucose Metabolism via Suppression of mTOR‑dependent HIF‑1α Protein Synthesis in Colon Cancer Cells |
Berberine | Colon Cancer | 7 | PM | 28846104 | 📋 | Berberine Binds RXRα to Suppress β-Catenin Signaling in Colon Cancer Cells |
Berberine | Colon Cancer | 19 | PM | 24173769 | 📋 | Berberine enhances chemosensitivity to irinotecan in colon cancer via inhibition of NF‑κB |
Berberine | Colon Cancer | 18 | PM | 24015932 | 📋 | Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling |
Berberine | Colon Cancer | 3 | PM | 22469784 | 📋 | Berberine Inhibits the Proliferation of Colon Cancer Cells by Inactivating Wnt/β-catenin Signaling |
Berberine | Colon Cancer | 21 | PM | 21747769 | 📋 | Berberine Reduces cAMP-Induced Chloride Secretion in T84 Human Colonic Carcinoma Cells through Inhibition of Basolateral KCNQ1 Channels |
Berberine | Colon Cancer | 1 | PM | 21246838 | 📋 | [Preventive Effects of Berberine on Experimental Colon Cancer and Relationship With cyclooxygenase-2 Expression] |
Berberine | Colorectal Cancer | 39 | PM | 38742849 | 📋 | Berberine: Potential preventive and therapeutic strategies for human colorectal cancer |
Berberine | Colorectal Cancer | 38 | PM | 38049785 | 📋 | Identification of FtfL as a novel target of berberine in intestinal bacteria |
Berberine | Colorectal Cancer | 37 | PM | 37757496 | 📋 | Berberine: An inspiring resource for the treatment of colorectal diseases |
Berberine | Colorectal Cancer | 36 | PM | 37553874 | 📋 | Berberine might block colorectal carcinogenesis by inhibiting the regulation of B-cell function by Veillonella parvula |
Berberine | Colorectal Cancer | 35 | PM | 37404762 | 📋 | Liquid chromatography-tandem mass spectrometry analysis of a ratio-optimized drug pair of Sophora flavescens Aiton and Coptis chinensis Franch and study on the mechanism of anti-colorectal cancer effect of two alkaloids thereof |
Berberine | Colorectal Cancer | 32 | PM | 37151876 | 📋 | Berberine inhibits high fat diet-associated colorectal cancer through modulation of the gut microbiota-mediated lysophosphatidylcholine |
Berberine | Colorectal Cancer | 31 | PM | 37059377 | 📋 | Berberine induces SOCS1 pathway to reprogram the M1 polarization of macrophages via miR-155-5p in colitis-associated colorectal cancer |
Berberine | Colorectal Cancer | 30 | PM | 37028248 | 📋 | Berberine is a suppressor of Hedgehog signaling cascade in colorectal cancer |
Berberine | Colorectal Cancer | 29 | PM | 36822301 | 📋 | Berberine promotes IGF2BP3 ubiquitination by TRIM21 to induce G1/S phase arrest in colorectal cancer cells |
Berberine | Colorectal Cancer | 28 | PM | 36394793 | 📋 | Zinc Acts Synergistically with Berberine for Enhancing Its Efficacy as an Anti-cancer Agent by Inducing Clusterin-Dependent Apoptosis in HT-29 Colorectal Cancer Cells |
Berberine | Colorectal Cancer | 27 | PM | 36130331 | 📋 | Berberine inhibits tumour growth in vivo and in vitro through suppressing the lincROR-Wnt/β-catenin regulatory axis in colorectal cancer |
Berberine | Colorectal Cancer | 26 | PM | 35992091 | 📋 | Chemoproteomics reveals berberine directly binds to PKM2 to inhibit the progression of colorectal cancer |
Berberine | Colorectal Cancer | 25 | PM | 35802997 | 📋 | Berberine inhibited the formation of metastasis by intervening the secondary homing of colorectal cancer cells in the blood circulation to the lung and liver through HEY2 |
Berberine | Colorectal Cancer | 24 | PM | 35679795 | 📋 | Berberine suppresses colorectal cancer by regulation of Hedgehog signaling pathway activity and gut microbiota |
Berberine | Colorectal Cancer | 23 | PM | 35660350 | 📋 | Berberine regulates short-chain fatty acid metabolism and alleviates the colitis-associated colorectal tumorigenesis through remodeling intestinal flora |
Berberine | Colorectal Cancer | 22 | PM | 35600365 | 📋 | Berberine and Oligomeric Proanthocyanidins Exhibit Synergistic Efficacy Through Regulation of PI3K-Akt Signaling Pathway in Colorectal Cancer |
Berberine | Colorectal Cancer | 21 | PM | 35596224 | 📋 | Berberine inhibits intestinal carcinogenesis by suppressing intestinal pro-inflammatory genes and oncogenic factors through modulating gut microbiota |
Berberine | Colorectal Cancer | 20 | PM | 35572960 | 📋 | Berberine as a Potential Agent for the Treatment of Colorectal Cancer |
Berberine | Colorectal Cancer | 19 | PM | 35337060 | 📋 | A Combined Treatment with Berberine and Andrographis Exhibits Enhanced Anti-Cancer Activity through Suppression of DNA Replication in Colorectal Cancer |
Berberine | Colorectal Cancer | 16 | PM | 35215376 | 📋 | Pre-Administration of Berberine Exerts Chemopreventive Effects in AOM/DSS-Induced Colitis-Associated Carcinogenesis Mice via Modulating Inflammation and Intestinal Microbiota |
Berberine | Colorectal Cancer | 18 | PM | 34869024 | 📋 | Berberine Suppresses Stemness and Tumorigenicity of Colorectal Cancer Stem-Like Cells by Inhibiting m 6 A Methylation |
Berberine | Colorectal Cancer | 17 | PM | 34509605 | 📋 | Efficacy and safety of berberine in preventing recurrence of colorectal adenomas: A systematic review and meta-analysis |
Berberine | Colorectal Cancer | 14 | PM | 33450878 | 📋 | Berberine Inhibits Telomerase Activity and Induces Cell Cycle Arrest and Telomere Erosion in Colorectal Cancer Cell Line, HCT 116 |
Berberine | Colorectal Cancer | 13 | PM | 33072135 | 📋 | A Holistic View of Berberine Inhibiting Intestinal Carcinogenesis in Conventional Mice Based on Microbiome-Metabolomics Analysis |
Berberine | Colorectal Cancer | 12 | PM | 32958873 | 📋 | Berberine inhibits colorectal tumor growth by suppressing SHH secretion |
Berberine | Colorectal Cancer | 11 | PM | 32926933 | 📋 | Berberine inhibits proliferation and induces G0/G1 phase arrest in colorectal cancer cells by downregulating IGF2BP3 |
Berberine | Colorectal Cancer | 10 | PM | 32109457 | 📋 | Combined Effects of Berberine and Evodiamine on Colorectal Cancer Cells and Cardiomyocytes in Vitro |
Berberine | Colorectal Cancer | 1 | PM | 31926918 | 📋 | Berberine Versus Placebo for the Prevention of Recurrence of Colorectal Adenoma: A Multicentre, Double-Blinded, Randomised Controlled Study |
Berberine | Colorectal Cancer | 9 | PM | 31743135 | 📋 | Berberine Inhibits Proliferation and Migration of Colorectal Cancer Cells by Downregulation of GRP78 |
Berberine | Colorectal Cancer | 15 | PM | 31173223 | 📋 | Long non‑coding RNA CASC2 enhances berberine‑induced cytotoxicity in colorectal cancer cells by silencing BCL2 |
Berberine | Colorectal Cancer | 6 | PM | 30257361 | 📋 | Effects of Berberine on Tumor Growth and Intestinal Permeability in HCT116 Tumor-Bearing Mice Using Polyamines as Targets |
Berberine | Colorectal Cancer | 7 | PM | 30205580 | 📋 | The Effects of Berberine on the Gut Microbiota in Apc min/+ Mice Fed With a High Fat Diet |
Berberine | Colorectal Cancer | 5 | PM | 28759012 | 📋 | Berberine Inhibits Colitis-Associated Tumorigenesis via Suppressing Inflammatory Responses and the Consequent EGFR Signaling-Involved Tumor Cell Growth |
Berberine | Colorectal Cancer | 3 | PM | 28098901 | 📋 | Effect of Evodiamine and Berberine on the Interaction Between DNMTs and Target microRNAs During Malignant Transformation of the Colon by TGF-β1 |
Berberine | Colorectal Cancer | 4 | PM | 27493671 | 📋 | Berberine Inhibits Intestinal Polyps Growth in Apc (Min/+) Mice via Regulation of Macrophage Polarization |
Berberine | Colorectal Cancer | 8 | PM | 26463023 | 📋 | [Effect and Mechanism of EGFR Expression in Macrophages on the Anti-Cancer Effect of Berberine on Colorectal Cancer] |
Berberine | Colorectal Cancer | 2 | PM | 25954974 | 📋 | Berberine Inhibits Invasion and Metastasis of Colorectal Cancer Cells via COX-2/PGE2 Mediated JAK2/STAT3 Signaling Pathway |
Berberine | Colorectal Cancer | 33 | PM | 23604974 | 📋 | Berberine inhibits the growth of human colorectal adenocarcinoma in vitro and in vivo |
Berberine | Colorectal Cancer | 34 | PM | 22193446 | 📋 | [Berberine activates volume-sensitive chloride channel in human colorectal carcinoma cells] |
Berberine | Diarrhea | 3 | PM | 33149763 | 📋 | Berberine for diarrhea in children and adults: a systematic review and meta-analysis |
Berberine | Diarrhea | 2 | PM | 32283882 | 📋 | Role of a Berberine-Based Nutritional Supplement in Reducing Diarrhea in Subjects With Functional Gastrointestinal Disorders |
Berberine | Diarrhea | 1 | PM | 19243699 | 📋 | The Effect of Berberine in Vitro on Tight Junctions in Human Caco-2 Intestinal Epithelial Cells |
Berberine | Diarrhea | 4 | PM | 3935203 | 📋 | Clinical trial of berberine in acute watery diarrhoea |
Berberine | Dysbiosis | 21 | PM | 37599699 | 📋 | Berberine influences multiple diseases by modifying gut microbiota |
Berberine | Dysbiosis | 20 | PM | 36465656 | 📋 | Multi-target regulation of intestinal microbiota by berberine to improve type 2 diabetes mellitus |
Berberine | Dysbiosis | 19 | PM | 35721198 | 📋 | Modulation of Gut Microbiota and Metabolites by Berberine in Treating Mice With Disturbances in Glucose and Lipid Metabolism |
Berberine | Dysbiosis | 18 | PM | 35611943 | 📋 | Responses of human gut microbiota abundance and amino acid metabolism in vitro to berberine |
Berberine | Dysbiosis | 17 | PM | 35499044 | 📋 | Gut microbiota specifically mediates the anti-hypercholesterolemic effect of berberine (BBR) and facilitates to predict BBR's cholesterol-decreasing efficacy in patients |
Berberine | Dysbiosis | 16 | PM | 35082799 | 📋 | The Potential Prebiotic Berberine Combined With Methimazole Improved the Therapeutic Effect of Graves' Disease Patients Through Regulating the Intestinal Microbiome |
Berberine | Dysbiosis | 15 | PM | 34984827 | 📋 | Berberine ameliorates aGVHD by gut microbiota remodelling, TLR4 signalling suppression and colonic barrier repairment for NLRP3 inflammasome inhibition |
Berberine | Dysbiosis | 14 | PM | 34921647 | 📋 | Anti-obesity and Gut Microbiota Modulation Effect of Astragalus Polysaccharides Combined with Berberine on High-Fat Diet-Fed Obese Mice |
Berberine | Dysbiosis | 13 | PM | 34480937 | 📋 | Berberine combined with stachyose improves glycometabolism and gut microbiota through regulating colonic microRNA and gene expression in diabetic rats |
Berberine | Dysbiosis | 12 | PM | 34365978 | 📋 | Effectiveness and safety of Bifidobacterium and berberine in human hyperglycemia and their regulatory effect on the gut microbiota: a multi-center, double-blind, randomized, parallel-controlled study |
Berberine | Dysbiosis | 11 | PM | 34025574 | 📋 | Berberine Slows the Progression of Prediabetes to Diabetes in Zucker Diabetic Fatty Rats by Enhancing Intestinal Secretion of Glucagon-Like Peptide-2 and Improving the Gut Microbiota |
Berberine | Dysbiosis | 10 | PM | 33923174 | 📋 | Prebiotic Effect of Berberine and Curcumin Is Associated with the Improvement of Obesity in Mice |
Berberine | Dysbiosis | 9 | PM | 33716449 | 📋 | Effect of berberine on hyperglycaemia and gut microbiota composition in type 2 diabetic Goto-Kakizaki rats |
Berberine | Dysbiosis | 8 | PM | 33680978 | 📋 | Effects of Berberine on the Gastrointestinal Microbiota |
Berberine | Dysbiosis | 7 | PM | 33623004 | 📋 | Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson's disease by regulating gut microbiota |
Berberine | Dysbiosis | 6 | PM | 33558654 | 📋 | Berberine alleviates visceral hypersensitivity in rats by altering gut microbiome and suppressing spinal microglial activation |
Berberine | Dysbiosis | 5 | PM | 33493658 | 📋 | Berberine ameliorates ovariectomy-induced anxiety-like behaviors by enrichment in equol generating gut microbiota |
Berberine | Dysbiosis | 4 | PM | 33430766 | 📋 | Berberine alters gut microbial function through modulation of bile acids |
Berberine | Dysbiosis | 3 | PM | 33359679 | 📋 | Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota Are Attributable to Its Key Ingredient Berberine |
Berberine | Dysbiosis | 2 | PM | 32937246 | 📋 | Berberine alleviates type 2 diabetic symptoms by altering gut microbiota and reducing aromatic amino acids |
Berberine | Dysbiosis | 1 | PM | 32231564 | 📋 | Effect of Berberine on Atherosclerosis and Gut Microbiota Modulation and Their Correlation in High-Fat Diet-Fed ApoE-/- Mice |
Berberine | Esophageal Cancer | 1 | PM | 28465635 | 📋 | Berberine Displays Antitumor Activity in Esophageal Cancer Cells in vitro |
Berberine | Esophageal Cancer | 2 | PM | 27876206 | 📋 | Synergistic anti-cancer effects of galangin and berberine through apoptosis induction and proliferation inhibition in oesophageal carcinoma cells |
Berberine | Esophageal Cancer | 4 | PM | 26667771 | 📋 | Role of Berberine on molecular markers involved in migration of esophageal cancer cells |
Berberine | Esophageal Cancer | 3 | PM | 24025355 | 📋 | Berberine enhances radiosensitivity of esophageal squamous cancer by targeting HIF-1α in vitro and in vivo |
Berberine | Familial Adenomatous Polyposis | 1 | PM | 27493671 | 📋 | Berberine Inhibits Intestinal Polyps Growth in Apc (Min/+) Mice via Regulation of Macrophage Polarization |
Berberine | Familial Adenomatous Polyposis | 2 | PM | 24015932 | 📋 | Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling |
Berberine | Gastric Cancer | 13 | PM | 36108874 | 📋 | Berberine for gastric cancer prevention and treatment: Multi-step actions on the Correa's cascade underlie its therapeutic effects |
Berberine | Gastric Cancer | 12 | PM | 35582103 | 📋 | Berberine retarded the growth of gastric cancer xenograft tumors by targeting hepatocyte nuclear factor 4α |
Berberine | Gastric Cancer | 11 | PM | 35341784 | 📋 | Combination of berberine and low glucose inhibits gastric cancer through the PP2A/GSK3β/MCL-1 signaling pathway |
Berberine | Gastric Cancer | 10 | PM | 34968467 | 📋 | Berberine inhibits gastric cancer development and progression by regulating the JAK2/STAT3 pathway and downregulating IL-6 |
Berberine | Gastric Cancer | 9 | PM | 34712379 | 📋 | Berberine Suppresses EMT in Liver and Gastric Carcinoma Cells through Combination with TGF β R Regulating TGF- β/Smad Pathway |
Berberine | Gastric Cancer | 8 | PM | 34055022 | 📋 | Effects of Berberine on Circular RNA Expression Profiles in Human Gastric Cancer Cells |
Berberine | Gastric Cancer | 7 | PM | 33362566 | 📋 | Berberine Improves Chemo-Sensitivity to Cisplatin by Enhancing Cell Apoptosis and Repressing PI3K/AKT/mTOR Signaling Pathway in Gastric Cancer |
Berberine | Gastric Cancer | 6 | PM | 32454290 | 📋 | Berberine Represses Human Gastric Cancer Cell Growth in Vitro and in Vivo by Inducing Cytostatic Autophagy via Inhibition of MAPK/mTOR/p70S6K and Akt Signaling Pathways |
Berberine | Gastric Cancer | 5 | PM | 32328135 | 📋 | Berberine Suppressed Tumor Growth Through Regulating Fatty Acid Metabolism and Triggering Cell Apoptosis via Targeting FABPs |
Berberine | Gastric Cancer | 4 | PM | 32277648 | 📋 | Berberine Inhibits Human Gastric Cancer Cell Growth via Deactivation of p38/JNK Pathway, Induction of Mitochondrial-Mediated Apoptosis, Caspase Activation and NF-κB Inhibition |
Berberine | Gastric Cancer | 2 | PM | 27142767 | 📋 | Berberine Modulates Cisplatin Sensitivity of Human Gastric Cancer Cells by Upregulation of miR-203 |
Berberine | Gastric Cancer | 1 | PM | 26492225 | 📋 | Berberine and Curcumin Target Survivin and STAT3 in Gastric Cancer Cells and Synergize Actions of Standard Chemotherapeutic 5-Fluorouracil |
Berberine | Gastric Cancer | 3 | PM | 25045784 | 📋 | Synergistic Inhibitory Effect of Berberine and D-Limonene on Human Gastric Carcinoma Cell Line MGC803 |
Berberine | Gastric Cancer | 14 | PM | 24063987 | 📋 | Berberine counteracts enhanced IL-8 expression of AGS cells induced by evodiamine |
Berberine | Gastric Ulcer | 1 | PM | 38193042 | 📋 | Protective Effect of Berberine on Acute Gastric Ulcer by Promotion of Tricarboxylic Acid Cycle-Mediated Arachidonic Acid Metabolism |
Berberine | Gastritis | 1 | PM | 29345340 | 📋 | Berberine Demonstrates Anti-Inflammatory Properties in Helicobacter Pylori-Infected Mice With Chronic Gastritis by Attenuating the Th17 Response Triggered by the B Cell-Activating Factor |
Berberine | Gastrointestinal Cancer | 4 | PM | 37047563 | 📋 | Berberine Induces Combined Cell Death in Gastrointestinal Cell Lines |
Berberine | Gastrointestinal Cancer | 3 | PM | 36915942 | 📋 | The therapeutic effects of berberine for gastrointestinal cancers |
Berberine | Gastrointestinal Cancer | 2 | PM | 33130557 | 📋 | Berberine represses β-catenin translation involving 4E-BPs in hepatocellular carcinoma cells |
Berberine | Gastrointestinal Cancer | 1 | PM | 30125974 | 📋 | Berberine: A Potential Adjunct for the Treatment of Gastrointestinal Cancers? |
Berberine | Gastrointestinal Cancer | 5 | PM | 24279644 | 📋 | Chemopreventive effects of berberine on intestinal tumor development in Apcmin/+ mice |
Berberine | Gastroparesis | 1 | PM | 37026044 | 📋 | Berberine ameliorates the neurological dysfunction of the gastric fundus by promoting calcium channels dependent release of ACh in STZ-induced diabetic rats |
Berberine | GERD | 1 | PM | 24137243 | 📋 | Berberine protects against esophageal mucosal damage in reflux esophagitis by suppressing proinflammatory cytokines |
Berberine | Helicobacter Pylori Infection | 8 | PM | 37469024 | 📋 | Efficacy and safety of triple therapy containing berberine, amoxicillin, and vonoprazan for Helicobacter pylori initial treatment: A randomized controlled trial |
Berberine | Helicobacter Pylori Infection | 7 | PM | 36415112 | 📋 | Efficacy and safety of triple therapy containing berberine hydrochloride, amoxicillin and rabeprazole in the eradication of Helicobacter pylori |
Berberine | Helicobacter Pylori Infection | 6 | PM | 33340526 | 📋 | Berberine regulates macrophage polarization through IL-4-STAT6 signaling pathway in Helicobacter pylori-induced chronic atrophic gastritis |
Berberine | Helicobacter Pylori Infection | 1 | PM | 32116685 | 📋 | The Efficacy of Berberine-Containing Quadruple Therapy on Helicobacter Pylori Eradication in China: A Systematic Review and Meta-Analysis of Randomized Clinical Trials |
Berberine | Helicobacter Pylori Infection | 4 | PM | 32097666 | 📋 | Mechanism of Berberine in Treating Helicobacter Pylori Induced Chronic Atrophic Gastritis Through IRF8-IFN-γ Signaling Axis Suppressing |
Berberine | Helicobacter Pylori Infection | 3 | PM | 29345340 | 📋 | Berberine Demonstrates Anti-Inflammatory Properties in Helicobacter Pylori-Infected Mice With Chronic Gastritis by Attenuating the Th17 Response Triggered by the B Cell-Activating Factor |
Berberine | Helicobacter Pylori Infection | 2 | PM | 28796053 | 📋 | Berberine Containing Quadruple Therapy for Initial Helicobacter Pylori Eradication: An Open-Label Randomized Phase IV Trial |
Berberine | Helicobacter Pylori Infection | 5 | PM | 25892872 | 📋 | Inhibitory Effects of Emodin, Baicalin, Schizandrin and Berberine on hefA Gene: Treatment of Helicobacter Pylori-Induced Multidrug Resistance |
Berberine | Hepatic Encephalopathy | 1 | PM | 37371422 | 📋 | Effect of Berberine against Cognitive Deficits in Rat Model of Thioacetamide-Induced Liver Cirrhosis and Hepatic Encephalopathy (Behavioral, Biochemical, Molecular and Histological Evaluations) |
Berberine | Hepatic Fibrosis | 5 | PM | 37062521 | 📋 | Berberine attenuates liver fibrosis by autophagy inhibition triggering apoptosis via the miR-30a-5p/ATG5 axis |
Berberine | Hepatic Fibrosis | 4 | PM | 35308208 | 📋 | Therapeutic Effects of Berberine on Liver Fibrosis are associated With Lipid Metabolism and Intestinal Flora |
Berberine | Hepatic Fibrosis | 2 | PM | 34864819 | 📋 | Berberine alleviates liver fibrosis through inducing ferrous redox to activate ROS-mediated hepatic stellate cells ferroptosis |
Berberine | Hepatic Fibrosis | 1 | PM | 30138605 | 📋 | Antioxidant and Anti-Inflammatory Activities of Berberine Attenuate Hepatic Fibrosis Induced by Thioacetamide Injection in Rats |
Berberine | Hepatic Fibrosis | 6 | PM | 23734997 | 📋 | Resolution of liver fibrosis by isoquinoline alkaloid berberine in CCl₄-intoxicated mice is mediated by suppression of oxidative stress and upregulation of MMP-2 expression |
Berberine | Hepatic Fibrosis | 7 | PM | 23190573 | 📋 | A comparative study on the hepatoprotective action of bear bile and Coptidis Rhizoma aqueous extract on experimental liver fibrosis in rats |
Berberine | Hepatic Fibrosis | 3 | PM | 19721228 | 📋 | Berberine Inhibits Hepatic Stellate Cell Proliferation and Prevents Experimental Liver Fibrosis |
Berberine | Hepatic Ischemia-Reperfusion | 1 | PM | 37780378 | 📋 | Berberine protects hepatocyte from hypoxia/reoxygenation-induced injury through inhibiting circDNTTIP2 |
Berberine | Hepatic Steatosis | 4 | PM | 35722423 | 📋 | Methyltransferase SETD2 mediates hepatoprotection of berberine against steatosis |
Berberine | Hepatic Steatosis | 3 | PM | 34790723 | 📋 | Berberine attenuates atherosclerotic lesions and hepatic steatosis in ApoE -/- mice by down-regulating PCSK9 via ERK1/2 pathway |
Berberine | Hepatic Steatosis | 2 | PM | 29477657 | 📋 | Berberine Induces miR-373 Expression in Hepatocytes to Inactivate Hepatic Steatosis Associated AKT-S6 Kinase Pathway |
Berberine | Hepatic Steatosis | 1 | PM | 29065221 | 📋 | Berberine Attenuates Hepatic Steatosis and Enhances Energy Expenditure in Mice by Inducing Autophagy and Fibroblast Growth Factor 21 |
Berberine | Hepatic Steatosis | 5 | PM | 28900305 | 📋 | Berberine ameliorates fatty acid-induced oxidative stress in human hepatoma cells |
Berberine | Hepatitis C | 1 | PM | 32276448 | 📋 | Targeting Autophagy Augments BBR-Mediated Cell Death in Human Hepatoma Cells Harboring Hepatitis C Virus RNA |
Berberine | Inflammatory Bowel Disease | 5 | PM | 35083737 | 📋 | Berberine and its derivatives represent as the promising therapeutic agents for inflammatory disorders |
Berberine | Inflammatory Bowel Disease | 4 | PM | 34358871 | 📋 | Berberine improves intestinal barrier function and reduces inflammation, immunosuppression, and oxidative stress by regulating the NF-κB/MAPK signaling pathway in deoxynivalenol-challenged piglets |
Berberine | Inflammatory Bowel Disease | 2 | PM | 33285228 | 📋 | Berberine improves colitis by triggering AhR activation by microbial tryptophan catabolites |
Berberine | Inflammatory Bowel Disease | 3 | PM | 33174609 | 📋 | Anti‑inflammatory mechanism of berberine on lipopolysaccharide‑induced IEC‑18 models based on comparative transcriptomics |
Berberine | Inflammatory Bowel Disease | 1 | PM | 27697643 | 📋 | Berberine and Inflammatory Bowel Disease: A Concise Review |
Berberine | Inflammatory Bowel Disease | 6 | PM | 22173918 | 📋 | Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice |
Berberine | Intestinal Injury | 4 | PM | 38474567 | 📋 | LC-MS-Based Metabolomics Reveals the Mechanism of Protection of Berberine against Indomethacin-Induced Gastric Injury in Rats |
Berberine | Intestinal Injury | 2 | PM | 35158228 | 📋 | Berberine suppresses cecal ligation and puncture induced intestinal injury by enhancing Treg cell function |
Berberine | Intestinal Injury | 1 | PM | 34174323 | 📋 | Berberine and/or zinc protect against methotrexate-induced intestinal damage: Role of GSK-3β/NRF2 and JAK1/STAT-3 signaling pathways |
Berberine | Intestinal Injury | 3 | PM | 21963898 | 📋 | Berberine protects against lipopolysaccharide-induced intestinal injury in mice via alpha 2 adrenoceptor-independent mechanisms |
Berberine | Intestinal Metaplasia | 1 | PM | 38837097 | 📋 | Exploring the therapeutic mechanisms of Coptidis Rhizoma in gastric precancerous lesions: a network pharmacology approach |
Berberine | Intestinal Mucositis | 1 | PM | 34795594 | 📋 | Berberine Improves Irinotecan-Induced Intestinal Mucositis Without Impairing the Anti-colorectal Cancer Efficacy of Irinotecan by Inhibiting Bacterial β-glucuronidase |
Berberine | Intestinal Permeability | 23 | PM | 38758516 | 📋 | Berberine mitigates diclofenac-induced intestinal mucosal mechanical barrier dysfunction through the restoration of autophagy by inhibiting exosome-mediated lncRNA H19 |
Berberine | Intestinal Permeability | 22 | PM | 38108311 | 📋 | Berberine decreases S100B generation to regulate gut vascular barrier permeability in mice with burn injury |
Berberine | Intestinal Permeability | 15 | PM | 37046128 | 📋 | Berberine Enhances Intestinal Mucosal Barrier Function by Promoting Vitamin D Receptor Activity |
Berberine | Intestinal Permeability | 14 | PM | 36168925 | 📋 | Berberine alleviates intestinal barrier dysfunction in glucolipid metabolism disorder hamsters by modulating gut microbiota and gut microbiota-related tryptophan metabolites |
Berberine | Intestinal Permeability | 13 | PM | 35693534 | 📋 | Anti-Hyperglycemic Agents in the Adjuvant Treatment of Sepsis: Improving Intestinal Barrier Function |
Berberine | Intestinal Permeability | 12 | PM | 35280677 | 📋 | Berberine ameliorates DSS-induced intestinal mucosal barrier dysfunction through microbiota-dependence and Wnt/β-catenin pathway |
Berberine | Intestinal Permeability | 11 | PM | 35259053 | 📋 | Berberine represses Wnt/β-catenin pathway activation via modulating the microRNA-103a-3p/Bromodomain-containing protein 4 axis, thereby refraining pyroptosis and reducing the intestinal mucosal barrier defect induced via colitis |
Berberine | Intestinal Permeability | 10 | PM | 34984827 | 📋 | Berberine ameliorates aGVHD by gut microbiota remodelling, TLR4 signalling suppression and colonic barrier repairment for NLRP3 inflammasome inhibition |
Berberine | Intestinal Permeability | 9 | PM | 34358871 | 📋 | Berberine improves intestinal barrier function and reduces inflammation, immunosuppression, and oxidative stress by regulating the NF-κB/MAPK signaling pathway in deoxynivalenol-challenged piglets |
Berberine | Intestinal Permeability | 8 | PM | 34253428 | 📋 | Dihydroberberine, an isoquinoline alkaloid, exhibits protective effect against dextran sulfate sodium-induced ulcerative colitis in mice |
Berberine | Intestinal Permeability | 7 | PM | 34025574 | 📋 | Berberine Slows the Progression of Prediabetes to Diabetes in Zucker Diabetic Fatty Rats by Enhancing Intestinal Secretion of Glucagon-Like Peptide-2 and Improving the Gut Microbiota |
Berberine | Intestinal Permeability | 6 | PM | 33285228 | 📋 | Berberine improves colitis by triggering AhR activation by microbial tryptophan catabolites |
Berberine | Intestinal Permeability | 5 | PM | 32961234 | 📋 | Berberine reduces gut-vascular barrier permeability via modulation of ApoM/S1P pathway in a model of polymicrobial sepsis |
Berberine | Intestinal Permeability | 4 | PM | 32750460 | 📋 | Berberine inhibits intestinal epithelial barrier dysfunction in colon caused by peritoneal dialysis fluid by improving cell migration |
Berberine | Intestinal Permeability | 3 | PM | 32403887 | 📋 | [Discussion on the Curative Effect and Mechanisms of Berberine in Rats With Non-Alcoholic Fatty Liver] |
Berberine | Intestinal Permeability | 2 | PM | 32360278 | 📋 | Berberine Improved Intestinal Barrier Function by Modulating the Intestinal Microbiota in Blunt Snout Bream (Megalobrama Amblycephala) Under Dietary High-Fat and High-Carbohydrate Stress |
Berberine | Intestinal Permeability | 20 | PM | 29202334 | 📋 | Berberine treatment increases Akkermansia in the gut and improves high-fat diet-induced atherosclerosis in Apoe-/- mice |
Berberine | Intestinal Permeability | 19 | PM | 29200733 | 📋 | Amelioration of Intestinal Barrier Dysfunction by Berberine in the Treatment of Nonalcoholic Fatty Liver Disease in Rats |
Berberine | Intestinal Permeability | 18 | PM | 29154866 | 📋 | Activation of IGF-1/IGFBP-3 signaling by berberine improves intestinal mucosal barrier of rats with acute endotoxemia |
Berberine | Intestinal Permeability | 17 | PM | 23757509 | 📋 | Alteration of the intestinal barrier and GLP2 secretion in Berberine-treated type 2 diabetic rats |
Berberine | Intestinal Permeability | 16 | PM | 23671580 | 📋 | Amelioration of IFN-γ and TNF-α-induced intestinal epithelial barrier dysfunction by berberine via suppression of MLCK-MLC phosphorylation signaling pathway |
Berberine | Intestinal Permeability | 21 | PM | 21592990 | 📋 | Berberine ameliorates intestinal epithelial tight-junction damage and down-regulates myosin light chain kinase pathways in a mouse model of endotoxinemia |
Berberine | Intestinal Permeability | 1 | PM | 20149867 | 📋 | Berberine Attenuates Pro-Inflammatory Cytokine-Induced Tight Junction Disruption in an in Vitro Model of Intestinal Epithelial Cells |
Berberine | Irritable Bowel Syndrome | 8 | PM | 38674895 | 📋 | The Possible Synergistic Pharmacological Effect of an Oral Berberine (BBR) and Curcumin (CUR) Complementary Therapy Alleviates Symptoms of Irritable Bowel Syndrome (IBS): Results from a Real-Life, Routine Clinical Practice Settings-Based Study |
Berberine | Irritable Bowel Syndrome | 6 | PM | 34594213 | 📋 | Therapeutic Effects of Berberine Hydrochloride on Stress-Induced Diarrhea-Predominant Irritable Bowel Syndrome Rats by Inhibiting Neurotransmission in Colonic Smooth Muscle |
Berberine | Irritable Bowel Syndrome | 5 | PM | 33558654 | 📋 | Berberine alleviates visceral hypersensitivity in rats by altering gut microbiome and suppressing spinal microglial activation |
Berberine | Irritable Bowel Syndrome | 4 | PM | 32283882 | 📋 | Role of a Berberine-Based Nutritional Supplement in Reducing Diarrhea in Subjects With Functional Gastrointestinal Disorders |
Berberine | Irritable Bowel Syndrome | 2 | PM | 31413530 | 📋 | Berberine Prevents Stress-Induced Gut Inflammation and Visceral Hypersensitivity and Reduces Intestinal Motility in Rats |
Berberine | Irritable Bowel Syndrome | 3 | PM | 29891588 | 📋 | Berberine Upregulates P-Glycoprotein in Human Caco-2 Cells and in an Experimental Model of Colitis in the Rat via Activation of Nrf2-Dependent Mechanisms |
Berberine | Irritable Bowel Syndrome | 1 | PM | 26700862 | 📋 | Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner |
Berberine | Irritable Bowel Syndrome | 7 | PM | 23600391 | 📋 | Effects of berberine on rat jejunal motility |
Berberine | Liver Cancer | 34 | PM | 38750718 | 📋 | Berberine increases the killing effect of pirarubicin on HCC cells by inhibiting ATG4B-autophagy pathway |
Berberine | Liver Cancer | 33 | PM | 38693042 | 📋 | The potential of the nutraceutical berberine in the treatment of hepatocellular carcinoma and other liver diseases such as NAFLD and NASH |
Berberine | Liver Cancer | 32 | PM | 38301771 | 📋 | Berberine prevents NAFLD and HCC by modulating metabolic disorders |
Berberine | Liver Cancer | 31 | PM | 38084140 | 📋 | Inhibition of hepatocellular carcinoma growth via modulation of the miR-221/SOX11 axis by curcumin and berberine |
Berberine | Liver Cancer | 25 | PM | 37148713 | 📋 | Berberine activates PPARδ and promotes gut microbiota-derived butyric acid to suppress hepatocellular carcinoma |
Berberine | Liver Cancer | 24 | PM | 36191360 | 📋 | Hepatocellular cancer cell lines, Hep-3B and Hep-G2 display the pleiotropic response to resveratrol and berberine |
Berberine | Liver Cancer | 23 | PM | 36090480 | 📋 | Berberine inhibits carcinogenesis through antagonizing the ATX-LPA-LPAR2-p38-leptin axis in a mouse hepatoma model |
Berberine | Liver Cancer | 22 | PM | 34787617 | 📋 | Antiproliferative activity of berberine in HepG2 cells via inducing apoptosis and arresting cell cycle |
Berberine | Liver Cancer | 21 | PM | 34712379 | 📋 | Berberine Suppresses EMT in Liver and Gastric Carcinoma Cells through Combination with TGF β R Regulating TGF- β/Smad Pathway |
Berberine | Liver Cancer | 20 | PM | 34460138 | 📋 | A novel combined resveratrol/berberine phytochemotheraputic using the HePG2 cell line as a model for the treatment of hepatocarcinoma |
Berberine | Liver Cancer | 19 | PM | 34395446 | 📋 | Probing Synergistic Targets by Natural Compounds for Hepatocellular Carcinoma |
Berberine | Liver Cancer | 18 | PM | 34220494 | 📋 | Berberine Sensitizes Human Hepatoma Cells to Regorafenib via Modulating Expression of Circular RNAs |
Berberine | Liver Cancer | 17 | PM | 33130557 | 📋 | Berberine represses β-catenin translation involving 4E-BPs in hepatocellular carcinoma cells |
Berberine | Liver Cancer | 29 | PM | 32815562 | 📋 | Berberine, a natural alkaloid sensitizes human hepatocarcinoma to ionizing radiation by blocking autophagy and cell cycle arrest resulting in senescence |
Berberine | Liver Cancer | 16 | PM | 32606742 | 📋 | Berberine Inhibits the Apoptosis-Induced Metastasis by Suppressing the iPLA2/LOX-5/LTB4 Pathway in Hepatocellular Carcinoma |
Berberine | Liver Cancer | 15 | PM | 32276448 | 📋 | Targeting Autophagy Augments BBR-Mediated Cell Death in Human Hepatoma Cells Harboring Hepatitis C Virus RNA |
Berberine | Liver Cancer | 2 | PM | 32021249 | 📋 | Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake |
Berberine | Liver Cancer | 11 | PM | 31545468 | 📋 | Exploring the Active Mechanism of Berberine Against HCC by Systematic Pharmacology and Experimental Validation |
Berberine | Liver Cancer | 4 | PM | 31217846 | 📋 | Berberine Prevents Non-Alcoholic Steatohepatitis-Derived Hepatocellular Carcinoma by Inhibiting Inflammation and Angiogenesis in Mice |
Berberine | Liver Cancer | 3 | PM | 30565332 | 📋 | Synergistic Effect of Berberine and HMQ1611 Impairs Cell Proliferation and Migration by Regulating Wnt Signaling Pathway in Hepatocellular Carcinoma |
Berberine | Liver Cancer | 10 | PM | 30015938 | 📋 | Berberine, a Natural Plant Alkaloid, Synergistically Sensitizes Human Liver Cancer Cells to Sorafenib |
Berberine | Liver Cancer | 6 | PM | 29626488 | 📋 | Berberine Induced Modulation of PHLPP2-Akt-MST1 Kinase Signaling Is Coupled With Mitochondrial Impairment and Hepatoma Cell Death |
Berberine | Liver Cancer | 5 | PM | 29360760 | 📋 | Regulation of Akt/FoxO3a/Skp2 Axis Is Critically Involved in Berberine-Induced Cell Cycle Arrest in Hepatocellular Carcinoma Cells |
Berberine | Liver Cancer | 7 | PM | 28572744 | 📋 | Berberine Regulates the Protein Expression of Multiple Tumorigenesis-Related Genes in Hepatocellular Carcinoma Cell Lines |
Berberine | Liver Cancer | 8 | PM | 28277195 | 📋 | Induction of Apoptosis by Berberine in Hepatocellular Carcinoma HepG2 Cells via Downregulation of NF-κB |
Berberine | Liver Cancer | 14 | PM | 27854312 | 📋 | Berberine Suppresses Cyclin D1 Expression Through Proteasomal Degradation in Human Hepatoma Cells |
Berberine | Liver Cancer | 9 | PM | 27311637 | 📋 | Antiproliferation of Berberine Is Mediated by Epigenetic Modification of Constitutive Androstane Receptor (CAR) Metabolic Pathway in Hepatoma Cells |
Berberine | Liver Cancer | 13 | PM | 27092498 | 📋 | Up-Regulation of PAI-1 and Down-Regulation of uPA Are Involved in Suppression of Invasiveness and Motility of Hepatocellular Carcinoma Cells by a Natural Compound Berberine |
Berberine | Liver Cancer | 28 | PM | 23999088 | 📋 | Berberine and S allyl cysteine mediated amelioration of DEN+CCl4 induced hepatocarcinoma |
Berberine | Liver Cancer | 27 | PM | 23784371 | 📋 | Berberine induces apoptosis via the mitochondrial pathway in liver cancer cells |
Berberine | Liver Cancer | 26 | PM | 23732865 | 📋 | Berberine induces selective apoptosis through the AMPK‑mediated mitochondrial/caspase pathway in hepatocellular carcinoma |
Berberine | Liver Cancer | 30 | PM | 21443647 | 📋 | Berberine induces cell death in human hepatoma cells in vitro by downregulating CD147 |
Berberine | Liver Cancer | 12 | PM | 19724899 | 📋 | Coptis Chinensis Inhibits Hepatocellular Carcinoma Cell Growth Through Nonsteroidal Anti-Inflammatory Drug-Activated Gene Activation |
Berberine | Liver Cancer | 1 | PM | 19408145 | 📋 | Berbamine Induces Fas-mediated Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells and Inhibits Its Tumor Growth in Nude Mice |
Berberine | Liver Damage | 1 | PM | 35436630 | 📋 | Hydrochloride Berberine ameliorates alcohol-induced liver injury by regulating inflammation and lipid metabolism |
Berberine | Liver Damage | 6 | PM | 35078575 | 📋 | [Berberine hydrochloride attenuates liver injury induced by acute hypoxic exposure by inhibiting TNF-α/caspase-8/caspase-3 signaling pathway] |
Berberine | Liver Disease | 4 | PM | 38693042 | 📋 | The potential of the nutraceutical berberine in the treatment of hepatocellular carcinoma and other liver diseases such as NAFLD and NASH |
Berberine | Liver Disease | 3 | PM | 34056769 | 📋 | Molecular updates on berberine in liver diseases: Bench to bedside |
Berberine | Liver Disease | 2 | PM | 33068590 | 📋 | The pharmacological activity of berberine, a review for liver protection |
Berberine | Liver Disease | 1 | PM | 32265720 | 📋 | The Impacts of Herbal Medicines and Natural Products on Regulating the Hepatic Lipid Metabolism |
Berberine | MAFLD | 35 | PM | 38762210 | 📋 | Berberine directly targets AKR1B10 protein to modulate lipid and glucose metabolism disorders in NAFLD |
Berberine | MAFLD | 34 | PM | 38723878 | 📋 | Berberine ameliorates nonalcoholic fatty liver disease-induced bone loss by inhibiting ferroptosis |
Berberine | MAFLD | 33 | PM | 38673787 | 📋 | Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease-Clinical and Pre-Clinical Overview and Systematic Review of the Literature |
Berberine | MAFLD | 32 | PM | 38429794 | 📋 | The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review |
Berberine | MAFLD | 31 | PM | 38301771 | 📋 | Berberine prevents NAFLD and HCC by modulating metabolic disorders |
Berberine | MAFLD | 28 | PM | 37293270 | 📋 | Berberine alleviates non-alcoholic hepatic steatosis partially by promoting SIRT1 deacetylation of CPT1A in mice |
Berberine | MAFLD | 27 | PM | 36838862 | 📋 | Berberine Ameliorates Metabolic-Associated Fatty Liver Disease Mediated Metabolism Disorder and Redox Homeostasis by Upregulating Clock Genes: Clock and Bmal1 Expressions |
Berberine | MAFLD | 26 | PM | 36079717 | 📋 | Berberine in Non-Alcoholic Fatty Liver Disease-A Review |
Berberine | MAFLD | 25 | PM | 35873595 | 📋 | Berberrubine, a Main Metabolite of Berberine, Alleviates Non-Alcoholic Fatty Liver Disease via Modulating Glucose and Lipid Metabolism and Restoring Gut Microbiota |
Berberine | MAFLD | 24 | PM | 35726797 | 📋 | Astragalus mongholicus polysaccharides ameliorate hepatic lipid accumulation and inflammation as well as modulate gut microbiota in NAFLD rats |
Berberine | MAFLD | 23 | PM | 35722423 | 📋 | Methyltransferase SETD2 mediates hepatoprotection of berberine against steatosis |
Berberine | MAFLD | 22 | PM | 35584453 | 📋 | The combination of berberine and evodiamine ameliorates high-fat diet-induced non-alcoholic fatty liver disease associated with modulation of gut microbiota in rats |
Berberine | MAFLD | 21 | PM | 35382695 | 📋 | Effect of berberine and bicyclol on Chinese patients with non-alcoholic fatty liver disease: a retrospective study |
Berberine | MAFLD | 20 | PM | 35359076 | 📋 | [Berberine alleviates programmed necrosis of metabolic-associated fatty liver disease via activating Nrf2 pathway in mice] |
Berberine | MAFLD | 19 | PM | 35250593 | 📋 | Combined Use of Bicyclol and Berberine Alleviates Mouse Nonalcoholic Fatty Liver Disease |
Berberine | MAFLD | 18 | PM | 34566663 | 📋 | Preclinical Evidence of Berberine on Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Animal Studies |
Berberine | MAFLD | 17 | PM | 34504563 | 📋 | Berberine ameliorates nonalcoholic fatty liver disease by decreasing the liver lipid content via reversing the abnormal expression of MTTP and LDLR |
Berberine | MAFLD | 16 | PM | 34094026 | 📋 | The therapeutic effects of berberine plus sitagliptin in a rat model of fatty liver disease |
Berberine | MAFLD | 15 | PM | 33831691 | 📋 | Therapeutic effect of oxyberberine on obese non-alcoholic fatty liver disease rats |
Berberine | MAFLD | 14 | PM | 33626003 | 📋 | Berberine inhibits liver damage in rats with non-alcoholic fatty liver disease by regulating TLR4/MyD88/NF-κB pathway |
Berberine | MAFLD | 13 | PM | 32429849 | 📋 | Anti-inflammatory Activity of Berberine in Non-Alcoholic Fatty Liver Disease via the Angptl2 Pathway |
Berberine | MAFLD | 12 | PM | 32403887 | 📋 | [Discussion on the Curative Effect and Mechanisms of Berberine in Rats With Non-Alcoholic Fatty Liver] |
Berberine | MAFLD | 11 | PM | 32357187 | 📋 | Berberine Inhibits Free Fatty Acid and LPS-induced Inflammation via Modulating ER Stress Response in Macrophages and Hepatocytes |
Berberine | MAFLD | 1 | PM | 32194416 | 📋 | Berberine Inhibits Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation and Pyroptosis in Nonalcoholic Steatohepatitis via the ROS/TXNIP Axis |
Berberine | MAFLD | 7 | PM | 31226399 | 📋 | Berberine Attenuates Nonalcoholic Hepatic Steatosis Through the AMPK-SREBP-1c-SCD1 Pathway |
Berberine | MAFLD | 4 | PM | 30868489 | 📋 | Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway |
Berberine | MAFLD | 6 | PM | 30867696 | 📋 | Berberine Attenuates Hepatic Oxidative Stress in Rats With Non-Alcoholic Fatty Liver Disease via the Nrf2/ARE Signalling Pathway |
Berberine | MAFLD | 3 | PM | 30848932 | 📋 | Berberine Alleviates Nonalcoholic Fatty Liver Induced by a High-Fat Diet in Mice by Activating SIRT3 |
Berberine | MAFLD | 2 | PM | 29505790 | 📋 | Berberine Alleviates Hepatic Lipid Accumulation by Increasing ABCA1 Through the Protein Kinase C δ Pathway |
Berberine | MAFLD | 10 | PM | 29353208 | 📋 | Natural Products Berberine and Curcumin Exhibited Better Ameliorative Effects on Rats With Non-Alcohol Fatty Liver Disease Than Lovastatin |
Berberine | MAFLD | 29 | PM | 29200733 | 📋 | Amelioration of Intestinal Barrier Dysfunction by Berberine in the Treatment of Nonalcoholic Fatty Liver Disease in Rats |
Berberine | MAFLD | 8 | PM | 26936230 | 📋 | Berberine Ameliorates Hepatic Steatosis and Suppresses Liver and Adipose Tissue Inflammation in Mice With Diet-induced Obesity |
Berberine | MAFLD | 9 | PM | 26857750 | 📋 | Berberine Prevents Progression From Hepatic Steatosis to Steatohepatitis and Fibrosis by Reducing Endoplasmic Reticulum Stress |
Berberine | MAFLD | 5 | PM | 26252777 | 📋 | Efficacy of Berberine in Patients With Non-Alcoholic Fatty Liver Disease |
Berberine | MAFLD | 30 | PM | 21839075 | 📋 | Berberine reducing insulin resistance by up-regulating IRS-2 mRNA expression in nonalcoholic fatty liver disease (NAFLD) rat liver |
Berberine | Nasopharyngeal Cancer | 7 | PM | 38213727 | 📋 | Berberine-mediated Ferroptosis through System Xc-/GSH/GPX4 Axis Inhibits Metastasis of Nasopharyngeal Carcinoma |
Berberine | Nasopharyngeal Cancer | 3 | PM | 28350122 | 📋 | Berberine Sensitizes Nasopharyngeal Carcinoma Cells to Radiation Through Inhibition of Sp1 and EMT |
Berberine | Nasopharyngeal Cancer | 1 | PM | 28259949 | 📋 | Berberine Inhibits the Proliferation of Human Nasopharyngeal Carcinoma Cells via an Epstein-Barr Virus Nuclear Antigen 1-dependent Mechanism |
Berberine | Nasopharyngeal Cancer | 6 | PM | 24641420 | 📋 | Berberine hydrochloride impact on physiological processes and modulation of twist levels in nasopharyngeal carcinoma CNE-1 cells |
Berberine | Nasopharyngeal Cancer | 5 | PM | 24380387 | 📋 | Berberine suppresses tumorigenicity and growth of nasopharyngeal carcinoma cells by inhibiting STAT3 activation induced by tumor associated fibroblasts |
Berberine | Nasopharyngeal Cancer | 4 | PM | 24325635 | 📋 | Berberine radiosensitizes human nasopharyngeal carcinoma by suppressing hypoxia-inducible factor-1α expression |
Berberine | Nasopharyngeal Cancer | 2 | PM | 19513545 | 📋 | Berberine Inhibits Rho GTPases and Cell Migration at Low Doses but Induces G2 Arrest and Apoptosis at High Doses in Human Cancer Cells |
Berberine | Necrotizing Enterocolitis | 1 | PM | 30542485 | 📋 | Berberine Reduces the Occurrence of Neonatal Necrotizing Enterocolitis by Reducing the Inflammatory Response |
Berberine | Non-Alcoholic Steatohepatitis | 10 | PM | 37652508 | 📋 | Comparing the Influences of Metformin and Berberine on the Intestinal Microbiota of Rats With Nonalcoholic Steatohepatitis |
Berberine | Non-Alcoholic Steatohepatitis | 9 | PM | 34686466 | 📋 | Berberine mitigates nonalcoholic hepatic steatosis by downregulating SIRT1-FoxO1-SREBP2 pathway for cholesterol synthesis |
Berberine | Non-Alcoholic Steatohepatitis | 8 | PM | 34603061 | 📋 | Berberine Alleviates Non-alcoholic Steatohepatitis Through Modulating Gut Microbiota Mediated Intestinal FXR Activation |
Berberine | Non-Alcoholic Steatohepatitis | 7 | PM | 34566663 | 📋 | Preclinical Evidence of Berberine on Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Animal Studies |
Berberine | Non-Alcoholic Steatohepatitis | 6 | PM | 33494295 | 📋 | Berberine Prevents Disease Progression of Nonalcoholic Steatohepatitis through Modulating Multiple Pathways |
Berberine | Non-Alcoholic Steatohepatitis | 5 | PM | 32524150 | 📋 | Berberine Attenuates Non-Alcoholic Steatohepatitis by Regulating chemerin/CMKLR1 Signalling Pathway and Treg/Th17 Ratio |
Berberine | Non-Alcoholic Steatohepatitis | 2 | PM | 32194416 | 📋 | Berberine Inhibits Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation and Pyroptosis in Nonalcoholic Steatohepatitis via the ROS/TXNIP Axis |
Berberine | Non-Alcoholic Steatohepatitis | 4 | PM | 31217846 | 📋 | Berberine Prevents Non-Alcoholic Steatohepatitis-Derived Hepatocellular Carcinoma by Inhibiting Inflammation and Angiogenesis in Mice |
Berberine | Non-Alcoholic Steatohepatitis | 3 | PM | 29075339 | 📋 | Berberine Ameliorates Non-Alcoholic Steatohepatitis in ApoE -/- Mice |
Berberine | Non-Alcoholic Steatohepatitis | 1 | PM | 26923892 | 📋 | Modulation of Gut Microbiota by Berberine Improves Steatohepatitis in High-Fat Diet-Fed BALB/C Mice |
Berberine | Oral Cancer | 1 | PM | 29113353 | 📋 | Berberine-targeted miR-21 Chemosensitizes Oral Carcinomas Stem Cells |
Berberine | Oral Candidiasis | 1 | PM | 38729536 | 📋 | Coptidis rhizoma extract alleviates oropharyngeal candidiasis by gC1qR-EGFR/ERK/c-fos axis-induced endocytosis of oral epithelial cells |
Berberine | Pancreatic Cancer | 8 | PM | 38502348 | 📋 | Berberine chloride suppresses pancreatic adenocarcinoma proliferation and growth by targeting inflammation-related genes: an in silico analysis with in vitro and vivo validation |
Berberine | Pancreatic Cancer | 7 | PM | 36500723 | 📋 | Effects of Berberine against Pancreatitis and Pancreatic Cancer |
Berberine | Pancreatic Cancer | 6 | PM | 36297310 | 📋 | Berberine Overcomes Gemcitabine-Associated Chemoresistance through Regulation of Rap1/PI3K-Akt Signaling in Pancreatic Ductal Adenocarcinoma |
Berberine | Pancreatic Cancer | 5 | PM | 35784732 | 📋 | Berberine Suppresses Lung Metastasis of Cancer via Inhibiting Endothelial Transforming Growth Factor Beta Receptor 1 |
Berberine | Pancreatic Cancer | 4 | PM | 34890544 | 📋 | Berberine inhibits pancreatic intraepithelial neoplasia by inhibiting glycolysis via the adenosine monophosphate -activated protein kinase pathway |
Berberine | Pancreatic Cancer | 3 | PM | 34185423 | 📋 | Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression |
Berberine | Pancreatic Cancer | 2 | PM | 32692565 | 📋 | Cell metabolomics reveal berberine inhibited pancreatic cancer cell viability and metastasis by regulating citrate metabolism |
Berberine | Pancreatic Cancer | 1 | PM | 20455200 | 📋 | Berberine Inhibits Cell Growth and Mediates Caspase-Independent Cell Death in Human Pancreatic Cancer Cells |
Berberine | Pancreatic Fibrosis | 1 | PM | 32721432 | 📋 | Berberine attenuates severity of chronic pancreatitis and fibrosis via AMPK-mediated inhibition of TGF-β1/Smad signaling and M2 polarization |
Berberine | Pancreatitis | 2 | PM | 36500723 | 📋 | Effects of Berberine against Pancreatitis and Pancreatic Cancer |
Berberine | Pancreatitis | 1 | PM | 34890544 | 📋 | Berberine inhibits pancreatic intraepithelial neoplasia by inhibiting glycolysis via the adenosine monophosphate -activated protein kinase pathway |
Berberine | Pancreatitis | 4 | PM | 32721432 | 📋 | Berberine attenuates severity of chronic pancreatitis and fibrosis via AMPK-mediated inhibition of TGF-β1/Smad signaling and M2 polarization |
Berberine | Peritoneal Adhesions | 1 | PM | 32528829 | 📋 | Berberine Prevents Primary Peritoneal Adhesion and Adhesion Reformation by Directly Inhibiting TIMP-1 |
Berberine | Primary Sclerosing Cholangitis | 2 | PM | 38332450 | 📋 | Berberine ameliorates the progression of primary sclerosing cholangitis by activating farnesoid X receptor |
Berberine | Primary Sclerosing Cholangitis | 1 | PM | 38273376 | 📋 | Therapeutic potential of berberine in attenuating cholestatic liver injury: insights from a PSC mouse model |
Berberine | Tongue Cancer | 1 | PM | 19303753 | 📋 | Berberine Inhibits Human Tongue Squamous Carcinoma Cancer Tumor Growth in a Murine Xenograft Model |
Berberine | Ulcerative Colitis | 29 | PM | 38184271 | 📋 | Berberine regulates intestinal microbiome and metabolism homeostasis to treat ulcerative colitis |
Berberine | Ulcerative Colitis | 28 | PM | 38154262 | 📋 | Berberine alleviates inflammation and suppresses PLA2-COX-2-PGE2-EP2 pathway through targeting gut microbiota in DSS-induced ulcerative colitis |
Berberine | Ulcerative Colitis | 27 | PM | 37930330 | 📋 | Coptis chinensis and Berberine Ameliorate Chronic Ulcerative Colitis: An Integrated Microbiome-Metabolomics Study |
Berberine | Ulcerative Colitis | 25 | PM | 37820424 | 📋 | Synergistic effect of berberine hydrochloride and dehydrocostus lactone in the treatment of ulcerative colitis: Take gut microbiota as the target |
Berberine | Ulcerative Colitis | 24 | PM | 37683590 | 📋 | Berberine improves DSS-induced colitis in mice by modulating the fecal-bacteria-related bile acid metabolism |
Berberine | Ulcerative Colitis | 23 | PM | 37595814 | 📋 | Combination of Coptis chinensis polysaccharides and berberine ameliorates ulcerative colitis by regulating gut microbiota and activating AhR/IL-22 pathway |
Berberine | Ulcerative Colitis | 22 | PM | 36923882 | 📋 | Berberine promotes M2 macrophage polarisation through the IL-4-STAT6 signalling pathway in ulcerative colitis treatment |
Berberine | Ulcerative Colitis | 21 | PM | 36561763 | 📋 | Berberine a traditional Chinese drug repurposing: Its actions in inflammation-associated ulcerative colitis and cancer therapy |
Berberine | Ulcerative Colitis | 20 | PM | 36287004 | 📋 | Berberine Depresses Inflammation and Adjusts Smooth Muscle to Ameliorate Ulcerative Colitis of Cats by Regulating Gut Microbiota |
Berberine | Ulcerative Colitis | 19 | PM | 36147325 | 📋 | Pharmacological effects of berberine on models of ulcerative colitis: A meta-analysis and systematic review of animal studies |
Berberine | Ulcerative Colitis | 18 | PM | 36144733 | 📋 | Effect and Mechanism of Pharmaceutical Excipients on Berberine to Alleviate Ulcerative Colitis via Regulating Gut Microbiota |
Berberine | Ulcerative Colitis | 17 | PM | 36046871 | 📋 | [Experimental study on effects of berberine combined with 6-shogaol on intestinal inflammation and flora in mice with ulcerative colitis] |
Berberine | Ulcerative Colitis | 16 | PM | 35893243 | 📋 | Berberine Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis and Inhibits the Secretion of Gut Lysozyme via Promoting Autophagy |
Berberine | Ulcerative Colitis | 15 | PM | 35812150 | 📋 | Berberine inhibits IFN-γ signaling pathway in DSS-induced ulcerative colitis |
Berberine | Ulcerative Colitis | 14 | PM | 35280677 | 📋 | Berberine ameliorates DSS-induced intestinal mucosal barrier dysfunction through microbiota-dependence and Wnt/β-catenin pathway |
Berberine | Ulcerative Colitis | 13 | PM | 34749293 | 📋 | Berberine inhibits dendritic cells differentiation in DSS-induced colitis by promoting Bacteroides fragilis |
Berberine | Ulcerative Colitis | 12 | PM | 34253428 | 📋 | Dihydroberberine, an isoquinoline alkaloid, exhibits protective effect against dextran sulfate sodium-induced ulcerative colitis in mice |
Berberine | Ulcerative Colitis | 11 | PM | 34211579 | 📋 | Exploring the Mechanism of Berberine Intervention in Ulcerative Colitis from the Perspective of Inflammation and Immunity Based on Systemic Pharmacology |
Berberine | Ulcerative Colitis | 10 | PM | 33658925 | 📋 | Berberine Suppresses Colonic Inflammation in Dextran Sulfate Sodium-Induced Murine Colitis Through Inhibition of Cytosolic Phospholipase A2 Activity |
Berberine | Ulcerative Colitis | 9 | PM | 33645048 | 📋 | [Research progress of effect of berberine in treatment of ulcerative colitis based on cell signaling pathway] |
Berberine | Ulcerative Colitis | 8 | PM | 33348308 | 📋 | Berberine in the treatment of ulcerative colitis: A possible pathway through Tuft cells |
Berberine | Ulcerative Colitis | 7 | PM | 32432470 | 📋 | Anti-inflammatory Efficacy of Combined Natural Alkaloid Berberine and S1PR Modulator Fingolimod at Low Doses in Ulcerative Colitis Preclinical Models |
Berberine | Ulcerative Colitis | 6 | PM | 32382284 | 📋 | Effect of Berberine From Coptis chinensis on Apoptosis of Intestinal Epithelial Cells in a Mouse Model of Ulcerative Colitis: Role of Endoplasmic Reticulum Stress |
Berberine | Ulcerative Colitis | 5 | PM | 32332711 | 📋 | Intervention of Oncostatin M-driven Mucosal Inflammation by Berberine Exerts Therapeutic Property in Chronic Ulcerative Colitis |
Berberine | Ulcerative Colitis | 4 | PM | 32140391 | 📋 | Protective Role of Berberine on Ulcerative Colitis Through Modulating Enteric Glial Cells-Intestinal Epithelial Cells-Immune Cells Interactions |
Berberine | Ulcerative Colitis | 1 | PM | 31867696 | 📋 | Berberine Ameliorates Colonic Damage Accompanied With the Modulation of Dysfunctional Bacteria and Functions in Ulcerative Colitis Rats |
Berberine | Ulcerative Colitis | 3 | PM | 30771347 | 📋 | iTRAQ-based Pharmacoproteomics Reveals Potential Targets of Berberine, a Promising Therapy for Ulcerative Colitis |
Berberine | Ulcerative Colitis | 26 | PM | 30743078 | 📋 | Protective effects of berberine hydrochloride on DSS-induced ulcerative colitis in rats |
Berberine | Ulcerative Colitis | 2 | PM | 29904348 | 📋 | Berberine Regulates Treg/Th17 Balance to Treat Ulcerative Colitis Through Modulating the Gut Microbiota in the Colon |