| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Tanshinone | Abdominal Aortic Aneurysm | 1 | PM | 23302465 | 📋 | [Tanshinone IIA attenuates the development of elastase-induced abdominal aortic aneurysm of rat] |
| Tanshinone | Abdominal Aortic Aneurysm | 2 | PM | 22640888 | 📋 | Inhibition of experimental abdominal aortic aneurysm in a rat model by way of tanshinone IIA |
| Tanshinone | Angina Pectoris | 1 | PM | 37651454 | 📋 | The efficacy and safety of sodium tanshinone ⅡA sulfonate injection in the treatment of unstable angina pectoris: A systematic review and meta-analysis |
| Tanshinone | Aortic Valve Stenosis | 1 | PM | 37771422 | 📋 | Tanshinone IIA attenuates valvular interstitial cells' calcification induced by oxidized low density lipoprotein via reducing endoplasmic reticulum stress |
| Tanshinone | Arterial Restenosis | 1 | PM | 16780164 | 📋 | [Experimental study of effect of tanshinone on artery restenosis in rat carotid injury model] |
| Tanshinone | Atherosclerosis | 10 | PM | 38108067 | 📋 | Tanshinone IIA: a Chinese herbal ingredient for the treatment of atherosclerosis |
| Tanshinone | Atherosclerosis | 9 | PM | 37955049 | 📋 | Tanshinone IIA attenuates ox-LDL-induced endothelial cell injury by inhibiting NF-kapaB pathway via circ_0000231/miR-590-5p/TXNIP axis |
| Tanshinone | Atherosclerosis | 8 | PM | 37886125 | 📋 | Tanshinone IIA alleviates atherosclerosis in LDLR-/- mice by regulating efferocytosis of macrophages |
| Tanshinone | Atherosclerosis | 7 | PM | 37778998 | 📋 | Tanshinone IIA Regulates MAPK/mTOR Signal-Mediated Autophagy to Alleviate Atherosclerosis through the miR-214-3p/ATG16L1 Axis |
| Tanshinone | Atherosclerosis | 6 | PM | 37713995 | 📋 | Salvia miltiorrhiza and Tanshinone IIA reduce endothelial inflammation and atherosclerotic plaque formation through inhibiting COX-2 |
| Tanshinone | Atherosclerosis | 5 | PM | 37392987 | 📋 | Protective Effects of Tanshinone IIA on Porphyromonas gingivalis-induced Atherosclerosis via the Downregulation of the NOX2/NOX4-ROS Mediation of NF-κB Signaling Pathway |
| Tanshinone | Atherosclerosis | 4 | PM | 37257708 | 📋 | Puerarin-Tanshinone IIA Suppresses atherosclerosis inflammatory plaque via targeting succinate/HIF-1α/IL-1β axis |
| Tanshinone | Atherosclerosis | 1 | PM | 31887543 | 📋 | Combination of tanshinone IIA and astragaloside IV attenuate atherosclerotic plaque vulnerability in ApoE(-/-) mice by activating PI3K/AKT signaling and suppressing TRL4/NF-κB signaling |
| Tanshinone | Atherosclerosis | 3 | PM | 31512787 | 📋 | Tanshinone IIA inhibits the adipogenesis and inflammatory response in ox-LDL-challenged human monocyte-derived macrophages via regulating miR-130b/WNT5A |
| Tanshinone | Atherosclerosis | 2 | PM | 31402870 | 📋 | Tanshinone IIA Exerts Anti-Inflammatory and Immune-Regulating Effects on Vulnerable Atherosclerotic Plaque Partially via the TLR4/MyD88/NF-κB Signal Pathway |
| Tanshinone | Blood-Brain Barrier Permeability | 1 | PM | 35839080 | 📋 | Tanshinone IIA protected against lipopolysaccharide-induced brain injury through the protective effect of the blood-brain barrier and the suppression of oxidant stress and inflammatory response |
| Tanshinone | Brain Aneurysm | 1 | PM | 31257487 | 📋 | Tanshinone IIA attenuates cerebral aneurysm formation by inhibiting the NF‑κB‑mediated inflammatory response |
| Tanshinone | Cardiac Arrhythmia | 1 | PM | 19775284 | 📋 | Tanshinone IIA protects against sudden cardiac death induced by lethal arrhythmias via repression of microRNA-1 |
| Tanshinone | Cardiac Hypertrophy | 1 | PM | 35191812 | 📋 | Tanshinone IIA alleviates cardiac hypertrophy through m6A modification of galectin-3 |
| Tanshinone | Cardiotoxicity | 2 | PM | 36182795 | 📋 | Tanshinone IIA inhibits cardiomyocyte apoptosis and rescues cardiac function during doxorubicin-induced cardiotoxicity by activating the DAXX/MEK/ERK1/2 pathway |
| Tanshinone | Cardiotoxicity | 1 | PM | 36108374 | 📋 | Tanshinone I inhibits doxorubicin-induced cardiotoxicity by regulating Nrf2 signaling pathway |
| Tanshinone | Cardiovascular Disease | 2 | PM | 35432718 | 📋 | Targeting Oxidative Stress and Endothelial Dysfunction Using Tanshinone IIA for the Treatment of Tissue Inflammation and Fibrosis |
| Tanshinone | Cardiovascular Disease | 1 | PM | 32807822 | 📋 | Tanshinone II A attenuates vascular remodeling through klf4 mediated smooth muscle cell phenotypic switching |
| Tanshinone | Cerebral Ischemia | 1 | PM | 32729296 | 📋 | Tanshinone IIA alleviates the damage of neurocytes by targeting GLUT1 in ischaemia reperfusion model (in vivo and in vitro experiments) |
| Tanshinone | Cerebral Ischemia-Reperfusion | 2 | PM | 38549714 | 📋 | Tanshinone IIA Alleviates Traumatic Brain Injury by Reducing Ischemia‒Reperfusion via the miR-124-5p/FoxO1 Axis |
| Tanshinone | Cerebral Ischemia-Reperfusion | 1 | PM | 35982135 | 📋 | Tanshinone IIA reduces AQP4 expression and astrocyte swelling after OGD/R by inhibiting the HMGB1/RAGE/NF-κB/IL-6 pro-inflammatory axis |
| Tanshinone | Coronary Artery Disease | 1 | PM | 29434774 | 📋 | Tanshinone IIA and Astragaloside IV Promote the Angiogenesis of Mesenchymal Stem Cell-Derived Endothelial Cell-Like Cells via Upregulation of Cx37, Cx40 and Cx43 |
| Tanshinone | Diabetic Cardiomyopathy | 1 | PM | 37128721 | 📋 | Tanshinone IIA ameliorates experimental diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress in cardiomyocytes via SIRT1 |
| Tanshinone | Endothelial Dysfunction | 1 | PM | 35432718 | 📋 | Targeting Oxidative Stress and Endothelial Dysfunction Using Tanshinone IIA for the Treatment of Tissue Inflammation and Fibrosis |
| Tanshinone | Endothelial Injury | 1 | PM | 37955049 | 📋 | Tanshinone IIA attenuates ox-LDL-induced endothelial cell injury by inhibiting NF-kapaB pathway via circ_0000231/miR-590-5p/TXNIP axis |
| Tanshinone | Hemorrhagic Stroke | 1 | PM | 33123006 | 📋 | Mechanism Study of the Protective Effects of Sodium Tanshinone IIA Sulfonate Against Atorvastatin-Induced Cerebral Hemorrhage in Zebrafish: Transcriptome Analysis |
| Tanshinone | Infantile Hemangioma | 1 | PM | 38323180 | 📋 | The efficacy of extracted Tanshinone compounds for infantile hemangiomas of the skin: results from a pilot study |
| Tanshinone | Ischemia-Reperfusion Injuries | 2 | PM | 37314409 | 📋 | Tanshinone IIA inhibits ischemia-reperfusion-induced inflammation, ferroptosis and apoptosis through activation of the PI3K/Akt/mTOR pathway |
| Tanshinone | Ischemia-Reperfusion Injuries | 1 | PM | 34804370 | 📋 | Targeting the Ang2/Tie2 Axis with Tanshinone IIA Elicits Vascular Normalization in Ischemic Injury and Colon Cancer |
| Tanshinone | Ischemic Stroke | 1 | PM | 36066030 | 📋 | Neuroprotective investigation of tanshinone in the cerebral infarction model in the Keap1-Nrf2/ARE pathway |
| Tanshinone | Ischemic Stroke | 4 | PM | 35635784 | 📋 | Combination of puerarin and tanshinone IIA alleviates ischaemic stroke injury in rats via activating the Nrf2/ARE signalling pathway |
| Tanshinone | Ischemic Stroke | 3 | PM | 35392650 | 📋 | Molecular Mechanism of Salvia miltiorrhiza Bunge in Treating Cerebral Infarction |
| Tanshinone | Ischemic Stroke | 2 | PM | 33617968 | 📋 | A Network-Based Method for Mechanistic Investigation and Neuroprotective Effect on treatment of Tanshinone Ⅰ Against Ischemic Stroke in Mouse |
| Tanshinone | Kawasaki Disease | 1 | PM | 35498027 | 📋 | Tanshinone IIA Has a Potential Therapeutic Effect on Kawasaki Disease and Suppresses Megakaryocytes in Rabbits With Immune Vasculitis |
| Tanshinone | Myocardial Fibrosis | 4 | PM | 35924522 | 📋 | [Mechanism of tanshinone II A inhibiting myocardial remodeling by Galectin-3] |
| Tanshinone | Myocardial Fibrosis | 3 | PM | 35014054 | 📋 | Tanshinone IIA from Salvia miltiorrhiza exerts anti-fibrotic effects on cardiac fibroblasts and rat heart tissues by suppressing the levels of pro-fibrotic factors: The key role of miR-618 |
| Tanshinone | Myocardial Fibrosis | 1 | PM | 31629735 | 📋 | Effects of the combination of tanshinone IIA and puerarin on cardiac function and inflammatory response in myocardial ischemia mice |
| Tanshinone | Myocardial Fibrosis | 2 | PM | 30574749 | 📋 | Tanshinone IIA protects against cardiac fibrosis through inhibition of β-tubulin expression |
| Tanshinone | Myocardial Hypoxia | 1 | PM | 28389356 | 📋 | Compatibility of Tanshinone IIA and Astragaloside IV in Attenuating Hypoxia-Induced Cardiomyocytes Injury |
| Tanshinone | Myocardial Infarction | 4 | PM | 37991600 | 📋 | Intervention of Tanshinone IIA on the PGK1-PDHK1 Pathway to Reprogram Macrophage Phenotype After Myocardial Infarction |
| Tanshinone | Myocardial Infarction | 3 | PM | 37766966 | 📋 | Tanshinone IIA inhibits cardiomyocyte pyroptosis through TLR4/NF-κB p65 pathway after acute myocardial infarction |
| Tanshinone | Myocardial Infarction | 2 | PM | 35697130 | 📋 | Tanshinone IIA improves cardiac function via regulating miR-499-5p dependent angiogenesis in myocardial ischemic mice |
| Tanshinone | Myocardial Infarction | 1 | PM | 34978223 | 📋 | Potential of natural products in the treatment of myocardial infarction: focus on molecular mechanisms |
| Tanshinone | Myocardial Injury | 3 | PM | 37164920 | 📋 | Mechanism for effect of tanshinone IIA on alleviating cardiomyocyte injury induced by oxygen glucose deprivation |
| Tanshinone | Myocardial Injury | 2 | PM | 36039734 | 📋 | Tanshinone IIA reduces pyroptosis in rats with coronary microembolization by inhibiting the TLR4/MyD88/NF-κB/NLRP3 pathway |
| Tanshinone | Myocardial Injury | 1 | PM | 30502766 | 📋 | Sodium tanshinone IIA sulfonate attenuates cardiac dysfunction and improves survival of rats with cecal ligation and puncture-induced sepsis |
| Tanshinone | Myocardial Ischemia | 1 | PM | 31629735 | 📋 | Effects of the combination of tanshinone IIA and puerarin on cardiac function and inflammatory response in myocardial ischemia mice |
| Tanshinone | Myocardial Ischemia-Reperfusion | 8 | PM | 38419127 | 📋 | The combination of Tanshinone IIA and Astragaloside IV attenuates myocardial ischemia-reperfusion injury by inhibiting the STING pathway |
| Tanshinone | Myocardial Ischemia-Reperfusion | 7 | PM | 37800609 | 📋 | Tanshinone IIA confers protection against myocardial ischemia/reperfusion injury by inhibiting ferroptosis and apoptosis via VDAC1 |
| Tanshinone | Myocardial Ischemia-Reperfusion | 6 | PM | 37406848 | 📋 | TanshinoneⅡA inhibits excessive autophagy and protects myocardium against ischemia/reperfusion injury via 14-3-3η/Akt/Beclin1 pathway |
| Tanshinone | Myocardial Ischemia-Reperfusion | 5 | PM | 37366130 | 📋 | [Tanshinone IIA inhibits hypoxia/reoxygenation-induced cardiomyocyte apoptosis and autophagy by regulating ABCE1] |
| Tanshinone | Myocardial Ischemia-Reperfusion | 4 | PM | 37261285 | 📋 | Effect of tanshinone IIA for myocardial ischemia/reperfusion injury in animal model: preclinical evidence and possible mechanisms |
| Tanshinone | Myocardial Ischemia-Reperfusion | 3 | PM | 36327403 | 📋 | Tanshinone IIA ameliorates myocardial ischemia/reperfusion injury in rats by regulation of NLRP3 inflammasome activation and Th17 cells differentiation |
| Tanshinone | Myocardial Ischemia-Reperfusion | 2 | PM | 35924522 | 📋 | [Mechanism of tanshinone II A inhibiting myocardial remodeling by Galectin-3] |
| Tanshinone | Myocardial Ischemia-Reperfusion | 1 | PM | 32220226 | 📋 | Tanshinone IIA alleviates hypoxia/reoxygenation induced cardiomyocyte injury via lncRNA AK003290/miR-124-5p signaling |
| Tanshinone | Poor Circulation | 1 | PM | 34804370 | 📋 | Targeting the Ang2/Tie2 Axis with Tanshinone IIA Elicits Vascular Normalization in Ischemic Injury and Colon Cancer |
| Tanshinone | Subarachnoid Hemorrhage | 1 | PM | 38057100 | 📋 | Tanshinone IIA alleviates early brain injury after subarachnoid hemorrhage in rats by inhibiting the activation of NF-κB/NLRP3 inflammasome |
| Tanshinone | Vascular Calcification | 1 | PM | 36594383 | 📋 | [Tanshinone IIa attenuates vascular calcification through inhibition of NF-κB and β-catenin signaling pathways] |
| Tanshinone | Vascular Disorders | 1 | PM | 35432718 | 📋 | Targeting Oxidative Stress and Endothelial Dysfunction Using Tanshinone IIA for the Treatment of Tissue Inflammation and Fibrosis |
| Tanshinone | Vasculitis | 1 | PM | 35498027 | 📋 | Tanshinone IIA Has a Potential Therapeutic Effect on Kawasaki Disease and Suppresses Megakaryocytes in Rabbits With Immune Vasculitis |
