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List of Salidroside and group Circulatory System intersectionsRows: 120■ Human ■ Animal ■ Risk ■ Review

SubstanceConditionSeqSrc
PMID
Dtl
Title
Salidroside Aplastic Anemia
1
PM
37439434📋Salidroside affects the Th17/Treg cell balance in aplastic anemia via the STAT3/HIF-1α/RORγt pathway
Salidroside Atherosclerosis
1
PM
34504429📋Salidroside Ameliorated Intermittent Hypoxia-Aggravated Endothelial Barrier Disruption and Atherosclerosis via the cAMP/PKA/RhoA Signaling Pathway
Salidroside Atherosclerosis
3
PM
33732368📋Salidroside and isorhamnetin attenuate urotensin II-induced inflammatory response in vivo and in vitro: Involvement in regulating the RhoA/ROCK II pathway
Salidroside Atherosclerosis
2
PM
33341055📋Salidroside simultaneously reduces de novo lipogenesis and cholesterol biosynthesis to attenuate atherosclerosis in mice
Salidroside Atherosclerosis
12
PM
32685103📋Salidroside-Mediated Autophagic Targeting of Active Src and Caveolin-1 Suppresses Low-Density Lipoprotein Transcytosis across Endothelial Cells
Salidroside Atherosclerosis
11
PM
32076940📋Salidroside Decreases Atherosclerosis Plaque Formation via Inhibiting Endothelial Cell Pyroptosis
Salidroside Atherosclerosis
10
PM
31656544📋Salidroside prevents tumor necrosis factor-α-induced vascular inflammation by blocking mitogen-activated protein kinase and NF-κB signaling activation
Salidroside Atherosclerosis
9
PM
31146723📋Salidroside protects against ox-LDL-induced endothelial injury by enhancing autophagy mediated by SIRT1-FoxO1 pathway
Salidroside Atherosclerosis
8
PM
29289557📋Salidroside attenuates endothelial cellular senescence via decreasing the expression of inflammatory cytokines and increasing the expression of SIRT3
Salidroside Atherosclerosis
7
PM
29115447📋Salidroside slows the progression of EA.hy926 cell senescence by regulating the cell cycle in an atherosclerosis model
Salidroside Atherosclerosis
5
PM
29017559📋Salidroside protects against foam cell formation and apoptosis, possibly via the MAPK and AKT signaling pathways
Salidroside Atherosclerosis
6
PM
26187353📋Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK/PI3K/Akt/eNOS pathway
Salidroside Atherosclerosis
4
PM
23093983📋Salidroside decreases atherosclerotic plaque formation in low-density lipoprotein receptor-deficient mice
Salidroside Atrial Fibrillation
1
PM
37920527📋Salidroside attenuates atrial fibrosis and atrial fibrillation vulnerability induced by angiotensin-II through inhibition of LOXL2-TGF-β1-Smad2/3 pathway
Salidroside Blood-Brain Barrier Permeability
2
PM
38417575📋Salidroside promotes pro-angiogenesis and repair of blood brain barrier via Notch/ITGB1 signal path in CSVD Model
Salidroside Blood-Brain Barrier Permeability
1
PM
23339921📋Effects of salidroside pretreatment on expression of tumor necrosis factor-alpha and permeability of blood brain barrier in rat model of focal cerebralischemia-reperfusion injury
Salidroside Cardiac Arrhythmia
1
PM
32946036📋Rhodiola crenulata reduces ventricular arrhythmia through mitigating the activation of IL-17 and inhibiting the MAPK signaling pathway
Salidroside Cardiac Hypertrophy
2
PM
36512326📋Salidroside ameliorates pathological cardiac hypertrophy via TLR4-TAK1-dependent signaling
Salidroside Cardiac Hypertrophy
1
PM
35479323📋Salidroside Ameliorates Cardiomyocyte Hypertrophy by Upregulating Peroxisome Proliferator-Activated Receptor-α
Salidroside Cardiotoxicity
1
PM
35180677📋Salidroside inhibits doxorubicin-induced cardiomyopathy by modulating a ferroptosis-dependent pathway
Salidroside Cardiotoxicity
2
PM
32671648📋Salidroside Attenuates Doxorubicin-Induced Cardiac Dysfunction Partially Through Activation of QKI/FoxO1 Pathway
Salidroside Cardiotoxicity
4
PM
24072175📋Salidroside improves doxorubicin-induced cardiac dysfunction by suppression of excessive oxidative stress and cardiomyocyte apoptosis
Salidroside Cardiotoxicity
3
PM
22770377📋Protective effects of salidroside on epirubicin-induced early left ventricular regional systolic dysfunction in patients with breast cancer
Salidroside Cardiotoxicity
5
PM
21563965📋Salidroside protects against hydrogen peroxide-induced injury in cardiac H9c2 cells via PI3K-Akt dependent pathway
Salidroside Cardiovascular Disease
1
PM
33991395📋The therapeutic effects and mechanisms of salidroside on cardiovascular and metabolic diseases: An updated review
Salidroside Cardiovascular Disease
2
PM
33062029📋Antioxidant Effects of Salidroside in the Cardiovascular System
Salidroside Cerebral Hypoperfusion
1
PM
25858674📋Salidroside prevents cognitive impairment induced by chronic cerebral hypoperfusion in rats
Salidroside Cerebral Hypoxia
1
PM
29434685📋Salidroside attenuates hypoxia/reoxygenation-induced human brain vascular smooth muscle cell injury by activating the SIRT1/FOXO3α pathway
Salidroside Cerebral Ischemia
7
PM
38643543📋Salidroside promotes angiogenesis after cerebral ischemia in mice through Shh signaling pathway
Salidroside Cerebral Ischemia
1
PM
34181207📋Protective Effect of Salidroside on Mitochondrial Disturbances via Reducing Mitophagy and Preserving Mitochondrial Morphology in OGD-induced Neuronal Injury
Salidroside Cerebral Ischemia
2
PM
33389472📋Salidroside Inhibits Reactive Astrogliosis and Glial Scar Formation in Late Cerebral Ischemia via the Akt/GSK-3β Pathway
Salidroside Cerebral Ischemia
6
PM
30223020📋2-(4-Methoxyphenyl)ethyl-2-Acetamido-2-deoxy-β-d-pyranoside (A Salidroside Analog) Confers Neuroprotection with a Wide Therapeutic Window by Regulating Local Glucose Metabolism in a Rat Model of Cerebral Ischemic Injury
Salidroside Cerebral Ischemia
5
PM
28478514📋Salidroside Inhibits Inflammation Through PI3K/Akt/HIF Signaling After Focal Cerebral Ischemia in Rats
Salidroside Cerebral Ischemia
4
PM
26563497📋Suppressing Receptor-Interacting Protein 140: a New Sight for Salidroside to Treat Cerebral Ischemia
Salidroside Cerebral Ischemia
3
PM
22095090📋Neuroprotective effects of Salidroside and its analogue tyrosol galactoside against focal cerebral ischemia in vivo and H2O2-induced neurotoxicity in vitro
Salidroside Cerebral Ischemia-Reperfusion
6
PM
36472035📋[Protection of salidroside on endothelial cell barrier in cerebral ischemia-reperfusion model rats]
Salidroside Cerebral Ischemia-Reperfusion
5
PM
36374318📋Salidroside attenuates cerebral ischemia/reperfusion injury by regulating TSC2-induced autophagy
Salidroside Cerebral Ischemia-Reperfusion
4
PM
35976554📋Salidroside inhibited cerebral ischemia/reperfusion-induced oxidative stress and apoptosis via Nrf2/Trx1 signaling pathway
Salidroside Cerebral Ischemia-Reperfusion
1
PM
35543160📋Salidroside Ameliorates Ischemia-Induced Neuronal Injury through AMPK Dependent and Independent Pathways to Maintain Mitochondrial Quality Control
Salidroside Cerebral Ischemia-Reperfusion
3
PM
34988203📋Salidroside inhibits NLRP3 inflammasome activation and apoptosis in microglia induced by cerebral ischemia/reperfusion injury by inhibiting the TLR4/NF-κB signaling pathway
Salidroside Cerebral Ischemia-Reperfusion
2
PM
33747287📋Salidroside regulates imbalance of Th17/Treg and promotes ischemic tolerance by targeting STAT-3 in cerebral ischemia-reperfusion injury
Salidroside Cerebral Ischemia-Reperfusion
11
PM
33240590📋Effects of rhodioloside on the neurological functions of rats with total cerebral ischemia/reperfusion and cone neuron injury in the hippocampal CA1 region
Salidroside Cerebral Ischemia-Reperfusion
8
PM
31920641📋Neuroprotective Effects of Salidroside on Cerebral Ischemia/Reperfusion-Induced Behavioral Impairment Involves the Dopaminergic System
Salidroside Cerebral Ischemia-Reperfusion
10
PM
29434685📋Salidroside attenuates hypoxia/reoxygenation-induced human brain vascular smooth muscle cell injury by activating the SIRT1/FOXO3α pathway
Salidroside Cerebral Ischemia-Reperfusion
9
PM
25911293📋Salidroside-Mediated Neuroprotection is Associated with Induction of Early Growth Response Genes (Egrs) Across a Wide Therapeutic Window
Salidroside Cerebral Ischemia-Reperfusion
7
PM
23339921📋Effects of salidroside pretreatment on expression of tumor necrosis factor-alpha and permeability of blood brain barrier in rat model of focal cerebralischemia-reperfusion injury
Salidroside Coronary Artery Disease
1
PM
37308900📋Mechanism of salidroside against coronary artery disease by network pharmacology analysis
Salidroside Diabetic Cardiomyopathy
2
PM
34467560📋Salidroside attenuates cardiac dysfunction in a rat model of diabetes
Salidroside Diabetic Cardiomyopathy
1
PM
34056772📋Salidroside protects cardiac function in mice with diabetic cardiomyopathy via activation of mitochondrial biogenesis and SIRT3
Salidroside Diabetic Cardiomyopathy
3
PM
33422954📋Salidroside protects against cardiomyocyte apoptosis and ventricular remodeling by AKT/HO-1 signaling pathways in a diabetic cardiomyopathy mouse model
Salidroside Diabetic Vasculopathy
1
PM
28803422📋Salidroside improved cerebrovascular vasodilation in streptozotocin-induced diabetic rats through restoring the function of BKCa channel in smooth muscle cells
Salidroside Endothelial Dysfunction
4
PM
37308414📋[Protective effects of salidroside on vascular endothelial cells in rats with frostbite after chronic hypoxia]
Salidroside Endothelial Dysfunction
3
PM
36472035📋[Protection of salidroside on endothelial cell barrier in cerebral ischemia-reperfusion model rats]
Salidroside Endothelial Dysfunction
2
PM
34269814📋Salidroside Prevents Hypoxia-Induced Human Retinal Microvascular Endothelial Cell Damage Via miR-138/ROBO4 Axis
Salidroside Endothelial Dysfunction
1
PM
34011327📋Salidroside protects endothelial cells against LPS-induced inflammatory injury by inhibiting NLRP3 and enhancing autophagy
Salidroside Endothelial Dysfunction
12
PM
32945356📋Salidroside downregulates microRNA‑133a and inhibits endothelial cell apoptosis induced by oxidized low‑density lipoprotein
Salidroside Endothelial Dysfunction
10
PM
31747547📋Salidroside ameliorates endothelial inflammation and oxidative stress by regulating the AMPK/NF-κB/NLRP3 signaling pathway in AGEs-induced HUVECs
Salidroside Endothelial Dysfunction
11
PM
31701353📋Salidroside Restores an Anti-inflammatory Endothelial Phenotype by Selectively Inhibiting Endothelial Complement After Oxidative Stress
Salidroside Endothelial Dysfunction
9
PM
29289557📋Salidroside attenuates endothelial cellular senescence via decreasing the expression of inflammatory cytokines and increasing the expression of SIRT3
Salidroside Endothelial Dysfunction
8
PM
29115447📋Salidroside slows the progression of EA.hy926 cell senescence by regulating the cell cycle in an atherosclerosis model
Salidroside Endothelial Dysfunction
7
PM
27848074📋Induction of autophagy by salidroside through the AMPK-mTOR pathway protects vascular endothelial cells from oxidative stress-induced apoptosis
Salidroside Endothelial Dysfunction
6
PM
26187353📋Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK/PI3K/Akt/eNOS pathway
Salidroside Endothelial Dysfunction
5
PM
23589720📋Salidroside improves homocysteine-induced endothelial dysfunction by reducing oxidative stress
Salidroside Endothelial Injury
1
PM
34504429📋Salidroside Ameliorated Intermittent Hypoxia-Aggravated Endothelial Barrier Disruption and Atherosclerosis via the cAMP/PKA/RhoA Signaling Pathway
Salidroside Endothelial Injury
6
PM
31146723📋Salidroside protects against ox-LDL-induced endothelial injury by enhancing autophagy mediated by SIRT1-FoxO1 pathway
Salidroside Endothelial Injury
2
PM
30942428📋Salidroside attenuates oxidized low‑density lipoprotein‑induced endothelial cell injury via promotion of the AMPK/SIRT1 pathway
Salidroside Endothelial Injury
5
PM
27809414📋Salidroside protects against homocysteine-induced injury in human umbilical vein endothelial cells via the regulation of endoplasmic reticulum stress
Salidroside Endothelial Injury
4
PM
27517893📋Salidroside Suppresses HUVECs Cell Injury Induced by Oxidative Stress through Activating the Nrf2 Signaling Pathway
Salidroside Endothelial Injury
3
PM
23660824📋Salidroside protects against hydrogen peroxide-induced injury in HUVECs via the regulation of REDD1 and mTOR activation
Salidroside Gestational Hypertension
1
PM
38641312📋Salidroside prevents gestational hypertension-induced impairment of offspring learning and memory via Wnt/Skp2 pathway
Salidroside Hepatic Ischemia-Reperfusion
1
PM
35978104📋Salidroside alleviates hepatic ischemia-reperfusion injury during liver transplant in rat through regulating TLR-4/NF-κB/NLRP3 inflammatory pathway
Salidroside Hepatic Ischemia-Reperfusion
3
PM
28721018📋Salidroside pretreatment attenuates apoptosis and autophagy during hepatic ischemia-reperfusion injury by inhibiting the mitogen-activated protein kinase pathway in mice
Salidroside Hepatic Ischemia-Reperfusion
2
PM
28411054📋Salidroside protects rat liver against ischemia/reperfusion injury by regulating the GSK-3β/Nrf2-dependent antioxidant response and mitochondrial permeability transition
Salidroside Hypertension
1
PM
28441970📋Salidroside contributes to reducing blood pressure and alleviating cerebrovascular contractile activity in diabetic Goto-Kakizaki Rats by inhibition of L-type calcium channel in smooth muscle cells
Salidroside Intestinal Ischemia-Reperfusion
1
PM
37530723📋Network pharmacology analysis combined with experimental validation to explore the therapeutic mechanism of salidroside on intestine ischemia reperfusion
Salidroside Ischemia Injury
1
PM
36060000📋Therapeutic potential and molecular mechanisms of salidroside in ischemic diseases
Salidroside Ischemia-Reperfusion Injuries
1
PM
36907990📋Salidroside postconditioning attenuates ferroptosis-mediated lung ischemia-reperfusion injury by activating the Nrf2/SLC7A11 signaling axis
Salidroside Ischemia-Reperfusion Injuries
2
PM
32774670📋Salidroside Ameliorates Mitochondria-Dependent Neuronal Apoptosis after Spinal Cord Ischemia-Reperfusion Injury Partially through Inhibiting Oxidative Stress and Promoting Mitophagy
Salidroside Ischemic Stroke
7
PM
38488455📋Salidroside directly activates HSC70, revealing a new role for HSC70 in BDNF signalling and neurogenesis after cerebral ischemia
Salidroside Ischemic Stroke
3
PM
36374318📋Salidroside attenuates cerebral ischemia/reperfusion injury by regulating TSC2-induced autophagy
Salidroside Ischemic Stroke
2
PM
34988203📋Salidroside inhibits NLRP3 inflammasome activation and apoptosis in microglia induced by cerebral ischemia/reperfusion injury by inhibiting the TLR4/NF-κB signaling pathway
Salidroside Ischemic Stroke
1
PM
33389472📋Salidroside Inhibits Reactive Astrogliosis and Glial Scar Formation in Late Cerebral Ischemia via the Akt/GSK-3β Pathway
Salidroside Ischemic Stroke
6
PM
32603893📋Salidroside as a potential neuroprotective agent for ischemic stroke: a review of sources, pharmacokinetics, mechanism and safety
Salidroside Ischemic Stroke
5
PM
32518214📋Fibroblast growth factor 2 contributes to the effect of salidroside on dendritic and synaptic plasticity after cerebral ischemia/reperfusion injury
Salidroside Ischemic Stroke
4
PM
26889188📋Neuroprotective effects of salidroside on focal cerebral ischemia/reperfusion injury involve the nuclear erythroid 2-related factor 2 pathway
Salidroside Middle Cerebral Artery Occlusion
1
PM
35543160📋Salidroside Ameliorates Ischemia-Induced Neuronal Injury through AMPK Dependent and Independent Pathways to Maintain Mitochondrial Quality Control
Salidroside Middle Cerebral Artery Occlusion
2
PM
31230155📋Salidroside Reduces Inflammation and Brain Injury After Permanent Middle Cerebral Artery Occlusion in Rats by Regulating PI3K/PKB/Nrf2/NFκB Signaling Rather than Complement C3 Activity
Salidroside Myocardial Fibrosis
1
PM
37544102📋Integrating network pharmacology and experimental verification to explore the mechanisms of salidroside against myocardial fibrosis
Salidroside Myocardial Hypoxia
4
PM
38737233📋The application of proteomics and phosphoproteomics to reveal the molecular mechanism of salidroside in ameliorating myocardial hypoxia
Salidroside Myocardial Hypoxia
2
PM
32489291📋Mechanism of salidroside relieving the acute hypoxia-induced myocardial injury through the PI3K/Akt pathway
Salidroside Myocardial Hypoxia
3
PM
31918273📋Metabolic profiling reveals that salidroside antagonizes hypoxic injury via modulating energy and lipid metabolism in cardiomyocytes
Salidroside Myocardial Hypoxia
1
PM
30805019📋Effects of Modulation of Ion Channel Currents by Salidroside in H9C2 Myocardial Cells in Hypoxia and Reoxygenation
Salidroside Myocardial Infarction
1
PM
31792327📋Protective effects of Salidroside on cardiac function in mice with myocardial infarction
Salidroside Myocardial Injury
5
PM
31647492📋Salidroside protects the cardiac function of exhausted rats by inducing Nrf2 expression
Salidroside Myocardial Injury
6
PM
31448659📋Salidroside pretreatment protects against myocardial injury induced by heat stroke in mice
Salidroside Myocardial Injury
4
PM
28905500📋Salidroside suppressing LPS-induced myocardial injury by inhibiting ROS-mediated PI3K/Akt/mTOR pathway in vitro and in vivo
Salidroside Myocardial Injury
3
PM
26167242📋The Protective Effects of Salidroside from Exhaustive Exercise-Induced Heart Injury by Enhancing the PGC-1 α -NRF1/NRF2 Pathway and Mitochondrial Respiratory Function in Rats
Salidroside Myocardial Injury
2
PM
25682470📋Effects of Salidroside on Myocardial Injury In Vivo In Vitro via Regulation of Nox/NF-κB/AP1 Pathway
Salidroside Myocardial Injury
1
PM
24454984📋The protection of salidroside of the heart against acute exhaustive injury and molecular mechanism in rat
Salidroside Myocardial Ischemia
2
PM
31701727📋[The effects of salidroside on the apoptosis pathway of myocardial cells in acute exhausted rats]
Salidroside Myocardial Ischemia
1
PM
21160132📋Salidroside attenuates apoptosis in ischemic cardiomyocytes: a mechanism through a mitochondria-dependent pathway
Salidroside Myocardial Ischemia-Reperfusion
10
PM
38552436📋Salidroside pretreatment alleviates ferroptosis induced by myocardial ischemia/reperfusion through mitochondrial superoxide-dependent AMPKα2 activation
Salidroside Myocardial Ischemia-Reperfusion
9
PM
37740139📋Salidroside Ameliorates Ischemia/Reperfusion-Induced Human Cardiomyocyte Injury by Inhibiting the Circ_0097682/miR-671-5p/USP46 Pathway
Salidroside Myocardial Ischemia-Reperfusion
3
PM
35927086📋Salidroside Inhibits Ischemia/Reperfusion-Induced Myocardial Apoptosis by Targeting Mir-378a-3p Via the Igf1r/Pi3k/Akt Signaling Pathway
Salidroside Myocardial Ischemia-Reperfusion
1
PM
35659894📋Salidroside attenuates myocardial ischemia/reperfusion injury via AMPK-induced suppression of endoplasmic reticulum stress and mitochondrial fission
Salidroside Myocardial Ischemia-Reperfusion
2
PM
32858179📋Salidroside inhibits apoptosis and autophagy of cardiomyocyte by regulation of circular RNA hsa_circ_0000064 in cardiac ischemia-reperfusion injury
Salidroside Myocardial Ischemia-Reperfusion
8
PM
32104217📋MicroRNA-21 mediates the protective effects of salidroside against hypoxia/reoxygenation-induced myocardial oxidative stress and inflammatory response
Salidroside Myocardial Ischemia-Reperfusion
7
PM
27155549📋Cardioprotective effects of salidroside on myocardial ischemia-reperfusion injury in coronary artery occlusion-induced rats and Langendorff-perfused rat hearts
Salidroside Myocardial Ischemia-Reperfusion
6
PM
26385354📋The cardioprotective effect of salidroside against myocardial ischemia reperfusion injury in rats by inhibiting apoptosis and inflammation
Salidroside Myocardial Ischemia-Reperfusion
4
PM
23418859📋Salidroside attenuates myocardial ischemia-reperfusion injury via PI3K/Akt signaling pathway
Salidroside Myocardial Ischemia-Reperfusion
5
PM
22771701📋Salidroside and tyrosol from Rhodiola protect H9c2 cells from ischemia/reperfusion-induced apoptosis
Salidroside Myocarditis
1
PM
26104971📋Salidroside Mitigates Sepsis-Induced Myocarditis in Rats by Regulating IGF-1/PI3K/Akt/GSK-3β Signaling
Salidroside Peripheral Arterial Disease
1
PM
28266625📋Inhibition of PHD3 by salidroside promotes neovascularization through cell-cell communications mediated by muscle-secreted angiogenic factors
Salidroside Platelet Aggregation
1
PM
32352928📋Salidroside inhibits platelet function and thrombus formation through AKT/GSK3β signaling pathway
Salidroside RBC Count High
1
PM
33164438📋[Proteomics analysis of erythrocyte membrane in rats with high altitude polycythemia before and after intervention with salidroside]
Salidroside Renal Ischemia-Reperfusion
1
PM
37822587📋Salidroside inhibits renal ischemia/reperfusion injury‑induced ferroptosis by the PI3K/AKT signaling pathway
Salidroside Right Ventricular Hypertrophy
1
PM
25772255📋Salidroside attenuates chronic hypoxia-induced pulmonary hypertension via adenosine A2a receptor related mitochondria-dependent apoptosis pathway
Salidroside Thrombosis
1
PM
32352928📋Salidroside inhibits platelet function and thrombus formation through AKT/GSK3β signaling pathway
Salidroside Vascular Disorders
2
PM
31656544📋Salidroside prevents tumor necrosis factor-α-induced vascular inflammation by blocking mitogen-activated protein kinase and NF-κB signaling activation
Salidroside Vasodilation
1
PM
28803422📋Salidroside improved cerebrovascular vasodilation in streptozotocin-induced diabetic rats through restoring the function of BKCa channel in smooth muscle cells