| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Metformin | Abdominal Aortic Aneurysm | 4 | PM | 38239055 | 📋 | Association of metformin use with abdominal aortic aneurysm: A systematic review and meta-analysis |
| Metformin | Abdominal Aortic Aneurysm | 3 | PM | 38055889 | 📋 | Influence of cardiometabolic medications on abdominal aortic aneurysm growth in the UK Aneurysm Growth Study: metformin and angiotensin-converting enzyme inhibitors associated with slower aneurysm growth |
| Metformin | Abdominal Aortic Aneurysm | 2 | PM | 37168662 | 📋 | Mechanisms and efficacy of metformin-mediated suppression of established experimental abdominal aortic aneurysms |
| Metformin | Abdominal Aortic Aneurysm | 1 | PM | 35677692 | 📋 | Association Between Metformin and Abdominal Aortic Aneurysm: A Meta-Analysis |
| Metformin | Aortic Valve Stenosis | 1 | PM | 38052777 | 📋 | Metformin ameliorates valve interstitial cell calcification by promoting autophagic flux |
| Metformin | Arterial Stiffness | 1 | PM | 37165762 | 📋 | Effects of first-line antidiabetic drugs on the improvement of arterial stiffness: A Bayesian network meta-analysis |
| Metformin | Atherosclerosis | 5 | PM | 37968424 | 📋 | Therapeutic efficacies of mitochondria-targeted esculetin and metformin in the improvement of age-associated atherosclerosis via regulating AMPK activation |
| Metformin | Atherosclerosis | 4 | PM | 37800110 | 📋 | Metformin Reduces the Progression of Atherogenesis by Regulating the Sestrin2-mTOR Pathway in Obese and Diabetic Rats |
| Metformin | Atherosclerosis | 3 | PM | 37631325 | 📋 | Metformin Impedes Oxidation of LDL In Vitro |
| Metformin | Atherosclerosis | 2 | PM | 36160906 | 📋 | Metformin suppresses foam cell formation, inflammation and ferroptosis via the AMPK/ERK signaling pathway in ox‑LDL‑induced THP‑1 monocytes |
| Metformin | Atherosclerosis | 1 | PM | 32800550 | 📋 | Metformin, resveratrol, and exendin-4 inhibit high phosphate-induced vascular calcification via AMPK-RANKL signaling |
| Metformin | Atrial Fibrillation | 1 | PM | 36223777 | 📋 | Transcriptomics-based network medicine approach identifies metformin as a repurposable drug for atrial fibrillation |
| Metformin | Atrial Fibrillation | 3 | PM | 33693008 | 📋 | Metformin Use Is Associated With a Lower Incidence of Hospitalization for Atrial Fibrillation in Patients With Type 2 Diabetes Mellitus |
| Metformin | Atrial Fibrillation | 2 | PM | 32844365 | 📋 | Activation of AMP-Activated Protein Kinases Prevents Atrial Fibrillation |
| Metformin | Blood-Brain Barrier Permeability | 1 | PM | 35660649 | 📋 | Metformin protects against pericyte apoptosis and promotes neurogenesis through suppressing JNK p38 MAPK signalling activation in ischemia/reperfusion injury |
| Metformin | Cardiac Hypertrophy | 1 | PM | 35833024 | 📋 | Metformin Attenuates Cardiac Hypertrophy Via the HIF-1α/PPAR-γ Signaling Pathway in High-Fat Diet Rats |
| Metformin | Cardiomyopathy | 1 | PM | 31153974 | 📋 | Endoplasmic reticulum stress-induced iRhom2 up-regulation promotes macrophage-regulated cardiac inflammation and lipid deposition in high fat diet (HFD)-challenged mice: Intervention of fisetin and metformin |
| Metformin | Cardiotoxicity | 7 | PM | 38487671 | 📋 | Metformin Inhibits Autophagy, Mitophagy and Antagonizes Doxorubicin-Induced Cardiomyocyte Death |
| Metformin | Cardiotoxicity | 6 | PM | 37933643 | 📋 | [Metformin mitigates doxorubicin-induced cardiotoxicity via the AMPK pathway] |
| Metformin | Cardiotoxicity | 5 | PM | 37501618 | 📋 | Metformin ameliorates cardiopulmonary toxicity induced by chlorpyrifos |
| Metformin | Cardiotoxicity | 4 | PM | 36790727 | 📋 | Metformin and Dapagliflozin Attenuate Doxorubicin-Induced Acute Cardiotoxicity in Wistar Rats: An Electrocardiographic, Biochemical, and Histopathological Approach |
| Metformin | Cardiotoxicity | 3 | PM | 36649752 | 📋 | Metformin ameliorates doxorubicin induced cardiotoxicity targeting HMGB1/TLR4/NLRP3 signaling pathway in mice |
| Metformin | Cardiotoxicity | 2 | PM | 36494039 | 📋 | Melatonin and metformin ameliorated trastuzumab-induced cardiotoxicity through the modulation of mitochondrial function and dynamics without reducing its anticancer efficacy |
| Metformin | Cardiotoxicity | 1 | PM | 34453902 | 📋 | Cardioprotective Effects of Melatonin and Metformin Against Doxorubicin-induced Cardiotoxicity in Rats are Through Preserving Mitochondrial Function and Dynamics |
| Metformin | Cardiovascular Disease | 11 | PM | 37307806 | 📋 | Cardiovascular Protection by Metformin: Latest Advances in Basic and Clinical Research |
| Metformin | Cardiovascular Disease | 10 | PM | 37051071 | 📋 | Metformin adherence and the risk of cardiovascular disease: a population-based cohort study |
| Metformin | Cardiovascular Disease | 9 | PM | 36972373 | 📋 | Metformin: evidence from preclinical and clinical studies for potential novel applications in cardiovascular disease |
| Metformin | Cardiovascular Disease | 8 | PM | 36918276 | 📋 | Metformin Monotherapy Alters the Human Plasma Lipidome Independent of Clinical Markers of Glycemic Control and Cardiovascular Disease Risk in a Type 2 Diabetes Clinical Cohort |
| Metformin | Cardiovascular Disease | 7 | PM | 36205446 | 📋 | Effects of glucose-lowering agents on cardiovascular and renal outcomes in subjects with type 2 diabetes: an updated meta-analysis of randomized controlled trials with external adjudication of events |
| Metformin | Cardiovascular Disease | 6 | PM | 36077136 | 📋 | From Diabetes to Atherosclerosis: Potential of Metformin for Management of Cardiovascular Disease |
| Metformin | Cardiovascular Disease | 5 | PM | 36071848 | 📋 | Cardiovascular outcomes of metformin use in patients with type 2 diabetes and chronic obstructive pulmonary disease |
| Metformin | Cardiovascular Disease | 4 | PM | 36052760 | 📋 | Protective effects of metformin in various cardiovascular diseases: Clinical evidence and AMPK-dependent mechanisms |
| Metformin | Cardiovascular Disease | 3 | PM | 35903672 | 📋 | Metformin Protects Cardiovascular Health in People With Diabetes |
| Metformin | Cardiovascular Disease | 1 | PM | 34801530 | 📋 | Berberine and lycopene as alternative or add-on therapy to metformin and statins, a review |
| Metformin | Cardiovascular Disease | 2 | PM | 34660673 | 📋 | Targeting Cardiovascular Risk Factors Through Dietary Adaptations and Caloric Restriction Mimetics |
| Metformin | Cerebral Hypoperfusion | 2 | PM | 37177813 | 📋 | Metformin attenuates white matter injury and cognitive impairment induced by chronic cerebral hypoperfusion |
| Metformin | Cerebral Hypoperfusion | 1 | PM | 35769369 | 📋 | Metformin, Rapamycin, or Nicotinamide Mononucleotide Pretreatment Attenuate Cognitive Impairment After Cerebral Hypoperfusion by Inhibiting Microglial Phagocytosis |
| Metformin | Cerebral Ischemia-Reperfusion | 2 | PM | 37741536 | 📋 | Metformin alleviates cerebral ischemia/reperfusion injury aggravated by hyperglycemia via regulating AMPK/ULK1/PINK1/Parkin pathway-mediated mitophagy and apoptosis |
| Metformin | Cerebral Ischemia-Reperfusion | 1 | PM | 35660649 | 📋 | Metformin protects against pericyte apoptosis and promotes neurogenesis through suppressing JNK p38 MAPK signalling activation in ischemia/reperfusion injury |
| Metformin | Diabetic Cardiomyopathy | 8 | PM | 37750221 | 📋 | Metformin inhibits mitochondrial dysfunction and apoptosis in cardiomyocytes induced by high glucose via upregulating AMPK activity |
| Metformin | Diabetic Cardiomyopathy | 7 | PM | 37353174 | 📋 | Metformin suppresses cardiac fibroblast proliferation under high-glucose conditions via regulating the mitochondrial complex I protein Grim-19 involved in the Sirt1/Stat3 signaling pathway |
| Metformin | Diabetic Cardiomyopathy | 6 | PM | 36481406 | 📋 | The combination of exercise and metformin inhibits TGF-β1/Smad pathway to attenuate myocardial fibrosis in db/db mice by reducing NF-κB-mediated inflammatory response |
| Metformin | Diabetic Cardiomyopathy | 5 | PM | 35935389 | 📋 | Effects of curcumin and metformin on oxidative stress and apoptosis in heart tissue of type 1 diabetic rats |
| Metformin | Diabetic Cardiomyopathy | 3 | PM | 35401934 | 📋 | Traditional Chinese Medicine Ginseng Dingzhi Decoction Ameliorates Myocardial Fibrosis and High Glucose-Induced Cardiomyocyte Injury by Regulating Intestinal Flora and Mitochondrial Dysfunction |
| Metformin | Diabetic Cardiomyopathy | 1 | PM | 34550826 | 📋 | Bee venom ameliorates cardiac dysfunction in diabetic hyperlipidemic rats |
| Metformin | Diabetic Cardiomyopathy | 4 | PM | 34102283 | 📋 | Effects of omega-3 fatty acids and metformin combination on diabetic cardiomyopathy in rats through autophagic pathway: Effects of omega-3 fatty acids and metformin combination on diabetic cardiomyopathy: Role of autophagy |
| Metformin | Diabetic Cardiomyopathy | 2 | PM | 31572181 | 📋 | Carvacrol Attenuates Diabetic Cardiomyopathy by Modulating the PI3K/AKT/GLUT4 Pathway in Diabetic Mice |
| Metformin | Diabetic Vasculopathy | 1 | PM | 37759984 | 📋 | AMPK-Dependent YAP Inhibition Mediates the Protective Effect of Metformin against Obesity-Associated Endothelial Dysfunction and Inflammation |
| Metformin | Endothelial Dysfunction | 8 | PM | 37759984 | 📋 | AMPK-Dependent YAP Inhibition Mediates the Protective Effect of Metformin against Obesity-Associated Endothelial Dysfunction and Inflammation |
| Metformin | Endothelial Dysfunction | 6 | PM | 37168843 | 📋 | Metformin mitigates SASP secretion and LPS-triggered hyper-inflammation in Doxorubicin-induced senescent endothelial cells |
| Metformin | Endothelial Dysfunction | 5 | PM | 36496468 | 📋 | Quercetin and metformin synergistically reverse endothelial dysfunction in the isolated aorta of streptozotocin-nicotinamide- induced diabetic rats |
| Metformin | Endothelial Dysfunction | 2 | PM | 33149857 | 📋 | Effects of alpha-mangostin on memory senescence induced by high glucose in human umbilical vein endothelial cells |
| Metformin | Endothelial Dysfunction | 4 | PM | 32863988 | 📋 | A novel mechanism of vitamin D anti-inflammatory/antioxidative potential in type 2 diabetic patients on metformin therapy |
| Metformin | Endothelial Dysfunction | 1 | PM | 31929697 | 📋 | Endothelial Dysfunction and Inflammatory Biomarkers as a Response Factor of Concurrent Coenzyme Q10 Add-On Metformin in Patients With Type 2 Diabetes Mellitus |
| Metformin | Endothelial Dysfunction | 3 | PM | 27247923 | 📋 | Nigella sativa seed decreases endothelial dysfunction in streptozotocin-induced diabetic rat aorta |
| Metformin | Endothelial Dysfunction | 7 | PM | 23981104 | 📋 | Long-term effects of metformin on endothelial function in type 2 diabetes: a randomized controlled trial |
| Metformin | Endothelial Injury | 2 | PM | 38333748 | 📋 | Metformin alleviates bevacizumab-induced vascular endothelial injury in mice through growth differentiation factor 15 upregulation |
| Metformin | Endothelial Injury | 1 | PM | 36613786 | 📋 | Metformin Alleviates Epirubicin-Induced Endothelial Impairment by Restoring Mitochondrial Homeostasis |
| Metformin | Heart Failure | 5 | PM | 38107711 | 📋 | Metformin effects on cardiac parameters in non-diabetic Iraqi patients with heart failure and mid-range ejection fraction - a comparative two-arm parallel clinical study |
| Metformin | Heart Failure | 4 | PM | 37816240 | 📋 | Effect of Metformin on Oxidative Stress and Left Ventricular Geometry in Nondiabetic Heart Failure Patients: A Randomized Controlled Trial |
| Metformin | Heart Failure | 3 | PM | 37717921 | 📋 | Prognostic impact of metformin in patients with type 2 diabetes mellitus and acute heart failure: Combined analysis of the EAHFE and RICA registries |
| Metformin | Heart Failure | 2 | PM | 37016750 | 📋 | The safe use of metformin in heart failure patients both with and without T2DM: a cross-sectional and longitudinal study |
| Metformin | Heart Failure | 1 | PM | 35906276 | 📋 | Metformin treatment is associated with improved outcome in patients with diabetes and advanced heart failure (HFrEF) |
| Metformin | Hematologic Malignancies | 2 | PM | 37364455 | 📋 | Repurposing Metformin in hematologic tumor: State of art |
| Metformin | Hematologic Malignancies | 1 | PM | 36830619 | 📋 | Action Mechanism of Metformin and Its Application in Hematological Malignancy Treatments: A Review |
| Metformin | Hemorrhoids | 1 | PM | 33664665 | 📋 | Chronic Metformin Therapy is Associated with a Lower Risk of Hemorrhoid in Patients with Type 2 Diabetes Mellitus |
| Metformin | Hypertension | 4 | PM | 37055870 | 📋 | Antihypertensive and antihyperglycemic effects of combinations of losartan with metformin and/or glibenclamide in desoxycorticosterone acetate and streptozotocin-induced hypertensive diabetic rats |
| Metformin | Hypertension | 3 | PM | 36985728 | 📋 | Metformin Suppresses Thioacetamide-Induced Chronic Kidney Disease in Association with the Upregulation of AMPK and Downregulation of Oxidative Stress and Inflammation as Well as Dyslipidemia and Hypertension |
| Metformin | Hypertension | 2 | PM | 36830842 | 📋 | Metformin Alleviates Diabetes-Associated Hypertension by Attenuating the Renal Epithelial Sodium Channel |
| Metformin | Hypertension | 1 | PM | 34032731 | 📋 | Therapeutic effects of puerarin on polycystic ovary syndrome: A randomized trial in Chinese women |
| Metformin | Intracerebral Hemorrhage | 1 | PM | 35852765 | 📋 | Metformin Alleviates Delayed Hydrocephalus after Intraventricular Hemorrhage by Inhibiting Inflammation and Fibrosis |
| Metformin | Ischemia-Reperfusion Injuries | 1 | PM | 38317565 | 📋 | Metformin alleviates lung ischemia-reperfusion injury in a rat lung transplantation model |
| Metformin | Ischemic Stroke | 4 | PM | 37291921 | 📋 | [Metformin use and risk of ischemic stroke in patients with type 2 diabetes: A cohort study] |
| Metformin | Ischemic Stroke | 3 | PM | 36611122 | 📋 | Metformin enhances neural precursor cells migration and functional recovery after ischemic stroke in mice |
| Metformin | Ischemic Stroke | 2 | PM | 36445542 | 📋 | Metformin treatment and acute ischemic stroke outcomes in patients with type 2 diabetes: a retrospective cohort study |
| Metformin | Ischemic Stroke | 1 | PM | 35863262 | 📋 | Effect of metformin on outcome after acute ischemic stroke in patients with type 2 diabetes mellitus |
| Metformin | Left Ventricular Hypertrophy | 2 | PM | 36088302 | 📋 | Effect of metformin on left ventricular mass and functional parameters in non-diabetic patients: a meta-analysis of randomized clinical trials |
| Metformin | Left Ventricular Hypertrophy | 1 | PM | 32462317 | 📋 | Hesperidin ameliorates signs of the metabolic syndrome and cardiac dysfunction via IRS/Akt/GLUT4 signaling pathway in a rat model of diet-induced metabolic syndrome |
| Metformin | Lymphedema | 1 | PM | 38391208 | 📋 | Metformin eliminates lymphedema in mice by alleviating inflammation and fibrosis: implications for human therapy |
| Metformin | Middle Cerebral Artery Occlusion | 1 | PM | 35660649 | 📋 | Metformin protects against pericyte apoptosis and promotes neurogenesis through suppressing JNK p38 MAPK signalling activation in ischemia/reperfusion injury |
| Metformin | Myocardial Fibrosis | 1 | PM | 35401934 | 📋 | Traditional Chinese Medicine Ginseng Dingzhi Decoction Ameliorates Myocardial Fibrosis and High Glucose-Induced Cardiomyocyte Injury by Regulating Intestinal Flora and Mitochondrial Dysfunction |
| Metformin | Myocardial Fibrosis | 2 | PM | 28230250 | 📋 | Metformin attenuates angiotensin II-induced TGFβ1 expression by targeting hepatocyte nuclear factor-4-α |
| Metformin | Myocardial Infarction | 4 | PM | 37196121 | 📋 | Acute, High Dose Metformin Therapy at Reperfusion Decreases Infarct Size in the High-Risk Aging Heart |
| Metformin | Myocardial Infarction | 3 | PM | 36826550 | 📋 | Metformin Directly Binds to MMP-9 to Improve Plaque Stability |
| Metformin | Myocardial Infarction | 2 | PM | 35998511 | 📋 | Effects of metformin on changes of miR-19a and miR-221 expression associated with myocardial infarction in patients with type 2 diabetes |
| Metformin | Myocardial Infarction | 1 | PM | 35950214 | 📋 | Aberrant HSF1 signaling activation underlies metformin amelioration of myocardial infarction in mice |
| Metformin | Myocardial Injury | 2 | PM | 37499052 | 📋 | Metformin Alleviates Sepsis-associated Myocardial Injury by Enhancing AMPK/mTOR Signaling Pathway-mediated Autophagy |
| Metformin | Myocardial Injury | 1 | PM | 24335026 | 📋 | Protective effect of metformin on myocardial injury in metabolic syndrome patients following percutaneous coronary intervention |
| Metformin | Myocardial Ischemia | 1 | PM | 37031594 | 📋 | Administration of metformin rescues age-related vulnerability to ischemic insults through mitochondrial energy metabolism |
| Metformin | Myocardial Ischemia-Reperfusion | 6 | PM | 37631036 | 📋 | Effects of Metformin on Ischemia/Reperfusion Injury: New Evidence and Mechanisms |
| Metformin | Myocardial Ischemia-Reperfusion | 5 | PM | 37288723 | 📋 | Metformin ameliorates ferroptosis in cardiac ischemia and reperfusion by reducing NOX4 expression via promoting AMPKα |
| Metformin | Myocardial Ischemia-Reperfusion | 4 | PM | 37196121 | 📋 | Acute, High Dose Metformin Therapy at Reperfusion Decreases Infarct Size in the High-Risk Aging Heart |
| Metformin | Myocardial Ischemia-Reperfusion | 3 | PM | 36322187 | 📋 | Metformin confers longitudinal cardiac protection by preserving mitochondrial homeostasis following myocardial ischemia/reperfusion injury |
| Metformin | Myocardial Ischemia-Reperfusion | 2 | PM | 35811313 | 📋 | Evaluating the cardioprotective effect of metformin on myocardial ischemia-reperfusion injury using dynamic 18 F-FDG micro-PET/CT imaging |
| Metformin | Myocardial Ischemia-Reperfusion | 1 | PM | 34527070 | 📋 | Potential Interaction of Fresh Garlic with Metformin during Ischemia-Reperfusion Induced Cardiac Injury in Diabetic Rats |
| Metformin | Platelet Aggregation | 1 | PM | 37975061 | 📋 | High Dose of Metformin Decreases Susceptibility to Occlusive Arterial Thrombosis in Diabetic Mice |
| Metformin | Retinal Ischemia-Reperfusion | 1 | PM | 37253410 | 📋 | Metformin protects against retinal ischemia/reperfusion injury through AMPK-mediated mitochondrial fusion |
| Metformin | Right Ventricular Hypertrophy | 1 | PM | 37389952 | 📋 | Metformin protects against pulmonary hypertension-induced right ventricular dysfunction in an age- and sex-specific manner independent of cardiac AMPK |
| Metformin | Stroke | 5 | PM | 38043334 | 📋 | Neuroprotective effects of oral metformin before stroke on cerebral small-vessel disease |
| Metformin | Stroke | 2 | PM | 36826550 | 📋 | Metformin Directly Binds to MMP-9 to Improve Plaque Stability |
| Metformin | Stroke | 1 | PM | 36408248 | 📋 | Neuropharmacological efficacy of metformin for stroke in rodents: A meta-analysis of preclinical trials |
| Metformin | Stroke | 3 | PM | 28939005 | 📋 | Antidiabetic drugs and stroke risk. Current evidence |
| Metformin | Stroke | 4 | PM | 24119365 | 📋 | Metformin-inclusive therapy reduces the risk of stroke in patients with diabetes: a 4-year follow-up study |
| Metformin | Subarachnoid Hemorrhage | 1 | PM | 35341746 | 📋 | Metformin attenuates early brain injury after subarachnoid hemorrhage in rats via AMPK-dependent mitophagy |
| Metformin | Thoracic Aortic Aneurysm | 1 | PM | 35636318 | 📋 | Patient-derived microphysiological model identifies the therapeutic potential of metformin for thoracic aortic aneurysm |
| Metformin | Thrombosis | 3 | PM | 37975061 | 📋 | High Dose of Metformin Decreases Susceptibility to Occlusive Arterial Thrombosis in Diabetic Mice |
| Metformin | Thrombosis | 2 | PM | 37503167 | 📋 | High Dose of Metformin Decreases Susceptibility to Occlusive Arterial Thrombosis in Diabetic Mice |
| Metformin | Thrombosis | 1 | PM | 35561893 | 📋 | Metformin inhibits multiple myeloma serum-induced endothelial cell thrombosis by down-regulating miR-532 |
| Metformin | Vascular Aging | 3 | PM | 37168843 | 📋 | Metformin mitigates SASP secretion and LPS-triggered hyper-inflammation in Doxorubicin-induced senescent endothelial cells |
| Metformin | Vascular Aging | 2 | PM | 36328749 | 📋 | Metformin suppresses vascular smooth muscle cell senescence by promoting autophagic flux |
| Metformin | Vascular Aging | 1 | PM | 35863470 | 📋 | Metformin mitigates stress-induced premature senescence by upregulating AMPKα at Ser485 phosphorylation induced SIRT3 expression and inactivating mitochondrial oxidants |
| Metformin | Vascular Calcification | 2 | PM | 36166694 | 📋 | Metformin protects against vascular calcification through the selective degradation of Runx2 by the p62 autophagy receptor |
| Metformin | Vascular Calcification | 1 | PM | 32800550 | 📋 | Metformin, resveratrol, and exendin-4 inhibit high phosphate-induced vascular calcification via AMPK-RANKL signaling |
| Metformin | Vascular Disorders | 1 | PM | 35909294 | 📋 | Repurposing Metformin for Vascular Disease |
| Metformin | Vasoconstriction | 1 | PM | 36914083 | 📋 | AMPK activation by metformin protects against pulmonary hypertension in rats and relaxes isolated human pulmonary artery |
