| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Hesperidin | Aging Heart | 1 | PM | 22943178 | 📋 | Hesperidin-mediated expression of Nrf2 and upregulation of antioxidant status in senescent rat heart |
| Hesperidin | Arterial Stiffness | 2 | PM | 36039965 | 📋 | Hesperidin Preferentially Stimulates Transient Receptor Potential Vanilloid 1, Leading to NO Production and Mas Receptor Expression in Human Umbilical Vein Endothelial Cells |
| Hesperidin | Arterial Stiffness | 1 | PM | 28780050 | 📋 | Hesperidin reverses perivascular adipose-mediated aortic stiffness with aging |
| Hesperidin | Atherosclerosis | 1 | PM | 35276933 | 📋 | Multifaceted Protective Effects of Hesperidin by Aromatic Hydrocarbon Receptor in Endothelial Cell Injury Induced by Benzo[a]Pyrene |
| Hesperidin | Atherosclerosis | 5 | PM | 33890787 | 📋 | Four Citrus Flavanones Exert Atherosclerosis Alleviation Effects in ApoE -/- Mice via Different Metabolic and Signaling Pathways |
| Hesperidin | Atherosclerosis | 4 | PM | 28899694 | 📋 | Anti-atherosclerotic effect of hesperidin in LDLr -/- mice and its possible mechanism |
| Hesperidin | Atherosclerosis | 2 | PM | 27704466 | 📋 | Anti-arthritogenic and Cardioprotective Action of Hesperidin and Daidzein in Collagen-Induced Rheumatoid Arthritis |
| Hesperidin | Blood-Brain Barrier Permeability | 1 | PM | 32916895 | 📋 | Yuzu and Hesperidin Ameliorate Blood-Brain Barrier Disruption during Hypoxia via Antioxidant Activity |
| Hesperidin | Cardiac Hypertrophy | 1 | PM | 30623541 | 📋 | Hesperidin regresses cardiac hypertrophy by virtue of PPAR-γ agonistic, anti-inflammatory, antiapoptotic, and antioxidant properties |
| Hesperidin | Cardiomyopathy | 1 | PM | 27651565 | 📋 | Radioprotective effects of hesperidin on oxidative damages and histopathological changes induced by X-irradiation in rats heart tissue |
| Hesperidin | Cardiotoxicity | 9 | PM | 38292716 | 📋 | The role of hesperidin as a cardioprotective strategy against doxorubicin-induced cardiotoxicity: The antioxidant, anti-inflammatory, antiapoptotic, and cytoprotective potentials |
| Hesperidin | Cardiotoxicity | 7 | PM | 37369581 | 📋 | Hesperidin via maintenance of mitochondrial function and antioxidant activity protects lithium toxicity in rat heart isolated mitochondria |
| Hesperidin | Cardiotoxicity | 6 | PM | 36874615 | 📋 | Rutin and Hesperidin Alleviate Paclitaxel-Induced Nephrocardiotoxicity in Wistar Rats via Suppressing the Oxidative Stress and Enhancing the Antioxidant Defense Mechanisms |
| Hesperidin | Cardiotoxicity | 5 | PM | 35606666 | 📋 | Hesperidin Attenuates Oxidative Stress, Inflammation, Apoptosis, and Cardiac Dysfunction in Sodium Fluoride-Induced Cardiotoxicity in Rats |
| Hesperidin | Cardiotoxicity | 4 | PM | 35522359 | 📋 | Investigating Radioprotective Effect of Hesperidin/Diosmin Compound Against 99m Tc-MIBI-Induced Cardiotoxicity: Animal Study |
| Hesperidin | Cardiotoxicity | 3 | PM | 35332348 | 📋 | Hesperidin protects against cisplatin-induced cardiotoxicity in mice by regulating the p62-Keap1-Nrf2 pathway |
| Hesperidin | Cardiotoxicity | 2 | PM | 34721041 | 📋 | Based on Activation of p62-Keap1-Nrf2 Pathway, Hesperidin Protects Arsenic-Trioxide-Induced Cardiotoxicity in Mice |
| Hesperidin | Cardiotoxicity | 1 | PM | 33099738 | 📋 | Attenuation of sodium arsenite-induced cardiotoxicity and neurotoxicity with the antioxidant, anti-inflammatory, and antiapoptotic effects of hesperidin |
| Hesperidin | Cardiotoxicity | 8 | PM | 31412747 | 📋 | Cardioprotective effects of hesperidin on carbon monoxide poisoned in rats |
| Hesperidin | Cardiovascular Disease | 3 | PM | 32443766 | 📋 | Effect of Hesperidin on Cardiovascular Disease Risk Factors: The Role of Intestinal Microbiota on Hesperidin Bioavailability |
| Hesperidin | Cardiovascular Disease | 1 | PM | 31298400 | 📋 | The Protective Effects of Berberine and Hesperidin on Inflammatory Factor-Stimulating Cardiac Fibroblasts |
| Hesperidin | Cardiovascular Disease | 2 | PM | 31271436 | 📋 | Effects of hesperidin consumption on cardiovascular risk biomarkers: a systematic review of animal studies and human randomized clinical trials |
| Hesperidin | Cerebral Hypoperfusion | 1 | PM | 25944567 | 📋 | Effects of Citrus Flavonoids Against Microvascular Damage Induced by Hypoperfusion and Reperfusion in Rat Pial Circulation |
| Hesperidin | Chronic Venous Insufficency | 3 | PM | 34717967 | 📋 | Lymphotonic activity of Ruscus extract, hesperidin methyl chalcone and vitamin C in human lymphatic smooth muscle cells |
| Hesperidin | Chronic Venous Insufficency | 5 | PM | 31503251 | 📋 | [Diosmin-containing phlebotropic drugs in varicose eczema] |
| Hesperidin | Chronic Venous Insufficency | 4 | PM | 23761871 | 📋 | Veno-active drugs for chronic venous disease: A randomized, double-blind, placebo-controlled parallel-design trial |
| Hesperidin | Chronic Venous Insufficency | 1 | PM | 16222383 | 📋 | Clinical and hemodynamic outcomes in patients with chronic venous insufficiency after oral micronized flavonoid therapy |
| Hesperidin | Chronic Venous Insufficency | 2 | PM | 12487623 | 📋 | Micronised purified flavonoid fraction: a review of its use in chronic venous insufficiency, venous ulcers and haemorrhoids |
| Hesperidin | Endothelial Dysfunction | 4 | PM | 36007378 | 📋 | Hesperidin alleviates vascular dysfunction and remodelling in high-fat/high-fructose diet-fed rats by modulating oxidative stress, inflammation, AdipoR1, and eNOS expression |
| Hesperidin | Endothelial Dysfunction | 3 | PM | 35889917 | 📋 | Hesperidin Functions as an Ergogenic Aid by Increasing Endothelial Function and Decreasing Exercise-Induced Oxidative Stress and Inflammation, Thereby Contributing to Improved Exercise Performance |
| Hesperidin | Endothelial Dysfunction | 1 | PM | 27363952 | 📋 | Long-term Treatment with Hesperidin Improves Endothelium-dependent Vasodilation in Femoral Artery of Spontaneously Hypertensive Rats: The Involvement of NO-synthase and K v Channels |
| Hesperidin | Endothelial Dysfunction | 2 | PM | 18329851 | 📋 | Glucosyl hesperidin prevents endothelial dysfunction and oxidative stress in spontaneously hypertensive rats |
| Hesperidin | Hematologic Disorders | 1 | PM | 34733484 | 📋 | Ameliorative effects of hesperidin and N-acetylcysteine against formaldehyde-induced-hemato- and genotoxicity |
| Hesperidin | Hemorrhoids | 6 | PM | 29934701 | 📋 | Flavonoid mixture (diosmin, troxerutin, rutin, hesperidin, quercetin) in the treatment of I-III degree hemorroidal disease: a double-blind multicenter prospective comparative study |
| Hesperidin | Hemorrhoids | 8 | PM | 25893991 | 📋 | Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: a prospective, randomized, triple-blind, controlled trial |
| Hesperidin | Hemorrhoids | 4 | PM | 16846547 | 📋 | The impact of micronized purified flavonoid fraction on the treatment of acute haemorrhoidal episodes |
| Hesperidin | Hemorrhoids | 3 | PM | 16117981 | 📋 | Prospective, randomized, controlled, observer-blinded trial of combined infrared photocoagulation and micronized purified flavonoid fraction versus each alone for the treatment of hemorrhoidal disease |
| Hesperidin | Hemorrhoids | 1 | PM | 15712573 | 📋 | Daflon for haemorrhoids: a prospective, multi-centre observational study |
| Hesperidin | Hemorrhoids | 2 | PM | 12518200 | 📋 | Efficacy of Daflon in the treatment of hemorrhoids |
| Hesperidin | Hemorrhoids | 7 | PM | 12487623 | 📋 | Micronised purified flavonoid fraction: a review of its use in chronic venous insufficiency, venous ulcers and haemorrhoids |
| Hesperidin | Hemorrhoids | 5 | PM | 10931020 | 📋 | Randomized clinical trial of micronized flavonoids in the early control of bleeding from acute internal haemorrhoids |
| Hesperidin | Hepatic Ischemia-Reperfusion | 2 | PM | 33174025 | 📋 | Hesperidin ameliorates liver ischemia/reperfusion injury via activation of the Akt pathway |
| Hesperidin | Hepatic Ischemia-Reperfusion | 1 | PM | 31493917 | 📋 | Hesperidin Ameliorates Hepatic Ischemia-Reperfusion Injury in Sprague-Dawley Rats |
| Hesperidin | Hypertension | 13 | PM | 38772688 | 📋 | Hesperidin reduces systolic blood pressure in diabetic patients and has no effect on blood pressure in healthy individuals: A systematic review and meta-analysis |
| Hesperidin | Hypertension | 12 | PM | 37502716 | 📋 | The effects of hesperidin supplementation on cardiovascular risk factors in adults: a systematic review and dose-response meta-analysis |
| Hesperidin | Hypertension | 8 | PM | 36039965 | 📋 | Hesperidin Preferentially Stimulates Transient Receptor Potential Vanilloid 1, Leading to NO Production and Mas Receptor Expression in Human Umbilical Vein Endothelial Cells |
| Hesperidin | Hypertension | 7 | PM | 34272817 | 📋 | Effects of Hesperidin Consumption on the Cardiovascular System in Pre- and Stage 1 Hypertensive Subjects: Targeted and Nontargeted Metabolomic Approaches (CITRUS Study) |
| Hesperidin | Hypertension | 1 | PM | 32661681 | 📋 | Effects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: a randomized controlled trial (Citrus study) |
| Hesperidin | Hypertension | 6 | PM | 32346448 | 📋 | Anti-hypertensive effect of crocin and hesperidin combination in high-fat diet treated rats |
| Hesperidin | Hypertension | 4 | PM | 29754503 | 📋 | Hesperidin Suppresses Renin-Angiotensin System Mediated NOX2 Over-Expression and Sympathoexcitation in 2K-1C Hypertensive Rats |
| Hesperidin | Hypertension | 2 | PM | 27363952 | 📋 | Long-term Treatment with Hesperidin Improves Endothelium-dependent Vasodilation in Femoral Artery of Spontaneously Hypertensive Rats: The Involvement of NO-synthase and K v Channels |
| Hesperidin | Hypertension | 10 | PM | 24418882 | 📋 | Effects of continuous ingestion of hesperidin and glucosyl hesperidin on vascular gene expression in spontaneously hypertensive rats |
| Hesperidin | Hypertension | 11 | PM | 22228501 | 📋 | Preventive effects of hesperidin, glucosyl hesperidin and naringin on hypertension and cerebral thrombosis in stroke-prone spontaneously hypertensive rats |
| Hesperidin | Hypertension | 9 | PM | 21068346 | 📋 | Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers |
| Hesperidin | Hypertension | 5 | PM | 18388414 | 📋 | Short-term effects of glucosyl hesperidin and hesperetin on blood pressure and vascular endothelial function in spontaneously hypertensive rats |
| Hesperidin | Hypertension | 3 | PM | 18329851 | 📋 | Glucosyl hesperidin prevents endothelial dysfunction and oxidative stress in spontaneously hypertensive rats |
| Hesperidin | Intestinal Ischemia-Reperfusion | 2 | PM | 38477785 | 📋 | Protective effects of hesperidin in gastric damage caused by experimental ischemia-reperfusion injury model in rats |
| Hesperidin | Intestinal Ischemia-Reperfusion | 1 | PM | 15663281 | 📋 | The effect of diosmin hesperidin on intestinal ischaemia--reperfusion injury |
| Hesperidin | Intracerebral Hemorrhage | 1 | PM | 31478148 | 📋 | Hesperidin reduces adverse symptomatic intracerebral hemorrhage by promoting TGF-β1 for treating ischemic stroke using tissue plasminogen activator |
| Hesperidin | Ischemia-Reperfusion Injuries | 1 | PM | 27555116 | 📋 | A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury |
| Hesperidin | Ischemic Stroke | 1 | PM | 31478148 | 📋 | Hesperidin reduces adverse symptomatic intracerebral hemorrhage by promoting TGF-β1 for treating ischemic stroke using tissue plasminogen activator |
| Hesperidin | Left Ventricular Hypertrophy | 1 | PM | 32462317 | 📋 | Hesperidin ameliorates signs of the metabolic syndrome and cardiac dysfunction via IRS/Akt/GLUT4 signaling pathway in a rat model of diet-induced metabolic syndrome |
| Hesperidin | Lymphedema | 2 | PM | 34890035 | 📋 | Effect of a dietary supplement on the reduction of lymphedema-progression in mouse tail-cut model |
| Hesperidin | Lymphedema | 1 | PM | 8919263 | 📋 | A lymphatic function of Daflon 500 mg |
| Hesperidin | Myocardial Infarction | 1 | PM | 29115547 | 📋 | Preventive effect of hesperidin modulates inflammatory responses and antioxidant status following acute myocardial infarction through the expression of PPAR‑γ and Bcl‑2 in model mice |
| Hesperidin | Myocardial Injury | 2 | PM | 34189126 | 📋 | Hesperidin Modulates Troponin-1 Serum Level and Decrease Heart Tissue Injury of Irradiated Rats |
| Hesperidin | Myocardial Ischemia-Reperfusion | 2 | PM | 30066841 | 📋 | Inhibition of autophagy via activation of PI3K/Akt/mTOR pathway contributes to the protection of hesperidin against myocardial ischemia/reperfusion injury |
| Hesperidin | Myocardial Ischemia-Reperfusion | 1 | PM | 27744432 | 📋 | Short-Term Hesperidin Pretreatment Attenuates Rat Myocardial Ischemia/Reperfusion Injury by Inhibiting High Mobility Group Box 1 Protein Expression via the PI3K/Akt Pathway |
| Hesperidin | Nosebleed | 1 | PM | 8376915 | 📋 | A double-blind, placebo-controlled trial of a new veno-active flavonoid fraction (S 5682) in the treatment of symptomatic capillary fragility |
| Hesperidin | Prehypertension | 1 | PM | 32661681 | 📋 | Effects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: a randomized controlled trial (Citrus study) |
| Hesperidin | Pulse Pressure Wide or Narrow | 1 | PM | 32661681 | 📋 | Effects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: a randomized controlled trial (Citrus study) |
| Hesperidin | Raynaud's Phenomenon | 1 | PM | 28514385 | 📋 | [The effects of diosmin and hesperidin on capillary blood flow of upper limbs in patients with secondary Raynaud's syndrome] |
| Hesperidin | Renal Ischemia-Reperfusion | 3 | PM | 37070880 | 📋 | The protective effects of hesperidin pretreatment on kidney and remote organs against renal ischemia-reperfusion injury |
| Hesperidin | Renal Ischemia-Reperfusion | 2 | PM | 32491283 | 📋 | The protective effect of hesperidin against renal ischemia-reperfusion injury involves the TLR-4/NF-κB/iNOS pathway in rats |
| Hesperidin | Renal Ischemia-Reperfusion | 1 | PM | 31493919 | 📋 | Hesperidin Shows Protective Effects on Renal Function in Ischemia-induced Acute Kidney Injury (Sprague-Dawley Rats) |
| Hesperidin | Subarachnoid Hemorrhage | 1 | PM | 30448580 | 📋 | Neuroprotective Effects of Hesperidin on Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Rats: Biochemical, Pathologic, and Histomorphometric Analysis |
| Hesperidin | Thrombosis | 1 | PM | 22228501 | 📋 | Preventive effects of hesperidin, glucosyl hesperidin and naringin on hypertension and cerebral thrombosis in stroke-prone spontaneously hypertensive rats |
| Hesperidin | Varicocele | 1 | PM | 31325243 | 📋 | Hesperidin attenuated apoptotic-related genes in testicle of a male rat model of varicocoele |
| Hesperidin | Varicose Veins | 1 | PM | 14626685 | 📋 | [Use of flavonoids (hesperidin) in the treatment of bleeding bladder varices] |
| Hesperidin | Vascular Disorders | 1 | PM | 36007378 | 📋 | Hesperidin alleviates vascular dysfunction and remodelling in high-fat/high-fructose diet-fed rats by modulating oxidative stress, inflammation, AdipoR1, and eNOS expression |
| Hesperidin | Vascular Injury | 1 | PM | 33185907 | 📋 | Hesperidin inhibits L-NAME-induced vascular and renal alterations in rats by suppressing the renin-angiotensin system, transforming growth factor-β1, and oxidative stress |
| Hesperidin | Vasodilation | 1 | PM | 27363952 | 📋 | Long-term Treatment with Hesperidin Improves Endothelium-dependent Vasodilation in Femoral Artery of Spontaneously Hypertensive Rats: The Involvement of NO-synthase and K v Channels |
| Hesperidin | Vasodilation | 2 | PM | 18329851 | 📋 | Glucosyl hesperidin prevents endothelial dysfunction and oxidative stress in spontaneously hypertensive rats |
| Hesperidin | Vasospasm | 1 | PM | 30448580 | 📋 | Neuroprotective Effects of Hesperidin on Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Rats: Biochemical, Pathologic, and Histomorphometric Analysis |
| Hesperidin | Venous Leg Ulcers | 2 | PM | 16193225 | 📋 | Daflon 500 mg and venous leg ulcer: new results from a meta-analysis |
| Hesperidin | Venous Leg Ulcers | 1 | PM | 12487623 | 📋 | Micronised purified flavonoid fraction: a review of its use in chronic venous insufficiency, venous ulcers and haemorrhoids |
