| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Ginkgolides | Abdominal Aortic Aneurysm | 1 | PM | 29777203 | 📋 | Ginkgo biloba extracts prevent aortic rupture in angiotensin II-infused hypercholesterolemic mice |
| Ginkgolides | Arterial Restenosis | 1 | PM | 38125702 | 📋 | Ginkgolide B Blocks Vascular Remodeling after Vascular Injury via Regulating Tgf β 1/Smad Signaling Pathway |
| Ginkgolides | Atherosclerosis | 10 | PM | 38239238 | 📋 | Anti-atherosclerotic effects and molecular targets of ginkgolide B from Ginkgo biloba |
| Ginkgolides | Atherosclerosis | 1 | PM | 33341056 | 📋 | Ginkgolide B treatment regulated intestinal flora to improve high-fat diet induced atherosclerosis in ApoE -/- mice |
| Ginkgolides | Atherosclerosis | 5 | PM | 31281844 | 📋 | Ginkgolide B Mediated Alleviation of Inflammatory Cascades and Altered Lipid Metabolism in HUVECs via Targeting PCSK-9 Expression and Functionality |
| Ginkgolides | Atherosclerosis | 6 | PM | 30136446 | 📋 | Ginkgolide B ameliorates oxidized low-density lipoprotein-induced endothelial dysfunction via modulating Lectin-like ox-LDL-receptor-1 and NADPH oxidase 4 expression and inflammatory cascades |
| Ginkgolides | Atherosclerosis | 9 | PM | 30029641 | 📋 | Ginkgolide B inhibits platelet and monocyte adhesion in TNFα-treated HUVECs under laminar shear stress |
| Ginkgolides | Atherosclerosis | 8 | PM | 26246869 | 📋 | Ginkgolide B Inhibits JAM-A, Cx43, and VE-Cadherin Expression and Reduces Monocyte Transmigration in Oxidized LDL-Stimulated Human Umbilical Vein Endothelial Cells |
| Ginkgolides | Atherosclerosis | 4 | PM | 25223809 | 📋 | Ginkgolide B inhibits platelet release by blocking Syk and p38 MAPK phosphorylation in thrombin-stimulated platelets |
| Ginkgolides | Atherosclerosis | 3 | PM | 24069345 | 📋 | Ginkgolide B reduces LOX-1 expression by inhibiting Akt phosphorylation and increasing Sirt1 expression in oxidized LDL-stimulated human umbilical vein endothelial cells |
| Ginkgolides | Atherosclerosis | 2 | PM | 22662117 | 📋 | Ginkgolide B reduces atherogenesis and vascular inflammation in ApoE(-/-) mice |
| Ginkgolides | Atherosclerosis | 7 | PM | 21655098 | 📋 | EGb761, a Ginkgo biloba extract, is effective against atherosclerosis in vitro, and in a rat model of type 2 diabetes |
| Ginkgolides | Cardiac Arrhythmia | 1 | PM | 24225402 | 📋 | Ginkgo biloba extract and ginkgolide antiarrhythmic potential by targeting hERG and ICa-L channel |
| Ginkgolides | Cardiac Hypertrophy | 1 | PM | 34257705 | 📋 | Ginkgolide B Protects Cardiomyocytes from Angiotensin II-Induced Hypertrophy via Regulation of Autophagy through SIRT1-FoxO1 |
| Ginkgolides | Cardiotoxicity | 1 | PM | 27973574 | 📋 | Ginkgolide B Exerts Cardioprotective Properties against Doxorubicin-Induced Cardiotoxicity by Regulating Reactive Oxygen Species, Akt and Calcium Signaling Pathways In Vitro and In Vivo |
| Ginkgolides | Cerebral Hypoperfusion | 1 | PM | 33557607 | 📋 | Ginkgolide B promotes oligodendrocyte precursor cell differentiation and survival via Akt/CREB/bcl-2 signaling pathway after white matter lesion |
| Ginkgolides | Cerebral Ischemia | 2 | PM | 33452698 | 📋 | Neuroprotective effects of Ginkgolide B in focal cerebral ischemia through selective activation of prostaglandin E2 receptor EP4 and the downstream transactivation of epidermal growth factor receptor |
| Ginkgolides | Cerebral Ischemia | 8 | PM | 31864312 | 📋 | The neuroprotective mechanisms of ginkgolides and bilobalide in cerebral ischemic injury: a literature review |
| Ginkgolides | Cerebral Ischemia | 10 | PM | 30066915 | 📋 | Ginkgolide K protects SH‑SY5Y cells against oxygen‑glucose deprivation‑induced injury by inhibiting the p38 and JNK signaling pathways |
| Ginkgolides | Cerebral Ischemia | 1 | PM | 27562518 | 📋 | Ginkgolides and bilobalide protect BV2 microglia cells against OGD/reoxygenation injury by inhibiting TLR2/4 signaling pathways |
| Ginkgolides | Cerebral Ischemia | 7 | PM | 25869596 | 📋 | Ginkgolide B Protects Neurons from Ischemic Injury by Inhibiting the Expression of RTP801 |
| Ginkgolides | Cerebral Ischemia | 5 | PM | 24327346 | 📋 | Neuroprotection against permanent focal cerebral ischemia by ginkgolides A and B is associated with obstruction of the mitochondrial apoptotic pathway via inhibition of c-Jun N-terminal kinase in rats |
| Ginkgolides | Cerebral Ischemia | 3 | PM | 24225258 | 📋 | Neuroprotective effect of Ginkgolide K against H2O2-induced PC12 cell cytotoxicity by ameliorating mitochondrial dysfunction and oxidative stress |
| Ginkgolides | Cerebral Ischemia | 6 | PM | 23201340 | 📋 | Ginkgolide B preconditioning on astrocytes promotes neuronal survival in ischemic injury via up-regulating erythropoietin secretion |
| Ginkgolides | Cerebral Ischemia | 4 | PM | 22120026 | 📋 | Neuroprotective effect of ginkgolide K on glutamate-induced cytotoxicity in PC 12 cells via inhibition of ROS generation and Ca(2+) influx |
| Ginkgolides | Cerebral Ischemia | 9 | PM | 21527331 | 📋 | Effect of ginkgolide B on striatal extracellular amino acids in middle cerebral artery occluded rats |
| Ginkgolides | Cerebral Ischemia-Reperfusion | 14 | PM | 37532074 | 📋 | Ginkgolide B attenuates cerebral ischemia-reperfusion injury via inhibition of ferroptosis through disrupting NCOA4-FTH1 interaction |
| Ginkgolides | Cerebral Ischemia-Reperfusion | 3 | PM | 37094696 | 📋 | Ginkgolide C attenuates cerebral ischemia/reperfusion-induced inflammatory impairments by suppressing CD40/NF-κB pathway |
| Ginkgolides | Cerebral Ischemia-Reperfusion | 2 | PM | 35370265 | 📋 | Exposure-Response Analysis and Mechanism of Ginkgolide B's Neuroprotective Effect in Acute Cerebral Ischemia/Reperfusion Stage in Rat |
| Ginkgolides | Cerebral Ischemia-Reperfusion | 1 | PM | 35279613 | 📋 | Extracts of Ginkgo flavonoids and ginkgolides improve cerebral ischaemia-reperfusion injury through the PI3K/Akt/Nrf2 signalling pathway and multicomponent in vivo processes |
| Ginkgolides | Cerebral Ischemia-Reperfusion | 8 | PM | 31333457 | 📋 | Ginkgo Flavonol Glycosides or Ginkgolides Tend to Differentially Protect Myocardial or Cerebral Ischemia-Reperfusion Injury via Regulation of TWEAK-Fn14 Signaling in Heart and Brain |
| Ginkgolides | Cerebral Ischemia-Reperfusion | 10 | PM | 30815818 | 📋 | Antioxidant effects of ginkgolides and bilobalide against cerebral ischemia injury by activating the Akt/Nrf2 pathway in vitro and in vivo |
| Ginkgolides | Cerebral Ischemia-Reperfusion | 13 | PM | 30028328 | 📋 | Ginkgolide B promotes the proliferation and differentiation of neural stem cells following cerebral ischemia/reperfusion injury, both in vivo and in vitro |
| Ginkgolides | Cerebral Ischemia-Reperfusion | 9 | PM | 29787772 | 📋 | Ginkgolide K promotes astrocyte proliferation and migration after oxygen-glucose deprivation via inducing protective autophagy through the AMPK/mTOR/ULK1 signaling pathway |
| Ginkgolides | Cerebral Ischemia-Reperfusion | 11 | PM | 29542683 | 📋 | Diterpene ginkgolides protect against cerebral ischemia/reperfusion damage in rats by activating Nrf2 and CREB through PI3K/Akt signaling |
| Ginkgolides | Cerebral Ischemia-Reperfusion | 12 | PM | 28514718 | 📋 | Exploring the neuroprotective effects of ginkgolides injection in a rodent model of cerebral ischemia-reperfusion injury by GC-MS based metabolomic profiling |
| Ginkgolides | Cerebral Ischemia-Reperfusion | 7 | PM | 24264075 | 📋 | Ginkgolide B prevents cathepsin-mediated cell death following cerebral ischemia/reperfusion injury |
| Ginkgolides | Cerebral Ischemia-Reperfusion | 5 | PM | 22850444 | 📋 | Inhibition of NF-κB activation is associated with anti-inflammatory and anti-apoptotic effects of Ginkgolide B in a mouse model of cerebral ischemia/reperfusion injury |
| Ginkgolides | Cerebral Ischemia-Reperfusion | 6 | PM | 21855632 | 📋 | Therapeutic neuroprotective effects of ginkgolide B on cortex and basal ganglia in a rat model of transient focal ischemia |
| Ginkgolides | Cerebral Ischemia-Reperfusion | 4 | PM | 19833202 | 📋 | Blood brain barrier permeability and therapeutic time window of Ginkgolide B in ischemia-reperfusion injury |
| Ginkgolides | Coronary Artery Disease | 1 | PM | 38125702 | 📋 | Ginkgolide B Blocks Vascular Remodeling after Vascular Injury via Regulating Tgf β 1/Smad Signaling Pathway |
| Ginkgolides | Diabetic Cardiomyopathy | 1 | PM | 32952955 | 📋 | Cardiac dysfunction is attenuated by ginkgolide B via reducing oxidative stress and fibrosis in diabetic rats |
| Ginkgolides | Diabetic Vasculopathy | 2 | PM | 36715760 | 📋 | Ginkgolide B caused the activation of the Akt/eNOS pathway through the antioxidant effect of SOD1 in the diabetic aorta |
| Ginkgolides | Diabetic Vasculopathy | 1 | PM | 25681539 | 📋 | Ginkgolide A reduces inflammatory response in high-glucose-stimulated human umbilical vein endothelial cells through STAT3-mediated pathway |
| Ginkgolides | Endothelial Dysfunction | 3 | PM | 30136446 | 📋 | Ginkgolide B ameliorates oxidized low-density lipoprotein-induced endothelial dysfunction via modulating Lectin-like ox-LDL-receptor-1 and NADPH oxidase 4 expression and inflammatory cascades |
| Ginkgolides | Endothelial Dysfunction | 4 | PM | 29441927 | 📋 | Ginkgolide A inhibits lipopolysaccharide-induced inflammatory response in human coronary artery endothelial cells via downregulation of TLR4-NF-κB signaling through PI3K/Akt pathway |
| Ginkgolides | Endothelial Dysfunction | 1 | PM | 25727037 | 📋 | Ginkgolide B increases hydrogen sulfide and protects against endothelial dysfunction in diabetic rats |
| Ginkgolides | Hypertension | 1 | PM | 31739841 | 📋 | Ginkgolide A protects adverse cardiac remodeling through enhancing antioxidation and nitric oxide utilization in mice with pressure overload |
| Ginkgolides | Intracerebral Hemorrhage | 1 | PM | 21878382 | 📋 | Ginkgolide B reduces neuronal cell apoptosis in the hemorrhagic rat brain: possible involvement of Toll-like receptor 4/nuclear factor-kappa B pathway |
| Ginkgolides | Ischemic Stroke | 9 | PM | 35902245 | 📋 | Multiple Mechanistic Models Reveal the Neuroprotective Effects of Diterpene Ginkgolides against Astrocyte-Mediated Demyelination via the PAF-PAFR Pathway |
| Ginkgolides | Ischemic Stroke | 8 | PM | 35837278 | 📋 | Ginkgolide B Protects Against Ischemic Stroke via Targeting AMPK/PINK1 |
| Ginkgolides | Ischemic Stroke | 6 | PM | 35513225 | 📋 | Ginkgolide B Targets and Inhibits Creatine Kinase B to Regulate the CCT/TRiC-SK1 Axis and Exerts Pro-Angiogenic Activity in Middle Cerebral Artery Occlusion Mice |
| Ginkgolides | Ischemic Stroke | 7 | PM | 35392576 | 📋 | The Efficacy and Safety of Ginkgo Terpene Lactone Preparations in the Treatment of Ischemic Stroke: A Systematic Review and Meta-Analysis of Randomized Clinical Trials |
| Ginkgolides | Ischemic Stroke | 5 | PM | 35347948 | 📋 | [Clinical comprehensive evaluation of Ginkgolide Injection in treatment of cerebral infarction] |
| Ginkgolides | Ischemic Stroke | 4 | PM | 34925044 | 📋 | Ginkgolide With Intravenous Alteplase Thrombolysis in Acute Ischemic Stroke Improving Neurological Function: A Multicenter, Cluster-Randomized Trial (GIANT) |
| Ginkgolides | Ischemic Stroke | 3 | PM | 34676982 | 📋 | Effect of Ginkgolide in Ischemic Stroke patients with large Artery Atherosclerosis: Results from a randomized trial |
| Ginkgolides | Ischemic Stroke | 2 | PM | 34121855 | 📋 | Neuroprotective effect of aspirin combined with ginkgolide injection on cerebral ischemic stroke rats and its effect on ERK12 signal pathway |
| Ginkgolides | Ischemic Stroke | 16 | PM | 32048567 | 📋 | The effect of intravenous ginkgolide on clinical improvement of patients with acute ischemic stroke |
| Ginkgolides | Ischemic Stroke | 15 | PM | 29890157 | 📋 | Ginkgolide K promotes angiogenesis in a middle cerebral artery occlusion mouse model via activating JAK2/STAT3 pathway |
| Ginkgolides | Ischemic Stroke | 11 | PM | 29058254 | 📋 | Neuroprotective effects of Ginkgo biloba extract and Ginkgolide B against oxygen-glucose deprivation/reoxygenation and glucose injury in a new in vitro multicellular network model |
| Ginkgolides | Ischemic Stroke | 12 | PM | 28689387 | 📋 | Ginkgolide B Modulates BDNF Expression in Acute Ischemic Stroke |
| Ginkgolides | Ischemic Stroke | 10 | PM | 28591721 | 📋 | Ginkgolide K attenuates neuronal injury after ischemic stroke by inhibiting mitochondrial fission and GSK-3β-dependent increases in mitochondrial membrane permeability |
| Ginkgolides | Ischemic Stroke | 13 | PM | 27306494 | 📋 | Ginkgolide B Protects Against Ischemic Stroke Via Modulating Microglia Polarization in Mice |
| Ginkgolides | Ischemic Stroke | 1 | PM | 26059355 | 📋 | Neuroprotective Effects of Ginkgolide B Against Ischemic Stroke: A Review of Current Literature |
| Ginkgolides | Ischemic Stroke | 14 | PM | 21611909 | 📋 | Neuroprotective effect of ginkgolide K against acute ischemic stroke on middle cerebral ischemia occlusion in rats |
| Ginkgolides | Middle Cerebral Artery Occlusion | 1 | PM | 35513225 | 📋 | Ginkgolide B Targets and Inhibits Creatine Kinase B to Regulate the CCT/TRiC-SK1 Axis and Exerts Pro-Angiogenic Activity in Middle Cerebral Artery Occlusion Mice |
| Ginkgolides | Myocardial Infarction | 2 | PM | 35367419 | 📋 | Ginkgolide A alleviates cardiac remodeling in mice with myocardial infarction via binding to matrix metalloproteinase-9 to attenuate inflammation |
| Ginkgolides | Myocardial Infarction | 1 | PM | 32521492 | 📋 | Ginkgolide B attenuates myocardial infarction-induced depression-like behaviors via repressing IL-1β in central nervous system |
| Ginkgolides | Myocardial Ischemia | 1 | PM | 27186946 | 📋 | Ginkgolide K protects the heart against endoplasmic reticulum stress injury by activating the inositol-requiring enzyme 1α/X box-binding protein-1 pathway |
| Ginkgolides | Myocardial Ischemia-Reperfusion | 5 | PM | 32377729 | 📋 | Ginkgolide B inhibits hydrogen peroxide‑induced apoptosis and attenuates cytotoxicity via activating the PI3K/Akt/mTOR signaling pathway in H9c2 cells |
| Ginkgolides | Myocardial Ischemia-Reperfusion | 6 | PM | 31681006 | 📋 | Ginkgolide B for Myocardial Ischemia/Reperfusion Injury: A Preclinical Systematic Review and Meta-Analysis |
| Ginkgolides | Myocardial Ischemia-Reperfusion | 1 | PM | 31333457 | 📋 | Ginkgo Flavonol Glycosides or Ginkgolides Tend to Differentially Protect Myocardial or Cerebral Ischemia-Reperfusion Injury via Regulation of TWEAK-Fn14 Signaling in Heart and Brain |
| Ginkgolides | Myocardial Ischemia-Reperfusion | 4 | PM | 30619251 | 📋 | Cardioprotection of Ginkgolide B on Myocardial Ischemia/Reperfusion-Induced Inflammatory Injury via Regulation of A20-NF-κB Pathway |
| Ginkgolides | Myocardial Ischemia-Reperfusion | 2 | PM | 29515442 | 📋 | Ginkgolide C Alleviates Myocardial Ischemia/Reperfusion-Induced Inflammatory Injury via Inhibition of CD40-NF-κB Pathway |
| Ginkgolides | Myocardial Ischemia-Reperfusion | 3 | PM | 26382046 | 📋 | Ginkgolide B Reduces the Degradation of Membrane Phospholipids to Prevent Ischemia/Reperfusion Myocardial Injury in Rats |
| Ginkgolides | Platelet Aggregation | 1 | PM | 25223809 | 📋 | Ginkgolide B inhibits platelet release by blocking Syk and p38 MAPK phosphorylation in thrombin-stimulated platelets |
| Ginkgolides | Platelet Aggregation | 2 | PM | 22662117 | 📋 | Ginkgolide B reduces atherogenesis and vascular inflammation in ApoE(-/-) mice |
| Ginkgolides | Retinal Ischemia-Reperfusion | 1 | PM | 38442447 | 📋 | The anti-apoptotic role of Ginkgolide B via mitochondrial permeability transition pore inhibition in retinal ischemia-reperfusion |
| Ginkgolides | Stroke | 2 | PM | 31691373 | 📋 | Ginkgolide B protects human pulmonary alveolar epithelial A549 cells from lipopolysaccharide-induced inflammatory responses by reducing TRIM37-mediated NF-κB activation |
| Ginkgolides | Stroke | 1 | PM | 26059355 | 📋 | Neuroprotective Effects of Ginkgolide B Against Ischemic Stroke: A Review of Current Literature |
| Ginkgolides | Vascular Injury | 1 | PM | 38125702 | 📋 | Ginkgolide B Blocks Vascular Remodeling after Vascular Injury via Regulating Tgf β 1/Smad Signaling Pathway |
| Ginkgolides | Vasoconstriction | 1 | PM | 25727037 | 📋 | Ginkgolide B increases hydrogen sulfide and protects against endothelial dysfunction in diabetic rats |
| Ginkgolides | Vasodilation | 1 | PM | 25727037 | 📋 | Ginkgolide B increases hydrogen sulfide and protects against endothelial dysfunction in diabetic rats |
