| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Crocin | Atherosclerosis | 3 | PM | 35880561 | 📋 | Mechanistic insights on the effect of crocin, an active ingredient of saffron, on atherosclerosis in apolipoprotein E knockout mice |
| Crocin | Atherosclerosis | 2 | PM | 34978526 | 📋 | Crocin ameliorates atherosclerosis by promoting the reverse cholesterol transport and inhibiting the foam cell formation via regulating PPARγ/LXR-α |
| Crocin | Atherosclerosis | 1 | PM | 29248792 | 📋 | Crocin Alleviates Coronary Atherosclerosis via Inhibiting Lipid Synthesis and Inducing M2 Macrophage Polarization |
| Crocin | Atrial Fibrillation | 1 | PM | 36583176 | 📋 | Evaluation of the effect of crocin on prevention of atrial fibrillation after coronary artery bypass grafting or heart valve replacement: A double-blind, randomized, placebo-controlled trial |
| Crocin | Cardiac Arrhythmia | 1 | PM | 36312395 | 📋 | Analysis of Anti-Arrhythmic Impacts of Crocin through Estimation of Expression of Cx43 in Myocardial Infarction Using a Rat Animal Model |
| Crocin | Cardiotoxicity | 3 | PM | 34981476 | 📋 | Evaluation of the Effect of Crocin on Doxorubicin-Induced Cardiotoxicity |
| Crocin | Cardiotoxicity | 2 | PM | 34567153 | 📋 | Protective Effect of Crocin on Malathion-induced Cardiotoxicity in Rats: A Biochemical, Histopathological and Proteomics Study |
| Crocin | Cardiotoxicity | 1 | PM | 34322808 | 📋 | Antioxidant, anti-inflammatory, and anti-apoptotic effects of crocin against doxorubicin-induced myocardial toxicity in rats |
| Crocin | Cardiotoxicity | 4 | PM | 33793778 | 📋 | Study of the cardioprotective effects of crocin on Human Cardiac Myocyte cells and reduction of oxidative stress produced by aluminum phosphide poisoning |
| Crocin | Cardiotoxicity | 5 | PM | 32388215 | 📋 | Crocin protects against cardiotoxicity induced by doxorubicin through TLR-2/NF-κB signal pathway in vivo and vitro |
| Crocin | Cardiovascular Disease | 1 | PM | 28678929 | 📋 | Cardioprotective Effect of Crocin Combined With Voluntary Exercise in Rat: Role of Mir-126 and Mir-210 in Heart Angiogenesis |
| Crocin | Cerebral Hypoxia | 2 | PM | 35702067 | 📋 | Neuroprotective mechanism of crocin via PI3K/Akt/mTOR signaling pathway after cerebral infarction: an in vitro study |
| Crocin | Cerebral Hypoxia | 1 | PM | 33613888 | 📋 | Crocin Treatment after Maternal Hypoxia Attenuates Spatial Memory Impairment and Expression of BACE1 and HIF-1α in Rat Offspring Brain |
| Crocin | Cerebral Ischemia | 4 | PM | 32738637 | 📋 | The effect of crocin on memory, hippocampal acetylcholine level, and apoptosis in a rat model of cerebral ischemia |
| Crocin | Cerebral Ischemia | 2 | PM | 28059805 | 📋 | Crocin Protects Against Cerebral- Ischemia-Induced Damage in Aged Rats Through Maintaining the Integrity of Blood-Brain Barrier |
| Crocin | Cerebral Ischemia-Reperfusion | 3 | PM | 33099290 | 📋 | Crocin regulates the proliferation and migration of neural stem cells after cerebral ischemia by activating the Notch1 pathway |
| Crocin | Cerebral Ischemia-Reperfusion | 2 | PM | 31114499 | 📋 | Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota |
| Crocin | Cerebral Ischemia-Reperfusion | 1 | PM | 27117584 | 📋 | The Antioxidant and Antiapoptotic Effects of Crocin Pretreatment on Global Cerebral Ischemia Reperfusion Injury Induced by Four Vessels Occlusion in Rats |
| Crocin | Coronary Artery Disease | 2 | PM | 36244155 | 📋 | Effect of crocin on glycated human low-density lipoprotein: A protective and mechanistic approach |
| Crocin | Coronary Artery Disease | 1 | PM | 31797473 | 📋 | Effects of Crocin and Saffron Aqueous Extract on Gene Expression of SIRT1, AMPK, LOX1, NF-κB, and MCP-1 in Patients With Coronary Artery Disease: A Randomized Placebo-Controlled Clinical Trial |
| Crocin | Deep Vein Thrombosis | 1 | PM | 37807309 | 📋 | Crocin improves lower extremity deep venous thrombosis by regulating the PIM1/FOXO3a axis |
| Crocin | Diabetic Cardiomyopathy | 5 | PM | 38113243 | 📋 | Effect of crocin and treadmill exercise on oxidative stress and heart damage in diabetic rats |
| Crocin | Diabetic Cardiomyopathy | 4 | PM | 34981484 | 📋 | Crocin Improves Diabetes-Induced Oxidative Stress via Downregulating the Nox-4 in Myocardium of Diabetic Rats |
| Crocin | Diabetic Cardiomyopathy | 3 | PM | 33553037 | 📋 | Crocin attenuates oxidative stress and inflammation in myocardial infarction induced by isoprenaline via PPARγ activation in diabetic rats |
| Crocin | Diabetic Cardiomyopathy | 2 | PM | 30017436 | 📋 | Treatment With Crocin Improves Cardiac Dysfunction by Normalizing Autophagy and Inhibiting Apoptosis in STZ-induced Diabetic Cardiomyopathy |
| Crocin | Diabetic Cardiomyopathy | 1 | PM | 28229629 | 📋 | Protective Effect of Crocin and Voluntary Exercise Against Oxidative Stress in the Heart of High-Fat Diet-Induced Type 2 Diabetic Rats |
| Crocin | Endothelial Dysfunction | 2 | PM | 33777959 | 📋 | Crocin Improves Endothelial Mitochondrial Dysfunction via GPx1/ROS/KCa3.1 Signal Axis in Diabetes |
| Crocin | Endothelial Dysfunction | 1 | PM | 32440316 | 📋 | Evaluation of Possible Effects of Crocin Against Nitrate Tolerance and Endothelial Dysfunction |
| Crocin | Endothelial Injury | 1 | PM | 29524452 | 📋 | Protective Effects of Saffron and Its Active Components Against Oxidative Stress and Apoptosis in Endothelial Cells |
| Crocin | Gestational Hypertension | 1 | PM | 33442028 | 📋 | Crocin exhibits an antihypertensive effect in a rat model of gestational hypertension and activates the Nrf-2/HO-1 signaling pathway |
| Crocin | Hemorrhagic Shock | 2 | PM | 33482612 | 📋 | Protective Effect of Crocin on Liver Function and Survival in Rats With Traumatic Hemorrhagic Shock |
| Crocin | Hemorrhagic Shock | 1 | PM | 28453369 | 📋 | Inhibition of Inflammatory Response by Crocin Attenuates Hemorrhagic Shock-Induced Organ Damages in Rats |
| Crocin | Hepatic Ischemia-Reperfusion | 1 | PM | 28367266 | 📋 | The Hepatoprotective and MicroRNAs Downregulatory Effects of Crocin Following Hepatic Ischemia-Reperfusion Injury in Rats |
| Crocin | Hypertension | 3 | PM | 32641946 | 📋 | The Relaxant Effect of Crocin on Rat Tracheal Smooth Muscle and Its Possible Mechanisms |
| Crocin | Hypertension | 4 | PM | 32346448 | 📋 | Anti-hypertensive effect of crocin and hesperidin combination in high-fat diet treated rats |
| Crocin | Hypertension | 1 | PM | 29710548 | 📋 | Diosmin and Crocin Alleviate Nephropathy in Metabolic Syndrome Rat Model: Effect on Oxidative Stress and Low Grade Inflammation |
| Crocin | Hypertension | 2 | PM | 26402666 | 📋 | Effects of Crocetin Esters and Crocetin From Crocus Sativus L. On Aortic Contractility in Rat Genetic Hypertension |
| Crocin | Intracerebral Hemorrhage | 1 | PM | 35380368 | 📋 | Crocin Alleviates Intracerebral Hemorrhage-Induced Neuronal Ferroptosis by Facilitating Nrf2 Nuclear Translocation |
| Crocin | Ischemia-Reperfusion Injuries | 3 | PM | 37181854 | 📋 | Effect of crocin on experimental gastrocnemius muscle ischemia/reperfusion injury in rat |
| Crocin | Ischemia-Reperfusion Injuries | 2 | PM | 29710463 | 📋 | A comprehensive review on regulatory effects of crocin on ischemia/reperfusion injury in multiple organs |
| Crocin | Ischemia-Reperfusion Injuries | 1 | PM | 28228808 | 📋 | Protective Effect of Crocin on Gastric Mucosal Lesions Induced by Ischemia-Reperfusion Injury in Rats |
| Crocin | Ischemic Stroke | 1 | PM | 35991882 | 📋 | Crocins for Ischemic Stroke: A Review of Current Evidence |
| Crocin | Lymphoma | 1 | PM | 34276918 | 📋 | Crocin Promotes Apoptosis in Human EBV-Transformed B-Lymphocyte via Intrinsic Pathway |
| Crocin | Middle Cerebral Artery Occlusion | 2 | PM | 31150648 | 📋 | Crocin induces anti-ischemia in middle cerebral artery occlusion rats and inhibits autophagy by regulating the mammalian target of rapamycin |
| Crocin | Middle Cerebral Artery Occlusion | 1 | PM | 17215084 | 📋 | Protective Effects of Carotenoids From Saffron on Neuronal Injury in Vitro and in Vivo |
| Crocin | Myocardial Fibrosis | 1 | PM | 31392383 | 📋 | Crocin Attenuates Isoprenaline-Induced Myocardial Fibrosis by Targeting TLR4/NF-κB Signaling: Connecting Oxidative Stress, Inflammation, and Apoptosis |
| Crocin | Myocardial Infarction | 3 | PM | 36484363 | 📋 | Crocin inhibits KBTBD7 to prevent excessive inflammation and cardiac dysfunction following myocardial infarction |
| Crocin | Myocardial Infarction | 2 | PM | 34538161 | 📋 | Effects of pinealectomy and crocin treatment on rats with isoproterenol-induced myocardial infarction |
| Crocin | Myocardial Infarction | 1 | PM | 29479012 | 📋 | Crocin Attenuates Oxidative Stress and Myocardial Infarction Injury in Rats |
| Crocin | Myocardial Injury | 2 | PM | 33974754 | 📋 | Crocin attenuates oxidative and inflammatory stress-related periodontitis in cardiac tissues in rats |
| Crocin | Myocardial Ischemia | 1 | PM | 35656072 | 📋 | Protective effect of crocin on hemodynamic parameters, electrocardiogram parameters, and oxidative stress in isolated hearts of rats exposed to PM 10 |
| Crocin | Myocardial Ischemia-Reperfusion | 2 | PM | 36484363 | 📋 | Crocin inhibits KBTBD7 to prevent excessive inflammation and cardiac dysfunction following myocardial infarction |
| Crocin | Myocardial Ischemia-Reperfusion | 1 | PM | 27109157 | 📋 | Crocin-Elicited Autophagy Rescues Myocardial Ischemia/Reperfusion Injury via Paradoxical Mechanisms |
| Crocin | Myocarditis | 1 | PM | 35282269 | 📋 | Protective Effect of Crocin on Immune Checkpoint Inhibitors-Related Myocarditis Through Inhibiting NLRP3 Mediated Pyroptosis in Cardiomyocytes via NF-κB Pathway |
| Crocin | Renal Ischemia-Reperfusion | 1 | PM | 28852439 | 📋 | Crocin Has Anti-Inflammatory and Protective Effects in Ischemia-Reperfusion Induced Renal Injuries |
| Crocin | Renal Ischemia-Reperfusion | 2 | PM | 16401388 | 📋 | Protective Effect of Aqueous Saffron Extract (Crocus Sativus L.) and Crocin, Its Active Constituent, on Renal Ischemia-Reperfusion-Induced Oxidative Damage in Rats |
| Crocin | Thoracic Aortic Aneurysm | 1 | PM | 35463768 | 📋 | Artificial Intelligence Uncovers Natural MMP Inhibitor Crocin as a Potential Treatment of Thoracic Aortic Aneurysm and Dissection |
| Crocin | Vascular Disorders | 1 | PM | 31352499 | 📋 | Effects of diosmin and crocin on metabolic syndrome-associated cardio-vascular complications in rats |
| Crocin | Vasoconstriction | 1 | PM | 26402666 | 📋 | Effects of Crocetin Esters and Crocetin From Crocus Sativus L. On Aortic Contractility in Rat Genetic Hypertension |
