| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Cocoa | Arterial Stiffness | 6 | PM | 35769385 | 📋 | Assessing Variability in Vascular Response to Cocoa With Personal Devices: A Series of Double-Blind Randomized Crossover n-of-1 Trials |
| Cocoa | Arterial Stiffness | 5 | PM | 32126803 | 📋 | Chronic and acute effects of cocoa products intake on arterial stiffness and platelet count and function: A systematic review and dose-response Meta-analysis of randomized clinical trials |
| Cocoa | Arterial Stiffness | 3 | PM | 31029045 | 📋 | Randomized study of the effects of cocoa-rich chocolate on the ventricle-arterial coupling and vascular function of young, healthy adults |
| Cocoa | Arterial Stiffness | 1 | PM | 30529883 | 📋 | Effects of regular high-cocoa chocolate intake on arterial stiffness and metabolic characteristics during exercise |
| Cocoa | Arterial Stiffness | 2 | PM | 27881914 | 📋 | Habitual cocoa intake reduces arterial stiffness in postmenopausal women regardless of intake frequency: a randomized parallel-group study |
| Cocoa | Arterial Stiffness | 4 | PM | 27493901 | 📋 | Relation of Habitual Chocolate Consumption to Arterial Stiffness in a Community-Based Sample: Preliminary Findings |
| Cocoa | Arterial Stiffness | 7 | PM | 24274771 | 📋 | Effects of dark chocolate and cocoa consumption on endothelial function and arterial stiffness in overweight adults |
| Cocoa | Atherosclerosis | 5 | PM | 36452001 | 📋 | The action of phytochemicals present in cocoa in the prevention of vascular dysfunction and atherosclerosis |
| Cocoa | Atherosclerosis | 4 | PM | 29119920 | 📋 | Polyphenols: Inflammation |
| Cocoa | Atherosclerosis | 3 | PM | 27070643 | 📋 | Effect of Cocoa and Its Flavonoids on Biomarkers of Inflammation: Studies of Cell Culture, Animals and Humans |
| Cocoa | Atherosclerosis | 2 | PM | 26980943 | 📋 | Dietary Cocoa Powder Improves Hyperlipidemia and Reduces Atherosclerosis in apoE Deficient Mice through the Inhibition of Hepatic Endoplasmic Reticulum Stress |
| Cocoa | Atherosclerosis | 1 | PM | 20655129 | 📋 | Chocolate consumption is inversely associated with calcified atherosclerotic plaque in the coronary arteries: the NHLBI Family Heart Study |
| Cocoa | Cardiac Hypertrophy | 1 | PM | 32645737 | 📋 | Cacao Bean Polyphenols Inhibit Cardiac Hypertrophy and Systolic Dysfunction in Pressure Overload-induced Heart Failure Model Mice |
| Cocoa | Cardiotoxicity | 1 | PM | 37324470 | 📋 | Computational and experimental pharmacology to decode the efficacy of Theobroma cacao L. against doxorubicin-induced organ toxicity in EAC-mediated solid tumor-induced mice |
| Cocoa | Cardiovascular Disease | 20 | PM | 35460393 | 📋 | Relationship between chocolate consumption and overall and cause-specific mortality, systematic review and updated meta-analysis |
| Cocoa | Cardiovascular Disease | 19 | PM | 34959821 | 📋 | Cardiovascular Effects of Chocolate and Wine-Narrative Review |
| Cocoa | Cardiovascular Disease | 15 | PM | 34329196 | 📋 | Chocolate consumption and all-cause and cause-specific mortality in a US population: a post hoc analysis of the PLCO cancer screening trial |
| Cocoa | Cardiovascular Disease | 13 | PM | 30620683 | 📋 | Cardioprotective Mechanisms of Cocoa |
| Cocoa | Cardiovascular Disease | 2 | PM | 30061161 | 📋 | Chocolate consumption and risk of cardiovascular diseases: a meta-analysis of prospective studies |
| Cocoa | Cardiovascular Disease | 16 | PM | 29723102 | 📋 | Cardioprotection by Cocoa Polyphenols and ω-3 Fatty Acids: A Disease-Prevention Perspective on Aging-Associated Cardiovascular Risk |
| Cocoa | Cardiovascular Disease | 4 | PM | 29290347 | 📋 | Can chocolate consumption reduce cardio-cerebrovascular risk? A systematic review and meta-analysis |
| Cocoa | Cardiovascular Disease | 17 | PM | 28933419 | 📋 | The Cardiovascular Effects of Cocoa Polyphenols-An Overview |
| Cocoa | Cardiovascular Disease | 18 | PM | 28824916 | 📋 | Cocoa, Blood Pressure, and Vascular Function |
| Cocoa | Cardiovascular Disease | 12 | PM | 28691541 | 📋 | Effects of hazelnuts and cocoa on vascular reactivity in healthy subjects: a randomised study |
| Cocoa | Cardiovascular Disease | 10 | PM | 27091601 | 📋 | Dark chocolate attenuates intracellular pro-inflammatory reactivity to acute psychosocial stress in men: A randomized controlled trial |
| Cocoa | Cardiovascular Disease | 14 | PM | 27070643 | 📋 | Effect of Cocoa and Its Flavonoids on Biomarkers of Inflammation: Studies of Cell Culture, Animals and Humans |
| Cocoa | Cardiovascular Disease | 5 | PM | 26983749 | 📋 | Daily chocolate consumption is inversely associated with insulin resistance and liver enzymes in the Observation of Cardiovascular Risk Factors in Luxembourg study |
| Cocoa | Cardiovascular Disease | 11 | PM | 26076934 | 📋 | Habitual chocolate consumption and risk of cardiovascular disease among healthy men and women |
| Cocoa | Cardiovascular Disease | 9 | PM | 25869509 | 📋 | Effects of high flavanol dark chocolate on cardiovascular function and platelet aggregation |
| Cocoa | Cardiovascular Disease | 3 | PM | 22301923 | 📋 | Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials |
| Cocoa | Cardiovascular Disease | 1 | PM | 21875885 | 📋 | Chocolate consumption and cardiometabolic disorders: systematic review and meta-analysis |
| Cocoa | Cardiovascular Disease | 6 | PM | 20354055 | 📋 | Chocolate consumption in relation to blood pressure and risk of cardiovascular disease in German adults |
| Cocoa | Cardiovascular Disease | 8 | PM | 19776136 | 📋 | Effect of cocoa powder on the modulation of inflammatory biomarkers in patients at high risk of cardiovascular disease |
| Cocoa | Cardiovascular Disease | 7 | PM | 18510961 | 📋 | Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial |
| Cocoa | Coronary Artery Disease | 4 | PM | 34483344 | 📋 | Chocolate consumption and risk of coronary artery disease: the Million Veteran Program |
| Cocoa | Coronary Artery Disease | 1 | PM | 28671591 | 📋 | Chocolate Consumption and Risk of Coronary Heart Disease, Stroke, and Diabetes: A Meta-Analysis of Prospective Studies |
| Cocoa | Coronary Artery Disease | 3 | PM | 20858571 | 📋 | Chocolate consumption is inversely associated with prevalent coronary heart disease: the National Heart, Lung, and Blood Institute Family Heart Study |
| Cocoa | Coronary Artery Disease | 2 | PM | 20655129 | 📋 | Chocolate consumption is inversely associated with calcified atherosclerotic plaque in the coronary arteries: the NHLBI Family Heart Study |
| Cocoa | Endothelial Dysfunction | 16 | PM | 36164983 | 📋 | Cocoa flavanol consumption improves lower extremity endothelial function in healthy individuals and people with type 2 diabetes |
| Cocoa | Endothelial Dysfunction | 15 | PM | 35860885 | 📋 | The Relationships Between Chocolate Consumption and Endothelial Dysfunction in Patients with Heart Failure |
| Cocoa | Endothelial Dysfunction | 13 | PM | 35094491 | 📋 | Flavanol Consumption in Healthy Men Preserves Integrity of Immunological-Endothelial Barrier Cell Functions: Nutri(epi)genomic Analysis |
| Cocoa | Endothelial Dysfunction | 11 | PM | 34010747 | 📋 | Chocolate enriched by extra virgin olive oil improves endothelial function and oxidative stress in patients with diabetes |
| Cocoa | Endothelial Dysfunction | 10 | PM | 33801767 | 📋 | Cocoa Flavanols Improve Vascular Responses to Acute Mental Stress in Young Healthy Adults |
| Cocoa | Endothelial Dysfunction | 14 | PM | 33096196 | 📋 | Preventive effect of cocoa flavanols against glucotoxicity-induced vascular inflammation in the arteria of diabetic rats and on the inflammatory process in TNF-α-stimulated endothelial cells |
| Cocoa | Endothelial Dysfunction | 12 | PM | 32185628 | 📋 | Cocoa Flavanols Protect Human Endothelial Cells from Oxidative Stress |
| Cocoa | Endothelial Dysfunction | 19 | PM | 31294557 | 📋 | Cocoa Flavanols Improve Endothelial Functional Integrity in Healthy Young and Elderly Subjects |
| Cocoa | Endothelial Dysfunction | 3 | PM | 29329924 | 📋 | Effects of dark chocolate on endothelial function in patients with non-alcoholic steatohepatitis |
| Cocoa | Endothelial Dysfunction | 4 | PM | 28794213 | 📋 | Brachial and Cerebrovascular Functions Are Enhanced in Postmenopausal Women after Ingestion of Chocolate with a High Concentration of Cocoa |
| Cocoa | Endothelial Dysfunction | 18 | PM | 23533716 | 📋 | Characterisation of hypertensive patients with improved endothelial function after dark chocolate consumption |
| Cocoa | Endothelial Dysfunction | 17 | PM | 23209885 | 📋 | Consumption of high-polyphenol dark chocolate improves endothelial function in individuals with stage 1 hypertension and excess body weight |
| Cocoa | Endothelial Dysfunction | 7 | PM | 23039340 | 📋 | High-polyphenol chocolate reduces endothelial dysfunction and oxidative stress during acute transient hyperglycaemia in Type 2 diabetes: a pilot randomized controlled trial |
| Cocoa | Endothelial Dysfunction | 8 | PM | 22811444 | 📋 | Postprandial effects of dark chocolate on portal hypertension in patients with cirrhosis: results of a phase 2, double-blind, randomized controlled trial |
| Cocoa | Endothelial Dysfunction | 5 | PM | 22173910 | 📋 | Cardiovascular effects of flavanol-rich chocolate in patients with heart failure |
| Cocoa | Endothelial Dysfunction | 9 | PM | 18614724 | 📋 | Acute dark chocolate and cocoa ingestion and endothelial function: a randomized controlled crossover trial |
| Cocoa | Endothelial Dysfunction | 2 | PM | 18510961 | 📋 | Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial |
| Cocoa | Endothelial Dysfunction | 1 | PM | 16794456 | 📋 | Chronic consumption of flavanol-rich cocoa improves endothelial function and decreases vascular cell adhesion molecule in hypercholesterolemic postmenopausal women |
| Cocoa | Endothelial Dysfunction | 6 | PM | 15190043 | 📋 | Flavonoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adults |
| Cocoa | Heart Failure | 1 | PM | 32645737 | 📋 | Cacao Bean Polyphenols Inhibit Cardiac Hypertrophy and Systolic Dysfunction in Pressure Overload-induced Heart Failure Model Mice |
| Cocoa | Heart Failure | 2 | PM | 28425931 | 📋 | Chocolate Consumption and Risk of Heart Failure: A Meta-Analysis of Prospective Studies |
| Cocoa | Heart Failure | 4 | PM | 22173910 | 📋 | Cardiovascular effects of flavanol-rich chocolate in patients with heart failure |
| Cocoa | Hypertension | 24 | PM | 38200066 | 📋 | Dark chocolate intake and cardiovascular diseases: a Mendelian randomization study |
| Cocoa | Hypertension | 23 | PM | 37760002 | 📋 | Cocoa Shell Extract Reduces Blood Pressure in Aged Hypertensive Rats via the Cardiovascular Upregulation of Endothelial Nitric Oxide Synthase and Nuclear Factor (Erythroid-Derived 2)-like 2 Protein Expression |
| Cocoa | Hypertension | 21 | PM | 37526943 | 📋 | Cocoa flavanols improve peakVO2 and exercise capacity in a randomized double blinded clinical trial in healthy elderly people |
| Cocoa | Hypertension | 20 | PM | 37242181 | 📋 | Regular Consumption of Cocoa and Red Berries as a Strategy to Improve Cardiovascular Biomarkers via Modulation of Microbiota Metabolism in Healthy Aging Adults |
| Cocoa | Hypertension | 14 | PM | 35804776 | 📋 | Effect of Cocoa Beverage and Dark Chocolate Consumption on Blood Pressure in Those with Normal and Elevated Blood Pressure: A Systematic Review and Meta-Analysis |
| Cocoa | Hypertension | 13 | PM | 35064574 | 📋 | Consumption of caffeinated and decaffeinated coffee enriched with cocoa and fructo-oligosaccharides among non-diabetic persons: Double blind randomized clinical trial |
| Cocoa | Hypertension | 11 | PM | 34681387 | 📋 | Cocoa ( Theobroma cacao L.) Seed-Derived Peptides Reduce Blood Pressure by Interacting with the Catalytic Site of the Angiotensin-Converting Enzyme |
| Cocoa | Hypertension | 12 | PM | 34676690 | 📋 | Dose-effect relation between regular consumption of 100% cocoa powder and blood pressure in young, healthy black Africans |
| Cocoa | Hypertension | 6 | PM | 31982982 | 📋 | Consumption of cocoa-containing foods and risk of hypertension in French women |
| Cocoa | Hypertension | 2 | PM | 31654654 | 📋 | Acute consumption of flavanol-rich cocoa beverage improves attenuated cutaneous microvascular function in healthy young African Americans |
| Cocoa | Hypertension | 8 | PM | 29119920 | 📋 | Polyphenols: Inflammation |
| Cocoa | Hypertension | 9 | PM | 28439881 | 📋 | Effect of cocoa on blood pressure |
| Cocoa | Hypertension | 5 | PM | 27037002 | 📋 | Cocoa extract intake for 4 weeks reduces postprandial systolic blood pressure response of obese subjects, even after following an energy-restricted diet |
| Cocoa | Hypertension | 22 | PM | 25429467 | 📋 | Short term effects of cocoa consumption on blood pressure |
| Cocoa | Hypertension | 19 | PM | 23533716 | 📋 | Characterisation of hypertensive patients with improved endothelial function after dark chocolate consumption |
| Cocoa | Hypertension | 1 | PM | 22301923 | 📋 | Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials |
| Cocoa | Hypertension | 16 | PM | 20404213 | 📋 | Does dark chocolate have a role in the prevention and management of hypertension?: commentary on the evidence |
| Cocoa | Hypertension | 3 | PM | 20354055 | 📋 | Chocolate consumption in relation to blood pressure and risk of cardiovascular disease in German adults |
| Cocoa | Hypertension | 17 | PM | 18716168 | 📋 | Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate |
| Cocoa | Hypertension | 7 | PM | 18614724 | 📋 | Acute dark chocolate and cocoa ingestion and endothelial function: a randomized controlled crossover trial |
| Cocoa | Hypertension | 18 | PM | 18045712 | 📋 | Acute effect of oral flavonoid-rich dark chocolate intake on coronary circulation, as compared with non-flavonoid white chocolate, by transthoracic Doppler echocardiography in healthy adults |
| Cocoa | Hypertension | 4 | PM | 17609490 | 📋 | Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide: a randomized controlled trial |
| Cocoa | Hypertension | 10 | PM | 16794446 | 📋 | Hypertension, the Kuna, and the epidemiology of flavanols |
| Cocoa | Hypertension | 15 | PM | 16027246 | 📋 | Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives |
| Cocoa | Hypertension | 25 | PM | 15755830 | 📋 | Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons |
| Cocoa | Hypotension | 1 | PM | 22811444 | 📋 | Postprandial effects of dark chocolate on portal hypertension in patients with cirrhosis: results of a phase 2, double-blind, randomized controlled trial |
| Cocoa | Lymphoma | 1 | PM | 20961452 | 📋 | Antitumor activity against murine lymphoma L5178Y model of proteins from cacao (Theobroma cacao L.) seeds in relation with in vitro antioxidant activity |
| Cocoa | Myocardial Infarction | 1 | PM | 26936339 | 📋 | Chocolate consumption and risk of myocardial infarction: a prospective study and meta-analysis |
| Cocoa | Myocardial Ischemia | 1 | PM | 26936339 | 📋 | Chocolate consumption and risk of myocardial infarction: a prospective study and meta-analysis |
| Cocoa | Myocarditis | 1 | PM | 26657007 | 📋 | Cacao polyphenols ameliorate autoimmune myocarditis in mice |
| Cocoa | Peripheral Arterial Disease | 2 | PM | 38189132 | 📋 | Cocoa flavanols, Nrf2 activation, and oxidative stress in peripheral artery disease: Mechanistic findings in muscle based on outcomes from a randomized trial |
| Cocoa | Peripheral Arterial Disease | 1 | PM | 32078436 | 📋 | Cocoa to Improve Walking Performance in Older People With Peripheral Artery Disease: The COCOA-PAD Pilot Randomized Clinical Trial |
| Cocoa | Platelet Aggregation | 3 | PM | 38533262 | 📋 | New light on changes in the number and function of blood platelets stimulated by cocoa and its products |
| Cocoa | Platelet Aggregation | 1 | PM | 25869509 | 📋 | Effects of high flavanol dark chocolate on cardiovascular function and platelet aggregation |
| Cocoa | Platelet Aggregation | 2 | PM | 12791625 | 📋 | Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function |
| Cocoa | Poor Circulation | 3 | PM | 21903881 | 📋 | Dose-dependent increases in flow-mediated dilation following acute cocoa ingestion in healthy older adults |
| Cocoa | Poor Circulation | 2 | PM | 18045712 | 📋 | Acute effect of oral flavonoid-rich dark chocolate intake on coronary circulation, as compared with non-flavonoid white chocolate, by transthoracic Doppler echocardiography in healthy adults |
| Cocoa | Poor Circulation | 1 | PM | 16702322 | 📋 | Long-term ingestion of high flavanol cocoa provides photoprotection against UV-induced erythema and improves skin condition in women |
| Cocoa | Prehypertension | 1 | PM | 33679445 | 📋 | Weekly Physiological Changes in Blood Pressure During Three Weeks Daily Consumption of 10 Grams of Cocoa Powder Among Young Black Africans in Côte d'Ivoire |
| Cocoa | Pulse Pressure Wide or Narrow | 1 | PM | 31029045 | 📋 | Randomized study of the effects of cocoa-rich chocolate on the ventricle-arterial coupling and vascular function of young, healthy adults |
| Cocoa | Pulse Pressure Wide or Narrow | 2 | PM | 27088635 | 📋 | Flavanol-rich chocolate acutely improves arterial function and working memory performance counteracting the effects of sleep deprivation in healthy individuals |
| Cocoa | Stroke | 1 | PM | 28671591 | 📋 | Chocolate Consumption and Risk of Coronary Heart Disease, Stroke, and Diabetes: A Meta-Analysis of Prospective Studies |
| Cocoa | Stroke | 3 | PM | 28324761 | 📋 | Chocolate consumption and risk of stroke among men and women: A large population-based, prospective cohort study |
| Cocoa | Stroke | 2 | PM | 21875885 | 📋 | Chocolate consumption and cardiometabolic disorders: systematic review and meta-analysis |
| Cocoa | Thrombosis | 1 | PM | 12791625 | 📋 | Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function |
| Cocoa | Vascular Disorders | 1 | PM | 36452001 | 📋 | The action of phytochemicals present in cocoa in the prevention of vascular dysfunction and atherosclerosis |
| Cocoa | Vasculitis | 1 | PM | 33096196 | 📋 | Preventive effect of cocoa flavanols against glucotoxicity-induced vascular inflammation in the arteria of diabetic rats and on the inflammatory process in TNF-α-stimulated endothelial cells |
| Cocoa | Vasodilation | 3 | PM | 37526943 | 📋 | Cocoa flavanols improve peakVO2 and exercise capacity in a randomized double blinded clinical trial in healthy elderly people |
| Cocoa | Vasodilation | 1 | PM | 24274771 | 📋 | Effects of dark chocolate and cocoa consumption on endothelial function and arterial stiffness in overweight adults |
| Cocoa | Vasodilation | 2 | PM | 21903881 | 📋 | Dose-dependent increases in flow-mediated dilation following acute cocoa ingestion in healthy older adults |
| Cocoa | Vasodilation | 4 | PM | 16027246 | 📋 | Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives |
| Cocoa | Venous Thromboembolism | 1 | PM | 38200066 | 📋 | Dark chocolate intake and cardiovascular diseases: a Mendelian randomization study |
