| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Retinoic Acid | Acute Myeloid Leukemia | 6 | PM | 38204257 | 📋 | Combination of Ethacrynic Acid and ATRA Triggers Differentiation and/or Apoptosis of Acute Myeloid Leukemia Cells through ROS |
| Retinoic Acid | Acute Myeloid Leukemia | 5 | PM | 36058034 | 📋 | All-trans retinoic acid enhanced the antileukemic efficacy of ABT-199 in acute myeloid leukemia by downregulating the expression of S100A8 |
| Retinoic Acid | Acute Myeloid Leukemia | 4 | PM | 33742137 | 📋 | Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapy |
| Retinoic Acid | Acute Myeloid Leukemia | 3 | PM | 33140666 | 📋 | Differentiation of acute myeloid leukemia (AML) cells with ATRA reduces 18 F-FDG uptake and increases sensitivity towards ABT-737-induced apoptosis |
| Retinoic Acid | Acute Myeloid Leukemia | 2 | PM | 32882760 | 📋 | All-Trans Retinoic Acid Synergizes with Enasidenib to Induce Differentiation of IDH2-Mutant Acute Myeloid Leukemia Cells |
| Retinoic Acid | Acute Myeloid Leukemia | 1 | PM | 32699982 | 📋 | Efficacy of All-Trans-Retinoic Acid in High-Risk Acute Myeloid Leukemia with Overexpression of EVI1 |
| Retinoic Acid | Acute Promyelocytic Leukemia | 7 | PM | 37380920 | 📋 | Treatment of Pediatric Acute Promyelocytic Leukemia with Retinoic Acid and Arsenic Trioxide along with Chemotherapy |
| Retinoic Acid | Acute Promyelocytic Leukemia | 6 | PM | 37085055 | 📋 | Silymarin in combination with ATRA enhances apoptosis induction in human acute promyelocytic NB4 cells |
| Retinoic Acid | Acute Promyelocytic Leukemia | 5 | PM | 36258250 | 📋 | Oral arsenic and retinoic acid for high-risk acute promyelocytic leukemia |
| Retinoic Acid | Acute Promyelocytic Leukemia | 4 | PM | 34087869 | 📋 | Successful treatment of acute promyelocytic leukemia in a 92-year-old man using all-trans retinoic acid combined with oral arsenic: A case report |
| Retinoic Acid | Acute Promyelocytic Leukemia | 3 | PM | 34077242 | 📋 | Arsenic Combined With All-Trans Retinoic Acid for Pediatric Acute Promyelocytic Leukemia: Report From the CCLG-APL2016 Protocol Study |
| Retinoic Acid | Acute Promyelocytic Leukemia | 2 | PM | 33614484 | 📋 | Oral Realgar-Indigo Naturalis Formula Plus Retinoic Acid for Acute Promyelocytic Leukemia |
| Retinoic Acid | Acute Promyelocytic Leukemia | 1 | PM | 32765864 | 📋 | Combined effect of (-)-epigallocatechin-3-gallate and all-trans retinoic acid in FLT3-mutated cell lines |
| Retinoic Acid | Bladder Cancer | 3 | PM | 38539513 | 📋 | The Effect of Retinoic Acid on Arsenite-Transformed Malignant UROtsa Bladder Cancer Cells: In Vitro Model of Basal Muscle-Invasive Bladder Cancer |
| Retinoic Acid | Bladder Cancer | 2 | PM | 33805295 | 📋 | Vitamin A and Retinoids in Bladder Cancer Chemoprevention and Treatment: A Narrative Review of Current Evidence, Challenges and Future Prospects |
| Retinoic Acid | Bladder Cancer | 1 | PM | 33128775 | 📋 | Retinoic acid signaling and bladder cancer: Epigenetic deregulation, therapy and beyond |
| Retinoic Acid | Breast Cancer | 9 | PM | 37700002 | 📋 | Combined dandelion extract and all-trans retinoic acid induces cytotoxicity in human breast cancer cells |
| Retinoic Acid | Breast Cancer | 8 | PM | 36818177 | 📋 | Anticancer activity of retinoic acid against breast cancer cells derived from an Iraqi patient |
| Retinoic Acid | Breast Cancer | 7 | PM | 36230951 | 📋 | Combination Treatment of Retinoic Acid Plus Focal Adhesion Kinase Inhibitor Prevents Tumor Growth and Breast Cancer Cell Metastasis |
| Retinoic Acid | Breast Cancer | 6 | PM | 35327497 | 📋 | hTERT DNA Methylation Analysis Identifies a Biomarker for Retinoic Acid-Induced hTERT Repression in Breast Cancer Cell Lines |
| Retinoic Acid | Breast Cancer | 4 | PM | 34136389 | 📋 | Retinoic Acid Downregulates HSPB8 Gene Expression in Human Breast Cancer Cells MCF-7 |
| Retinoic Acid | Breast Cancer | 3 | PM | 33081033 | 📋 | Retinoic Acid Sensitivity of Triple-Negative Breast Cancer Cells Characterized by Constitutive Activation of the notch1 Pathway: The Role of Rarβ |
| Retinoic Acid | Breast Cancer | 2 | PM | 32865619 | 📋 | Protein Kinase C Alpha (PKCα) overexpression leads to a better response to retinoid acid therapy through Retinoic Acid Receptor Beta (RARβ) activation in mammary cancer cells |
| Retinoic Acid | Breast Cancer | 1 | PM | 32384653 | 📋 | All-Trans Retinoic Acid Stimulates Viral Mimicry, Interferon Responses and Antigen Presentation in Breast-Cancer Cells |
| Retinoic Acid | Breast Cancer | 5 | PM | 30216095 | 📋 | Differential Potentiation of Retinoic Acid Effects against Human Breast Cancer Cells by Unsaturated Fatty Acids |
| Retinoic Acid | Cancer | 1 | PM | 32902409 | 📋 | CD44 and vimentin, markers involved with epithelial-mesenchymal transition: A proteomic analysis of sequential proteins extraction of triple-negative breast cancer cells after treatment with all-trans retinoic acid |
| Retinoic Acid | Cervical Cancer | 2 | PM | 35688951 | 📋 | Inhibition of myeloid-derived suppressive cell function with all-trans retinoic acid enhanced anti-PD-L1 efficacy in cervical cancer |
| Retinoic Acid | Cervical Cancer | 1 | PM | 33653777 | 📋 | All-Trans Retinoic Acid Potentiates Antitumor Efficacy of Cisplatin by Increasing Differentiation of Cancer Stem-Like Cells in Cervical Cancer |
| Retinoic Acid | Cisplatin Toxicity | 1 | PM | 32719599 | 📋 | Retinoic Acid Alleviates Cisplatin-Induced Acute Kidney Injury Through Activation of Autophagy |
| Retinoic Acid | Colon Cancer | 2 | PM | 38239861 | 📋 | Potential antitumour effect of all-trans retinoic acid on regorafenib-treated human colon cancer cell lines |
| Retinoic Acid | Colon Cancer | 1 | PM | 36247302 | 📋 | Involvement of hedgehog signaling in all-trans retinoic acid-mediated suppression of colon cancer |
| Retinoic Acid | Colorectal Cancer | 2 | PM | 34877501 | 📋 | Retinoic acid signaling drives differentiation toward the absorptive lineage in colorectal cancer |
| Retinoic Acid | Colorectal Cancer | 1 | PM | 34335757 | 📋 | All-Trans Retinoic Acid Enhances Chemosensitivity to 5-FU by Targeting miR-378c/E2F7 Axis in Colorectal Cancer |
| Retinoic Acid | Esophageal Cancer | 1 | PM | 37038094 | 📋 | All-Trans Retinoic Acid Promotes a Tumor Suppressive OTUD6B-β-TrCP-SNAIL Axis in Esophageal Squamous Cell Carcinoma and Enhances Immunotherapy |
| Retinoic Acid | Gastric Cancer | 4 | PM | 37951921 | 📋 | Anti-tumor activity of all-trans retinoic acid in gastric-cancer: gene-networks and molecular mechanisms |
| Retinoic Acid | Gastric Cancer | 3 | PM | 35973456 | 📋 | All-trans retinoic acid-mediated miR-30a up-regulation suppresses autophagy and sensitizes gastric cancer cells to cisplatin |
| Retinoic Acid | Gastric Cancer | 2 | PM | 35225106 | 📋 | All-Trans Retinoic Acid Prevents the Progression of Gastric Precancerous Lesions by Regulating Disordered Retinoic Acid Metabolism |
| Retinoic Acid | Gastric Cancer | 1 | PM | 32959699 | 📋 | All-Trans Retinoic Acid Rescues the Tumor Suppressive Role of RAR-β by Inhibiting LncHOXA10 Expression in Gastric Tumorigenesis |
| Retinoic Acid | Head and Neck Cancer | 3 | PM | 36734294 | 📋 | Combined all-trans retinoic acid with low-dose apatinib in treatment of recurrent/metastatic head and neck adenoid cystic carcinoma: A single-center, secondary analysis of a phase II study |
| Retinoic Acid | Head and Neck Cancer | 2 | PM | 34091189 | 📋 | A phase II trial of all-trans retinoic acid (ATRA) in advanced adenoid cystic carcinoma |
| Retinoic Acid | Head and Neck Cancer | 1 | PM | 33791153 | 📋 | Establishment of patient-derived xenograft models of adenoid cystic carcinoma to assess pre-clinical efficacy of combination therapy of a PI3K inhibitor and retinoic acid |
| Retinoic Acid | Leukemia | 1 | PM | 36718308 | 📋 | Synergistic Anti-Cancer Activity of the Combination of 1,25-Dihydroxyvitamin D3 and Retinoic Acid in U937 Cell Line |
| Retinoic Acid | Liver Cancer | 4 | PM | 37537668 | 📋 | ATRA sensitized the response of hepatocellular carcinoma to Sorafenib by downregulation of p21-activated kinase 1 |
| Retinoic Acid | Liver Cancer | 3 | PM | 37301119 | 📋 | All-trans-retinoic acid inhibits hepatocellular carcinoma progression by targeting myeloid-derived suppressor cells and inhibiting angiogenesis |
| Retinoic Acid | Liver Cancer | 2 | PM | 36157492 | 📋 | All-trans retinoic acid inhibits the malignant behaviors of hepatocarcinoma cells by regulating ferroptosis |
| Retinoic Acid | Liver Cancer | 1 | PM | 33194073 | 📋 | All-trans-retinoic acid inhibits the malignant behaviors of hepatocarcinoma cells by regulating autophagy |
| Retinoic Acid | Lung Cancer | 2 | PM | 34543639 | 📋 | Regulation of inflammation and COX-2 gene expression in benzo (a) pyrene induced lung carcinogenesis in mice by all trans retinoic acid (ATRA) |
| Retinoic Acid | Lung Cancer | 1 | PM | 33550205 | 📋 | Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin |
| Retinoic Acid | Melanoma | 5 | PM | 36378549 | 📋 | Targeting MDSC differentiation using ATRA: a phase I/II clinical trial combining pembrolizumab and all-trans retinoic acid for metastatic melanoma |
| Retinoic Acid | Melanoma | 4 | PM | 33947313 | 📋 | Protective role of All Trans Retinoic Acid on B16F10 melanoma cell line metastasis in C57BL/6 mice by enhancing RAR- β protein and homeostasis maintenance |
| Retinoic Acid | Melanoma | 3 | PM | 33889575 | 📋 | Retinoic Acid Inhibits Tumor-Associated Mesenchymal Stromal Cell Transformation in Melanoma |
| Retinoic Acid | Melanoma | 1 | PM | 33022719 | 📋 | In Vitro Anticancer Effects of All-trans Retinoic Acid in Combination with Dacarbazine against CD117+ Melanoma Cells |
| Retinoic Acid | Melanoma | 2 | PM | 30195874 | 📋 | Molecular mechanism and cytotoxicity of allicin and all-trans retinoic acid against CD44 + versus CD117 + melanoma cells |
| Retinoic Acid | Neuroblastoma | 4 | PM | 38339295 | 📋 | Retinoid Therapy for Neuroblastoma: Historical Overview, Regulatory Challenges, and Prospects |
| Retinoic Acid | Neuroblastoma | 3 | PM | 38328117 | 📋 | Mitochondrial uncoupler and retinoic acid synergistically induce differentiation and inhibit proliferation in neuroblastoma |
| Retinoic Acid | Neuroblastoma | 2 | PM | 33809565 | 📋 | Differentiating Neuroblastoma: A Systematic Review of the Retinoic Acid, Its Derivatives, and Synergistic Interactions |
| Retinoic Acid | Neuroblastoma | 1 | PM | 32705280 | 📋 | Retinoic acid induces differentiation in neuroblastoma via ROR1 by modulating retinoic acid response elements |
| Retinoic Acid | Ovarian Cancer | 1 | PM | 33227893 | 📋 | Association among Vitamin D, Retinoic Acid-Related Orphan Receptors, and Vitamin D Hydroxyderivatives in Ovarian Cancer |
| Retinoic Acid | Pancreatic Cancer | 1 | PM | 33730072 | 📋 | Treatment of 13-cis retinoic acid and 1,25-dihydroxyvitamin D3 inhibits TNF-alpha-mediated expression of MMP-9 protein and cell invasion through the suppression of JNK pathway and microRNA 221 in human pancreatic adenocarcinoma cancer cells |
| Retinoic Acid | Prostate Cancer | 2 | PM | 33531604 | 📋 | Neuroendocrine prostate cancer has distinctive, non-prostatic HOX code that is represented by the loss of HOXB13 expression |
| Retinoic Acid | Prostate Cancer | 1 | PM | 32881426 | 📋 | Retinoic acid receptor γ is a therapeutically targetable driver of growth and survival in prostate cancer |
