| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Nobiletin | Acute Myeloid Leukemia | 1 | PM | 30507186 | 📋 | Nobiletin Down-Regulates c-KIT Gene Expression and Exerts Antileukemic Effects on Human Acute Myeloid Leukemia Cells |
| Nobiletin | Acute Myeloid Leukemia | 2 | PM | 25164609 | 📋 | Nobiletin suppresses the proliferation and induces apoptosis involving MAPKs and caspase-8/-9/-3 signals in human acute myeloid leukemia cells |
| Nobiletin | Biliary Tract Cancer | 1 | PM | 36263164 | 📋 | Nobiletin suppresses cholangiocarcinoma proliferation via inhibiting GSK3β |
| Nobiletin | Bladder Cancer | 1 | PM | 31398899 | 📋 | Involvement of Mitochondrial Dysfunction, Endoplasmic Reticulum Stress, and the PI3K/AKT/mTOR Pathway in Nobiletin-Induced Apoptosis of Human Bladder Cancer Cells |
| Nobiletin | Bone Cancer | 1 | PM | 27144433 | 📋 | Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression |
| Nobiletin | Breast Cancer | 11 | PM | 38721626 | 📋 | Nobiletin Inhibits Breast Cancer Stem Cell by Regulating the Cell Cycle: A Comprehensive Bioinformatics Analysis and In Vitro Experiments |
| Nobiletin | Breast Cancer | 10 | PM | 36584607 | 📋 | Nobiletin inhibits breast cancer cell migration and invasion by suppressing the IL-6-induced ERK-STAT and JNK-c-JUN pathways |
| Nobiletin | Breast Cancer | 9 | PM | 35440077 | 📋 | ROR activation by Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer |
| Nobiletin | Breast Cancer | 8 | PM | 34257674 | 📋 | The Application of Citrus folium in Breast Cancer and the Mechanism of Its Main Component Nobiletin: A Systematic Review |
| Nobiletin | Breast Cancer | 7 | PM | 33728753 | 📋 | Nobiletin promotes the pyroptosis of breast cancer via regulation of miR-200b/JAZF1 axis |
| Nobiletin | Breast Cancer | 2 | PM | 32706791 | 📋 | Nobiletin affects circadian rhythms and oncogenic characteristics in a cell-dependent manner |
| Nobiletin | Breast Cancer | 1 | PM | 32479009 | 📋 | Nobiletin Attenuates Cell Proliferation by Modulating the Activating Protein-1 Signaling Pathway in 7,12-Dimethylbenz[a]anthracene-Induced Mammary Carcinogenesis |
| Nobiletin | Breast Cancer | 6 | PM | 30574046 | 📋 | Nobiletin inhibits breast cancer via p38 mitogen-activated protein kinase, nuclear transcription factor-κB, and nuclear factor erythroid 2-related factor 2 pathways in MCF-7 cells |
| Nobiletin | Breast Cancer | 3 | PM | 29408579 | 📋 | Nobiletin bioactivation in MDA-MB-468 breast cancer cells by cytochrome P450 CYP1 enzymes |
| Nobiletin | Breast Cancer | 5 | PM | 28468300 | 📋 | Nobiletin Inhibits Angiogenesis by Regulating Src/FAK/STAT3-Mediated Signaling through PXN in ER⁺ Breast Cancer Cells |
| Nobiletin | Breast Cancer | 4 | PM | 28177754 | 📋 | Comparison of the effects of nobiletin and letrozole on the activity and expression of aromatase in the MCF-7 breast cancer cell line |
| Nobiletin | Cancer | 12 | PM | 37185325 | 📋 | Nobiletin in cancer therapy; mechanisms and therapy perspectives |
| Nobiletin | Cancer | 11 | PM | 36495495 | 📋 | Multifunctional role of Nobiletin in cancer chemoprevention |
| Nobiletin | Cancer | 10 | PM | 36378586 | 📋 | Nobiletin and xanthohumol counteract the TNFα-mediated activation of endothelial cells through the inhibition of the NF-κB signaling pathway |
| Nobiletin | Cancer | 9 | PM | 35344715 | 📋 | Transcriptomics, molecular docking, and cross-resistance profiling of nobiletin in cancer cells and synergistic interaction with doxorubicin upon SOX5 transfection |
| Nobiletin | Cancer | 8 | PM | 35312885 | 📋 | Nobiletin as an inducer of programmed cell death in cancer: a review |
| Nobiletin | Cancer | 7 | PM | 35089821 | 📋 | Nobiletin as a chemopreventive natural product against cancer, a comprehensive review |
| Nobiletin | Cancer | 2 | PM | 32380783 | 📋 | Nobiletin in Cancer Therapy: How This Plant Derived-Natural Compound Targets Various Oncogene and Onco-Suppressor Pathways |
| Nobiletin | Cancer | 3 | PM | 32212785 | 📋 | Bioinformatics Studies Provide Insight into Possible Target and Mechanisms of Action of Nobiletin against Cancer Stem Cells |
| Nobiletin | Cancer | 1 | PM | 31884406 | 📋 | Nobiletin potentiates paclitaxel anticancer efficacy in A549/T xenograft model: Pharmacokinetic and pharmacological study |
| Nobiletin | Cancer | 6 | PM | 29914089 | 📋 | Nobiletin Inhibits CD36-Dependent Tumor Angiogenesis, Migration, Invasion, and Sphere Formation Through the Cd36/Stat3/Nf-Κb Signaling Axis |
| Nobiletin | Cancer | 5 | PM | 27761146 | 📋 | The Multifunctional Effects of Nobiletin and Its Metabolites In Vivo and In Vitro |
| Nobiletin | Cancer | 4 | PM | 26689156 | 📋 | Nobiletin enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cancer cells |
| Nobiletin | Chronic Myeloid Leukemia | 1 | PM | 32260160 | 📋 | Nobiletin Promotes Megakaryocytic Differentiation through the MAPK/ERK-Dependent EGR1 Expression and Exerts Anti-Leukemic Effects in Human Chronic Myeloid Leukemia (CML) K562 Cells |
| Nobiletin | Cisplatin Toxicity | 3 | PM | 38570541 | 📋 | Nobiletin alleviates cisplatin-induced ototoxicity via activating autophagy and inhibiting NRF2/GPX4-mediated ferroptosis |
| Nobiletin | Cisplatin Toxicity | 2 | PM | 33650929 | 📋 | Protective effects of nobiletin on cisplatin induced neurotoxicity in rats |
| Nobiletin | Cisplatin Toxicity | 1 | PM | 26002685 | 📋 | Nobiletin ameliorates cisplatin-induced acute kidney injury due to its anti-oxidant, anti-inflammatory and anti-apoptotic effects |
| Nobiletin | Colon Cancer | 6 | PM | 36454256 | 📋 | Nobiletin is capable of regulating certain anti-cancer pathways in a colon cancer cell line |
| Nobiletin | Colon Cancer | 5 | PM | 32144766 | 📋 | Synergistic anticancer effects of curcumin and 3',4'-didemethylnobiletin in combination on colon cancer cells |
| Nobiletin | Colon Cancer | 4 | PM | 28207072 | 📋 | Synergistic chemopreventive effects of nobiletin and atorvastatin on colon carcinogenesis |
| Nobiletin | Colon Cancer | 2 | PM | 28107678 | 📋 | Nobiletin and its colonic metabolites suppress colitis-associated colon carcinogenesis by down-regulating iNOS, inducing antioxidative enzymes and arresting cell cycle progression |
| Nobiletin | Colon Cancer | 3 | PM | 26445322 | 📋 | Chemopreventive effects of nobiletin and its colonic metabolites on colon carcinogenesis |
| Nobiletin | Colon Cancer | 1 | PM | 23137376 | 📋 | Multidrug resistance reversal and apoptosis induction in human colon cancer cells by some flavonoids present in citrus plants |
| Nobiletin | Colorectal Cancer | 4 | PM | 34439086 | 📋 | Nobiletin and Xanthohumol Sensitize Colorectal Cancer Stem Cells to Standard Chemotherapy |
| Nobiletin | Colorectal Cancer | 3 | PM | 31234411 | 📋 | Nobiletin and Derivatives: Functional Compounds from Citrus Fruit Peel for Colon Cancer Chemoprevention |
| Nobiletin | Colorectal Cancer | 2 | PM | 30468657 | 📋 | Nobiletin sensitizes colorectal cancer cells to oxaliplatin by PI3K/Akt/MTOR pathway |
| Nobiletin | Colorectal Cancer | 1 | PM | 29313727 | 📋 | Polymethoxylated Flavones from Orange Peels Inhibit Cell Proliferation in a 3D Cell Model of Human Colorectal Cancer |
| Nobiletin | Gastric Cancer | 4 | PM | 38547624 | 📋 | Nobiletin targets SREBP1/ACLY to induce autophagy-dependent cell death of gastric cancer cells through PI3K/Akt/mTOR signaling pathway |
| Nobiletin | Gastric Cancer | 3 | PM | 37270969 | 📋 | Nobiletin inhibits de novo FA synthesis to alleviate gastric cancer progression by regulating endoplasmic reticulum stress |
| Nobiletin | Gastric Cancer | 2 | PM | 32479014 | 📋 | Nobiletin Inhibits Helicobacterium pylori Infection-Induced Gastric Carcinogenic Signaling by Blocking Inflammation, Apoptosis, and Mitogen-Activated Protein Kinase Events in Gastric Epithelial-1 Cells |
| Nobiletin | Gastric Cancer | 1 | PM | 27428937 | 📋 | Nobiletin Induces Protective Autophagy Accompanied by ER-Stress Mediated Apoptosis in Human Gastric Cancer SNU-16 Cells |
| Nobiletin | Glioblastoma | 1 | PM | 28339056 | 📋 | Nobiletin inhibits invasion via inhibiting AKT/GSK3β/β-catenin signaling pathway in Slug-expressing glioma cells |
| Nobiletin | Glioblastoma | 2 | PM | 26560814 | 📋 | Nobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways |
| Nobiletin | Head and Neck Cancer | 1 | PM | 37715445 | 📋 | Nobiletin regulates invasion, migration and metastasis in hypopharyngeal squamous cell carcinoma |
| Nobiletin | Kidney Cancer | 1 | PM | 31354472 | 📋 | Nobiletin Inhibits Cell Viability via the SRC/AKT/STAT3/YY1AP1 Pathway in Human Renal Carcinoma Cells |
| Nobiletin | Liver Cancer | 1 | PM | 23537747 | 📋 | Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells |
| Nobiletin | Lung Cancer | 8 | PM | 37716621 | 📋 | The novel small molecule BH3 mimetic nobiletin synergizes with vorinostat to induce apoptosis and autophagy in small cell lung cancer |
| Nobiletin | Lung Cancer | 7 | PM | 35003309 | 📋 | Nobiletin Inhibits Non-Small-Cell Lung Cancer by Inactivating WNT/ β-Catenin Signaling through Downregulating miR-15-5p |
| Nobiletin | Lung Cancer | 5 | PM | 34576006 | 📋 | Mechanistic Insights of Anti-Immune Evasion by Nobiletin through Regulating miR-197/STAT3/PD-L1 Signaling in Non-Small Cell Lung Cancer (NSCLC) Cells |
| Nobiletin | Lung Cancer | 6 | PM | 32082977 | 📋 | Nobiletin and its derivatives overcome multidrug resistance (MDR) in cancer: total synthesis and discovery of potent MDR reversal agents |
| Nobiletin | Lung Cancer | 3 | PM | 31664275 | 📋 | Inhibitory effects of nobiletin and its major metabolites on lung tumorigenesis |
| Nobiletin | Lung Cancer | 4 | PM | 30486290 | 📋 | Nobiletin Enhances Chemosensitivity to Adriamycin through Modulation of the Akt/GSK3β/β⁻Catenin/MYCN/MRP1 Signaling Pathway in A549 Human Non-Small-Cell Lung Cancer Cells |
| Nobiletin | Lung Cancer | 2 | PM | 26012256 | 📋 | Nobiletin inhibited hypoxia-induced epithelial-mesenchymal transition of lung cancer cells by inactivating of Notch-1 signaling and switching on miR-200b |
| Nobiletin | Lung Cancer | 1 | PM | 24687742 | 📋 | Synergistic antitumor effect of a combination of paclitaxel and carboplatin with nobiletin from Citrus depressa on non-small-cell lung cancer cell lines |
| Nobiletin | Melanoma | 1 | PM | 35350242 | 📋 | Nobiletin Induces Ferroptosis in Human Skin Melanoma Cells Through the GSK3β-Mediated Keap1/Nrf2/HO-1 Signalling Pathway |
| Nobiletin | Nasopharyngeal Cancer | 2 | PM | 30918653 | 📋 | Nobiletin induces growth inhibition and apoptosis in human nasopharyngeal carcinoma C666-1 cells through regulating PARP-2/SIRT1/AMPK signaling pathway |
| Nobiletin | Nasopharyngeal Cancer | 1 | PM | 25563790 | 📋 | Nobiletin inhibits invasion and migration of human nasopharyngeal carcinoma cell lines by involving ERK1/2 and transcriptional inhibition of MMP-2 |
| Nobiletin | Oral Cancer | 1 | PM | 32868254 | 📋 | Nobiletin selectively inhibits oral cancer cell growth by promoting apoptosis and DNA damage in vitro |
| Nobiletin | Oral Cancer | 2 | PM | 32724614 | 📋 | Nobiletin inhibits cell growth through restraining aerobic glycolysis via PKA-CREB pathway in oral squamous cell carcinoma |
| Nobiletin | Ovarian Cancer | 3 | PM | 31955565 | 📋 | Nobiletin Triggers Reactive Oxygen Species-Mediated Pyroptosis through Regulating Autophagy in Ovarian Cancer Cells |
| Nobiletin | Ovarian Cancer | 2 | PM | 29635125 | 📋 | Nobiletin (NOB) suppresses autophagic degradation via over-expressing AKT pathway and enhances apoptosis in multidrug-resistant SKOV3/TAX ovarian cancer cells |
| Nobiletin | Ovarian Cancer | 1 | PM | 25845666 | 📋 | The flavonoid nobiletin inhibits tumor growth and angiogenesis of ovarian cancers via the Akt pathway |
| Nobiletin | Pancreatic Cancer | 1 | PM | 32521908 | 📋 | Nobiletin flavone inhibits the growth and metastasis of human pancreatic cancer cells via induction of autophagy, G0/G1 cell cycle arrest and inhibition of NF-kB signalling pathway |
| Nobiletin | Prostate Cancer | 3 | PM | 34548474 | 📋 | Selective degradation of AR-V7 to overcome castration resistance of prostate cancer |
| Nobiletin | Prostate Cancer | 2 | PM | 33121290 | 📋 | Evaluation of the Effects of Nobiletin on Toll-Like Receptor 3 Signaling Pathways in Prostate Cancer In Vitro |
| Nobiletin | Prostate Cancer | 4 | PM | 32048561 | 📋 | Anti-inflammatory effects of nobiletin on TLR4/TRIF/IRF3 and TLR9/IRF7 signaling pathways in prostate cancer cells |
| Nobiletin | Prostate Cancer | 1 | PM | 31037974 | 📋 | Synergistic Effects of Nobiletin and Sorafenib Combination on Metastatic Prostate Cancer Cells |
| Nobiletin | Renal Cell Carcinoma | 3 | PM | 33628597 | 📋 | Nobiletin downregulates the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and shows synergistic effects with palbociclib on renal cell carcinoma |
| Nobiletin | Renal Cell Carcinoma | 2 | PM | 33040836 | 📋 | Nobiletin inhibits viability of human renal carcinoma cells via the JAK2/STAT3 and PI3K/Akt pathway |
| Nobiletin | Renal Cell Carcinoma | 1 | PM | 30203502 | 📋 | Nobiletin inhibits hypoxia-induced epithelial-mesenchymal transition in renal cell carcinoma cells |
| Nobiletin | Skin Cancer | 1 | PM | 21126077 | 📋 | Tangeretin reduces ultraviolet B (UVB)-induced cyclooxygenase-2 expression in mouse epidermal cells by blocking mitogen-activated protein kinase (MAPK) activation and reactive oxygen species (ROS) generation |
| Nobiletin | Thyroid Cancer | 1 | PM | 31287730 | 📋 | Nobiletin Alone or in Combination with Cisplatin Decreases the Viability of Anaplastic Thyroid Cancer Cell Lines |
