| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Hesperidin | Acute Myeloid Leukemia | 2 | PM | 36534417 | 📋 | Evidence for Hesperidin as an Effective Factor in Initiating the Intrinsic Pathway of Apoptosis in KG1a Leukemia Cells |
| Hesperidin | Acute Myeloid Leukemia | 1 | PM | 26148599 | 📋 | Enhancement of the cytotoxic effects of Cytarabine in synergism with Hesperidine and Silibinin in Acute Myeloid Leukemia: An in-vitro approach |
| Hesperidin | Biliary Tract Cancer | 1 | PM | 34984768 | 📋 | Hesperidin delays cell cycle progression into the G0/G1 phase via suspension of MAPK signaling pathway in intrahepatic cholangiocarcinoma |
| Hesperidin | Breast Cancer | 14 | PM | 38233443 | 📋 | Synergistic effects of bee venom, hesperidin, and piperine with tamoxifen on apoptotic and angiogenesis biomarker molecules against xerographic MCF-7 injected rats |
| Hesperidin | Breast Cancer | 4 | PM | 37581480 | 📋 | Hesperidin suppressed metastasis, angiogenesis and tumour growth in Balb/c mice model of breast cancer |
| Hesperidin | Breast Cancer | 13 | PM | 37080525 | 📋 | Therapeutic potential of hesperidin: Apoptosis induction in breast cancer cell lines |
| Hesperidin | Breast Cancer | 12 | PM | 36978836 | 📋 | Naringenin and Hesperidin as Promising Alternatives for Prevention and Co-Adjuvant Therapy for Breast Cancer |
| Hesperidin | Breast Cancer | 7 | PM | 36967442 | 📋 | In vitro synergistic effect of hesperidin and doxorubicin downregulates epithelial-mesenchymal transition in highly metastatic breast cancer cells |
| Hesperidin | Breast Cancer | 11 | PM | 34866972 | 📋 | Hesperidin and its aglycone hesperetin in breast cancer therapy: A review of recent developments and future prospects |
| Hesperidin | Breast Cancer | 9 | PM | 34575098 | 📋 | Hesperidin and Chlorogenic Acid Synergistically Inhibit the Growth of Breast Cancer Cells via Estrogen Receptor/Mitochondrial Pathway |
| Hesperidin | Breast Cancer | 10 | PM | 34530017 | 📋 | Protective effects of hesperidin through attenuation of Ki67 expression against DMBA-induced breast cancer in female rats |
| Hesperidin | Breast Cancer | 8 | PM | 34368589 | 📋 | Bioactivity Studies of Hesperidin and XAV939 |
| Hesperidin | Breast Cancer | 5 | PM | 33360419 | 📋 | Identification of key genes of hesperidin in inhibition of breast cancer stem cells by functional network analysis |
| Hesperidin | Breast Cancer | 6 | PM | 33157089 | 📋 | Effects of dietary patterns combined with dietary phytochemicals on breast cancer metastasis |
| Hesperidin | Breast Cancer | 2 | PM | 32993087 | 📋 | Apigenin and Hesperidin Downregulate DNA Repair Genes in MCF-7 Breast Cancer Cells and Augment Doxorubicin Toxicity |
| Hesperidin | Breast Cancer | 3 | PM | 31936263 | 📋 | Inhibitory Effect of Hesperidin on the Expression of Programmed Death Ligand (PD-L1) in Breast Cancer |
| Hesperidin | Breast Cancer | 1 | PM | 30021371 | 📋 | Hesperidin, Piperine and Bee Venom Synergistically Potentiate the Anticancer Effect of Tamoxifen Against Breast Cancer Cells |
| Hesperidin | Cancer | 7 | PM | 37446814 | 📋 | Hesperidin, a Bioflavonoid in Cancer Therapy: A Review for a Mechanism of Action through the Modulation of Cell Signaling Pathways |
| Hesperidin | Cancer | 5 | PM | 34273640 | 📋 | A mechanistic review of the anticancer potential of hesperidin, a natural flavonoid from citrus fruits |
| Hesperidin | Cancer | 6 | PM | 30975541 | 📋 | Therapeutic potential of hesperidin and its aglycone hesperetin: Cell cycle regulation and apoptosis induction in cancer models |
| Hesperidin | Cancer | 4 | PM | 27470573 | 📋 | Hesperidin and tiger nut reduced carcinogenicity of DMBA in female rats |
| Hesperidin | Cancer | 3 | PM | 26770908 | 📋 | Hesperidin Inhibits Vascular Formation by Blocking the AKT/mTOR Signaling Pathways |
| Hesperidin | Cancer | 2 | PM | 26099723 | 📋 | Effect of hesperidin on mice bearing Ehrlich solid carcinoma maintained on doxorubicin |
| Hesperidin | Cancer | 1 | PM | 22174562 | 📋 | Cancer chemoprevention by citrus pulp and juices containing high amounts of β-cryptoxanthin and hesperidin |
| Hesperidin | Cervical Cancer | 2 | PM | 34047379 | 📋 | Targeting Jab1 using hesperidin (dietary phytocompound) for inducing apoptosis in HeLa cervical cancer cells |
| Hesperidin | Cisplatin Toxicity | 7 | PM | 38629504 | 📋 | Hesperidin activates Nrf2 to protect cochlear hair cells from cisplatin-induced damage |
| Hesperidin | Cisplatin Toxicity | 4 | PM | 35844386 | 📋 | Hesperidin ameliorates cisplatin induced hepatotoxicity and attenuates oxidative damage, cell apoptosis, and inflammation in rats |
| Hesperidin | Cisplatin Toxicity | 2 | PM | 35337092 | 📋 | Protective and Therapeutic Efficacy of Hesperidin versus Cisplatin against Ehrlich Ascites Carcinoma-Induced Renal Damage in Mice |
| Hesperidin | Cisplatin Toxicity | 3 | PM | 35332348 | 📋 | Hesperidin protects against cisplatin-induced cardiotoxicity in mice by regulating the p62-Keap1-Nrf2 pathway |
| Hesperidin | Cisplatin Toxicity | 1 | PM | 34703797 | 📋 | The Role of Bone Marrow-Derived Mesenchymal Stromal Cells and Hesperidin in Ameliorating Nephrotoxicity Induced by Cisplatin in Male Wistar Rats |
| Hesperidin | Cisplatin Toxicity | 6 | PM | 23552266 | 📋 | Hesperidin protects brain and sciatic nerve tissues against cisplatin-induced oxidative, histological and electromyographical side effects in rats |
| Hesperidin | Cisplatin Toxicity | 5 | PM | 23353054 | 📋 | Hesperidin attenuates cisplatin-induced acute renal injury by decreasing oxidative stress, inflammation and DNA damage |
| Hesperidin | Colon Cancer | 2 | PM | 36239003 | 📋 | Hesperidin potentially interacts with the catalytic site of gamma-secretase and modifies notch sensitive genes and cancer stemness marker expression in colon cancer cells and colonosphere |
| Hesperidin | Colon Cancer | 1 | PM | 33818196 | 📋 | Effect of Hesperidin against Induced Colon Cancer in Rats: Impact of Smad4 and Activin A Signaling Pathway |
| Hesperidin | Colon Cancer | 3 | PM | 23377175 | 📋 | Hesperidin alleviates oxidative stress and downregulates the expressions of proliferative and inflammatory markers in azoxymethane-induced experimental colon carcinogenesis in mice |
| Hesperidin | Colorectal Cancer | 1 | PM | 37367061 | 📋 | Synergistic Chemopreventive Effects of a Novel Combined Plant Extract Comprising Gallic Acid and Hesperidin on Colorectal Cancer |
| Hesperidin | Gallbladder Cancer | 1 | PM | 30265812 | 📋 | Hesperidin Induces ROS-Mediated Apoptosis along with Cell Cycle Arrest at G2/M Phase in Human Gall Bladder Carcinoma |
| Hesperidin | Gastric Cancer | 1 | PM | 36558440 | 📋 | Hesperidin Reversed Long-Term N-methyl- N-nitro- N-Nitroguanidine Exposure Induced EMT and Cell Proliferation by Activating Autophagy in Gastric Tissues of Rats |
| Hesperidin | Kidney Cancer | 2 | PM | 26551080 | 📋 | Chemopreventive efficacy of hesperidin against chemically induced nephrotoxicity and renal carcinogenesis via amelioration of oxidative stress and modulation of multiple molecular pathways |
| Hesperidin | Liver Cancer | 9 | PM | 34683980 | 📋 | Sesame Extract Promotes Chemopreventive Effect of Hesperidin on Early Phase of Diethylnitrosamine-Initiated Hepatocarcinogenesis in Rats |
| Hesperidin | Liver Cancer | 8 | PM | 34368589 | 📋 | Bioactivity Studies of Hesperidin and XAV939 |
| Hesperidin | Liver Cancer | 3 | PM | 31489981 | 📋 | Hesperidin suppressed hepatic precancerous lesions via modulation of exophagy in rats |
| Hesperidin | Liver Cancer | 1 | PM | 31053173 | 📋 | Apigenin and Hesperidin Augment the Toxic Effect of Doxorubicin Against HepG2 Cells |
| Hesperidin | Liver Cancer | 7 | PM | 31021496 | 📋 | Hesperidin-CAMKIV interaction and its impact on cell proliferation and apoptosis in the human hepatic carcinoma and neuroblastoma cells |
| Hesperidin | Liver Cancer | 4 | PM | 30779474 | 📋 | Involvement of PI3K/Akt pathway in the protective effect of hesperidin against a chemically induced liver cancer in rats |
| Hesperidin | Liver Cancer | 10 | PM | 28935427 | 📋 | Hesperidin protects against chemically induced hepatocarcinogenesis via modulation of Nrf2/ARE/HO-1, PPARγ and TGF-β1/Smad3 signaling, and amelioration of oxidative stress and inflammation |
| Hesperidin | Liver Cancer | 2 | PM | 28754618 | 📋 | Hepatoprotective effect of hesperidin in hepatocellular carcinoma: Involvement of Wnt signaling pathways |
| Hesperidin | Liver Cancer | 5 | PM | 28130850 | 📋 | Demethylating and anti-hepatocarcinogenic potential of hesperidin, a natural polyphenol of Citrus juices |
| Hesperidin | Liver Cancer | 6 | PM | 26194866 | 📋 | Hesperidin from Citrus seed induces human hepatocellular carcinoma HepG2 cell apoptosis via both mitochondrial and death receptor pathways |
| Hesperidin | Lung Cancer | 5 | PM | 36589667 | 📋 | Hesperidin inhibits tobacco smoke-induced pulmonary cell proliferation and EMT in mouse lung tissues via the p38 signaling pathway |
| Hesperidin | Lung Cancer | 4 | PM | 36157229 | 📋 | Hesperidin Inhibits the p53-MDMXInteraction-Induced Apoptosis of Non-Small-Cell Lung Cancer and Enhances the Antitumor Effect of Carboplatin |
| Hesperidin | Lung Cancer | 1 | PM | 35847001 | 📋 | Hesperidin Inhibits Lung Cancer In Vitro and In Vivo Through PinX1 |
| Hesperidin | Lung Cancer | 3 | PM | 33125117 | 📋 | Hesperidin administration suppresses the proliferation of lung cancer cells by promoting apoptosis via targeting the miR‑132/ZEB2 signalling pathway |
| Hesperidin | Lung Cancer | 2 | PM | 29604270 | 📋 | Hesperidin suppresses the migration and invasion of non-small cell lung cancer cells by inhibiting the SDF-1/CXCR-4 pathway |
| Hesperidin | Lung Cancer | 6 | PM | 29138795 | 📋 | Hesperidin induces apoptosis and G0/G1 arrest in human non-small cell lung cancer A549 cells |
| Hesperidin | Mesothelioma | 1 | PM | 24130923 | 📋 | Hesperidin Induces Apoptosis by Inhibiting Sp1 and Its Regulatory Protein in MSTO-211H Cells |
| Hesperidin | Neuroblastoma | 1 | PM | 31021496 | 📋 | Hesperidin-CAMKIV interaction and its impact on cell proliferation and apoptosis in the human hepatic carcinoma and neuroblastoma cells |
| Hesperidin | Oral Cancer | 4 | PM | 38435153 | 📋 | Hesperidin Inhibits Oral Cancer Cell Growth via Apoptosis and Inflammatory Signaling-Mediated Mechanisms: Evidence From In Vitro and In Silico Analyses |
| Hesperidin | Oral Cancer | 3 | PM | 34500779 | 📋 | Anticancer Activities of Hesperidin via Suppression of Up-Regulated Programmed Death-Ligand 1 Expression in Oral Cancer Cells |
| Hesperidin | Oral Cancer | 2 | PM | 9000563 | 📋 | Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis in rats by flavonoids diosmin and hesperidin, each alone and in combination |
| Hesperidin | Oral Cancer | 1 | PM | 8062259 | 📋 | Chemoprevention of 4-nitroquinoline 1-oxide-induced Oral Carcinogenesis by Dietary Curcumin and Hesperidin: Comparison With the Protective Effect of Beta-Carotene |
| Hesperidin | Ovarian Cancer | 1 | PM | 29142606 | 📋 | Hesperidin inhibits ovarian cancer cell viability through endoplasmic reticulum stress signaling pathways |
| Hesperidin | Prostate Cancer | 3 | PM | 37249616 | 📋 | The anti-tumoral role of Hesperidin and Aprepitant on prostate cancer cells through redox modifications |
| Hesperidin | Prostate Cancer | 2 | PM | 36139707 | 📋 | Hesperidin Suppresses the Proliferation of Prostate Cancer Cells by Inducing Oxidative Stress and Disrupting Ca 2+ Homeostasis |
| Hesperidin | Prostate Cancer | 1 | PM | 33455106 | 📋 | Hesperidin induces anticancer effects on human prostate cancer cells via ROS-mediated necrosis like cell death |
| Hesperidin | Renal Cell Carcinoma | 1 | PM | 30098279 | 📋 | Anti-carcinogenic effect of hesperidin against renal cell carcinoma by targeting COX-2/PGE2 pathway in Wistar rats |
| Hesperidin | Skin Cancer | 1 | PM | 31720442 | 📋 | Chemopreventive effect of hesperidin, a citrus bioflavonoid in two stage skin carcinogenesis in Swiss albino mice |
| Hesperidin | Tongue Cancer | 1 | PM | 8062259 | 📋 | Chemoprevention of 4-nitroquinoline 1-oxide-induced Oral Carcinogenesis by Dietary Curcumin and Hesperidin: Comparison With the Protective Effect of Beta-Carotene |
