| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Emodin | Bladder Cancer | 1 | PM | 38504574 | 📋 | The Role of Emodin in the Treatment of Bladder Cancer based on Network Pharmacology and Experimental Verification |
| Emodin | Bone Cancer | 1 | PM | 38495151 | 📋 | The p53-mediated cell cycle regulation is a potential mechanism for emodin-suppressing osteosarcoma cells |
| Emodin | Breast Cancer | 12 | PM | 37821408 | 📋 | Emodin reduces surgical wounding-accelerated tumor growth and metastasis via macrophage suppression in a murine triple-negative breast cancer model |
| Emodin | Breast Cancer | 4 | PM | 37633004 | 📋 | Systems biology based miRNA-mRNA expression pattern analysis of Emodin in breast cancer cell lines |
| Emodin | Breast Cancer | 2 | PM | 37484373 | 📋 | Emodin attenuates high lipid-induced liver metastasis through the AKT and ERK pathways in vitro in breast cancer cells and in a mouse xenograft model |
| Emodin | Breast Cancer | 1 | PM | 36430215 | 📋 | Cell Metabolomics Reveals the Potential Mechanism of Aloe Emodin and Emodin Inhibiting Breast Cancer Metastasis |
| Emodin | Breast Cancer | 11 | PM | 33645356 | 📋 | Identification of Potential Therapeutic Genes and Pathways in Phytoestrogen Emodin Treated Breast Cancer Cell Lines via Network Biology Approaches |
| Emodin | Breast Cancer | 9 | PM | 33542691 | 📋 | Emodin Inhibits the Proliferation of MCF-7 Human Breast Cancer Cells Through Activation of Aryl Hydrocarbon Receptor (AhR) |
| Emodin | Breast Cancer | 8 | PM | 32735937 | 📋 | Combinatorial therapy of Thymoquinone and Emodin synergistically enhances apoptosis, attenuates cell migration and reduces stemness efficiently in breast cancer |
| Emodin | Breast Cancer | 7 | PM | 32724475 | 📋 | Emodin reduces Breast Cancer Lung Metastasis by suppressing Macrophage-induced Breast Cancer Cell Epithelial-mesenchymal transition and Cancer Stem Cell formation |
| Emodin | Breast Cancer | 6 | PM | 32682817 | 📋 | Berberine and Emodin abrogates breast cancer growth and facilitates apoptosis through inactivation of SIK3-induced mTOR and Akt signaling pathway |
| Emodin | Breast Cancer | 14 | PM | 32550907 | 📋 | Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription |
| Emodin | Breast Cancer | 5 | PM | 30274778 | 📋 | Low Dose Emodin Induces Tumor Senescence for Boosting Breast Cancer Chemotherapy via Silencing NRARP |
| Emodin | Breast Cancer | 3 | PM | 23864887 | 📋 | Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ER α Inhibition |
| Emodin | Cancer | 6 | PM | 37732372 | 📋 | Research Progress and New Perspectives of Anticancer Effects of Emodin |
| Emodin | Cancer | 4 | PM | 36612288 | 📋 | A Survey of Naturally Occurring Molecules as New Endoplasmic Reticulum Stress Activators with Selective Anticancer Activity |
| Emodin | Cancer | 3 | PM | 35637953 | 📋 | The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers |
| Emodin | Cancer | 2 | PM | 34073059 | 📋 | Is Emodin with Anticancer Effects Completely Innocent? Two Sides of the Coin |
| Emodin | Cancer | 1 | PM | 33722736 | 📋 | A metabolite that exhibits anti-neoplastic activities by modulating multiple oncogenic targets |
| Emodin | Cancer | 5 | PM | 32289000 | 📋 | Anticancer potential of emodin |
| Emodin | Cervical Cancer | 5 | PM | 37720346 | 📋 | Anticancer action of naturally occurring emodin for the controlling of cervical cancer |
| Emodin | Cervical Cancer | 1 | PM | 35955645 | 📋 | Emodin Sensitizes Cervical Cancer Cells to Vinblastine by Inducing Apoptosis and Mitotic Death |
| Emodin | Cervical Cancer | 4 | PM | 34119706 | 📋 | EFFECTS OF PHOTODYNAMIC THERAPY MEDIATED BY EMODIN IN CERVICAL CARCINOMA CELLS |
| Emodin | Cervical Cancer | 3 | PM | 30711945 | 📋 | Emodin Induces Death in Human Cervical Cancer Cells Through Mitotic Catastrophe |
| Emodin | Cervical Cancer | 2 | PM | 29061789 | 📋 | Changes in the Lysosomal System of Cervical Cancer Cells Induced by Emodin Action |
| Emodin | Chronic Myeloid Leukemia | 1 | PM | 32999163 | 📋 | Emodin Inhibits Resistance to Imatinib by Downregulation of Bcr-Abl and STAT5 and Allosteric Inhibition in Chronic Myeloid Leukemia Cells |
| Emodin | Colon Cancer | 3 | PM | 33731248 | 📋 | Erratum |
| Emodin | Colon Cancer | 1 | PM | 30003723 | 📋 | Antitumor Effects of Emodin in CACO-2 Human Colon Carcinoma Cells Are Mediated via Apoptosis, Cell Cycle Arrest and Downregulation of PI3K/AKT Signalling Pathway |
| Emodin | Colon Cancer | 2 | PM | 28762328 | 📋 | Emodin Induces Apoptosis of Colon Cancer Cells via Induction of Autophagy in a ROS-Dependent Manner |
| Emodin | Colorectal Cancer | 5 | PM | 38704789 | 📋 | Emodin induces ferroptosis in colorectal cancer through NCOA4-mediated ferritinophagy and NF-κb pathway inactivation |
| Emodin | Colorectal Cancer | 1 | PM | 35567995 | 📋 | ACSL4 promotes colorectal cancer and is a potential therapeutic target of emodin |
| Emodin | Colorectal Cancer | 4 | PM | 35018819 | 📋 | Emodin reduces tumor burden by diminishing M2-like macrophages in colorectal cancer |
| Emodin | Colorectal Cancer | 2 | PM | 33489875 | 📋 | Emodin Inhibits Inflammation, Carcinogenesis, and Cancer Progression in the AOM/DSS Model of Colitis-Associated Intestinal Tumorigenesis |
| Emodin | Colorectal Cancer | 3 | PM | 32509181 | 📋 | Emodin reverses 5-Fu resistance in human colorectal cancer via downregulation of PI3K/Akt signaling pathway |
| Emodin | Gallbladder Cancer | 1 | PM | 20005210 | 📋 | Emodin Enhances Sensitivity of Gallbladder Cancer Cells to Platinum Drugs via Glutathion Depletion and MRP1 Downregulation |
| Emodin | Gastric Cancer | 1 | PM | 25987055 | 📋 | Effects of Aloe-emodin and Emodin on Proliferation of the MKN45 Human Gastric Cancer Cell Line |
| Emodin | Gastrointestinal Cancer | 1 | PM | 34984952 | 📋 | Therapeutic Potential of Emodin for Gastrointestinal Cancers |
| Emodin | Glioblastoma | 2 | PM | 36253116 | 📋 | Emodin coupled with high LET neutron beam-a novel approach to treat on glioblastoma |
| Emodin | Glioblastoma | 1 | PM | 35272197 | 📋 | Emodin inhibits U87 glioblastoma cells migration by activating aryl hydrocarbon receptor (AhR) signaling pathway |
| Emodin | Liver Cancer | 7 | PM | 38099524 | 📋 | Emodin is a Potential Drug Targeting CD44-positive Hepatocellular Cancer |
| Emodin | Liver Cancer | 6 | PM | 37865957 | 📋 | Effect of emodin combined with cisplatin on the invasion and migration of HepG2 hepatoma cells |
| Emodin | Liver Cancer | 5 | PM | 35724456 | 📋 | Emodin regulates the autophagy via the miR-371a-5p/PTEN axis to inhibit hepatic malignancy |
| Emodin | Liver Cancer | 4 | PM | 35715752 | 📋 | Emodin inhibits invasion and migration of hepatocellular carcinoma cells via regulating autophagy-mediated degradation of snail and β-catenin |
| Emodin | Liver Cancer | 2 | PM | 35387564 | 📋 | Emodin suppresses hepatocellular carcinoma growth by regulating macrophage polarization via microRNA-26a/transforming growth factor beta 1/protein kinase B |
| Emodin | Liver Cancer | 3 | PM | 32464306 | 📋 | Emodin succinyl ester inhibits malignant proliferation and migration of hepatocellular carcinoma by suppressing the interaction of AR and EZH2 |
| Emodin | Liver Cancer | 1 | PM | 30321984 | 📋 | Emodin Sensitizes Hepatocellular Carcinoma Cells to the Anti-Cancer Effect of Sorafenib Through Suppression of Cholesterol Metabolism |
| Emodin | Liver Cancer | 8 | PM | 29676152 | 📋 | Anti-Cancer Effects of Emodin on HepG2 Cells as Revealed by 1H NMR Based Metabolic Profiling |
| Emodin | Lung Cancer | 3 | PM | 36154581 | 📋 | In vitro and in vivo anti-lung cancer activity of emodin: A RNA-seq transcriptome analysis |
| Emodin | Lung Cancer | 1 | PM | 35406121 | 📋 | Polygonum cuspidatum Extract (Pc-Ex) Containing Emodin Suppresses Lung Cancer-Induced Cachexia by Suppressing TCF4/TWIST1 Complex-Induced PTHrP Expression |
| Emodin | Lung Cancer | 8 | PM | 34785104 | 📋 | Emodin induces apoptosis and suppresses non-small-cell lung cancer growth via downregulation of sPLA2-IIa |
| Emodin | Lung Cancer | 7 | PM | 34001704 | 📋 | The role of emodin on cisplatin resistance reversal of lung adenocarcinoma A549/DDP cell |
| Emodin | Lung Cancer | 6 | PM | 33613719 | 📋 | Emodin enhances cisplatin sensitivity in non-small cell lung cancer through Pgp downregulation |
| Emodin | Lung Cancer | 5 | PM | 33407495 | 📋 | Emodin regulates cell cycle of non-small lung cancer (NSCLC) cells through hyaluronan synthase 2 (HA2)-HA-CD44/receptor for hyaluronic acid-mediated motility (RHAMM) interaction-dependent signaling pathway |
| Emodin | Lung Cancer | 4 | PM | 33403025 | 📋 | A Double-Edged Sword: The Anti-Cancer Effects of Emodin by Inhibiting the Redox-Protective Protein MTH1 and Augmenting ROS in NSCLC |
| Emodin | Lung Cancer | 2 | PM | 15941563 | 📋 | Emodin Induces Apoptosis in Human Lung Adenocarcinoma Cells Through a Reactive Oxygen Species-Dependent Mitochondrial Signaling Pathway |
| Emodin | Lymphoma | 1 | PM | 28901428 | 📋 | Emodin Promotes the Arrest of Human Lymphoma Raji Cell Proliferation Through the UHRF1‑DNMT3A‑∆Np73 Pathways |
| Emodin | Melanoma | 4 | PM | 34974127 | 📋 | Ascorbate-and iron-driven redox activity of Dp44mT and emodin facilitates peroxidation of micelles and bicelles |
| Emodin | Melanoma | 3 | PM | 33731543 | 📋 | Emodin suppresses the migration and invasion of melanoma cells |
| Emodin | Multiple Myeloma | 3 | PM | 35884943 | 📋 | Emodin Ameliorates the Efficacy of Carfilzomib in Multiple Myeloma Cells via Apoptosis and Autophagy |
| Emodin | Multiple Myeloma | 2 | PM | 33564319 | 📋 | In Vitro Investigation of the Cytotoxic Activity of Emodin 35 Derivative on Multiple Myeloma Cell Lines |
| Emodin | Multiple Myeloma | 1 | PM | 17363492 | 📋 | Emodin Has a Cytotoxic Activity Against Human Multiple Myeloma as a Janus-activated Kinase 2 Inhibitor |
| Emodin | Nasopharyngeal Cancer | 1 | PM | 38540100 | 📋 | The Application of Emodin Treatment on Nasopharyngeal Carcinoma Therapy |
| Emodin | Neuroblastoma | 2 | PM | 32930996 | 📋 | Promotion of Mitochondrial Protection by Emodin in Methylglyoxal-Treated Human Neuroblastoma SH-SY5Y Cells: Involvement of the AMPK/Nrf2/HO-1 Axis |
| Emodin | Neuroblastoma | 1 | PM | 32832542 | 📋 | Emodin Alleviates Hydrogen Peroxide-Induced Inflammation and Oxidative Stress via Mitochondrial Dysfunction by Inhibiting the PI3K/mTOR/GSK3 β Pathway in Neuroblastoma SH-SY5Y Cells |
| Emodin | Oral Cancer | 2 | PM | 20659264 | 📋 | Apoptotic effect of Polygonum Cuspidatum in oral cancer cells through the regulation of specificity protein 1 |
| Emodin | Ovarian Cancer | 4 | PM | 35661798 | 📋 | The isomers, aloe-emodin and emodin, possess differential inhibitory activities against CYP1B1 enzyme |
| Emodin | Ovarian Cancer | 3 | PM | 35154426 | 📋 | Emodin exerts antitumor effects in ovarian cancer cell lines by preventing the development of cancer stem cells via epithelial mesenchymal transition |
| Emodin | Ovarian Cancer | 2 | PM | 29512773 | 📋 | Emodin inhibits TGF-β2 by activating the FOXD3/miR‑199a axis in ovarian cancer cells in vitro |
| Emodin | Ovarian Cancer | 1 | PM | 28790850 | 📋 | Emodin Suppresses Proliferation, Migration and Invasion in Ovarian Cancer Cells by Down Regulating ILK in Vitro and in Vivo |
| Emodin | Pancreatic Cancer | 8 | PM | 37335741 | 📋 | A network pharmacology-based investigation of emodin against pancreatic adenocarcinoma |
| Emodin | Pancreatic Cancer | 4 | PM | 36545274 | 📋 | Emodin reverses resistance to gemcitabine in pancreatic cancer by suppressing stemness through regulation of the epithelial‑mesenchymal transition |
| Emodin | Pancreatic Cancer | 7 | PM | 33061461 | 📋 | Emodin Reverses Gemcitabine Resistance of Pancreatic Cancer Cell Lines Through Inhibition of IKKβ/NF-κB Signaling Pathway |
| Emodin | Pancreatic Cancer | 6 | PM | 32934734 | 📋 | Emodin alleviates gemcitabine resistance in pancreatic cancer by inhibiting MDR1/P-glycoprotein and MRPs expression |
| Emodin | Pancreatic Cancer | 2 | PM | 31572001 | 📋 | Emodin Sensitizes Human Pancreatic Cancer Cells to EGFR Inhibitor Through Suppressing Stat3 Signaling Pathway |
| Emodin | Pancreatic Cancer | 3 | PM | 26238071 | 📋 | Emodin Inhibits Angiogenesis in Pancreatic Cancer by Regulating the Transforming Growth factor-β/drosophila Mothers Against Decapentaplegic Pathway and Angiogenesis-Associated microRNAs |
| Emodin | Pancreatic Cancer | 1 | PM | 22375400 | 📋 | [Experimental Study on Anti-Metastasis Effect of Emodin on Human Pancreatic Cancer] |
| Emodin | Pancreatic Cancer | 5 | PM | 18407913 | 📋 | Feasibility Evaluation of Emodin (Rhubarb Extract) as an Inhibitor of Pancreatic Cancer Cell Proliferation in Vitro |
| Emodin | Prostate Cancer | 1 | PM | 37062702 | 📋 | Emodin-Induced Necroptosis in Prostate Cancer Cells via the Mitochondrial Fission HSP90/MLKL/PGAM Pathway |
| Emodin | Renal Cell Carcinoma | 1 | PM | 33532038 | 📋 | Emodin Induced Necroptosis and Inhibited Glycolysis in the Renal Cancer Cells by Enhancing ROS |
| Emodin | Skin Cancer | 1 | PM | 35682955 | 📋 | The Comparison of the Efficiency of Emodin and Aloe-Emodin in Photodynamic Therapy |
| Emodin | T-Cell Leukemia | 1 | PM | 17077332 | 📋 | Emodin and DHA Potently Increase Arsenic Trioxide Interferon-Alpha-Induced Cell Death of HTLV-I-transformed Cells by Generation of Reactive Oxygen Species and Inhibition of Akt and AP-1 |
| Emodin | Thyroid Cancer | 3 | PM | 37927413 | 📋 | Emodin treatment of papillary thyroid cancer cell lines in vitro inhibits proliferation and enhances apoptosis via downregulation of NF‑κB and its upstream TLR4 signaling |
| Emodin | Thyroid Cancer | 2 | PM | 34447468 | 📋 | Emodin inhibits the proliferation of papillary thyroid carcinoma by activating AMPK |
| Emodin | Thyroid Cancer | 1 | PM | 30272291 | 📋 | Emodin Suppresses Angiogenesis and Metastasis in Anaplastic Thyroid Cancer by Affecting TRAF6‑mediated Pathways in Vivo and in Vitro |
| Emodin | Tongue Cancer | 3 | PM | 20393018 | 📋 | Emodin, aloe-emodin and rhein induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells |
| Emodin | Tongue Cancer | 1 | PM | 20372784 | 📋 | Emodin, aloe-emodin and rhein inhibit migration and invasion in human tongue cancer SCC-4 cells through the inhibition of gene expression of matrix metalloproteinase-9 |
| Emodin | Tongue Cancer | 2 | PM | 19331169 | 📋 | Emodin Induces Apoptosis of Human Tongue Squamous Cancer SCC-4 Cells Through Reactive Oxygen Species and Mitochondria-Dependent Pathways |
