| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Crocin | Bone Cancer | 1 | PM | 32064472 | 📋 | Cytotoxic and osteogenic effects of crocin and bicarbonate from calcium phosphates for potential chemopreventative and anti-inflammatory applications in vitro and in vivo |
| Crocin | Breast Cancer | 16 | PM | 38661582 | 📋 | Crocin enhances the sensitivity to paclitaxel in human breast cancer cells by reducing BIRC5 expression |
| Crocin | Breast Cancer | 15 | PM | 38463069 | 📋 | Crocin inhibit the metastasis of MDA-MB-231 cell line by suppressing epithelial to mesenchymal transition through WNT/β-catenin signalling pathway |
| Crocin | Breast Cancer | 14 | PM | 36988377 | 📋 | Crocin suppresses breast cancer cell proliferation by down-regulating tumor promoter miR-122-5p and up-regulating tumor suppressors FOXP2 and SPRY2 |
| Crocin | Breast Cancer | 13 | PM | 35447530 | 📋 | Crocin attenuates NF-κB-mediated inflammation and proliferation in breast cancer cells by down-regulating PRKCQ |
| Crocin | Breast Cancer | 10 | PM | 33929675 | 📋 | Crocin and Metformin suppress metastatic breast cancer progression via VEGF and MMP9 downregulations: in vitro and in vivo studies |
| Crocin | Breast Cancer | 11 | PM | 32850295 | 📋 | Crocetin and crocin decreased cholesterol and triglyceride content of both breast cancer tumors and cell lines |
| Crocin | Breast Cancer | 12 | PM | 32353423 | 📋 | Cytosolic and mitochondrial ROS production resulted in apoptosis induction in breast cancer cells treated with Crocin: The role of FOXO3a, PTEN and AKT signaling |
| Crocin | Breast Cancer | 1 | PM | 31926253 | 📋 | Anti-metastatic Properties of a Potent Herbal Combination in Cell and Mice Models of Triple Negative Breast Cancer |
| Crocin | Breast Cancer | 7 | PM | 31903234 | 📋 | Antiangiogenic Effect of Crocin on Breast Cancer Cell MDA-MB-231 |
| Crocin | Breast Cancer | 4 | PM | 30351203 | 📋 | Inhibitory Effect of Crocin on Metastasis of Triple-Negative Breast Cancer by Interfering With Wnt/β-Catenin Pathway in Murine Model |
| Crocin | Breast Cancer | 6 | PM | 29969282 | 📋 | A Comparative Study on Anti-Invasion, Antimigration, and Antiadhesion Effects of the Bioactive Carotenoids of Saffron on 4T1 Breast Cancer Cells Through Their Effects on Wnt/β-Catenin Pathway Genes |
| Crocin | Breast Cancer | 2 | PM | 28367420 | 📋 | Comparative Study on The Preventive Effect of Saffron Carotenoids, Crocin and Crocetin, in NMU-Induced Breast Cancer in Rats |
| Crocin | Breast Cancer | 9 | PM | 28337976 | 📋 | Antiproliferative Activity of Crocin Involves Targeting of Microtubules in Breast Cancer Cells |
| Crocin | Breast Cancer | 3 | PM | 27039797 | 📋 | Molecular Mechanism of Crocin Induced Caspase Mediated MCF-7 Cell Death: In Vivo Toxicity Profiling and Ex Vivo Macrophage Activation |
| Crocin | Breast Cancer | 5 | PM | 27003728 | 📋 | Antiproliferative and Proapoptotic Effects of Crocin Combined With Hyperthermia on Human Breast Cancer Cells |
| Crocin | Breast Cancer | 8 | PM | 26693354 | 📋 | Synergistic Apoptotic Effect of Crocin and Paclitaxel or Crocin and Radiation on MCF-7 Cells, a Type of Breast Cancer Cell Line |
| Crocin | Cancer | 6 | PM | 37404473 | 📋 | Advances on the anti-tumor mechanisms of the carotenoid Crocin |
| Crocin | Cancer | 5 | PM | 35739971 | 📋 | An In Vitro Study of Saffron Carotenoids: The Effect of Crocin Extracts and Dimethylcrocetin on Cancer Cell Lines |
| Crocin | Cancer | 3 | PM | 33653190 | 📋 | Saffron anti-metastatic properties, ancient spice novel application |
| Crocin | Cancer | 2 | PM | 33251248 | 📋 | Is Crocin a Potential Anti-tumor Candidate Targeting Microtubules? Computational Insights From Molecular Docking and Dynamics Simulations |
| Crocin | Cancer | 1 | PM | 32405344 | 📋 | Role of Crocin in Several Cancer Cell Lines: An Updated Review |
| Crocin | Cancer | 4 | PM | 30599111 | 📋 | Crocetin and Crocin from Saffron in Cancer Chemotherapy and Chemoprevention |
| Crocin | Cervical Cancer | 3 | PM | 34648579 | 📋 | Synergistic effects of exosomal crocin or curcumin compounds and HPV L1-E7 polypeptide vaccine construct on tumor eradication in C57BL/6 mouse model |
| Crocin | Cervical Cancer | 2 | PM | 33241029 | 📋 | Crocin induces autophagic cell death and inhibits cell invasion of cervical cancer SiHa cells through activation of PI3K/AKT |
| Crocin | Cervical Cancer | 1 | PM | 28763753 | 📋 | The Anti-Proliferative and Apoptotic Effects of Crocin on Chemosensitive and Chemoresistant Cervical Cancer Cells |
| Crocin | Cisplatin Toxicity | 4 | PM | 38010604 | 📋 | Nutritional Support of Crocin on Neurobehavioral Disabilities Induced by Cisplatin-Based Chemotherapy in Rats |
| Crocin | Cisplatin Toxicity | 3 | PM | 34584648 | 📋 | Evaluation of apoptotic effect of crocin, cisplatin, and their combination in human oral squamous cell carcinoma cell line HN5 |
| Crocin | Cisplatin Toxicity | 2 | PM | 34470647 | 📋 | The protective effect of crocin on cisplatin-induced testicular impairment in rats |
| Crocin | Cisplatin Toxicity | 1 | PM | 32259551 | 📋 | Crocin attenuates cisplatin-induced hepatotoxicity via TLR4/NF-κBp50 signaling and BAMBI modulation of TGF-β activity: Involvement of miRNA-9 and miRNA-29 |
| Crocin | Colon Cancer | 4 | PM | 37700733 | 📋 | Crocin exerts anti-tumor effect in colon cancer cells via repressing the JAK pathway |
| Crocin | Colon Cancer | 3 | PM | 35563808 | 📋 | Crocin Inhibits Angiogenesis and Metastasis in Colon Cancer via TNF-α/NF-kB/VEGF Pathways |
| Crocin | Colon Cancer | 2 | PM | 34202689 | 📋 | Saffron and Its Major Ingredients' Effect on Colon Cancer Cells with Mismatch Repair Deficiency and Microsatellite Instability |
| Crocin | Colon Cancer | 1 | PM | 32010302 | 📋 | Crocin Has Pharmacological Effects Against the Pathological Behavior of Colon Cancer Cells by Interacting With the STAT3 Signaling Pathway |
| Crocin | Colorectal Cancer | 4 | PM | 37464834 | 📋 | Crocin Suppresses Colorectal Cancer Cell Proliferation By Regulating Mir-143/145 And Kras/Rreb1 Pathways |
| Crocin | Colorectal Cancer | 3 | PM | 35988102 | 📋 | Synergistic anticancer effects of curcumin and crocin on human colorectal cancer cells |
| Crocin | Colorectal Cancer | 2 | PM | 33841156 | 📋 | The Protection of Crocin Against Ulcerative Colitis and Colorectal Cancer via Suppression of NF-κB-Mediated Inflammation |
| Crocin | Colorectal Cancer | 1 | PM | 18004240 | 📋 | Crocin From Crocus Sativus Possesses Significant Anti-Proliferation Effects on Human Colorectal Cancer Cells |
| Crocin | Gastric Cancer | 6 | PM | 37718528 | 📋 | Crocin Combined With Cisplatin Regulates Proliferation, Apoptosis And Emt Of Gastric Cancer Cells Via The Fgfr3/Mapk/Erk Pathway In Vitro And In Vivo |
| Crocin | Gastric Cancer | 5 | PM | 33456997 | 📋 | Crocin reverses 1-methyl-3-nitroso-1-nitroguanidine (MNNG)-induced malignant transformation in GES-1 cells through the Nrf2/Hippo signaling pathway |
| Crocin | Gastric Cancer | 4 | PM | 33442270 | 📋 | Inhibitory Effect of Crocin Against Gastric Carcinoma via Regulating TPM4 Gene |
| Crocin | Gastric Cancer | 3 | PM | 32711421 | 📋 | Crocin Increases Gastric Cancer Cells' Sensitivity to Doxorubicin |
| Crocin | Gastric Cancer | 1 | PM | 32509062 | 📋 | Pathogenesis and Anti-Proliferation Mechanisms of Crocin in Human Gastric Carcinoma Cells |
| Crocin | Gastric Cancer | 2 | PM | 30851060 | 📋 | Crocin Inhibits the Migration, Invasion, and Epithelial-Mesenchymal Transition of Gastric Cancer Cells via miR-320/KLF5/HIF-1α Signaling |
| Crocin | Glioma | 1 | PM | 36936719 | 📋 | Combination of Caffeic Acid Phenethyl Ester and Crocin Realign Potential Molecular Markers in U87-MG Glioma Cells |
| Crocin | Head and Neck Cancer | 1 | PM | 28496478 | 📋 | Study of Crocin & Radiotherapy-induced Cytotoxicity and Apoptosis in the Head and Neck Cancer (HN-5) Cell Line |
| Crocin | Leukemia | 1 | PM | 27398676 | 📋 | The Effect and Mechanisms of Proliferative Inhibition of Crocin on Human Leukaemia Jurkat Cells |
| Crocin | Liver Cancer | 4 | PM | 37627094 | 📋 | Combining Crocin and Sorafenib Improves Their Tumor-Inhibiting Effects in a Rat Model of Diethylnitrosamine-Induced Cirrhotic-Hepatocellular Carcinoma |
| Crocin | Liver Cancer | 3 | PM | 36139719 | 📋 | Therapeutic Effects of Crocin Alone or in Combination with Sorafenib against Hepatocellular Carcinoma: In Vivo & In Vitro Insights |
| Crocin | Liver Cancer | 2 | PM | 32942000 | 📋 | Chemo-preventive effect of crocin against experimentally-induced hepatocarcinogenesis via regulation of apoptotic and Nrf2 signaling pathways |
| Crocin | Liver Cancer | 1 | PM | 26522014 | 📋 | Saffron-Based Crocin Prevents Early Lesions of Liver Cancer: In Vivo, In Vitro and Network Analyses |
| Crocin | Lung Cancer | 1 | PM | 26798587 | 📋 | Crocin Inhibits Cell Proliferation and Enhances Cisplatin and Pemetrexed Chemosensitivity in Lung Cancer Cells |
| Crocin | Lymphoma | 1 | PM | 34276918 | 📋 | Crocin Promotes Apoptosis in Human EBV-Transformed B-Lymphocyte via Intrinsic Pathway |
| Crocin | Melanoma | 1 | PM | 28441796 | 📋 | Role of Dietary Crocin in In Vivo Melanoma Tumor Remission |
| Crocin | Oral Cancer | 2 | PM | 34584648 | 📋 | Evaluation of apoptotic effect of crocin, cisplatin, and their combination in human oral squamous cell carcinoma cell line HN5 |
| Crocin | Oral Cancer | 1 | PM | 28718677 | 📋 | Evaluation of the Cytotoxic Activity of Crocin and Safranal, Constituents of Saffron, in Oral Squamous Cell Carcinoma (KB Cell Line) |
| Crocin | Ovarian Cancer | 2 | PM | 27342070 | 📋 | Crocin Suppresses Multidrug Resistance in MRP Overexpressing Ovarian Cancer Cell Line |
| Crocin | Ovarian Cancer | 1 | PM | 25920253 | 📋 | Ovarian Cancer HO-8910 Cell Apoptosis Induced by Crocin in Vitro |
| Crocin | Pancreatic Cancer | 1 | PM | 32604971 | 📋 | Dietary Crocin Is Protective in Pancreatic Cancer While Reducing Radiation-Induced Hepatic Oxidative Damage |
| Crocin | Retinoblastoma | 1 | PM | 30672053 | 📋 | Crocin Inhibits Proliferation and Induces Apoptosis Through Suppressing MYCN Expression in Retinoblastoma |
| Crocin | Skin Cancer | 2 | PM | 37284388 | 📋 | Investigation of the Ability of Crocin to Treat Skin Cancer Chemically Induced in Mice via the Inhibition of the Wnt/β-Catenin and Fibrotic Pathway |
| Crocin | Skin Cancer | 1 | PM | 30542463 | 📋 | Crocin Promotes Apoptosis of Human Skin Cancer Cells by Inhibiting the JAK/STAT Pathway |
| Crocin | Squamous Cell Carcinoma | 1 | PM | 34320900 | 📋 | Crocin exerts anti-proliferative and apoptotic effects on cutaneous squamous cell carcinoma via miR-320a/ATG2B |
| Crocin | Testicular Cancer | 1 | PM | 31911963 | 📋 | Ameliorative Effects of Crocin on Paraquat-Induced Oxidative Stress in Testis of Adult Mice: An Experimental Study |
| Crocin | Thyroid Cancer | 3 | PM | 37211223 | 📋 | Network pharmacology-based prediction and experimental verification of the involvement of the PI3K/Akt pathway in the anti-thyroid cancer activity of crocin |
| Crocin | Thyroid Cancer | 2 | PM | 35085590 | 📋 | Crocin induces ROS-mediated papillary thyroid cancer cell apoptosis by modulating the miR-34a-5p/PTPN4 axis in vitro |
| Crocin | Thyroid Cancer | 1 | PM | 32886819 | 📋 | Crocin treatment promotes the oxidative stress and apoptosis in human thyroid cancer cells FTC-133 through the inhibition of STAT/JAK signaling pathway |
