| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Cannabidiol | Acute Lymphoblastic Leukemia | 3 | PM | 33379175 | 📋 | Phenolic Compounds Cannabidiol, Curcumin and Quercetin Cause Mitochondrial Dysfunction and Suppress Acute Lymphoblastic Leukemia Cells |
| Cannabidiol | Acute Lymphoblastic Leukemia | 2 | PM | 31611561 | 📋 | Cannabidiol Directly Targets Mitochondria and Disturbs Calcium Homeostasis in Acute Lymphoblastic Leukemia |
| Cannabidiol | Acute Lymphoblastic Leukemia | 1 | PM | 12091357 | 📋 | Targeting CB2 Cannabinoid Receptors as a Novel Therapy to Treat Malignant Lymphoblastic Disease |
| Cannabidiol | Acute Myeloid Leukemia | 1 | PM | 28560402 | 📋 | Anticancer Effects of Phytocannabinoids Used With Chemotherapy in Leukaemia Cells Can Be Improved by Altering the Sequence of Their Administration |
| Cannabidiol | Acute Myeloid Leukemia | 2 | PM | 14692532 | 📋 | Gamma-irradiation Enhances Apoptosis Induced by Cannabidiol, a Non-Psychotropic Cannabinoid, in Cultured HL-60 Myeloblastic Leukemia Cells |
| Cannabidiol | Biliary Tract Cancer | 2 | PM | 35740979 | 📋 | Cannabidiol and Cannabigerol Inhibit Cholangiocarcinoma Growth In Vitro via Divergent Cell Death Pathways |
| Cannabidiol | Biliary Tract Cancer | 1 | PM | 19916793 | 📋 | The Dual Effects of delta(9)-tetrahydrocannabinol on Cholangiocarcinoma Cells: Anti-Invasion Activity at Low Concentration and Apoptosis Induction at High Concentration |
| Cannabidiol | Bladder Cancer | 4 | PM | 36870996 | 📋 | Anticancer properties of cannabidiol and ?9-tetrahydrocannabinol and synergistic effects with gemcitabine and cisplatin in bladder cancer cell lines |
| Cannabidiol | Bladder Cancer | 3 | PM | 34575494 | 📋 | Cannabidiol Effectively Promoted Cell Death in Bladder Cancer and the Improved Intravesical Adhesion Drugs Delivery Strategy Could Be Better Used for Treatment |
| Cannabidiol | Bladder Cancer | 1 | PM | 25445433 | 📋 | Regulation of Inflammation and Proliferation of Human Bladder Carcinoma Cells by type-1 and type-2 Cannabinoid Receptors |
| Cannabidiol | Bladder Cancer | 2 | PM | 20546877 | 📋 | TRPV2 Activation Induces Apoptotic Cell Death in Human T24 Bladder Cancer Cells: A Potential Therapeutic Target for Bladder Cancer |
| Cannabidiol | Bone Cancer | 2 | PM | 36848028 | 📋 | The synergistic anticancer effect of CBD and DOX in osteosarcoma |
| Cannabidiol | Bone Cancer | 1 | PM | 35273722 | 📋 | Cannabidiol promotes apoptosis of osteosarcoma cells in vitro and in vivo by activating the SP1-CBX2 axis |
| Cannabidiol | Breast Cancer | 25 | PM | 38067615 | 📋 | In Vitro Evidence of Selective Pro-Apoptotic Action of the Pure Cannabidiol and Cannabidiol-Rich Extract |
| Cannabidiol | Breast Cancer | 24 | PM | 37173983 | 📋 | Cannabidiol as a Promising Adjuvant Therapy for Estrogen Receptor-Positive Breast Tumors: Unveiling Its Benefits with Aromatase Inhibitors |
| Cannabidiol | Breast Cancer | 23 | PM | 35806150 | 📋 | Cannabidiol Antiproliferative Effect in Triple-Negative Breast Cancer MDA-MB-231 Cells Is Modulated by Its Physical State and by IGF-1 |
| Cannabidiol | Breast Cancer | 22 | PM | 35217991 | 📋 | Anticancer and chemosensitization effects of cannabidiol in 2D and 3D cultures of TNBC: involvement of GADD45α, integrin-α5, -β5, -β1, and autophagy |
| Cannabidiol | Breast Cancer | 21 | PM | 34830821 | 📋 | Cannabidiol Suppresses Angiogenesis and Stemness of Breast Cancer Cells by Downregulation of Hypoxia-Inducible Factors-1α |
| Cannabidiol | Breast Cancer | 20 | PM | 34576262 | 📋 | Synergistic Interactions of Cannabidiol with Chemotherapeutic Drugs in MCF7 Cells: Mode of Interaction and Proteomics Analysis of Mechanisms |
| Cannabidiol | Breast Cancer | 19 | PM | 34046425 | 📋 | Cannabidiol Modulates Mitochondrial Redox and Dynamics in MCF7 Cancer Cells: A Study Using Fluorescence Lifetime Imaging Microscopy of NAD(P)H |
| Cannabidiol | Breast Cancer | 18 | PM | 33722705 | 📋 | Unveiling the mechanism of action behind the anti-cancer properties of cannabinoids in ER + breast cancer cells: impact on aromatase and steroid receptors |
| Cannabidiol | Breast Cancer | 14 | PM | 33066359 | 📋 | Cannabinoid Combination Induces Cytoplasmic Vacuolation in MCF-7 Breast Cancer Cells |
| Cannabidiol | Breast Cancer | 13 | PM | 32244518 | 📋 | CBD Reverts the Mesenchymal Invasive Phenotype of Breast Cancer Cells Induced by the Inflammatory Cytokine IL-1β |
| Cannabidiol | Breast Cancer | 12 | PM | 31811927 | 📋 | CBD Loaded Microparticles as a Potential Formulation to Improve Paclitaxel and Doxorubicin-Based Chemotherapy in Breast Cancer |
| Cannabidiol | Breast Cancer | 16 | PM | 31561450 | 📋 | Enhancing Breast Cancer Treatment Using a Combination of Cannabidiol and Gold Nanoparticles for Photodynamic Therapy |
| Cannabidiol | Breast Cancer | 5 | PM | 30987191 | 📋 | Future Aspects for Cannabinoids in Breast Cancer Therapy |
| Cannabidiol | Breast Cancer | 17 | PM | 30007266 | 📋 | Novel Mechanism of Cannabidiol-Induced Apoptosis in Breast Cancer Cell Lines |
| Cannabidiol | Breast Cancer | 10 | PM | 27633508 | 📋 | Phyto-, Endo- And Synthetic Cannabinoids: Promising Chemotherapeutic Agents in the Treatment of Breast and Prostate Carcinomas |
| Cannabidiol | Breast Cancer | 3 | PM | 25660577 | 📋 | Modulation of the Tumor Microenvironment and Inhibition of EGF/EGFR Pathway: Novel Anti-Tumor Mechanisms of Cannabidiol in Breast Cancer |
| Cannabidiol | Breast Cancer | 2 | PM | 21915267 | 📋 | Crosstalk Between Chemokine Receptor CXCR4 and Cannabinoid Receptor CB2 in Modulating Breast Cancer Growth and Invasion |
| Cannabidiol | Breast Cancer | 6 | PM | 21566064 | 📋 | Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-Talk Between Apoptosis and Autophagy |
| Cannabidiol | Breast Cancer | 4 | PM | 20859676 | 📋 | Pathways Mediating the Effects of Cannabidiol on the Reduction of Breast Cancer Cell Proliferation, Invasion, and Metastasis |
| Cannabidiol | Breast Cancer | 11 | PM | 20649976 | 📋 | Cannabinoids Reduce ErbB2-driven Breast Cancer Progression Through Akt Inhibition |
| Cannabidiol | Breast Cancer | 15 | PM | 18383828 | 📋 | Delta(9)-tetrahydrocannabinol Inhibits 17beta-estradiol-induced Proliferation and Fails to Activate Androgen and Estrogen Receptors in MCF7 Human Breast Cancer Cells |
| Cannabidiol | Breast Cancer | 7 | PM | 18025276 | 📋 | Cannabidiol as a Novel Inhibitor of Id-1 Gene Expression in Aggressive Breast Cancer Cells |
| Cannabidiol | Breast Cancer | 8 | PM | 16728591 | 📋 | Antitumor Activity of Plant Cannabinoids With Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma |
| Cannabidiol | Breast Cancer | 9 | PM | 16337199 | 📋 | Cannabinoid Receptor Ligands Mediate Growth Inhibition and Cell Death in Mantle Cell Lymphoma |
| Cannabidiol | Breast Cancer | 1 | PM | 9653194 | 📋 | The Endogenous Cannabinoid Anandamide Inhibits Human Breast Cancer Cell Proliferation |
| Cannabidiol | Burkitt's Lymphoma | 1 | PM | 31587870 | 📋 | The Evaluation of Cannabidiol's Effect on the Immunotherapy of Burkitt Lymphoma |
| Cannabidiol | Cancer | 31 | PM | 38731434 | 📋 | Research Progress on the Mechanism of the Antitumor Effects of Cannabidiol |
| Cannabidiol | Cancer | 30 | PM | 36755953 | 📋 | Cannabidiol regulates apoptosis and autophagy in inflammation and cancer: A review |
| Cannabidiol | Cancer | 29 | PM | 36535544 | 📋 | The role of Cannabidiol and tetrahydrocannabivarin to overcome doxorubicin resistance in MDA-MB-231 xenografts in athymic nude mice |
| Cannabidiol | Cancer | 28 | PM | 36361743 | 📋 | Role of Cannabidiol for Improvement of the Quality of Life in Cancer Patients: Potential and Challenges |
| Cannabidiol | Cancer | 27 | PM | 35741337 | 📋 | Mechanisms of Cannabidiol (CBD) in Cancer Treatment: A Review |
| Cannabidiol | Cancer | 26 | PM | 35643249 | 📋 | Biological Effects of Cannabidiol on Human Cancer Cells: Systematic Review of the Literature |
| Cannabidiol | Cancer | 25 | PM | 35337163 | 📋 | Cannabidiol on the Path from the Lab to the Cancer Patient: Opportunities and Challenges |
| Cannabidiol | Cancer | 24 | PM | 35277658 | 📋 | Cannabinoids as anticancer drugs: current status of preclinical research |
| Cannabidiol | Cancer | 23 | PM | 35205633 | 📋 | Cannabidiol (CBD) in Cancer Management |
| Cannabidiol | Cancer | 22 | PM | 34832951 | 📋 | Cannabidiol Induces Cell Death in Human Lung Cancer Cells and Cancer Stem Cells |
| Cannabidiol | Cancer | 21 | PM | 34259916 | 📋 | Cannabinoids in the landscape of cancer |
| Cannabidiol | Cancer | 20 | PM | 33921049 | 📋 | Repurposing Cannabidiol as a Potential Drug Candidate for Anti-Tumor Therapies |
| Cannabidiol | Cancer | 19 | PM | 33919010 | 📋 | Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action |
| Cannabidiol | Cancer | 18 | PM | 33466435 | 📋 | The Role of Cannabinoids as Anticancer Agents in Pediatric Oncology |
| Cannabidiol | Cancer | 17 | PM | 33265945 | 📋 | Short-Term Medical Cannabis Treatment Regimens Produced Beneficial Effects among Palliative Cancer Patients |
| Cannabidiol | Cancer | 12 | PM | 31775230 | 📋 | Cannabidiol-from Plant to Human Body: A Promising Bioactive Molecule With Multi-Target Effects in Cancer |
| Cannabidiol | Cancer | 15 | PM | 30627539 | 📋 | Cannabis sativa L. And Nonpsychoactive Cannabinoids: Their Chemistry and Role Against Oxidative Stress, Inflammation, and Cancer |
| Cannabidiol | Cancer | 6 | PM | 30150937 | 📋 | Cannabidiol (CBD) Is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer |
| Cannabidiol | Cancer | 4 | PM | 30019449 | 📋 | Anti-tumour Actions of Cannabinoids |
| Cannabidiol | Cancer | 13 | PM | 29473338 | 📋 | The Current State and Future Perspectives of Cannabinoids in Cancer Biology |
| Cannabidiol | Cancer | 8 | PM | 29066974 | 📋 | Cannabinoids Modulate Neuronal Activity and Cancer by CB1 and CB2 Receptor-Independent Mechanisms |
| Cannabidiol | Cancer | 10 | PM | 28515817 | 📋 | Systematic Review of the Potential Role of Cannabinoids as Antiproliferative Agents for Urological Cancers |
| Cannabidiol | Cancer | 11 | PM | 28119804 | 📋 | Targeting Calcium Signaling in Cancer Therapy |
| Cannabidiol | Cancer | 9 | PM | 27774065 | 📋 | Preclinical and Clinical Assessment of Cannabinoids as Anti-Cancer Agents |
| Cannabidiol | Cancer | 2 | PM | 27486335 | 📋 | Endocannabinoid System as a Regulator of Tumor Cell Malignancy - Biological Pathways and Clinical Significance |
| Cannabidiol | Cancer | 14 | PM | 26071989 | 📋 | The Use of Cannabinoids as Anticancer Agents |
| Cannabidiol | Cancer | 16 | PM | 25916739 | 📋 | The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids |
| Cannabidiol | Cancer | 3 | PM | 25777363 | 📋 | Cannabis in Cancer Care |
| Cannabidiol | Cancer | 5 | PM | 22624859 | 📋 | Cannabidiol Inhibits Angiogenesis by Multiple Mechanisms |
| Cannabidiol | Cancer | 1 | PM | 19896326 | 📋 | Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Efficacy, Safety, and Tolerability of THC:CBD Extract and THC Extract in Patients With Intractable Cancer-Related Pain |
| Cannabidiol | Cancer | 7 | PM | 18199524 | 📋 | Cannabinoids for Cancer Treatment: Progress and Promise |
| Cannabidiol | Cervical Cancer | 3 | PM | 37047123 | 📋 | Cytotoxic Effects of Combinative ZnPcS4 Photosensitizer Photodynamic Therapy (PDT) and Cannabidiol (CBD) on a Cervical Cancer Cell Line |
| Cannabidiol | Cervical Cancer | 2 | PM | 35481367 | 📋 | Enhancement of Conventional and Photodynamic Therapy for Treatment of Cervical Cancer with Cannabidiol |
| Cannabidiol | Cervical Cancer | 1 | PM | 27586579 | 📋 | Cannabidiol Rather Than Cannabis Sativa Extracts Inhibit Cell Growth and Induce Apoptosis in Cervical Cancer Cells |
| Cannabidiol | Chronic Myeloid Leukemia | 2 | PM | 38268604 | 📋 | A label free chemoproteomic-based platform to disclose cannabidiol molecular mechanism of action on chronic myelogenous leukemia cancer cells |
| Cannabidiol | Chronic Myeloid Leukemia | 1 | PM | 34971020 | 📋 | The effects of cannabidiol via TRPV2 channel in chronic myeloid leukemia cells and its combination with imatinib |
| Cannabidiol | Colon Cancer | 6 | PM | 37577382 | 📋 | Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer |
| Cannabidiol | Colon Cancer | 4 | PM | 30076849 | 📋 | Cannabinoid Pharmacology and Therapy in Gut Disorders |
| Cannabidiol | Colon Cancer | 2 | PM | 25269802 | 📋 | Colon Carcinogenesis Is Inhibited by the TRPM8 Antagonist Cannabigerol, a Cannabis-derived Non-Psychotropic Cannabinoid |
| Cannabidiol | Colon Cancer | 3 | PM | 22965195 | 📋 | O-1602, an Atypical Cannabinoid, Inhibits Tumor Growth in Colitis-Associated Colon Cancer Through Multiple Mechanisms |
| Cannabidiol | Colon Cancer | 1 | PM | 22231745 | 📋 | Chemopreventive Effect of the Non-Psychotropic Phytocannabinoid Cannabidiol on Experimental Colon Cancer |
| Cannabidiol | Colon Cancer | 5 | PM | 22110202 | 📋 | Induction of Apoptosis by Cannabinoids in Prostate and Colon Cancer Cells Is Phosphatase Dependent |
| Cannabidiol | Colorectal Cancer | 11 | PM | 38358093 | 📋 | Cannabidiol activates MAPK pathway to induce apoptosis, paraptosis, and autophagy in colorectal cancer cells |
| Cannabidiol | Colorectal Cancer | 10 | PM | 35960375 | 📋 | Cannabidiol inhibits invasion and metastasis in colorectal cancer cells by reversing epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathway |
| Cannabidiol | Colorectal Cancer | 9 | PM | 35598400 | 📋 | Cannabidiol exerts anti-proliferative activity via a cannabinoid receptor 2-dependent mechanism in human colorectal cancer cells |
| Cannabidiol | Colorectal Cancer | 7 | PM | 32765628 | 📋 | Cannabinoid Effects on Experimental Colorectal Cancer Models Reduce Aberrant Crypt Foci (ACF) and Tumor Volume: A Systematic Review |
| Cannabidiol | Colorectal Cancer | 6 | PM | 32752303 | 📋 | Cytotoxic Effects of Cannabinoids on Human HT-29 Colorectal Adenocarcinoma Cells: Different Mechanisms of THC, CBD, and CB83 |
| Cannabidiol | Colorectal Cancer | 8 | PM | 32294046 | 📋 | Possible Enhancement of Photodynamic Therapy (PDT) Colorectal Cancer Treatment when Combined with Cannabidiol |
| Cannabidiol | Colorectal Cancer | 3 | PM | 31195721 | 📋 | Cannabidiol Overcomes Oxaliplatin Resistance by Enhancing NOS3- And SOD2-Induced Autophagy in Human Colorectal Cancer Cells |
| Cannabidiol | Colorectal Cancer | 2 | PM | 31075907 | 📋 | Cannabidiol Enhances the Therapeutic Effects of TRAIL by Upregulating DR5 in Colorectal Cancer |
| Cannabidiol | Colorectal Cancer | 1 | PM | 30660647 | 📋 | Cannabidiol-induced Apoptosis Is Mediated by Activation of Noxa in Human Colorectal Cancer Cells |
| Cannabidiol | Colorectal Cancer | 4 | PM | 17583570 | 📋 | The Cannabinoid delta(9)-tetrahydrocannabinol Inhibits RAS-MAPK and PI3K-AKT Survival Signalling and Induces BAD-mediated Apoptosis in Colorectal Cancer Cells |
| Cannabidiol | Colorectal Cancer | 5 | PM | 17237277 | 📋 | HU-331, a Novel Cannabinoid-Based Anticancer Topoisomerase II Inhibitor |
| Cannabidiol | Endometrial Cancer | 2 | PM | 32751388 | 📋 | The Effects of Cannabidiol and Prognostic Role of TRPV2 in Human Endometrial Cancer |
| Cannabidiol | Endometrial Cancer | 1 | PM | 29441458 | 📋 | Cannabinoid-induced Cell Death in Endometrial Cancer Cells: Involvement of TRPV1 Receptors in Apoptosis |
| Cannabidiol | Gastric Cancer | 3 | PM | 31699976 | 📋 | Cannabidiol Promotes Apoptosis via Regulation of XIAP/Smac in Gastric Cancer |
| Cannabidiol | Gastric Cancer | 2 | PM | 31349651 | 📋 | Cannabidiol Induces Cell Cycle Arrest and Cell Apoptosis in Human Gastric Cancer SGC-7901 Cells |
| Cannabidiol | Gastric Cancer | 1 | PM | 19394652 | 📋 | Pharmacological Synergism Between Cannabinoids and Paclitaxel in Gastric Cancer Cell Lines |
| Cannabidiol | Glioblastoma | 22 | PM | 38583854 | 📋 | Cannabidiol induces ERK activation and ROS production to promote autophagy and ferroptosis in glioblastoma cells |
| Cannabidiol | Glioblastoma | 21 | PM | 35403130 | 📋 | Cannabidiol Μay Prolong Survival in Patients With Glioblastoma Multiforme |
| Cannabidiol | Glioblastoma | 20 | PM | 35356807 | 📋 | Cannabidiol inhibits RAD51 and sensitizes glioblastoma to temozolomide in multiple orthotopic tumor models |
| Cannabidiol | Glioblastoma | 19 | PM | 34918964 | 📋 | Inhalant Cannabidiol Inhibits Glioblastoma Progression Through Regulation of Tumor Microenvironment |
| Cannabidiol | Glioblastoma | 18 | PM | 33916466 | 📋 | Specific Compositions of Cannabis sativa Compounds Have Cytotoxic Activity and Inhibit Motility and Colony Formation of Human Glioblastoma Cells In Vitro |
| Cannabidiol | Glioblastoma | 17 | PM | 33562819 | 📋 | Cannabigerol Is a Potential Therapeutic Agent in a Novel Combined Therapy for Glioblastoma |
| Cannabidiol | Glioblastoma | 16 | PM | 32145324 | 📋 | The Effects of Cannabinoids on Glioblastoma Growth: A Systematic Review With Meta-Analysis of Animal Model Studies |
| Cannabidiol | Glioblastoma | 15 | PM | 32060308 | 📋 | Inhibition of Autophagic Flux Differently Modulates Cannabidiol-Induced Death in 2D and 3D Glioblastoma Cell Cultures |
| Cannabidiol | Glioblastoma | 7 | PM | 30597288 | 📋 | Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells |
| Cannabidiol | Glioblastoma | 6 | PM | 29867351 | 📋 | Cannabinoids in Glioblastoma Therapy: New Applications for Old Drugs |
| Cannabidiol | Glioblastoma | 11 | PM | 27149140 | 📋 | The Influence of Biomechanical Properties and Cannabinoids on Tumor Invasion |
| Cannabidiol | Glioblastoma | 8 | PM | 25903924 | 📋 | Cannabidiol Stimulates Aml-1a-dependent Glial Differentiation and Inhibits Glioma Stem-Like Cells Proliferation by Inducing Autophagy in a TRPV2-dependent Manner |
| Cannabidiol | Glioblastoma | 4 | PM | 25590811 | 📋 | Reactive Oxygen Species-Mediated Therapeutic Response and Resistance in Glioblastoma |
| Cannabidiol | Glioblastoma | 5 | PM | 23349970 | 📋 | Local Delivery of Cannabinoid-Loaded Microparticles Inhibits Tumor Growth in a Murine Xenograft Model of Glioblastoma Multiforme |
| Cannabidiol | Glioblastoma | 13 | PM | 23079154 | 📋 | Triggering of the TRPV2 Channel by Cannabidiol Sensitizes Glioblastoma Cells to Cytotoxic Chemotherapeutic Agents |
| Cannabidiol | Glioblastoma | 12 | PM | 20307616 | 📋 | Opposite Changes in Cannabinoid CB1 and CB2 Receptor Expression in Human Gliomas |
| Cannabidiol | Glioblastoma | 3 | PM | 20053780 | 📋 | Cannabidiol Enhances the Inhibitory Effects of delta9-tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival |
| Cannabidiol | Glioblastoma | 2 | PM | 19425170 | 📋 | Cannabinoid Action Induces Autophagy-Mediated Cell Death Through Stimulation of ER Stress in Human Glioma Cells |
| Cannabidiol | Glioblastoma | 9 | PM | 18088200 | 📋 | Cannabinoids as Potential New Therapy for the Treatment of Gliomas |
| Cannabidiol | Glioblastoma | 14 | PM | 17934890 | 📋 | Delta 9-tetrahydrocannabinol Inhibits Cell Cycle Progression by Downregulation of E2F1 in Human Glioblastoma Multiforme Cells |
| Cannabidiol | Glioblastoma | 10 | PM | 16078104 | 📋 | Cannabinoids Selectively Inhibit Proliferation and Induce Death of Cultured Human Glioblastoma Multiforme Cells |
| Cannabidiol | Glioblastoma | 1 | PM | 15313899 | 📋 | Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas |
| Cannabidiol | Glioma | 23 | PM | 34458247 | 📋 | Transient Receptor Potential (TRP) Ion Channels Involved in Malignant Glioma Cell Death and Therapeutic Perspectives |
| Cannabidiol | Glioma | 22 | PM | 34456736 | 📋 | Cannabidiol Induces Apoptosis and Perturbs Mitochondrial Function in Human and Canine Glioma Cells |
| Cannabidiol | Glioma | 21 | PM | 33629929 | 📋 | Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4 |
| Cannabidiol | Glioma | 5 | PM | 31848037 | 📋 | Potential Role of Cannabidiol for Seizure Control in a Patient With Recurrent Glioma |
| Cannabidiol | Glioma | 2 | PM | 30713832 | 📋 | Case Report: Clinical Outcome and Image Response of Two Patients With Secondary High-Grade Glioma Treated With Chemoradiation, PCV, and Cannabidiol |
| Cannabidiol | Glioma | 17 | PM | 30472144 | 📋 | Lipid Nanocapsules Decorated and Loaded With Cannabidiol as Targeted Prolonged Release Carriers for Glioma Therapy: In Vitro Screening of Critical Parameters |
| Cannabidiol | Glioma | 16 | PM | 26504004 | 📋 | Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells |
| Cannabidiol | Glioma | 8 | PM | 25398831 | 📋 | The Combination of Cannabidiol and Δ9-tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model |
| Cannabidiol | Glioma | 19 | PM | 24204703 | 📋 | Cannabidiol, a Non-Psychoactive Cannabinoid Compound, Inhibits Proliferation and Invasion in U87-MG and T98G Glioma Cells Through a Multitarget Effect |
| Cannabidiol | Glioma | 4 | PM | 21336992 | 📋 | Spontaneous Regression of Septum pellucidum/forniceal Pilocytic Astrocytomas--Possible Role of Cannabis Inhalation |
| Cannabidiol | Glioma | 14 | PM | 20307616 | 📋 | Opposite Changes in Cannabinoid CB1 and CB2 Receptor Expression in Human Gliomas |
| Cannabidiol | Glioma | 1 | PM | 19425170 | 📋 | Cannabinoid Action Induces Autophagy-Mediated Cell Death Through Stimulation of ER Stress in Human Glioma Cells |
| Cannabidiol | Glioma | 6 | PM | 19229996 | 📋 | Amphiregulin Is a Factor for Resistance of Glioma Cells to Cannabinoid-Induced Apoptosis |
| Cannabidiol | Glioma | 12 | PM | 18339876 | 📋 | Cannabinoids Inhibit Glioma Cell Invasion by Down-Regulating Matrix metalloproteinase-2 Expression |
| Cannabidiol | Glioma | 11 | PM | 18088200 | 📋 | Cannabinoids as Potential New Therapy for the Treatment of Gliomas |
| Cannabidiol | Glioma | 3 | PM | 17675107 | 📋 | Down-regulation of Tissue Inhibitor of metalloproteinases-1 in Gliomas: A New Marker of Cannabinoid Antitumoral Activity? |
| Cannabidiol | Glioma | 10 | PM | 16909207 | 📋 | The Non-Psychoactive Cannabidiol Triggers Caspase Activation and Oxidative Stress in Human Glioma Cells |
| Cannabidiol | Glioma | 15 | PM | 15700028 | 📋 | Cannabidiol Inhibits Human Glioma Cell Migration Through a Cannabinoid Receptor-Independent Mechanism |
| Cannabidiol | Glioma | 13 | PM | 15275820 | 📋 | Hypothesis: Cannabinoid Therapy for the Treatment of Gliomas? |
| Cannabidiol | Glioma | 7 | PM | 14617682 | 📋 | Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines |
| Cannabidiol | Glioma | 9 | PM | 12514108 | 📋 | Inhibition of Tumor Angiogenesis by Cannabinoids |
| Cannabidiol | Glioma | 20 | PM | 11903061 | 📋 | De Novo-Synthesized Ceramide Is Involved in Cannabinoid-Induced Apoptosis |
| Cannabidiol | Glioma | 18 | PM | 9771884 | 📋 | Delta9-tetrahydrocannabinol Induces Apoptosis in C6 Glioma Cells |
| Cannabidiol | Head and Neck Cancer | 1 | PM | 33244087 | 📋 | Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma |
| Cannabidiol | Leukemia | 1 | PM | 37837474 | 📋 | The potential protective and therapeutic effects of cannabidiol oil on experimental Leukemia induced by DMBA in male rats |
| Cannabidiol | Leukemia | 8 | PM | 16908594 | 📋 | Delta9-tetrahydrocannabinol-induced Apoptosis in Jurkat Leukemia T Cells Is Regulated by Translocation of Bad to Mitochondria |
| Cannabidiol | Leukemia | 6 | PM | 16754784 | 📋 | Cannabidiol-induced Apoptosis in Human Leukemia Cells: A Novel Role of Cannabidiol in the Regulation of p22phox and Nox4 Expression |
| Cannabidiol | Leukemia | 4 | PM | 16624285 | 📋 | The CB2 Cannabinoid Receptor Signals Apoptosis via Ceramide-Dependent Activation of the Mitochondrial Intrinsic Pathway |
| Cannabidiol | Leukemia | 3 | PM | 16458258 | 📋 | The Effects of Cannabinoids on P-glycoprotein Transport and Expression in Multidrug Resistant Cells |
| Cannabidiol | Leukemia | 7 | PM | 16139274 | 📋 | p38 MAPK Is Involved in CB2 Receptor-Induced Apoptosis of Human Leukaemia Cells |
| Cannabidiol | Leukemia | 5 | PM | 15978942 | 📋 | Targeting Cannabinoid Receptors to Treat Leukemia: Role of Cross-Talk Between Extrinsic and Intrinsic Pathways in Delta9-tetrahydrocannabinol (THC)-induced Apoptosis of Jurkat Cells |
| Cannabidiol | Leukemia | 9 | PM | 15454482 | 📋 | Cannabis-induced Cytotoxicity in Leukemic Cell Lines: The Role of the Cannabinoid Receptors and the MAPK Pathway |
| Cannabidiol | Liver Cancer | 4 | PM | 38825256 | 📋 | Cannabidiol reverts the malignant phenotype of hepatocellular carcinoma cells via the GPR55/TP53/MAPK axis |
| Cannabidiol | Liver Cancer | 3 | PM | 37568803 | 📋 | Cannabidiol Enhances Cabozantinib-Induced Apoptotic Cell Death via Phosphorylation of p53 Regulated by ER Stress in Hepatocellular Carcinoma |
| Cannabidiol | Liver Cancer | 2 | PM | 34350183 | 📋 | A Novel Mechanism of Cannabidiol in Suppressing Hepatocellular Carcinoma by Inducing GSDME Dependent Pyroptosis |
| Cannabidiol | Liver Cancer | 1 | PM | 21475304 | 📋 | Anti-tumoral Action of Cannabinoids on Hepatocellular Carcinoma: Role of AMPK-dependent Activation of Autophagy |
| Cannabidiol | Lung Cancer | 15 | PM | 38558822 | 📋 | Discovering single cannabidiol or synergistic antitumor effects of cannabidiol and cytokine-induced killer cells on non-small cell lung cancer cells |
| Cannabidiol | Lung Cancer | 14 | PM | 38503236 | 📋 | Synergistic effect of cannabidiol with dasatinib on lung cancer by SRC/PI3K/AKT signal pathway |
| Cannabidiol | Lung Cancer | 13 | PM | 36737540 | 📋 | Inhalant cannabidiol impedes tumor growth through decreased tumor stemness and impaired angiogenic switch in NCI-H1437-induced human lung cancer model |
| Cannabidiol | Lung Cancer | 12 | PM | 35267489 | 📋 | Cannabidiol Inhibits Tumorigenesis in Cisplatin-Resistant Non-Small Cell Lung Cancer via TRPV2 |
| Cannabidiol | Lung Cancer | 11 | PM | 34832951 | 📋 | Cannabidiol Induces Cell Death in Human Lung Cancer Cells and Cancer Stem Cells |
| Cannabidiol | Lung Cancer | 10 | PM | 34649854 | 📋 | Lung cancer patient who had declined conventional cancer treatment: could the self-administration of 'CBD oil' be contributing to the observed tumour regression? |
| Cannabidiol | Lung Cancer | 1 | PM | 30815264 | 📋 | Striking Lung Cancer Response to Self-Administration of Cannabidiol: A Case Report and Literature Review |
| Cannabidiol | Lung Cancer | 2 | PM | 25899283 | 📋 | In Vitro and in Vivo Evaluation of Δ⁹-tetrahidrocannabinol/PLGA Nanoparticles for Cancer Chemotherapy |
| Cannabidiol | Lung Cancer | 8 | PM | 25069049 | 📋 | Cannabinoids Increase Lung Cancer Cell Lysis by Lymphokine-Activated Killer Cells via Upregulation of ICAM-1 |
| Cannabidiol | Lung Cancer | 5 | PM | 24976505 | 📋 | Cannabinoids Inhibit Angiogenic Capacities of Endothelial Cells via Release of Tissue Inhibitor of Matrix metalloproteinases-1 From Lung Cancer Cells |
| Cannabidiol | Lung Cancer | 4 | PM | 23220503 | 📋 | COX-2 and PPAR-γ Confer Cannabidiol-Induced Apoptosis of Human Lung Cancer Cells |
| Cannabidiol | Lung Cancer | 3 | PM | 22198381 | 📋 | Cannabidiol Inhibits Lung Cancer Cell Invasion and Metastasis via Intercellular Adhesion molecule-1 |
| Cannabidiol | Lung Cancer | 6 | PM | 20668920 | 📋 | Decrease of Plasminogen Activator inhibitor-1 May Contribute to the Anti-Invasive Action of Cannabidiol on Human Lung Cancer Cells |
| Cannabidiol | Lung Cancer | 7 | PM | 19914218 | 📋 | Cannabidiol Inhibits Cancer Cell Invasion via Upregulation of Tissue Inhibitor of Matrix metalloproteinases-1 |
| Cannabidiol | Lung Cancer | 9 | PM | 17931597 | 📋 | Cannabinoid Receptor Agonists Are Mitochondrial Inhibitors: A Unified Hypothesis of How Cannabinoids Modulate Mitochondrial Function and Induce Cell Death |
| Cannabidiol | Lymphoma | 2 | PM | 32284791 | 📋 | Synergistic Cytotoxic Activity of Cannabinoids From cannabis sativa Against Cutaneous T-cell Lymphoma (CTCL) in-vitro and ex-vivo |
| Cannabidiol | Lymphoma | 1 | PM | 16936228 | 📋 | Cannabinoid Receptor-Mediated Apoptosis Induced by R(+)-methanandamide and Win55,212-2 Is Associated With Ceramide Accumulation and p38 Activation in Mantle Cell Lymphoma |
| Cannabidiol | Lymphoma | 3 | PM | 16337199 | 📋 | Cannabinoid Receptor Ligands Mediate Growth Inhibition and Cell Death in Mantle Cell Lymphoma |
| Cannabidiol | Melanoma | 5 | PM | 33428525 | 📋 | Effects of cannabidiol (CBD) on the inhibition of melanoma cells in vitro |
| Cannabidiol | Melanoma | 4 | PM | 33126621 | 📋 | The Influence of Hemp Extract in Combination with Ginger on the Metabolic Activity of Metastatic Cells and Microorganisms |
| Cannabidiol | Melanoma | 1 | PM | 30691796 | 📋 | Cannabinoids as a Potential New and Novel Treatment for Melanoma: A Pilot Study in a Murine Model |
| Cannabidiol | Melanoma | 3 | PM | 25674907 | 📋 | Exploiting Cannabinoid-Induced Cytotoxic Autophagy to Drive Melanoma Cell Death |
| Cannabidiol | Melanoma | 2 | PM | 17065222 | 📋 | Cannabinoid Receptors as Novel Targets for the Treatment of Melanoma |
| Cannabidiol | Multiple Myeloma | 2 | PM | 27769052 | 📋 | Cannabinoids Synergize With Carfilzomib, Reducing Multiple Myeloma Cells Viability and Migration |
| Cannabidiol | Multiple Myeloma | 1 | PM | 24293211 | 📋 | The Effects of Cannabidiol and Its Synergism With Bortezomib in Multiple Myeloma Cell Lines. A Role for Transient Receptor Potential Vanilloid type-2 |
| Cannabidiol | Neuroblastoma | 2 | PM | 30713602 | 📋 | Role of miRNA in the Regulation of Cannabidiol-Mediated Apoptosis in Neuroblastoma Cells |
| Cannabidiol | Neuroblastoma | 1 | PM | 27022310 | 📋 | In Vitro and in Vivo Efficacy of Non-Psychoactive Cannabidiol in Neuroblastoma |
| Cannabidiol | Oral Cancer | 2 | PM | 36555480 | 📋 | Real-Time Monitoring of the Cytotoxic and Antimetastatic Properties of Cannabidiol in Human Oral Squamous Cell Carcinoma Cells Using Electric Cell-Substrate Impedance Sensing |
| Cannabidiol | Oral Cancer | 1 | PM | 20516734 | 📋 | Cannabinoids Inhibit Cellular Respiration of Human Oral Cancer Cells |
| Cannabidiol | Ovarian Cancer | 3 | PM | 38603577 | 📋 | Cannabidiol Inhibits Epithelial Ovarian Cancer: Role of Gut Microbiome |
| Cannabidiol | Ovarian Cancer | 2 | PM | 36810933 | 📋 | A novel mechanism of cannabidiol in suppressing ovarian cancer through LAIR-1 mediated mitochondrial dysfunction and apoptosis |
| Cannabidiol | Ovarian Cancer | 1 | PM | 31193514 | 📋 | Dramatic Response to Laetrile and Cannabidiol (CBD) Oil in a Patient With Metastatic Low Grade Serous Ovarian Carcinoma |
| Cannabidiol | Pancreatic Cancer | 5 | PM | 35409142 | 📋 | A Low Dose of Pure Cannabidiol Is Sufficient to Stimulate the Cytotoxic Function of CIK Cells without Exerting the Downstream Mediators in Pancreatic Cancer Cells |
| Cannabidiol | Pancreatic Cancer | 4 | PM | 33126623 | 📋 | Cannabinoids Inhibited Pancreatic Cancer via P-21 Activated Kinase 1 Mediated Pathway |
| Cannabidiol | Pancreatic Cancer | 3 | PM | 32992648 | 📋 | Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines |
| Cannabidiol | Pancreatic Cancer | 1 | PM | 30706048 | 📋 | Potential Use of Cannabinoids for the Treatment of Pancreatic Cancer |
| Cannabidiol | Pancreatic Cancer | 2 | PM | 16500647 | 📋 | Cannabinoid Derivatives Induce Cell Death in Pancreatic MIA PaCa-2 Cells via a Receptor-Independent Mechanism |
| Cannabidiol | Prostate Cancer | 11 | PM | 38067615 | 📋 | In Vitro Evidence of Selective Pro-Apoptotic Action of the Pure Cannabidiol and Cannabidiol-Rich Extract |
| Cannabidiol | Prostate Cancer | 10 | PM | 37796968 | 📋 | Anti-proliferative effect of Cannabidiol in Prostate cancer cell PC3 is mediated by apoptotic cell death, NFκB activation, increased oxidative stress, and lower reduced glutathione status |
| Cannabidiol | Prostate Cancer | 9 | PM | 37703852 | 📋 | Cannabidiol Inhibits the Proliferation and Invasiveness of Prostate Cancer Cells |
| Cannabidiol | Prostate Cancer | 8 | PM | 36853473 | 📋 | Cannabidiol and Cannabis Sativa as a potential treatment in vitro prostate cancer cells silenced with RBBp6 and PC3 xenograft |
| Cannabidiol | Prostate Cancer | 7 | PM | 36736415 | 📋 | Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer |
| Cannabidiol | Prostate Cancer | 1 | PM | 27633508 | 📋 | Phyto-, Endo- And Synthetic Cannabinoids: Promising Chemotherapeutic Agents in the Treatment of Breast and Prostate Carcinomas |
| Cannabidiol | Prostate Cancer | 4 | PM | 22594963 | 📋 | Non-THC Cannabinoids Inhibit Prostate Carcinoma Growth in Vitro and in Vivo: Pro-Apoptotic Effects and Underlying Mechanisms |
| Cannabidiol | Prostate Cancer | 3 | PM | 22557710 | 📋 | The Role of Cannabinoids in Prostate Cancer: Basic Science Perspective and Potential Clinical Applications |
| Cannabidiol | Prostate Cancer | 5 | PM | 22110202 | 📋 | Induction of Apoptosis by Cannabinoids in Prostate and Colon Cancer Cells Is Phosphatase Dependent |
| Cannabidiol | Prostate Cancer | 2 | PM | 15753356 | 📋 | Cannabinoid Receptor as a Novel Target for the Treatment of Prostate Cancer |
| Cannabidiol | Prostate Cancer | 6 | PM | 10570948 | 📋 | Delta9-tetrahydrocannabinol Induces Apoptosis in Human Prostate PC-3 Cells via a Receptor-Independent Mechanism |
| Cannabidiol | Rhabdomyosarcoma | 1 | PM | 19509271 | 📋 | Cannabinoid Receptor 1 Is a Potential Drug Target for Treatment of Translocation-Positive Rhabdomyosarcoma |
| Cannabidiol | Skin Cancer | 2 | PM | 25921771 | 📋 | Differential Role of Cannabinoids in the Pathogenesis of Skin Cancer |
| Cannabidiol | Skin Cancer | 1 | PM | 12511587 | 📋 | Inhibition of Skin Tumor Growth and Angiogenesis in Vivo by Activation of Cannabinoid Receptors |
| Cannabidiol | Squamous Cell Carcinoma | 1 | PM | 36557911 | 📋 | Cannabidiol and Its Combinations with Nonsteroidal Anti-Inflammatory Drugs Induce Apoptosis and Inhibit Activation of NF-κB Signaling in Vulvar Squamous Cell Carcinoma |
| Cannabidiol | Thyroid Cancer | 1 | PM | 18197164 | 📋 | Cannabinoid 2 Receptor Induction by IL-12 and Its Potential as a Therapeutic Target for the Treatment of Anaplastic Thyroid Carcinoma |
| Cannabidiol | Thyroid Cancer | 2 | PM | 16728591 | 📋 | Antitumor Activity of Plant Cannabinoids With Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma |
