| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Berberine | Acute Lymphoblastic Leukemia | 3 | PM | 32494123 | 📋 | Berberine Induces Autophagic Cell Death in Acute Lymphoblastic Leukemia by Inactivating AKT/mTORC1 Signaling |
| Berberine | Acute Lymphoblastic Leukemia | 1 | PM | 32062612 | 📋 | Berberine Promotes XIAP-mediated Cells Apoptosis by Upregulation of miR-24-3p in Acute Lymphoblastic Leukemia |
| Berberine | Acute Lymphoblastic Leukemia | 2 | PM | 28703366 | 📋 | Synergistic Effect of TPD7 and Berberine Against Leukemia Jurkat Cell Growth Through Regulating Ephrin-B2 Signaling |
| Berberine | Acute Myeloid Leukemia | 1 | PM | 36871981 | 📋 | Berberine targets the electron transport chain complex I and reveals the landscape of OXPHOS dependency in acute myeloid leukemia with IDH1 mutation |
| Berberine | Acute Promyelocytic Leukemia | 1 | PM | 29025293 | 📋 | Berberine Induces Apoptotic Cell Death via Activation of Caspase-3 and -8 in HL-60 Human Leukemia Cells: Nuclear Localization and Structure-Activity Relationships |
| Berberine | Biliary Tract Cancer | 2 | PM | 36308362 | 📋 | Low Dose Berberine Suppresses Cholangiocarcinoma Cell Progression as a Multi-Kinase Inhibitor |
| Berberine | Biliary Tract Cancer | 1 | PM | 28566619 | 📋 | Berberine Induces Cell Cycle Arrest in Cholangiocarcinoma Cell Lines via Inhibition of NF-κB and STAT3 Pathways |
| Berberine | Bladder Cancer | 3 | PM | 37139621 | 📋 | Berberine Affects the Proliferation, Migration, Invasion, Cell Cycle, and Apoptosis of Bladder Cancer Cells T24 and 5637 by Down-Regulating the HER2/PI3K/AKT Signaling Pathway |
| Berberine | Bladder Cancer | 2 | PM | 34935059 | 📋 | Berberine enhances gemcitabine‑induced cytotoxicity in bladder cancer by downregulating Rad51 expression through inactivating the PI3K/Akt pathway |
| Berberine | Bladder Cancer | 1 | PM | 33887260 | 📋 | Berberine suppresses bladder cancer cell proliferation by inhibiting JAK1-STAT3 signaling via upregulation of miR-17-5p |
| Berberine | Bladder Cancer | 4 | PM | 21545798 | 📋 | Induction of G1 cell cycle arrest and apoptosis by berberine in bladder cancer cells |
| Berberine | Bone Cancer | 5 | PM | 36915782 | 📋 | Berberine inhibits the growth of osteosarcoma through modulating MMP/NM-23 and MAPK/JNK signal pathways |
| Berberine | Bone Cancer | 8 | PM | 33802664 | 📋 | Berberine and Cisplatin Exhibit Synergistic Anticancer Effects on Osteosarcoma MG-63 Cells by Inhibiting the MAPK Pathway |
| Berberine | Bone Cancer | 7 | PM | 33074411 | 📋 | Berberine reverses epithelial-mesenchymal transition and modulates histone methylation in osteosarcoma cells |
| Berberine | Bone Cancer | 6 | PM | 32474504 | 📋 | Berberine Enhances the Radiosensitivity of Osteosarcoma by Targeting Rad51 and Epithelial-Mesenchymal Transition |
| Berberine | Bone Cancer | 2 | PM | 28000894 | 📋 | Berberine Affects Osteosarcoma via Downregulating the caspase-1/IL-1β Signaling Axis |
| Berberine | Bone Cancer | 3 | PM | 27398330 | 📋 | Berberine Induced Apoptosis of Human Osteosarcoma Cells by Inhibiting Phosphoinositide 3 Kinase/Protein Kinase B (PI3K/Akt) Signal Pathway Activation |
| Berberine | Bone Cancer | 1 | PM | 25050485 | 📋 | Berberine Induces Apoptosis and DNA Damage in MG‑63 Human Osteosarcoma Cells |
| Berberine | Bone Cancer | 4 | PM | 19159633 | 📋 | Berberine Induces p53-dependent Cell Cycle Arrest and Apoptosis of Human Osteosarcoma Cells by Inflicting DNA Damage |
| Berberine | Breast Cancer | 1 | PM | 38709912 | 📋 | Berberine inhibits the progression of breast cancer by regulating METTL3-mediated m6A modification of FGF7 mRNA |
| Berberine | Breast Cancer | 41 | PM | 37682166 | 📋 | Integrated network pharmacology, bioinformatics, and molecular docking to explore the mechanisms of berberine regulating autophagy in breast cancer |
| Berberine | Breast Cancer | 40 | PM | 37669117 | 📋 | Invasive Breast Cancer: miR-24-2 Targets Genes Associated with Survival and Sensitizes MDA-MB-231 Cells to Berberine |
| Berberine | Breast Cancer | 39 | PM | 37315824 | 📋 | Berberine inhibits breast carcinoma proliferation and metastasis under hypoxic microenvironment involving gut microbiota and endogenous metabolites |
| Berberine | Breast Cancer | 32 | PM | 36920717 | 📋 | The Effect of Berberine Follow by Blue Light Irradiation and Valproic Acid on the Growth Inhibition of MDA-MB-231 Breast Cancer Cells |
| Berberine | Breast Cancer | 31 | PM | 36293390 | 📋 | Gut Microbiota, Metabolic Disorders and Breast Cancer: Could Berberine Turn Out to Be a Transversal Nutraceutical Tool? A Narrative Analysis |
| Berberine | Breast Cancer | 30 | PM | 36119505 | 📋 | Berberine as a potential agent for breast cancer therapy |
| Berberine | Breast Cancer | 29 | PM | 36060924 | 📋 | Enhancement of Sensitivity to Tamoxifen by Berberine in Breast Cancer Cells by Inhibiting ER-α36 Expression |
| Berberine | Breast Cancer | 28 | PM | 35504329 | 📋 | Berberine alkaloids inhibit the proliferation and metastasis of breast carcinoma cells involving Wnt/β-catenin signaling and EMT |
| Berberine | Breast Cancer | 27 | PM | 35026293 | 📋 | Pharmacotranscriptomic profiling of resistant triple-negative breast cancer cells treated with lapatinib and berberine shows upregulation of PI3K/Akt signaling under cytotoxic stress |
| Berberine | Breast Cancer | 26 | PM | 34056218 | 📋 | Berberine Reverses Breast Cancer Multidrug Resistance Based on Fluorescence Pharmacokinetics In Vitro and In Vivo |
| Berberine | Breast Cancer | 24 | PM | 33312221 | 📋 | Berberine Inhibits the Expression of SCT through miR-214-3p Stimulation in Breast Cancer Cells |
| Berberine | Breast Cancer | 23 | PM | 32707493 | 📋 | In-vitro and in-vivo anti-breast cancer activity of synergistic effect of berberine and exercise through promoting the apoptosis and immunomodulatory effects |
| Berberine | Breast Cancer | 22 | PM | 32682817 | 📋 | Berberine and Emodin abrogates breast cancer growth and facilitates apoptosis through inactivation of SIK3-induced mTOR and Akt signaling pathway |
| Berberine | Breast Cancer | 21 | PM | 32475643 | 📋 | Berberine-induced Nucleolar Stress Response in a Human Breast Cancer Cell Line |
| Berberine | Breast Cancer | 3 | PM | 32258115 | 📋 | Berberine Inhibits MDA-MB-231 Cells by Attenuating Their Inflammatory Responses |
| Berberine | Breast Cancer | 9 | PM | 31991634 | 📋 | Berberine Impairs the Survival of Triple Negative Breast Cancer Cells: Cellular and Molecular Analyses |
| Berberine | Breast Cancer | 11 | PM | 31779025 | 📋 | Berberine Inhibits Proliferative Ability of Breast Cancer Cells by Reducing Metadherin |
| Berberine | Breast Cancer | 10 | PM | 31412862 | 📋 | Berberine Inhibits NLRP3 Inflammasome Pathway in Human Triple-Negative Breast Cancer MDA-MB-231 Cell |
| Berberine | Breast Cancer | 7 | PM | 31338966 | 📋 | Berberine Attenuates XRCC1-mediated Base Excision Repair and Sensitizes Breast Cancer Cells to the Chemotherapeutic Drugs |
| Berberine | Breast Cancer | 19 | PM | 30957305 | 📋 | Different Mechanisms Involved in the Berberine-Induced Antiproliferation Effects in Triple-Negative Breast Cancer Cell Lines |
| Berberine | Breast Cancer | 15 | PM | 30343043 | 📋 | Antitumor Effects of Berberine Against EGFR, ERK1/2, P38 and AKT in MDA-MB231 and MCF-7 Breast Cancer Cells Using Molecular Modelling and in Vitro Study |
| Berberine | Breast Cancer | 25 | PM | 29805448 | 📋 | Studies on the Dual Cytotoxicity and Antioxidant Properties of Berberis vulgaris Extracts and Its Main Constituent Berberine |
| Berberine | Breast Cancer | 17 | PM | 29628980 | 📋 | Berberine Suppresses Fibronectin Expression Through Inhibition of c-Jun Phosphorylation in Breast Cancer Cells |
| Berberine | Breast Cancer | 18 | PM | 29414799 | 📋 | Berberine Suppresses Cell Motility Through Downregulation of TGF-β1 in Triple Negative Breast Cancer Cells |
| Berberine | Breast Cancer | 35 | PM | 29143794 | 📋 | Berberine Activates Aryl Hydrocarbon Receptor but Suppresses CYP1A1 Induction through miR-21-3p Stimulation in MCF-7 Breast Cancer Cells |
| Berberine | Breast Cancer | 6 | PM | 29061795 | 📋 | Berberine and Evodiamine Act Synergistically Against Human Breast Cancer MCF-7 Cells by Inducing Cell Cycle Arrest and Apoptosis |
| Berberine | Breast Cancer | 2 | PM | 28826092 | 📋 | Berberine Activates caspase-9/cytochrome C-Mediated Apoptosis to Suppress Triple-Negative Breast Cancer Cells in Vitro and in Vivo |
| Berberine | Breast Cancer | 4 | PM | 28544934 | 📋 | Preventive Effect of Berberine Against DMBA-induced Breast Cancer in Female Sprague Dawley Rats |
| Berberine | Breast Cancer | 13 | PM | 28190470 | 📋 | Berberine Inhibits the Proliferation and Migration of Breast Cancer ZR-75-30 Cells by Targeting Ephrin-B2 |
| Berberine | Breast Cancer | 20 | PM | 27416292 | 📋 | Berberine Reverses Lapatinib Resistance of HER2-positive Breast Cancer Cells by Increasing the Level of ROS |
| Berberine | Breast Cancer | 5 | PM | 27322681 | 📋 | Tumor Suppressor Berberine Binds VASP to Inhibit Cell Migration in Basal-Like Breast Cancer |
| Berberine | Breast Cancer | 16 | PM | 27177238 | 📋 | Berberine in Combination With Cisplatin Suppresses Breast Cancer Cell Growth Through Induction of DNA Breaks and caspase-3-dependent Apoptosis |
| Berberine | Breast Cancer | 14 | PM | 27081456 | 📋 | Berberine Suppresses Migration of MCF-7 Breast Cancer Cells Through Down-Regulation of Chemokine Receptors |
| Berberine | Breast Cancer | 34 | PM | 24137422 | 📋 | Berberine enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast cancer |
| Berberine | Breast Cancer | 33 | PM | 24000115 | 📋 | Antitumor effect of novel berberine derivatives in breast cancer cells |
| Berberine | Breast Cancer | 38 | PM | 22381172 | 📋 | Berberine suppresses the TPA-induced MMP-1 and MMP-9 expressions through the inhibition of PKC-α in breast cancer cells |
| Berberine | Breast Cancer | 37 | PM | 21964832 | 📋 | Effect of berberine on p53 expression by TPA in breast cancer cells |
| Berberine | Breast Cancer | 36 | PM | 21699261 | 📋 | Growth suppression of HER2-overexpressing breast cancer cells by berberine via modulation of the HER2/PI3K/Akt signaling pathway |
| Berberine | Breast Cancer | 12 | PM | 19800775 | 📋 | The Alkaloid Berberine Inhibits the Growth of Anoikis-resistant MCF-7 and MDA-MB-231 Breast Cancer Cell Lines by Inducing Cell Cycle Arrest |
| Berberine | Breast Cancer | 8 | PM | 18951337 | 📋 | Berberine Diminishes the Side Population and ABCG2 Transporter Expression in MCF-7 Breast Cancer Cells |
| Berberine | Cancer | 32 | PM | 38849013 | 📋 | Unlocking the Potential of Berberine: Advancing Cancer Therapy through Chemosensitization and Combination Treatments |
| Berberine | Cancer | 31 | PM | 38303534 | 📋 | Cancer Pathways Targeted by Berberine: Role of microRNAs |
| Berberine | Cancer | 27 | PM | 37416770 | 📋 | Natural Nrf2 Inhibitors: A Review of Their Potential for Cancer Treatment |
| Berberine | Cancer | 26 | PM | 36937842 | 📋 | Emerging trends and research foci of berberine on tumor from 2002 to 2021: A bibliometric article of the literature from WoSCC |
| Berberine | Cancer | 25 | PM | 36612288 | 📋 | A Survey of Naturally Occurring Molecules as New Endoplasmic Reticulum Stress Activators with Selective Anticancer Activity |
| Berberine | Cancer | 24 | PM | 36588295 | 📋 | Pharmacotherapeutic values of berberine: A Chinese herbal medicine for the human cancer management |
| Berberine | Cancer | 23 | PM | 36561763 | 📋 | Berberine a traditional Chinese drug repurposing: Its actions in inflammation-associated ulcerative colitis and cancer therapy |
| Berberine | Cancer | 22 | PM | 36144625 | 📋 | Berberine: An Important Emphasis on Its Anticancer Effects through Modulation of Various Cell Signaling Pathways |
| Berberine | Cancer | 21 | PM | 36016553 | 📋 | Structural modifications of berberine and their binding effects towards polymorphic deoxyribonucleic acid structures: A review |
| Berberine | Cancer | 20 | PM | 35629433 | 📋 | Antiproliferative Effect of Phellodendron amurense Rupr. Based on Angiogenesis |
| Berberine | Cancer | 19 | PM | 35231825 | 📋 | Berberine mediates tumor cell death by skewing tumor-associated immunosuppressive macrophages to inflammatory macrophages |
| Berberine | Cancer | 18 | PM | 35209812 | 📋 | Anticancer mechanisms of Berberine: a good choice for glioblastoma multiforme therapy |
| Berberine | Cancer | 17 | PM | 35153781 | 📋 | Apoptosis Induction, a Sharp Edge of Berberine to Exert Anti-Cancer Effects, Focus on Breast, Lung, and Liver Cancer |
| Berberine | Cancer | 16 | PM | 34885950 | 📋 | Berberine as a Potential Anticancer Agent: A Comprehensive Review |
| Berberine | Cancer | 15 | PM | 34643248 | 📋 | Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway |
| Berberine | Cancer | 14 | PM | 34047089 | 📋 | [Research progress in mechanism of berberine's antitumor action] |
| Berberine | Cancer | 11 | PM | 33559280 | 📋 | Berberine-A potent chemosensitizer and chemoprotector to conventional cancer therapies |
| Berberine | Cancer | 10 | PM | 33521059 | 📋 | Nanotechnology-Based Strategies for Berberine Delivery System in Cancer Treatment: Pulling Strings to Keep Berberine in Power |
| Berberine | Cancer | 9 | PM | 33354502 | 📋 | Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5 |
| Berberine | Cancer | 8 | PM | 32988344 | 📋 | Berberine Exerts Anti-cancer Activity by Modulating Adenosine Monophosphate-Activated Protein Kinase (AMPK) and the Phosphatidylinositol 3-Kinase/Protein Kinase B (PI3K/AKT) Signaling Pathways |
| Berberine | Cancer | 12 | PM | 32735398 | 📋 | Berberine: A novel therapeutic strategy for cancer |
| Berberine | Cancer | 7 | PM | 32702446 | 📋 | Berberine inhibits cancer cells growth by suppressing fatty acid synthesis and biogenesis of extracellular vesicles |
| Berberine | Cancer | 6 | PM | 32449796 | 📋 | A Review of the Chemopreventative and Chemotherapeutic Properties of the Phytochemicals Berberine, Resveratrol and Curcumin, and Their Influence on Cell Death via the Pathways of Apoptosis and Autophagy |
| Berberine | Cancer | 2 | PM | 32099466 | 📋 | The Anti-Cancer Mechanisms of Berberine: A Review |
| Berberine | Cancer | 3 | PM | 31447670 | 📋 | An Insight Into the Molecular Mechanism of Berberine Towards Multiple Cancer Types Through Systems Pharmacology |
| Berberine | Cancer | 1 | PM | 31208348 | 📋 | Anticancer Effect of Berberine Based on Experimental Animal Models of Various Cancers: A Systematic Review and Meta-Analysis |
| Berberine | Cancer | 30 | PM | 30837865 | 📋 | A Natural Isoquinoline Alkaloid With Antitumor Activity: Studies of the Biological Activities of Berberine |
| Berberine | Cancer | 28 | PM | 28611316 | 📋 | Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs |
| Berberine | Cancer | 29 | PM | 27917872 | 📋 | Advances in the study of berberine and its derivatives: a focus on anti-inflammatory and anti-tumor effects in the digestive system |
| Berberine | Cancer | 4 | PM | 26494507 | 📋 | Berberine and Coptidis Rhizoma as Potential Anticancer Agents: Recent Updates and Future Perspectives |
| Berberine | Cancer | 5 | PM | 26247019 | 📋 | Evaluation of Synergetic Anticancer Activity of Berberine and Curcumin on Different Models of A549, Hep-G2, MCF-7, Jurkat, and K562 Cell Lines |
| Berberine | Cancer | 13 | PM | 24007270 | 📋 | In vitro biological assessment of Berberis vulgaris and its active constituent, berberine: antioxidants, anti-acetylcholinesterase, anti-diabetic and anticancer effects |
| Berberine | Cervical Cancer | 4 | PM | 34776976 | 📋 | Targeting Aberrant Expression of STAT3 and AP-1 Oncogenic Transcription Factors and HPV Oncoproteins in Cervical Cancer by Berberis aquifolium |
| Berberine | Cervical Cancer | 3 | PM | 33045871 | 📋 | Berberine modulates Keratin 17 to inhibit cervical cancer cell viability and metastasis |
| Berberine | Cervical Cancer | 2 | PM | 33011398 | 📋 | Effect of Berberine Associated with Photodynamic Therapy in Cell Lines |
| Berberine | Cervical Cancer | 1 | PM | 28459539 | 📋 | Berberine Induces Toxicity in HeLa Cells Through Perturbation of Microtubule Polymerization by Binding to Tubulin at a Unique Site |
| Berberine | Cervical Cancer | 5 | PM | 22517511 | 📋 | Identification of molecular target proteins in berberine-treated cervix adenocarcinoma HeLa cells by proteomic and bioinformatic analyses |
| Berberine | Chondrosarcoma | 1 | PM | 26168133 | 📋 | Induction of G₂/M Arrest by Berberine via Activation of PI3K/Akt and p38 in Human Chondrosarcoma Cell Line |
| Berberine | Chronic Lymphocytic Leukemia | 2 | PM | 36175700 | 📋 | Anti-tumor effect of berberine on chronic lymphocytic leukemia cells |
| Berberine | Chronic Lymphocytic Leukemia | 1 | PM | 33174291 | 📋 | Apoptotic effect of berberine via Bcl-2, ROR1, and mir-21 in patients with B-chronic lymphocytic leukemia |
| Berberine | Chronic Myeloid Leukemia | 1 | PM | 32098768 | 📋 | Discovery of Berberine That Targetedly Induce Autophagic Degradation of Both BCR-ABL and BCR-ABL T315I Through Recruiting LRSAM1 for Overcoming Imatinib-Resistance |
| Berberine | Cisplatin Toxicity | 7 | PM | 36208663 | 📋 | Insights into the role of P2X7R/DUSP6/ERK1/2 and SIRT2/MDM2 signaling in the nephroprotective effect of berberine against cisplatin-induced renal fibrosis in rats |
| Berberine | Cisplatin Toxicity | 6 | PM | 35427583 | 📋 | Berberis integerrima hydro-alcoholic root extract ant its constituent berberine protect against cisplatin-induced nephro- and hepato-toxicity |
| Berberine | Cisplatin Toxicity | 5 | PM | 35153744 | 📋 | Berberine Alleviate Cisplatin-Induced Peripheral Neuropathy by Modulating Inflammation Signal via TRPV1 |
| Berberine | Cisplatin Toxicity | 4 | PM | 34800260 | 📋 | Protective effect of berberine chloride against cisplatin-induced ototoxicity |
| Berberine | Cisplatin Toxicity | 2 | PM | 33329722 | 📋 | Integrated Analysis of m6A Methylome in Cisplatin-Induced Acute Kidney Injury and Berberine Alleviation in Mouse |
| Berberine | Cisplatin Toxicity | 1 | PM | 32944532 | 📋 | Berberine alleviates cisplatin-induced acute kidney injury by regulating mitophagy via PINK 1/Parkin pathway |
| Berberine | Cisplatin Toxicity | 3 | PM | 32410067 | 📋 | Pretreatment With Berberine Protects Against Cisplatin-Induced Renal Injury in Male Wistar Rats |
| Berberine | Cisplatin Toxicity | 8 | PM | 24025684 | 📋 | Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis |
| Berberine | Colon Cancer | 24 | PM | 38312643 | 📋 | Berberine improved the microbiota in lung tissue of colon cancer and reversed the bronchial epithelial cell changes caused by cancer cells |
| Berberine | Colon Cancer | 23 | PM | 38020547 | 📋 | Study on the mechanism of action of effective monomeric, berberine of Xianglian Pill in inhibiting human colon cancer cells based on fatty acid synthase target |
| Berberine | Colon Cancer | 22 | PM | 37639199 | 📋 | Suppression of colon cancer growth by berberine mediated by the intestinal microbiota and the suppression of DNA methyltransferases (DNMTs) |
| Berberine | Colon Cancer | 17 | PM | 37175233 | 📋 | Berberine Inhibited Growth and Migration of Human Colon Cancer Cell Lines by Increasing Phosphatase and Tensin and Inhibiting Aquaporins 1, 3 and 5 Expressions |
| Berberine | Colon Cancer | 16 | PM | 35837174 | 📋 | c-MYC and HIF1α promoter G-quadruplexes dependent metabolic regulation mechanism of berberine in colon cancer |
| Berberine | Colon Cancer | 15 | PM | 35641094 | 📋 | Berberine suppresses the migration and invasion of colon cancer cells by inhibition of lipogenesis through modulation of promyelocytic leukemia zinc finger-mediated sterol-regulatory element binding proteins cleavage-activating protein ubiquitination |
| Berberine | Colon Cancer | 14 | PM | 35572672 | 📋 | Suppression of Berberine and Probiotics ( in vitro and in vivo) on the Growth of Colon Cancer With Modulation of Gut Microbiota and Butyrate Production |
| Berberine | Colon Cancer | 13 | PM | 35063579 | 📋 | β-catenin correlates with the progression of colon cancers and berberine inhibits the proliferation of colon cancer cells by regulating the β-catenin signaling pathway |
| Berberine | Colon Cancer | 12 | PM | 34028068 | 📋 | Demethyleneberberine promotes apoptosis and suppresses TGF-β/Smads induced EMT in the colon cancer cells HCT-116 |
| Berberine | Colon Cancer | 11 | PM | 33806918 | 📋 | Quantitative Proteomics Analysis of Berberine-Treated Colon Cancer Cells Reveals Potential Therapy Targets |
| Berberine | Colon Cancer | 10 | PM | 33417512 | 📋 | Berberine regulates the Notch1/PTEN/PI3K/AKT/mTOR pathway and acts synergistically with 17-AAG and SAHA in SW480 colon cancer cells |
| Berberine | Colon Cancer | 9 | PM | 32483416 | 📋 | Rescuing Dicer Expression in Inflamed Colon Tissues Alleviates Colitis and Prevents Colitis-Associated Tumorigenesis |
| Berberine | Colon Cancer | 2 | PM | 31874145 | 📋 | Berberine Suppresses Colon Cancer Cell Proliferation by Inhibiting the SCAP/SREBP-1 Signaling Pathway-Mediated Lipogenesis |
| Berberine | Colon Cancer | 4 | PM | 31663444 | 📋 | Berberine and Tinospora cordifolia Exert a Potential Anticancer Effect on Colon Cancer Cells by Acting on Specific Pathways |
| Berberine | Colon Cancer | 6 | PM | 30536375 | 📋 | Berberine Reversed the Epithelial-Mesenchymal Transition of Normal Colonic Epithelial Cells Induced by SW480 Cells Through Regulating the Important Components in the TGF-β Pathway |
| Berberine | Colon Cancer | 20 | PM | 30195873 | 📋 | Coptisine-induced apoptosis in human colon cancer cells (HCT-116) is mediated by PI3K/Akt and mitochondrial-associated apoptotic pathway |
| Berberine | Colon Cancer | 8 | PM | 29938466 | 📋 | Potential Prophylactic Effect of Berberine Against Rat Colon Carcinoma Induce by 1,2-Dimethyl Hydrazine |
| Berberine | Colon Cancer | 5 | PM | 29565467 | 📋 | Berberine Decelerates Glucose Metabolism via Suppression of mTOR‑dependent HIF‑1α Protein Synthesis in Colon Cancer Cells |
| Berberine | Colon Cancer | 7 | PM | 28846104 | 📋 | Berberine Binds RXRα to Suppress β-Catenin Signaling in Colon Cancer Cells |
| Berberine | Colon Cancer | 19 | PM | 24173769 | 📋 | Berberine enhances chemosensitivity to irinotecan in colon cancer via inhibition of NF‑κB |
| Berberine | Colon Cancer | 18 | PM | 24015932 | 📋 | Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling |
| Berberine | Colon Cancer | 3 | PM | 22469784 | 📋 | Berberine Inhibits the Proliferation of Colon Cancer Cells by Inactivating Wnt/β-catenin Signaling |
| Berberine | Colon Cancer | 21 | PM | 21747769 | 📋 | Berberine Reduces cAMP-Induced Chloride Secretion in T84 Human Colonic Carcinoma Cells through Inhibition of Basolateral KCNQ1 Channels |
| Berberine | Colon Cancer | 1 | PM | 21246838 | 📋 | [Preventive Effects of Berberine on Experimental Colon Cancer and Relationship With cyclooxygenase-2 Expression] |
| Berberine | Colorectal Cancer | 39 | PM | 38742849 | 📋 | Berberine: Potential preventive and therapeutic strategies for human colorectal cancer |
| Berberine | Colorectal Cancer | 38 | PM | 38049785 | 📋 | Identification of FtfL as a novel target of berberine in intestinal bacteria |
| Berberine | Colorectal Cancer | 37 | PM | 37757496 | 📋 | Berberine: An inspiring resource for the treatment of colorectal diseases |
| Berberine | Colorectal Cancer | 36 | PM | 37553874 | 📋 | Berberine might block colorectal carcinogenesis by inhibiting the regulation of B-cell function by Veillonella parvula |
| Berberine | Colorectal Cancer | 35 | PM | 37404762 | 📋 | Liquid chromatography-tandem mass spectrometry analysis of a ratio-optimized drug pair of Sophora flavescens Aiton and Coptis chinensis Franch and study on the mechanism of anti-colorectal cancer effect of two alkaloids thereof |
| Berberine | Colorectal Cancer | 32 | PM | 37151876 | 📋 | Berberine inhibits high fat diet-associated colorectal cancer through modulation of the gut microbiota-mediated lysophosphatidylcholine |
| Berberine | Colorectal Cancer | 31 | PM | 37059377 | 📋 | Berberine induces SOCS1 pathway to reprogram the M1 polarization of macrophages via miR-155-5p in colitis-associated colorectal cancer |
| Berberine | Colorectal Cancer | 30 | PM | 37028248 | 📋 | Berberine is a suppressor of Hedgehog signaling cascade in colorectal cancer |
| Berberine | Colorectal Cancer | 29 | PM | 36822301 | 📋 | Berberine promotes IGF2BP3 ubiquitination by TRIM21 to induce G1/S phase arrest in colorectal cancer cells |
| Berberine | Colorectal Cancer | 28 | PM | 36394793 | 📋 | Zinc Acts Synergistically with Berberine for Enhancing Its Efficacy as an Anti-cancer Agent by Inducing Clusterin-Dependent Apoptosis in HT-29 Colorectal Cancer Cells |
| Berberine | Colorectal Cancer | 27 | PM | 36130331 | 📋 | Berberine inhibits tumour growth in vivo and in vitro through suppressing the lincROR-Wnt/β-catenin regulatory axis in colorectal cancer |
| Berberine | Colorectal Cancer | 26 | PM | 35992091 | 📋 | Chemoproteomics reveals berberine directly binds to PKM2 to inhibit the progression of colorectal cancer |
| Berberine | Colorectal Cancer | 25 | PM | 35802997 | 📋 | Berberine inhibited the formation of metastasis by intervening the secondary homing of colorectal cancer cells in the blood circulation to the lung and liver through HEY2 |
| Berberine | Colorectal Cancer | 24 | PM | 35679795 | 📋 | Berberine suppresses colorectal cancer by regulation of Hedgehog signaling pathway activity and gut microbiota |
| Berberine | Colorectal Cancer | 23 | PM | 35660350 | 📋 | Berberine regulates short-chain fatty acid metabolism and alleviates the colitis-associated colorectal tumorigenesis through remodeling intestinal flora |
| Berberine | Colorectal Cancer | 22 | PM | 35600365 | 📋 | Berberine and Oligomeric Proanthocyanidins Exhibit Synergistic Efficacy Through Regulation of PI3K-Akt Signaling Pathway in Colorectal Cancer |
| Berberine | Colorectal Cancer | 21 | PM | 35596224 | 📋 | Berberine inhibits intestinal carcinogenesis by suppressing intestinal pro-inflammatory genes and oncogenic factors through modulating gut microbiota |
| Berberine | Colorectal Cancer | 20 | PM | 35572960 | 📋 | Berberine as a Potential Agent for the Treatment of Colorectal Cancer |
| Berberine | Colorectal Cancer | 19 | PM | 35337060 | 📋 | A Combined Treatment with Berberine and Andrographis Exhibits Enhanced Anti-Cancer Activity through Suppression of DNA Replication in Colorectal Cancer |
| Berberine | Colorectal Cancer | 16 | PM | 35215376 | 📋 | Pre-Administration of Berberine Exerts Chemopreventive Effects in AOM/DSS-Induced Colitis-Associated Carcinogenesis Mice via Modulating Inflammation and Intestinal Microbiota |
| Berberine | Colorectal Cancer | 18 | PM | 34869024 | 📋 | Berberine Suppresses Stemness and Tumorigenicity of Colorectal Cancer Stem-Like Cells by Inhibiting m 6 A Methylation |
| Berberine | Colorectal Cancer | 17 | PM | 34509605 | 📋 | Efficacy and safety of berberine in preventing recurrence of colorectal adenomas: A systematic review and meta-analysis |
| Berberine | Colorectal Cancer | 14 | PM | 33450878 | 📋 | Berberine Inhibits Telomerase Activity and Induces Cell Cycle Arrest and Telomere Erosion in Colorectal Cancer Cell Line, HCT 116 |
| Berberine | Colorectal Cancer | 13 | PM | 33072135 | 📋 | A Holistic View of Berberine Inhibiting Intestinal Carcinogenesis in Conventional Mice Based on Microbiome-Metabolomics Analysis |
| Berberine | Colorectal Cancer | 12 | PM | 32958873 | 📋 | Berberine inhibits colorectal tumor growth by suppressing SHH secretion |
| Berberine | Colorectal Cancer | 11 | PM | 32926933 | 📋 | Berberine inhibits proliferation and induces G0/G1 phase arrest in colorectal cancer cells by downregulating IGF2BP3 |
| Berberine | Colorectal Cancer | 10 | PM | 32109457 | 📋 | Combined Effects of Berberine and Evodiamine on Colorectal Cancer Cells and Cardiomyocytes in Vitro |
| Berberine | Colorectal Cancer | 1 | PM | 31926918 | 📋 | Berberine Versus Placebo for the Prevention of Recurrence of Colorectal Adenoma: A Multicentre, Double-Blinded, Randomised Controlled Study |
| Berberine | Colorectal Cancer | 9 | PM | 31743135 | 📋 | Berberine Inhibits Proliferation and Migration of Colorectal Cancer Cells by Downregulation of GRP78 |
| Berberine | Colorectal Cancer | 15 | PM | 31173223 | 📋 | Long non‑coding RNA CASC2 enhances berberine‑induced cytotoxicity in colorectal cancer cells by silencing BCL2 |
| Berberine | Colorectal Cancer | 6 | PM | 30257361 | 📋 | Effects of Berberine on Tumor Growth and Intestinal Permeability in HCT116 Tumor-Bearing Mice Using Polyamines as Targets |
| Berberine | Colorectal Cancer | 7 | PM | 30205580 | 📋 | The Effects of Berberine on the Gut Microbiota in Apc min/+ Mice Fed With a High Fat Diet |
| Berberine | Colorectal Cancer | 5 | PM | 28759012 | 📋 | Berberine Inhibits Colitis-Associated Tumorigenesis via Suppressing Inflammatory Responses and the Consequent EGFR Signaling-Involved Tumor Cell Growth |
| Berberine | Colorectal Cancer | 3 | PM | 28098901 | 📋 | Effect of Evodiamine and Berberine on the Interaction Between DNMTs and Target microRNAs During Malignant Transformation of the Colon by TGF-β1 |
| Berberine | Colorectal Cancer | 4 | PM | 27493671 | 📋 | Berberine Inhibits Intestinal Polyps Growth in Apc (Min/+) Mice via Regulation of Macrophage Polarization |
| Berberine | Colorectal Cancer | 8 | PM | 26463023 | 📋 | [Effect and Mechanism of EGFR Expression in Macrophages on the Anti-Cancer Effect of Berberine on Colorectal Cancer] |
| Berberine | Colorectal Cancer | 2 | PM | 25954974 | 📋 | Berberine Inhibits Invasion and Metastasis of Colorectal Cancer Cells via COX-2/PGE2 Mediated JAK2/STAT3 Signaling Pathway |
| Berberine | Colorectal Cancer | 33 | PM | 23604974 | 📋 | Berberine inhibits the growth of human colorectal adenocarcinoma in vitro and in vivo |
| Berberine | Colorectal Cancer | 34 | PM | 22193446 | 📋 | [Berberine activates volume-sensitive chloride channel in human colorectal carcinoma cells] |
| Berberine | Endometrial Cancer | 2 | PM | 35876160 | 📋 | Berberine inhibits the development of endometrial cancer through circ_ZNF608/miR-377-3p/COX2 axis |
| Berberine | Endometrial Cancer | 1 | PM | 29864910 | 📋 | Berberine Suppresses Growth and Metastasis of Endometrial Cancer Cells via miR-101/COX-2 |
| Berberine | Esophageal Cancer | 1 | PM | 28465635 | 📋 | Berberine Displays Antitumor Activity in Esophageal Cancer Cells in vitro |
| Berberine | Esophageal Cancer | 2 | PM | 27876206 | 📋 | Synergistic anti-cancer effects of galangin and berberine through apoptosis induction and proliferation inhibition in oesophageal carcinoma cells |
| Berberine | Esophageal Cancer | 4 | PM | 26667771 | 📋 | Role of Berberine on molecular markers involved in migration of esophageal cancer cells |
| Berberine | Esophageal Cancer | 3 | PM | 24025355 | 📋 | Berberine enhances radiosensitivity of esophageal squamous cancer by targeting HIF-1α in vitro and in vivo |
| Berberine | Gastric Cancer | 13 | PM | 36108874 | 📋 | Berberine for gastric cancer prevention and treatment: Multi-step actions on the Correa's cascade underlie its therapeutic effects |
| Berberine | Gastric Cancer | 12 | PM | 35582103 | 📋 | Berberine retarded the growth of gastric cancer xenograft tumors by targeting hepatocyte nuclear factor 4α |
| Berberine | Gastric Cancer | 11 | PM | 35341784 | 📋 | Combination of berberine and low glucose inhibits gastric cancer through the PP2A/GSK3β/MCL-1 signaling pathway |
| Berberine | Gastric Cancer | 10 | PM | 34968467 | 📋 | Berberine inhibits gastric cancer development and progression by regulating the JAK2/STAT3 pathway and downregulating IL-6 |
| Berberine | Gastric Cancer | 9 | PM | 34712379 | 📋 | Berberine Suppresses EMT in Liver and Gastric Carcinoma Cells through Combination with TGF β R Regulating TGF- β/Smad Pathway |
| Berberine | Gastric Cancer | 8 | PM | 34055022 | 📋 | Effects of Berberine on Circular RNA Expression Profiles in Human Gastric Cancer Cells |
| Berberine | Gastric Cancer | 7 | PM | 33362566 | 📋 | Berberine Improves Chemo-Sensitivity to Cisplatin by Enhancing Cell Apoptosis and Repressing PI3K/AKT/mTOR Signaling Pathway in Gastric Cancer |
| Berberine | Gastric Cancer | 6 | PM | 32454290 | 📋 | Berberine Represses Human Gastric Cancer Cell Growth in Vitro and in Vivo by Inducing Cytostatic Autophagy via Inhibition of MAPK/mTOR/p70S6K and Akt Signaling Pathways |
| Berberine | Gastric Cancer | 5 | PM | 32328135 | 📋 | Berberine Suppressed Tumor Growth Through Regulating Fatty Acid Metabolism and Triggering Cell Apoptosis via Targeting FABPs |
| Berberine | Gastric Cancer | 4 | PM | 32277648 | 📋 | Berberine Inhibits Human Gastric Cancer Cell Growth via Deactivation of p38/JNK Pathway, Induction of Mitochondrial-Mediated Apoptosis, Caspase Activation and NF-κB Inhibition |
| Berberine | Gastric Cancer | 2 | PM | 27142767 | 📋 | Berberine Modulates Cisplatin Sensitivity of Human Gastric Cancer Cells by Upregulation of miR-203 |
| Berberine | Gastric Cancer | 1 | PM | 26492225 | 📋 | Berberine and Curcumin Target Survivin and STAT3 in Gastric Cancer Cells and Synergize Actions of Standard Chemotherapeutic 5-Fluorouracil |
| Berberine | Gastric Cancer | 3 | PM | 25045784 | 📋 | Synergistic Inhibitory Effect of Berberine and D-Limonene on Human Gastric Carcinoma Cell Line MGC803 |
| Berberine | Gastric Cancer | 14 | PM | 24063987 | 📋 | Berberine counteracts enhanced IL-8 expression of AGS cells induced by evodiamine |
| Berberine | Gastrointestinal Cancer | 4 | PM | 37047563 | 📋 | Berberine Induces Combined Cell Death in Gastrointestinal Cell Lines |
| Berberine | Gastrointestinal Cancer | 3 | PM | 36915942 | 📋 | The therapeutic effects of berberine for gastrointestinal cancers |
| Berberine | Gastrointestinal Cancer | 2 | PM | 33130557 | 📋 | Berberine represses β-catenin translation involving 4E-BPs in hepatocellular carcinoma cells |
| Berberine | Gastrointestinal Cancer | 1 | PM | 30125974 | 📋 | Berberine: A Potential Adjunct for the Treatment of Gastrointestinal Cancers? |
| Berberine | Gastrointestinal Cancer | 5 | PM | 24279644 | 📋 | Chemopreventive effects of berberine on intestinal tumor development in Apcmin/+ mice |
| Berberine | Glioblastoma | 9 | PM | 35209812 | 📋 | Anticancer mechanisms of Berberine: a good choice for glioblastoma multiforme therapy |
| Berberine | Glioblastoma | 8 | PM | 33298057 | 📋 | Berberine reduces temozolomide resistance by inducing autophagy via the ERK1/2 signaling pathway in glioblastoma |
| Berberine | Glioblastoma | 7 | PM | 32410137 | 📋 | Berberine Induces Apoptosis in Glioblastoma Multiforme U87MG Cells via Oxidative Stress and Independent of AMPK Activity |
| Berberine | Glioblastoma | 4 | PM | 31841506 | 📋 | Combination Treatment of Berberine and Solid Lipid Curcumin Particles Increased Cell Death and Inhibited PI3K/Akt/mTOR Pathway of Human Cultured Glioblastoma Cells More Effectively Than Did Individual Treatments |
| Berberine | Glioblastoma | 2 | PM | 31070539 | 📋 | Berberine Inhibits Angiogenesis in Glioblastoma Xenografts by Targeting the VEGFR2/ERK Pathway |
| Berberine | Glioblastoma | 3 | PM | 27557493 | 📋 | Berberine Induces Autophagy in Glioblastoma by Targeting the AMPK/mTOR/ULK1-pathway |
| Berberine | Glioblastoma | 1 | PM | 25504754 | 📋 | Berberine Induces Senescence of Human Glioblastoma Cells by Downregulating the EGFR-MEK-ERK Signaling Pathway |
| Berberine | Glioblastoma | 6 | PM | 20930370 | 📋 | Berberine-induced Apoptosis in Human Glioblastoma T98G Cells Is Mediated by Endoplasmic Reticulum Stress Accompanying Reactive Oxygen Species and Mitochondrial Dysfunction |
| Berberine | Glioblastoma | 5 | PM | 18379040 | 📋 | Berberine Induces G1 Arrest and Apoptosis in Human Glioblastoma T98G Cells Through Mitochondrial/Caspases Pathway |
| Berberine | Glioma | 5 | PM | 36255058 | 📋 | Berberine Suppressed the Progression of Human Glioma Cells by Inhibiting the TGF-β1/SMAD2/3 Signaling Pathway |
| Berberine | Glioma | 4 | PM | 35944362 | 📋 | Berberine inhibits glioma cell migration and invasion by suppressing TGF-β1/COL11A1 pathway |
| Berberine | Glioma | 3 | PM | 34683083 | 📋 | Berberine Photo-Activation Potentiates Cytotoxicity in Human Astrocytoma Cells through Apoptosis Induction |
| Berberine | Glioma | 2 | PM | 33262612 | 📋 | Berberine Inhibits Cell Proliferation by Interfering with Wild-Type and Mutant P53 in Human Glioma Cells |
| Berberine | Glioma | 6 | PM | 32557203 | 📋 | Therapeutic Potential of Berberine in the Treatment of Glioma: Insights into Its Regulatory Mechanisms |
| Berberine | Glioma | 1 | PM | 31139563 | 📋 | Antitumor Effects of Berberine on Gliomas via Inactivation of Caspase-1-Mediated IL-1β and IL-18 Release |
| Berberine | Head and Neck Cancer | 3 | PM | 38712806 | 📋 | Berberine inhibits the malignant cell phenotype by inactivating PI3K/AKT/mTOR signaling in laryngeal squamous cell carcinoma |
| Berberine | Head and Neck Cancer | 2 | PM | 29460537 | 📋 | Pre-treatment With Berberine Enhances Effect of 5-fluorouracil and Cisplatin in HEP2 Laryngeal Cancer Cell Line |
| Berberine | Head and Neck Cancer | 1 | PM | 26503508 | 📋 | Berberine-induced Anticancer Activities in FaDu Head and Neck Squamous Cell Carcinoma Cells |
| Berberine | Kidney Cancer | 1 | PM | 37033923 | 📋 | Identification of berberine as a potential therapeutic strategy for kidney clear cell carcinoma and COVID-19 based on analysis of large-scale datasets |
| Berberine | Kidney Cancer | 2 | PM | 24002362 | 📋 | Berberine inhibits Wilms' tumor cell progression through upregulation of Wilms' tumor gene on the X chromosome |
| Berberine | Leukemia | 1 | PM | 35331097 | 📋 | Effects of berberine on leukemia with a focus on its molecular targets |
| Berberine | Leukemia | 3 | PM | 31881227 | 📋 | MDM2 Inhibition-Mediated Autophagy Contributes to the Pro-Apoptotic Effect of Berberine in p53-null Leukemic Cells |
| Berberine | Leukemia | 4 | PM | 31061758 | 📋 | Raman Spectrum Spectral Imaging Revealing the Molecular Mechanism of Berberine-induced Jurkat Cell Apoptosis and the Receptor-Mediated Berberine Delivery System |
| Berberine | Leukemia | 6 | PM | 19227007 | 📋 | Inhibition of Progression of Erythroleukemia Induced by Friend Virus in BALB/c Mice by Natural Products--Berberine, Curcumin and Picroliv |
| Berberine | Liver Cancer | 34 | PM | 38750718 | 📋 | Berberine increases the killing effect of pirarubicin on HCC cells by inhibiting ATG4B-autophagy pathway |
| Berberine | Liver Cancer | 33 | PM | 38693042 | 📋 | The potential of the nutraceutical berberine in the treatment of hepatocellular carcinoma and other liver diseases such as NAFLD and NASH |
| Berberine | Liver Cancer | 32 | PM | 38301771 | 📋 | Berberine prevents NAFLD and HCC by modulating metabolic disorders |
| Berberine | Liver Cancer | 31 | PM | 38084140 | 📋 | Inhibition of hepatocellular carcinoma growth via modulation of the miR-221/SOX11 axis by curcumin and berberine |
| Berberine | Liver Cancer | 25 | PM | 37148713 | 📋 | Berberine activates PPARδ and promotes gut microbiota-derived butyric acid to suppress hepatocellular carcinoma |
| Berberine | Liver Cancer | 24 | PM | 36191360 | 📋 | Hepatocellular cancer cell lines, Hep-3B and Hep-G2 display the pleiotropic response to resveratrol and berberine |
| Berberine | Liver Cancer | 23 | PM | 36090480 | 📋 | Berberine inhibits carcinogenesis through antagonizing the ATX-LPA-LPAR2-p38-leptin axis in a mouse hepatoma model |
| Berberine | Liver Cancer | 22 | PM | 34787617 | 📋 | Antiproliferative activity of berberine in HepG2 cells via inducing apoptosis and arresting cell cycle |
| Berberine | Liver Cancer | 21 | PM | 34712379 | 📋 | Berberine Suppresses EMT in Liver and Gastric Carcinoma Cells through Combination with TGF β R Regulating TGF- β/Smad Pathway |
| Berberine | Liver Cancer | 20 | PM | 34460138 | 📋 | A novel combined resveratrol/berberine phytochemotheraputic using the HePG2 cell line as a model for the treatment of hepatocarcinoma |
| Berberine | Liver Cancer | 19 | PM | 34395446 | 📋 | Probing Synergistic Targets by Natural Compounds for Hepatocellular Carcinoma |
| Berberine | Liver Cancer | 18 | PM | 34220494 | 📋 | Berberine Sensitizes Human Hepatoma Cells to Regorafenib via Modulating Expression of Circular RNAs |
| Berberine | Liver Cancer | 17 | PM | 33130557 | 📋 | Berberine represses β-catenin translation involving 4E-BPs in hepatocellular carcinoma cells |
| Berberine | Liver Cancer | 29 | PM | 32815562 | 📋 | Berberine, a natural alkaloid sensitizes human hepatocarcinoma to ionizing radiation by blocking autophagy and cell cycle arrest resulting in senescence |
| Berberine | Liver Cancer | 16 | PM | 32606742 | 📋 | Berberine Inhibits the Apoptosis-Induced Metastasis by Suppressing the iPLA2/LOX-5/LTB4 Pathway in Hepatocellular Carcinoma |
| Berberine | Liver Cancer | 15 | PM | 32276448 | 📋 | Targeting Autophagy Augments BBR-Mediated Cell Death in Human Hepatoma Cells Harboring Hepatitis C Virus RNA |
| Berberine | Liver Cancer | 2 | PM | 32021249 | 📋 | Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake |
| Berberine | Liver Cancer | 11 | PM | 31545468 | 📋 | Exploring the Active Mechanism of Berberine Against HCC by Systematic Pharmacology and Experimental Validation |
| Berberine | Liver Cancer | 4 | PM | 31217846 | 📋 | Berberine Prevents Non-Alcoholic Steatohepatitis-Derived Hepatocellular Carcinoma by Inhibiting Inflammation and Angiogenesis in Mice |
| Berberine | Liver Cancer | 3 | PM | 30565332 | 📋 | Synergistic Effect of Berberine and HMQ1611 Impairs Cell Proliferation and Migration by Regulating Wnt Signaling Pathway in Hepatocellular Carcinoma |
| Berberine | Liver Cancer | 10 | PM | 30015938 | 📋 | Berberine, a Natural Plant Alkaloid, Synergistically Sensitizes Human Liver Cancer Cells to Sorafenib |
| Berberine | Liver Cancer | 6 | PM | 29626488 | 📋 | Berberine Induced Modulation of PHLPP2-Akt-MST1 Kinase Signaling Is Coupled With Mitochondrial Impairment and Hepatoma Cell Death |
| Berberine | Liver Cancer | 5 | PM | 29360760 | 📋 | Regulation of Akt/FoxO3a/Skp2 Axis Is Critically Involved in Berberine-Induced Cell Cycle Arrest in Hepatocellular Carcinoma Cells |
| Berberine | Liver Cancer | 7 | PM | 28572744 | 📋 | Berberine Regulates the Protein Expression of Multiple Tumorigenesis-Related Genes in Hepatocellular Carcinoma Cell Lines |
| Berberine | Liver Cancer | 8 | PM | 28277195 | 📋 | Induction of Apoptosis by Berberine in Hepatocellular Carcinoma HepG2 Cells via Downregulation of NF-κB |
| Berberine | Liver Cancer | 14 | PM | 27854312 | 📋 | Berberine Suppresses Cyclin D1 Expression Through Proteasomal Degradation in Human Hepatoma Cells |
| Berberine | Liver Cancer | 9 | PM | 27311637 | 📋 | Antiproliferation of Berberine Is Mediated by Epigenetic Modification of Constitutive Androstane Receptor (CAR) Metabolic Pathway in Hepatoma Cells |
| Berberine | Liver Cancer | 13 | PM | 27092498 | 📋 | Up-Regulation of PAI-1 and Down-Regulation of uPA Are Involved in Suppression of Invasiveness and Motility of Hepatocellular Carcinoma Cells by a Natural Compound Berberine |
| Berberine | Liver Cancer | 28 | PM | 23999088 | 📋 | Berberine and S allyl cysteine mediated amelioration of DEN+CCl4 induced hepatocarcinoma |
| Berberine | Liver Cancer | 27 | PM | 23784371 | 📋 | Berberine induces apoptosis via the mitochondrial pathway in liver cancer cells |
| Berberine | Liver Cancer | 26 | PM | 23732865 | 📋 | Berberine induces selective apoptosis through the AMPK‑mediated mitochondrial/caspase pathway in hepatocellular carcinoma |
| Berberine | Liver Cancer | 30 | PM | 21443647 | 📋 | Berberine induces cell death in human hepatoma cells in vitro by downregulating CD147 |
| Berberine | Liver Cancer | 12 | PM | 19724899 | 📋 | Coptis Chinensis Inhibits Hepatocellular Carcinoma Cell Growth Through Nonsteroidal Anti-Inflammatory Drug-Activated Gene Activation |
| Berberine | Liver Cancer | 1 | PM | 19408145 | 📋 | Berbamine Induces Fas-mediated Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells and Inhibits Its Tumor Growth in Nude Mice |
| Berberine | Lung Cancer | 22 | PM | 38067530 | 📋 | Synergistic Inhibitory Effect of Berberine and Low-Temperature Plasma on Non-Small-Cell Lung Cancer Cells via PI3K-AKT-Driven Signaling Axis |
| Berberine | Lung Cancer | 21 | PM | 37938194 | 📋 | Identification of Autophagy-Related Targets of Berberine against Non-Small Cell Lung Cancer and Their Correlation with Immune Cell Infiltration By Combining Network Pharmacology, Molecular Docking, and Experimental Verification |
| Berberine | Lung Cancer | 20 | PM | 37070571 | 📋 | Berberine targets KIF20A and CCNE2 to inhibit the progression of nonsmall cell lung cancer via the PI3K/AKT pathway |
| Berberine | Lung Cancer | 19 | PM | 36359829 | 📋 | Multi-Target Potential of Berberine as an Antineoplastic and Antimetastatic Agent: A Special Focus on Lung Cancer Treatment |
| Berberine | Lung Cancer | 18 | PM | 35764017 | 📋 | Berberine regulates PADI4-related macrophage function to prevent lung cancer |
| Berberine | Lung Cancer | 16 | PM | 35571453 | 📋 | Berberine induces non-small cell lung cancer apoptosis via the activation of the ROS/ASK1/JNK pathway |
| Berberine | Lung Cancer | 15 | PM | 35173608 | 📋 | Berberine Inhibits FOXM1 Dependent Transcriptional Regulation of POLE2 and Interferes With the Survival of Lung Adenocarcinoma |
| Berberine | Lung Cancer | 14 | PM | 34826601 | 📋 | The natural product berberine synergizes with osimertinib preferentially against MET-amplified osimertinib-resistant lung cancer via direct MET inhibition |
| Berberine | Lung Cancer | 13 | PM | 34743246 | 📋 | Synergistic inhibitory effect of berberine and icotinib on non-small cell lung cancer cells via inducing autophagic cell death and apoptosis |
| Berberine | Lung Cancer | 12 | PM | 34448246 | 📋 | Berberine inhibits non-small cell lung cancer cell growth through repressing DNA repair and replication rather than through apoptosis |
| Berberine | Lung Cancer | 11 | PM | 32607786 | 📋 | Berberine Chloride Suppresses Non-Small Cell Lung Cancer by Deregulating Sin3A/TOP2B Pathway in Vitro and in Vivo |
| Berberine | Lung Cancer | 2 | PM | 32248643 | 📋 | Novel Regulation of miR-34a-5p and HOTAIR by the Combination of Berberine and Gefitinib Leading to Inhibition of EMT in Human Lung Cancer |
| Berberine | Lung Cancer | 7 | PM | 31978448 | 📋 | Berberine Induces Dose-Dependent Quiescence and Apoptosis in A549 Cancer Cells by Modulating Cell Cyclins and Inflammation Independent of mTOR Pathway |
| Berberine | Lung Cancer | 6 | PM | 31695492 | 📋 | Berberine Induces Apoptosis in Non-Small-Cell Lung Cancer Cells by Upregulating miR-19a Targeting Tissue Factor |
| Berberine | Lung Cancer | 4 | PM | 29725453 | 📋 | Berberine Hydrochloride Inhibits Cell Proliferation and Promotes Apoptosis of Non-Small Cell Lung Cancer via the Suppression of the MMP2 and Bcl-2/Bax Signaling Pathways |
| Berberine | Lung Cancer | 3 | PM | 29100319 | 📋 | Berberine and Cinnamaldehyde Together Prevent Lung Carcinogenesis |
| Berberine | Lung Cancer | 17 | PM | 28840963 | 📋 | The enhancement of combination of berberine and metformin in inhibition of DNMT1 gene expression through interplay of SP1 and PDPK1 |
| Berberine | Lung Cancer | 9 | PM | 26672764 | 📋 | Melatonin Inhibits AP-2β/hTERT, NF-κB/COX-2 and Akt/ERK and Activates caspase/Cyto C Signaling to Enhance the Antitumor Activity of Berberine in Lung Cancer Cells |
| Berberine | Lung Cancer | 5 | PM | 26503561 | 📋 | Berberine Increases Doxorubicin Sensitivity by Suppressing STAT3 in Lung Cancer |
| Berberine | Lung Cancer | 8 | PM | 26452787 | 📋 | Quantitative Evaluation of Berberine Subcellular Distribution and Cellular Accumulation in Non-Small Cell Lung Cancer Cells by UPLC-MS/MS |
| Berberine | Lung Cancer | 1 | PM | 24992757 | 📋 | Effect of Berberine on Activity and mRNA Expression of N-acetyltransferase in Human Lung Cancer Cell Line A549 |
| Berberine | Lung Cancer | 10 | PM | 23869238 | 📋 | Berberine Targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth |
| Berberine | Lymphoma | 1 | PM | 33930347 | 📋 | Berberine exerts anti-tumor activity in diffuse large B-cell lymphoma by modulating c-myc/CD47 axis |
| Berberine | Melanoma | 10 | PM | 35853472 | 📋 | Berberine Induces Autophagic Cell Death by Inactivating the Akt/mTOR Signaling Pathway |
| Berberine | Melanoma | 9 | PM | 34860319 | 📋 | Berberine increases the expression of cytokines and proteins linked to apoptosis in human melanoma cells |
| Berberine | Melanoma | 8 | PM | 33751936 | 📋 | Berberine-photodynamic induced apoptosis by activating endoplasmic reticulum stress-autophagy pathway involving CHOP in human malignant melanoma cells |
| Berberine | Melanoma | 7 | PM | 33716044 | 📋 | Berberine-photodynamic therapy sensitizes melanoma cells to cisplatin-induced apoptosis through ROS-mediated P38 MAPK pathways |
| Berberine | Melanoma | 6 | PM | 32915362 | 📋 | Cell Cycle Regulation by Berberine in Human Melanoma A375 Cells |
| Berberine | Melanoma | 1 | PM | 32229284 | 📋 | Development and In-Vitro Evaluation of Co-Loaded Berberine Chloride and Evodiamine Ethosomes for Treatment of Melanoma |
| Berberine | Melanoma | 2 | PM | 30104528 | 📋 | Berberine Inhibits Human Melanoma A375.S2 Cell Migration and Invasion via Affecting the FAK, uPA, and NF-κB Signaling Pathways and Inhibits PLX4032 Resistant A375.S2 Cell Migration In Vitro |
| Berberine | Melanoma | 14 | PM | 29724298 | 📋 | Inhibitory effect of berberine from Coptidis rhizoma on melanin synthesis of murine malignant melanoma |
| Berberine | Melanoma | 5 | PM | 28729227 | 📋 | Computational and Experimental Prediction of Molecules Involved in the Anti-Melanoma Action of Berberine |
| Berberine | Melanoma | 11 | PM | 24176840 | 📋 | Berberine in combination with doxorubicin suppresses growth of murine melanoma B16F10 cells in culture and xenograft |
| Berberine | Melanoma | 13 | PM | 22120676 | 📋 | Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression |
| Berberine | Melanoma | 3 | PM | 21953764 | 📋 | Berberine Inhibits Pulmonary Metastasis Through Down-Regulation of MMP in Metastatic B16F-10 Melanoma Cells |
| Berberine | Melanoma | 12 | PM | 21527846 | 📋 | Involvement of mitochondrial and B-RAF/ERK signaling pathways in berberine-induced apoptosis in human melanoma cells |
| Berberine | Melanoma | 4 | PM | 17661039 | 📋 | Different Concentrations of Berberine Result in Distinct Cellular Localization Patterns and Cell Cycle Effects in a Melanoma Cell Line |
| Berberine | Mesothelioma | 1 | PM | 30272347 | 📋 | Berberine Induces Mitochondrial‑mediated Apoptosis and Protective Autophagy in Human Malignant Pleural Mesothelioma NCI‑H2452 Cells |
| Berberine | Multiple Myeloma | 2 | PM | 35794284 | 📋 | Discovery of the oncogenic MDM2, a direct binding target of berberine and a potential therapeutic, in multiple myeloma |
| Berberine | Multiple Myeloma | 1 | PM | 32213189 | 📋 | Identification of Berberine as a Novel Drug for the Treatment of Multiple Myeloma via Targeting UHRF1 |
| Berberine | Nasopharyngeal Cancer | 7 | PM | 38213727 | 📋 | Berberine-mediated Ferroptosis through System Xc-/GSH/GPX4 Axis Inhibits Metastasis of Nasopharyngeal Carcinoma |
| Berberine | Nasopharyngeal Cancer | 3 | PM | 28350122 | 📋 | Berberine Sensitizes Nasopharyngeal Carcinoma Cells to Radiation Through Inhibition of Sp1 and EMT |
| Berberine | Nasopharyngeal Cancer | 1 | PM | 28259949 | 📋 | Berberine Inhibits the Proliferation of Human Nasopharyngeal Carcinoma Cells via an Epstein-Barr Virus Nuclear Antigen 1-dependent Mechanism |
| Berberine | Nasopharyngeal Cancer | 6 | PM | 24641420 | 📋 | Berberine hydrochloride impact on physiological processes and modulation of twist levels in nasopharyngeal carcinoma CNE-1 cells |
| Berberine | Nasopharyngeal Cancer | 5 | PM | 24380387 | 📋 | Berberine suppresses tumorigenicity and growth of nasopharyngeal carcinoma cells by inhibiting STAT3 activation induced by tumor associated fibroblasts |
| Berberine | Nasopharyngeal Cancer | 4 | PM | 24325635 | 📋 | Berberine radiosensitizes human nasopharyngeal carcinoma by suppressing hypoxia-inducible factor-1α expression |
| Berberine | Nasopharyngeal Cancer | 2 | PM | 19513545 | 📋 | Berberine Inhibits Rho GTPases and Cell Migration at Low Doses but Induces G2 Arrest and Apoptosis at High Doses in Human Cancer Cells |
| Berberine | Neuroblastoma | 3 | PM | 32855766 | 📋 | Beta-Blockers and Berberine: A Possible Dual Approach to Contrast Neuroblastoma Growth and Progression |
| Berberine | Neuroblastoma | 2 | PM | 27235712 | 📋 | Berberine Induces Neuronal Differentiation Through Inhibition of Cancer Stemness and Epithelial-Mesenchymal Transition in Neuroblastoma Cells |
| Berberine | Neuroblastoma | 1 | PM | 19189664 | 📋 | Berberine Inhibits Human Neuroblastoma Cell Growth Through Induction of p53-dependent Apoptosis |
| Berberine | Oral Cancer | 1 | PM | 29113353 | 📋 | Berberine-targeted miR-21 Chemosensitizes Oral Carcinomas Stem Cells |
| Berberine | Ovarian Cancer | 8 | PM | 36685297 | 📋 | Berberine enhances the sensitivity of radiotherapy in ovarian cancer cell line (SKOV-3) |
| Berberine | Ovarian Cancer | 7 | PM | 33482182 | 📋 | Berberine inhibits chemotherapy-exacerbated ovarian cancer stem cell-like characteristics and metastasis through GLI1 |
| Berberine | Ovarian Cancer | 6 | PM | 33407764 | 📋 | Berberine inhibited metastasis through miR-145/MMP16 axis in vitro |
| Berberine | Ovarian Cancer | 5 | PM | 33391417 | 📋 | Berberine inhibits the Warburg effect through TET3/miR-145/HK2 pathways in ovarian cancer cells |
| Berberine | Ovarian Cancer | 4 | PM | 33325633 | 📋 | Dual down-regulation of EGFR and ErbB2 by berberine contributes to suppression of migration and invasion of human ovarian cancer cells |
| Berberine | Ovarian Cancer | 2 | PM | 31319879 | 📋 | Berberine in Combination With Cisplatin Induces Necroptosis and Apoptosis in Ovarian Cancer Cells |
| Berberine | Ovarian Cancer | 1 | PM | 28990249 | 📋 | Berberine Inhibits the Chemotherapy-Induced Repopulation by Suppressing the Arachidonic Acid Metabolic Pathway and Phosphorylation of FAK in Ovarian Cancer |
| Berberine | Ovarian Cancer | 3 | PM | 28981112 | 📋 | Berberine Induces Oxidative DNA Damage and Impairs Homologous Recombination Repair in Ovarian Cancer Cells to Confer Increased Sensitivity to PARP Inhibition |
| Berberine | Ovarian Cancer | 10 | PM | 23903781 | 📋 | Modulation of the expression of folate cycle enzymes and polyamine metabolism by berberine in cisplatin-sensitive and -resistant human ovarian cancer cells |
| Berberine | Ovarian Cancer | 9 | PM | 23824073 | 📋 | Berberine sensitizes ovarian cancer cells to cisplatin through miR-21/PDCD4 axis |
| Berberine | Pancreatic Cancer | 8 | PM | 38502348 | 📋 | Berberine chloride suppresses pancreatic adenocarcinoma proliferation and growth by targeting inflammation-related genes: an in silico analysis with in vitro and vivo validation |
| Berberine | Pancreatic Cancer | 7 | PM | 36500723 | 📋 | Effects of Berberine against Pancreatitis and Pancreatic Cancer |
| Berberine | Pancreatic Cancer | 6 | PM | 36297310 | 📋 | Berberine Overcomes Gemcitabine-Associated Chemoresistance through Regulation of Rap1/PI3K-Akt Signaling in Pancreatic Ductal Adenocarcinoma |
| Berberine | Pancreatic Cancer | 5 | PM | 35784732 | 📋 | Berberine Suppresses Lung Metastasis of Cancer via Inhibiting Endothelial Transforming Growth Factor Beta Receptor 1 |
| Berberine | Pancreatic Cancer | 4 | PM | 34890544 | 📋 | Berberine inhibits pancreatic intraepithelial neoplasia by inhibiting glycolysis via the adenosine monophosphate -activated protein kinase pathway |
| Berberine | Pancreatic Cancer | 3 | PM | 34185423 | 📋 | Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression |
| Berberine | Pancreatic Cancer | 2 | PM | 32692565 | 📋 | Cell metabolomics reveal berberine inhibited pancreatic cancer cell viability and metastasis by regulating citrate metabolism |
| Berberine | Pancreatic Cancer | 1 | PM | 20455200 | 📋 | Berberine Inhibits Cell Growth and Mediates Caspase-Independent Cell Death in Human Pancreatic Cancer Cells |
| Berberine | Prostate Cancer | 3 | PM | 29029409 | 📋 | Metabolic characterization and pathway analysis of berberine protects against prostate cancer |
| Berberine | Prostate Cancer | 1 | PM | 26698234 | 📋 | Berberine Inhibits Androgen Synthesis by Interaction With Aldo-Keto Reductase 1C3 in 22Rv1 Prostate Cancer Cells |
| Berberine | Prostate Cancer | 5 | PM | 25394789 | 📋 | Berberine targets epidermal growth factor receptor signaling to suppress prostate cancer proliferation in vitro |
| Berberine | Prostate Cancer | 4 | PM | 21613449 | 📋 | Berberine suppresses androgen receptor signaling in prostate cancer |
| Berberine | Prostate Cancer | 2 | PM | 16505103 | 📋 | Berberine, a Natural Product, Induces G1-phase Cell Cycle Arrest and caspase-3-dependent Apoptosis in Human Prostate Carcinoma Cells |
| Berberine | Renal Cell Carcinoma | 2 | PM | 37217616 | 📋 | Berberine inhibits the progression of renal cell carcinoma cells by regulating reactive oxygen species generation and inducing DNA damage |
| Berberine | Renal Cell Carcinoma | 1 | PM | 31874443 | 📋 | Berberine Associated Photodynamic Therapy Promotes Autophagy and Apoptosis via ROS Generation in Renal Carcinoma Cells |
| Berberine | Retinoblastoma | 1 | PM | 29790698 | 📋 | Inhibition of Migration and Invasion by Berberine via Inactivation of PI3K/Akt and p38 in Human Retinoblastoma Cell Line |
| Berberine | Squamous Cell Carcinoma | 1 | PM | 30950357 | 📋 | Effects of Resveratrol, Berberine and Their Combinations on Reactive Oxygen Species, Survival and Apoptosis in Human Squamous Carcinoma (SCC-25) Cells |
| Berberine | Thyroid Cancer | 3 | PM | 37397788 | 📋 | Antitumor Activity of Berberine by Activating Autophagy and Apoptosis in CAL-62 and BHT-101 Anaplastic Thyroid Carcinoma Cell Lines |
| Berberine | Thyroid Cancer | 2 | PM | 28931215 | 📋 | Berberine could inhibit thyroid carcinoma cells by inducing mitochondrial apoptosis, G0/G1 cell cycle arrest and suppressing migration via PI3K-AKT and MAPK signaling pathways |
| Berberine | Thyroid Cancer | 1 | PM | 26307103 | 📋 | Selective Repression of RET Proto-Oncogene in Medullary Thyroid Carcinoma by a Natural Alkaloid Berberine |
| Berberine | Tongue Cancer | 1 | PM | 19303753 | 📋 | Berberine Inhibits Human Tongue Squamous Carcinoma Cancer Tumor Growth in a Murine Xenograft Model |
