| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Vitamin C | Aging Brain | 5 | PM | 34515324 | 📋 | Reversal of brain aging by targeting telomerase: A nutraceutical approach |
| Vitamin C | Aging Brain | 4 | PM | 34229598 | 📋 | Age and Dietary Vitamin C Intake Affect Brain Physiology in Genetically Modified Mice Expressing Human Lipoprotein(A) and Unable to Synthesize Vitamin C |
| Vitamin C | Aging Brain | 3 | PM | 33562628 | 📋 | Chronic Treatment of Ascorbic Acid Leads to Age-Dependent Neuroprotection against Oxidative Injury in Hippocampal Slice Cultures |
| Vitamin C | Aging Brain | 1 | PM | 30650605 | 📋 | Ascorbic Acid Mitigates D-galactose-Induced Brain Aging by Increasing Hippocampal Neurogenesis and Improving Memory Function |
| Vitamin C | Aging Brain | 2 | PM | 22366772 | 📋 | A critical review of vitamin C for the prevention of age-related cognitive decline and Alzheimer's disease |
| Vitamin C | Alzheimer's Disease | 11 | PM | 37537932 | 📋 | Therapeutic Potential of Ascorbic Acid in the Management of Alzheimer's Disease: An Update |
| Vitamin C | Alzheimer's Disease | 10 | PM | 36158537 | 📋 | A quantitative meta-analysis of vitamin C in the pathophysiology of Alzheimer's disease |
| Vitamin C | Alzheimer's Disease | 9 | PM | 36144245 | 📋 | LC-MS/MS Insight into Vitamin C Restoration to Metabolic Disorder Evoked by Amyloid β in Caenorhabditis elegans CL2006 |
| Vitamin C | Alzheimer's Disease | 7 | PM | 34537655 | 📋 | The impact of plasma vitamin C levels on the risk of cardiovascular diseases and Alzheimer's disease: A Mendelian randomization study |
| Vitamin C | Alzheimer's Disease | 1 | PM | 32218327 | 📋 | Schisandra Extract and Ascorbic Acid Synergistically Enhance Cognition in Mice Through Modulation of Mitochondrial Respiration |
| Vitamin C | Alzheimer's Disease | 5 | PM | 30074145 | 📋 | Preventive and Therapeutic Potential of Vitamin C in Mental Disorders |
| Vitamin C | Alzheimer's Disease | 6 | PM | 29596935 | 📋 | Inhibition of amyloid fibril formation of lysozyme by ascorbic acid and a probable mechanism of action |
| Vitamin C | Alzheimer's Disease | 2 | PM | 28192749 | 📋 | Ascorbic acid ameliorates behavioural deficits and neuropathological alterations in rat model of Alzheimer's disease |
| Vitamin C | Alzheimer's Disease | 4 | PM | 27665568 | 📋 | Dual Role of Vitamin C on the Neuroinflammation Mediated Neurodegeneration and Memory Impairments in Colchicine Induced Rat Model of Alzheimer Disease |
| Vitamin C | Alzheimer's Disease | 3 | PM | 24577081 | 📋 | High-dose of vitamin C supplementation reduces amyloid plaque burden and ameliorates pathological changes in the brain of 5XFAD mice |
| Vitamin C | Alzheimer's Disease | 8 | PM | 22366772 | 📋 | A critical review of vitamin C for the prevention of age-related cognitive decline and Alzheimer's disease |
| Vitamin C | Brain Inflammation | 1 | PM | 32224930 | 📋 | A Cecal Slurry Mouse Model of Sepsis Leads to Acute Consumption of Vitamin C in the Brain |
| Vitamin C | Brain Inflammation | 2 | PM | 30388518 | 📋 | Vitamin C alleviates LPS-induced cognitive impairment in mice by suppressing neuroinflammation and oxidative stress |
| Vitamin C | Brain Inflammation | 3 | PM | 27665568 | 📋 | Dual Role of Vitamin C on the Neuroinflammation Mediated Neurodegeneration and Memory Impairments in Colchicine Induced Rat Model of Alzheimer Disease |
| Vitamin C | Brain Inflammation | 4 | PM | 26831257 | 📋 | Neuroprotection by Vitamin C Against Ethanol-Induced Neuroinflammation Associated Neurodegeneration in the Developing Rat Brain |
| Vitamin C | Brain Tumor | 1 | PM | 35967781 | 📋 | Association between vitamins and risk of brain tumors: A systematic review and dose-response meta-analysis of observational studies |
| Vitamin C | Cerebral Ischemia | 2 | PM | 35306630 | 📋 | High-Dose Vitamin C Prevents Secondary Brain Damage After Stroke via Epigenetic Reprogramming of Neuroprotective Genes |
| Vitamin C | Cerebral Ischemia | 1 | PM | 32450129 | 📋 | Therapeutic treatment with vitamin C reduces focal cerebral ischemia-induced brain infarction in rats by attenuating disruptions of blood brain barrier and cerebral neuronal apoptosis |
| Vitamin C | Cognitive Disorders | 10 | PM | 38718917 | 📋 | Ascorbic acid supplementation improves adolescent stress-induced cognitive impairment through restoration of behavioral, biochemical and electrophysiological alterations in male rats |
| Vitamin C | Cognitive Disorders | 7 | PM | 34267240 | 📋 | Protective effects and mechanisms of high-dose vitamin C on sepsis-associated cognitive impairment in rats |
| Vitamin C | Cognitive Disorders | 6 | PM | 32977491 | 📋 | Positive Association of Ascorbate and Inverse Association of Urate with Cognitive Function in People with Parkinson's Disease |
| Vitamin C | Cognitive Disorders | 5 | PM | 30572228 | 📋 | Ascorbic acid attenuates cognitive impairment and brain oxidative stress in ovariectomized mice |
| Vitamin C | Cognitive Disorders | 3 | PM | 30388518 | 📋 | Vitamin C alleviates LPS-induced cognitive impairment in mice by suppressing neuroinflammation and oxidative stress |
| Vitamin C | Cognitive Disorders | 1 | PM | 29758939 | 📋 | Higher Blood Vitamin C Levels are Associated with Reduction of Apolipoprotein E E4-related Risks of Cognitive Decline in Women: The Nakajima Study |
| Vitamin C | Cognitive Disorders | 4 | PM | 28078842 | 📋 | Remission effect of vitamin C on isoflurane-induced apoptosis and its mechanism |
| Vitamin C | Cognitive Disorders | 2 | PM | 27387089 | 📋 | Beneficial effects of garlic on learning and memory deficits and brain tissue damages induced by lead exposure during juvenile rat growth is comparable to the effect of ascorbic acid |
| Vitamin C | Cognitive Disorders | 8 | PM | 24678261 | 📋 | The ameliorative effect of ascorbic acid and Ginkgo biloba on learning and memory deficits associated with fluoride exposure |
| Vitamin C | Cognitive Disorders | 9 | PM | 24081631 | 📋 | Protective effect of ascorbic acid and Ginkgo biloba against learning and memory deficits caused by fluoride |
| Vitamin C | Cognitive Performance | 4 | PM | 34476568 | 📋 | Vitamin C supplementation promotes mental vitality in healthy young adults: results from a cross-sectional analysis and a randomized, double-blind, placebo-controlled trial |
| Vitamin C | Cognitive Performance | 5 | PM | 33719957 | 📋 | Concentration-dependent Effects of Dietary L-Ascorbic Acid Fortification in the Brains of Healthy Mice |
| Vitamin C | Cognitive Performance | 2 | PM | 32337476 | 📋 | Gender Differences in Plasma Vitamin C Concentrations and Cognitive Function: A Pilot Cross-Sectional Study in Healthy Adults |
| Vitamin C | Cognitive Performance | 1 | PM | 31191268 | 📋 | Improvement in Cognition Following Double-Blind Randomized Micronutrient Interventions in the General Population |
| Vitamin C | Cognitive Performance | 3 | PM | 29172882 | 📋 | Feeding Vitamin C during Neonatal and Juvenile Growth Improves Learning and Memory of Rats |
| Vitamin C | Depression | 15 | PM | 38710330 | 📋 | Association of dietary vitamin C intake with depression in adults: A cross-sectional study of NHANES from 2005 to 2020 |
| Vitamin C | Depression | 14 | PM | 38344022 | 📋 | Higher serum ascorbic acid levels are associated with lower depression prevalence in US adults: a case-control study |
| Vitamin C | Depression | 13 | PM | 37375593 | 📋 | Vitamins C and D Exhibit Similar Antidepressant Effects to Escitalopram Mediated by NOx and FKBPL in a Stress-Induced Mice Model |
| Vitamin C | Depression | 12 | PM | 36261067 | 📋 | From Antioxidant to Neuromodulator: The Role of Ascorbate in The Management of Major Depression Disorder |
| Vitamin C | Depression | 11 | PM | 35464032 | 📋 | Associations of Dietary Vitamin C and E Intake With Depression. A Meta-Analysis of Observational Studies |
| Vitamin C | Depression | 3 | PM | 34825298 | 📋 | Antidepressant Like Effect of Ascorbic Acid in Mice: Possible Involvement of NO-sGC-cGMP Signaling |
| Vitamin C | Depression | 10 | PM | 33885252 | 📋 | Vitamin C protects against chronic social isolation stress-induced weight gain and depressive-like behavior in adult male rats |
| Vitamin C | Depression | 9 | PM | 33872575 | 📋 | A single administration of ascorbic acid rapidly reverses depressive-like behavior and hippocampal synaptic dysfunction induced by corticosterone in mice |
| Vitamin C | Depression | 2 | PM | 32745879 | 📋 | The role of vitamin C in stress-related disorders |
| Vitamin C | Depression | 1 | PM | 31476335 | 📋 | Ascorbic Acid Presents Rapid Behavioral and Hippocampal Synaptic Plasticity Effects |
| Vitamin C | Depression | 8 | PM | 31443769 | 📋 | The sour side of vitamin C might mediate neuroprotective, anticonvulsive and antidepressant-like effects |
| Vitamin C | Depression | 6 | PM | 30399569 | 📋 | Ascorbic acid therapy: A potential strategy against comorbid depression-like behavior in streptozotocin-nicotinamide-induced diabetic rats |
| Vitamin C | Depression | 7 | PM | 30074145 | 📋 | Preventive and Therapeutic Potential of Vitamin C in Mental Disorders |
| Vitamin C | Depression | 4 | PM | 29222646 | 📋 | Evidence for the involvement of opioid system in the antidepressant-like effect of ascorbic acid |
| Vitamin C | Depression | 5 | PM | 28827076 | 📋 | Metformin and ascorbic acid combination therapy ameliorates type 2 diabetes mellitus and comorbid depression in rats |
| Vitamin C | Encephalitis | 1 | PM | 26168898 | 📋 | Melatonin, minocycline and ascorbic acid reduce oxidative stress and viral titers and increase survival rate in experimental Venezuelan equine encephalitis |
| Vitamin C | Glioblastoma | 5 | PM | 35368869 | 📋 | Combination of Ascorbic Acid and Menadione Induces Cytotoxic Autophagy in Human Glioblastoma Cells |
| Vitamin C | Glioblastoma | 4 | PM | 34136195 | 📋 | Antioxidant vitamins promote anticancer effects on low-concentration methotrexate-treated glioblastoma cells via enhancing the caspase-3 death pathway |
| Vitamin C | Glioblastoma | 3 | PM | 33955499 | 📋 | Parenteral high‑dose ascorbate - A possible approach for the treatment of glioblastoma (Review) |
| Vitamin C | Glioblastoma | 2 | PM | 31306660 | 📋 | High doses of sodium ascorbate interfere with the expansion of glioblastoma multiforme cells in vitro and in vivo |
| Vitamin C | Glioblastoma | 1 | PM | 27031721 | 📋 | A Nutrient Mixture Inhibits Glioblastoma Xenograft U-87 MG Growth in Male Nude Mice |
| Vitamin C | Glioma | 4 | PM | 34812147 | 📋 | Vitamin C through upregulating SYNPO2 level suppresses the proliferation and migration of glioma cells |
| Vitamin C | Glioma | 2 | PM | 33719269 | 📋 | [Toxic effects of Vitamin C combined with temozolomide on glioma cells and its mechanism] |
| Vitamin C | Glioma | 3 | PM | 28528571 | 📋 | Induction Effect to Apoptosis by Maitake Polysaccharide: Synergistic Effect of Its Combination With Vitamin C in Neuroglioma Cell |
| Vitamin C | Glioma | 1 | PM | 28163212 | 📋 | Exogenous vitamin C boosts the antitumor efficacy of paclitaxel containing reduction-sensitive shell-sheddable micelles in vivo |
| Vitamin C | Hepatic Encephalopathy | 1 | PM | 36034085 | 📋 | Protective effect of probiotics and ascorbic acid on bile duct ligation-induced chronic hepatic encephalopathy in rats |
| Vitamin C | Ischemic Stroke | 3 | PM | 35911106 | 📋 | Vitamin C Intake and Ischemic Stroke |
| Vitamin C | Ischemic Stroke | 2 | PM | 32450129 | 📋 | Therapeutic treatment with vitamin C reduces focal cerebral ischemia-induced brain infarction in rats by attenuating disruptions of blood brain barrier and cerebral neuronal apoptosis |
| Vitamin C | Ischemic Stroke | 1 | PM | 30991005 | 📋 | BK Ca channel is a molecular target of vitamin C to protect against ischemic brain stroke |
| Vitamin C | Memory Disorders | 1 | PM | 32218327 | 📋 | Schisandra Extract and Ascorbic Acid Synergistically Enhance Cognition in Mice Through Modulation of Mitochondrial Respiration |
| Vitamin C | Memory Disorders | 6 | PM | 31711893 | 📋 | Vitamin C attenuates memory loss induced by post-traumatic stress like behavior in a rat model |
| Vitamin C | Memory Disorders | 5 | PM | 29966224 | 📋 | Spatial Memory Dysfunction Induced by Vitamin C Deficiency Is Associated with Changes in Monoaminergic Neurotransmitters and Aberrant Synapse Formation |
| Vitamin C | Memory Disorders | 7 | PM | 29788804 | 📋 | Vitamin C prevents memory impairment induced by waterpipe smoke: role of oxidative stress |
| Vitamin C | Memory Disorders | 3 | PM | 27920821 | 📋 | Protective effect of vitamin C, vitamin B12 and omega-3 on lead-induced memory impairment in rat |
| Vitamin C | Memory Disorders | 2 | PM | 26159088 | 📋 | Protective Effect of Berberine, an Isoquinoline Alkaloid Ameliorates Ethanol-Induced Oxidative Stress and Memory Dysfunction in Rats |
| Vitamin C | Memory Disorders | 4 | PM | 16822217 | 📋 | Comparative brain cholinesterase-inhibiting activity of Glycyrrhiza glabra, Myristica fragrans, ascorbic acid, and metrifonate in mice |
| Vitamin C | Memory Performance | 1 | PM | 35276972 | 📋 | Ascorbic Acid Reduces Neurotransmission, Synaptic Plasticity, and Spontaneous Hippocampal Rhythms in In Vitro Slices |
| Vitamin C | Migraine | 2 | PM | 32306462 | 📋 | Reduction in Migraine and Headache Frequency and Intensity With Combined Antioxidant Prophylaxis (N-acetylcysteine, Vitamin E, and Vitamin C): A Randomized Sham-Controlled Pilot Study |
| Vitamin C | Migraine | 3 | PM | 25815319 | 📋 | Vitamin supplementation as possible prophylactic treatment against migraine with aura and menstrual migraine |
| Vitamin C | Migraine | 4 | PM | 23479241 | 📋 | Efficacy of Pinus Radiata Bark Extract and Vitamin C Combination Product as a Prophylactic Therapy for Recalcitrant Migraine and Long-Term Results |
| Vitamin C | Migraine | 1 | PM | 16643582 | 📋 | Use of a Pine Bark Extract and Antioxidant Vitamin Combination Product as Therapy for Migraine in Patients Refractory to Pharmacologic Medication |
| Vitamin C | Psychiatric Disorders | 1 | PM | 31794791 | 📋 | Deficiency of ascorbic acid decreases the contents of tetrahydrobiopterin in the liver and the brain of ODS rats |
| Vitamin C | Psychiatric Disorders | 2 | PM | 28600627 | 📋 | Ascorbic Acid to Manage Psychiatric Disorders |
| Vitamin C | Schizophrenia | 1 | PM | 32780510 | 📋 | Ascorbic acid supplementation attenuates schizophrenia-like symptoms in an animal model induced by ketamine |
| Vitamin C | Schizophrenia | 2 | PM | 30074145 | 📋 | Preventive and Therapeutic Potential of Vitamin C in Mental Disorders |
| Vitamin C | Stress | 9 | PM | 38243361 | 📋 | Vitamin C supplementation promotes locomotor and exploratory behaviors in male Wistar rats exposed to varying stress models |
| Vitamin C | Stress | 1 | PM | 32745879 | 📋 | The role of vitamin C in stress-related disorders |
| Vitamin C | Stress | 5 | PM | 32640177 | 📋 | Psychosocial Vulnerabilities to Upper Respiratory Infectious Illness: Implications for Susceptibility to Coronavirus Disease 2019 (COVID-19) |
| Vitamin C | Stress | 3 | PM | 32184123 | 📋 | Ascorbic acid inhibits vascular remodeling induced by mental stress in overweight/obese men |
| Vitamin C | Stress | 6 | PM | 27397444 | 📋 | Effect of Vitamin C on adrenal suppression by etomidate induction in patients undergoing cardiac surgery: A randomized controlled trial |
| Vitamin C | Stress | 2 | PM | 15956466 | 📋 | Influence of supplemental magnesium, tryptophan, vitamin C, and vitamin E on stress responses of pigs to vibration |
| Vitamin C | Stress | 4 | PM | 11862365 | 📋 | A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress |
| Vitamin C | Stress | 7 | PM | 11590482 | 📋 | Vitamin C supplementation attenuates the increases in circulating cortisol, adrenaline and anti-inflammatory polypeptides following ultramarathon running |
| Vitamin C | Stress | 8 | PM | 11281614 | 📋 | Attenuation of increase in circulating cortisol and enhancement of the acute phase protein response in vitamin C-supplemented ultramarathoners |
| Vitamin C | Stroke | 4 | PM | 35306630 | 📋 | High-Dose Vitamin C Prevents Secondary Brain Damage After Stroke via Epigenetic Reprogramming of Neuroprotective Genes |
| Vitamin C | Stroke | 3 | PM | 25899606 | 📋 | Ascorbic Acid Reduces the Adverse Effects of Delayed Administration of Tissue Plasminogen Activator in a Rat Stroke Model |
| Vitamin C | Stroke | 1 | PM | 24284213 | 📋 | Vitamin C intake, circulating vitamin C and risk of stroke: a meta-analysis of prospective studies |
| Vitamin C | Stroke | 2 | PM | 18175738 | 📋 | Plasma vitamin C concentrations predict risk of incident stroke over 10 y in 20 649 participants of the European Prospective Investigation into Cancer Norfolk prospective population study |
| Vitamin C | Traumatic Brain Injury | 2 | PM | 36600753 | 📋 | The effect of Vitamins C and E on clinical outcomes of patients with severe traumatic brain injury: A propensity score matching study |
| Vitamin C | Traumatic Brain Injury | 1 | PM | 24250162 | 📋 | Effects of α-tocopherol and ascorbic acid in the severity and management of traumatic brain injury in albino rats |
