| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Vitamin B9 | Aging Brain | 3 | PM | 34509560 | 📋 | Vitamin B 12-folic acid supplementation regulates neuronal immediate early gene expression and improves hippocampal dendritic arborization and memory in old male mice |
| Vitamin B9 | Aging Brain | 1 | PM | 31757935 | 📋 | Folic acid delays age-related cognitive decline in senescence-accelerated mouse prone 8: alleviating telomere attrition as a potential mechanism |
| Vitamin B9 | Aging Brain | 2 | PM | 21170581 | 📋 | Beneficial effects of folic acid on enhancement of memory and antioxidant status in aged rat brain |
| Vitamin B9 | Alzheimer's Disease | 12 | PM | 38700503 | 📋 | Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials |
| Vitamin B9 | Alzheimer's Disease | 11 | PM | 38335403 | 📋 | Mendelian randomization to evaluate the effect of folic acid supplement on the risk of Alzheimer disease |
| Vitamin B9 | Alzheimer's Disease | 10 | PM | 36554305 | 📋 | 5-Methyltetrahydrofolate Alleviates Memory Impairment in a Rat Model of Alzheimer's Disease Induced by D-Galactose and Aluminum Chloride |
| Vitamin B9 | Alzheimer's Disease | 9 | PM | 35624693 | 📋 | Reversal of Lipid Metabolism Dysregulation by Selenium and Folic Acid Co-Supplementation to Mitigate Pathology in Alzheimer's Disease |
| Vitamin B9 | Alzheimer's Disease | 2 | PM | 34101780 | 📋 | Effects of Folic Acid and Vitamin B12 Supplementation on Cognitive Impairment and Inflammation in Patients with Alzheimer's Disease: A Randomized, Single-Blinded, Placebo-Controlled Trial |
| Vitamin B9 | Alzheimer's Disease | 3 | PM | 27340344 | 📋 | Folic Acid Supplementation Mitigates Alzheimer's Disease by Reducing Inflammation: A Randomized Controlled Trial |
| Vitamin B9 | Alzheimer's Disease | 6 | PM | 26627706 | 📋 | Folic Acid Alters Methylation Profile of JAK-STAT and Long-Term Depression Signaling Pathways in Alzheimer's Disease Models |
| Vitamin B9 | Alzheimer's Disease | 8 | PM | 26492244 | 📋 | Folic Acid Inhibits Amyloid β-Peptide Production through Modulating DNA Methyltransferase Activity in N2a-APP Cells |
| Vitamin B9 | Alzheimer's Disease | 4 | PM | 26345540 | 📋 | Folic acid deficiency enhances abeta accumulation in APP/PS1 mice brain and decreases amyloid-associated miRNAs expression |
| Vitamin B9 | Alzheimer's Disease | 7 | PM | 26224648 | 📋 | Folic acid attenuates the effects of amyloid β oligomers on DNA methylation in neuronal cells |
| Vitamin B9 | Alzheimer's Disease | 5 | PM | 25959374 | 📋 | Folic acid administration inhibits amyloid β-peptide accumulation in APP/PS1 transgenic mice |
| Vitamin B9 | Alzheimer's Disease | 1 | PM | 21205217 | 📋 | Genistein and Folic Acid Prevent Oxidative Injury Induced by β-Amyloid Peptide |
| Vitamin B9 | Cerebral Ischemia-Reperfusion | 1 | PM | 36370927 | 📋 | Folic Acid Ameliorates Synaptic Impairment following Cerebral Ischemia/Reperfusion Injury via Inhibiting Excessive Activation of NMDA Receptors |
| Vitamin B9 | Cognitive Disorders | 2 | PM | 37610560 | 📋 | Folic acid improved memory and learning function in a rat model of neuroinflammation induced by lipopolysaccharide |
| Vitamin B9 | Cognitive Disorders | 1 | PM | 34062190 | 📋 | Folic acid alleviates the blood brain barrier permeability and oxidative stress and prevents cognitive decline in sepsis-surviving rats |
| Vitamin B9 | Cognitive Performance | 1 | PM | 34562187 | 📋 | Folic acid attenuated learning and memory impairment via inhibition of oxidative damage and acetylcholinesterase activity in hypothyroid rats |
| Vitamin B9 | Depression | 3 | PM | 34450256 | 📋 | Folate as adjunct therapy to SSRI/SNRI for Major Depressive Disorder: Systematic Review & Meta-analysis |
| Vitamin B9 | Depression | 1 | PM | 34358572 | 📋 | Behavioral and neurochemical effects of folic acid in a mouse model of depression induced by TNF-α |
| Vitamin B9 | Depression | 8 | PM | 33459248 | 📋 | Evaluation of the Behavioural, Antioxidative and Histomorphological Effects of Folic Acid-Supplemented Diet in Dexamethasone-Induced Depression in Mice |
| Vitamin B9 | Depression | 2 | PM | 31941442 | 📋 | Folic acid ameliorates depression-like behaviour in a rat model of chronic unpredictable mild stress |
| Vitamin B9 | Headache | 1 | PM | 38042023 | 📋 | Vitamin B6 and folate intake are associated with lower risk of severe headache or migraine in adults: An analysis based on NHANES 1999-2004 |
| Vitamin B9 | Ischemic Stroke | 1 | PM | 35664672 | 📋 | An Integrated Metabolomic Screening Platform Discovers the Potential Biomarkers of Ischemic Stroke and Reveals the Protective Effect and Mechanism of Folic Acid |
| Vitamin B9 | Ischemic Stroke | 2 | PM | 31955011 | 📋 | Postischemic supplementation of folic acid improves neuronal survival and regeneration in vitro |
| Vitamin B9 | Memory Disorders | 1 | PM | 37981108 | 📋 | Vitamin B12-folic acid supplementation improves memory by altering mitochondrial dynamics, dendritic arborization, and neurodegeneration in old and amnesic male mice |
| Vitamin B9 | Migraine | 4 | PM | 38042023 | 📋 | Vitamin B6 and folate intake are associated with lower risk of severe headache or migraine in adults: An analysis based on NHANES 1999-2004 |
| Vitamin B9 | Migraine | 3 | PM | 28526386 | 📋 | The effects of folic acid and pyridoxine supplementation on characteristics of migraine attacks in migraine patients with aura: A double-blind, randomized placebo-controlled, clinical trial |
| Vitamin B9 | Migraine | 1 | PM | 25815319 | 📋 | Vitamin supplementation as possible prophylactic treatment against migraine with aura and menstrual migraine |
| Vitamin B9 | Migraine | 2 | PM | 19384265 | 📋 | The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability |
| Vitamin B9 | Mild Cognitive Impairment | 6 | PM | 38300291 | 📋 | Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild cognitive impairment: a meta-analysis of randomized controlled trials |
| Vitamin B9 | Mild Cognitive Impairment | 5 | PM | 34866142 | 📋 | Effectiveness of B Vitamins and Their Interactions with Aspirin in Improving Cognitive Functioning in Older People with Mild Cognitive Impairment: Pooled Post-Hoc Analyses of Two Randomized Trials |
| Vitamin B9 | Mild Cognitive Impairment | 4 | PM | 33749643 | 📋 | Effects of Folic Acid Combined with DHA Supplementation on Cognitive Function and Amyloid-β-Related Biomarkers in Older Adults with Mild Cognitive Impairment by a Randomized, Double Blind, Placebo-Controlled Trial |
| Vitamin B9 | Mild Cognitive Impairment | 3 | PM | 27876835 | 📋 | Folic acid supplementation improves cognitive function by reducing the levels of peripheral inflammatory cytokines in elderly Chinese subjects with MCI |
| Vitamin B9 | Mild Cognitive Impairment | 2 | PM | 26757190 | 📋 | Omega-3 Fatty Acid Status Enhances the Prevention of Cognitive Decline by B Vitamins in Mild Cognitive Impairment |
| Vitamin B9 | Mild Cognitive Impairment | 1 | PM | 21780182 | 📋 | Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial |
| Vitamin B9 | Schizophrenia | 1 | PM | 33786893 | 📋 | Effects of maternal folic acid supplementation on nuclear methyltransferase activity of adult rats subjected to an animal model of schizophrenia |
| Vitamin B9 | Stroke | 8 | PM | 38824900 | 📋 | Folic acid supplementation for stroke prevention: A systematic review and meta-analysis of 21 randomized clinical trials worldwide |
| Vitamin B9 | Stroke | 7 | PM | 38432716 | 📋 | Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review |
| Vitamin B9 | Stroke | 6 | PM | 36280851 | 📋 | Cost-effectiveness of folic acid therapy for primary prevention of stroke in patients with hypertension |
| Vitamin B9 | Stroke | 1 | PM | 35559538 | 📋 | Efficacy of B-Vitamin Supplementation in Stroke and Hypertension |
| Vitamin B9 | Stroke | 5 | PM | 33148481 | 📋 | Interaction of serum calcium and folic acid treatment on first stroke in hypertensive males |
| Vitamin B9 | Stroke | 2 | PM | 27729579 | 📋 | Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients |
| Vitamin B9 | Stroke | 3 | PM | 27528407 | 📋 | Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized Controlled Trials |
| Vitamin B9 | Stroke | 4 | PM | 17544768 | 📋 | Efficacy of folic acid supplementation in stroke prevention: a meta-analysis |
