| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Hesperidin | Alzheimer's Disease | 8 | PM | 37913913 | 📋 | Hesperidin ameliorates Amyloid-β toxicity and enhances oxidative stress resistance and lifespan of Caenorhabditis elegans through acr-16 mediated activation of the autophagy pathway |
| Hesperidin | Alzheimer's Disease | 7 | PM | 37895841 | 📋 | Dapagliflozin/Hesperidin Combination Mitigates Lipopolysaccharide-Induced Alzheimer's Disease in Rats |
| Hesperidin | Alzheimer's Disease | 4 | PM | 35956303 | 📋 | Hesperidin Improves Memory Function by Enhancing Neurogenesis in a Mouse Model of Alzheimer's Disease |
| Hesperidin | Alzheimer's Disease | 1 | PM | 35776430 | 📋 | Neuroprotective Effects of Hesperidin and Naringin in SK-N-AS Cell as an In Vitro Model for Alzheimer's Disease |
| Hesperidin | Alzheimer's Disease | 3 | PM | 34170456 | 📋 | Histological and imunohistochemical alterations of hippocampus and prefrontal cortex in a rat model of Alzheimer like-disease with a preferential role of the flavonoid "hesperidin" |
| Hesperidin | Alzheimer's Disease | 2 | PM | 29687202 | 📋 | Attenuation of Aluminum Chloride-Induced Neuroinflammation and Caspase Activation Through the AKT/GSK-3β Pathway by Hesperidin in Wistar Rats |
| Hesperidin | Alzheimer's Disease | 6 | PM | 26391026 | 📋 | Hesperidin attenuates learning and memory deficits in APP/PS1 mice through activation of Akt/Nrf2 signaling and inhibition of RAGE/NF-κB signaling |
| Hesperidin | Alzheimer's Disease | 5 | PM | 23475456 | 📋 | Protective effects of hesperidin against amyloid-β (Aβ) induced neurotoxicity through the voltage dependent anion channel 1 (VDAC1)-mediated mitochondrial apoptotic pathway in PC12 cells |
| Hesperidin | Brain Inflammation | 1 | PM | 33099738 | 📋 | Attenuation of sodium arsenite-induced cardiotoxicity and neurotoxicity with the antioxidant, anti-inflammatory, and antiapoptotic effects of hesperidin |
| Hesperidin | Cerebral Hypoperfusion | 1 | PM | 25944567 | 📋 | Effects of Citrus Flavonoids Against Microvascular Damage Induced by Hypoperfusion and Reperfusion in Rat Pial Circulation |
| Hesperidin | Cognitive Disorders | 2 | PM | 34826046 | 📋 | Hesperidin Preserves Cognitive Functions and Hippocampus Histological Architecture in Albino Wistar Rats Subjected to Stress Through Enhancement of Brain-Derived Neurotrophic Factor |
| Hesperidin | Cognitive Disorders | 1 | PM | 26391026 | 📋 | Hesperidin attenuates learning and memory deficits in APP/PS1 mice through activation of Akt/Nrf2 signaling and inhibition of RAGE/NF-κB signaling |
| Hesperidin | Depression | 15 | PM | 38107143 | 📋 | Hesperidin reduces depressive symptoms in post-coronary artery bypass graft patients with mild depression |
| Hesperidin | Depression | 14 | PM | 37950769 | 📋 | Immunoregulatory role of hesperidin against ovalbumin (OVA)-induced bronchial asthma and depression in rats |
| Hesperidin | Depression | 10 | PM | 37169143 | 📋 | Hesperidin may improve depressive symptoms by binding NLRP3 and influencing the pyroptosis pathway in a rat model |
| Hesperidin | Depression | 9 | PM | 32982741 | 📋 | The Antidepressant-Like Effects of Hesperidin in Streptozotocin-Induced Diabetic Rats by Activating Nrf2/ARE/Glyoxalase 1 Pathway |
| Hesperidin | Depression | 8 | PM | 32922291 | 📋 | The Anti-Depressive Effects of Hesperidin and the Relative Mechanisms Based on the NLRP3 Inflammatory Signaling Pathway |
| Hesperidin | Depression | 7 | PM | 32853749 | 📋 | Hesperidin alleviates chronic restraint stress and lipopolysaccharide-induced Hippocampus and Frontal cortex damage in mice: Role of TLR4/NF-κB, p38 MAPK/JNK, Nrf2/ARE signaling |
| Hesperidin | Depression | 2 | PM | 32458386 | 📋 | Hesperidin Ameliorates Anxiety-Depressive-Like Behavior in 6-OHDA Model of Parkinson's Disease by Regulating Striatal Cytokine and Neurotrophic Factors Levels and Dopaminergic Innervation Loss in the Striatum of Mice |
| Hesperidin | Depression | 4 | PM | 32445019 | 📋 | Antidepressant-Like Effects of Hesperidin in Animal Model of Post-Traumatic Stress Disorder |
| Hesperidin | Depression | 5 | PM | 30928632 | 📋 | The antidepressant effects of hesperidin on chronic unpredictable mild stress-induced mice |
| Hesperidin | Depression | 3 | PM | 30352242 | 📋 | Hesperidin attenuates depression-related symptoms in mice with mild traumatic brain injury |
| Hesperidin | Depression | 6 | PM | 27378528 | 📋 | Hesperidin Alleviates Lipopolysaccharide-Induced Neuroinflammation in Mice by Promoting the miRNA-132 Pathway |
| Hesperidin | Depression | 1 | PM | 24709058 | 📋 | Hesperidin Exerts Antidepressant-Like Effects in Acute and Chronic Treatments in Mice: Possible Role of l-arginine-NO-cGMP Pathway and BDNF Levels |
| Hesperidin | Depression | 13 | PM | 23672047 | 📋 | [Effect of hesperidin on behavior and HPA axis of rat model of chronic stress-induced depression] |
| Hesperidin | Depression | 12 | PM | 23178563 | 📋 | Kappa-opioid receptors mediate the antidepressant-like activity of hesperidin in the mouse forced swimming test |
| Hesperidin | Depression | 11 | PM | 22996046 | 📋 | Evidence for the involvement of the serotonergic 5-HT(1A) receptors in the antidepressant-like effect caused by hesperidin in mice |
| Hesperidin | Hepatic Encephalopathy | 1 | PM | 36526046 | 📋 | Hepatoprotective and cognitive-enhancing effects of hesperidin against thioacetamide-induced hepatic encephalopathy in rats |
| Hesperidin | Intracerebral Hemorrhage | 1 | PM | 31478148 | 📋 | Hesperidin reduces adverse symptomatic intracerebral hemorrhage by promoting TGF-β1 for treating ischemic stroke using tissue plasminogen activator |
| Hesperidin | Ischemic Stroke | 1 | PM | 31478148 | 📋 | Hesperidin reduces adverse symptomatic intracerebral hemorrhage by promoting TGF-β1 for treating ischemic stroke using tissue plasminogen activator |
| Hesperidin | Memory Disorders | 2 | PM | 35956303 | 📋 | Hesperidin Improves Memory Function by Enhancing Neurogenesis in a Mouse Model of Alzheimer's Disease |
| Hesperidin | Memory Disorders | 1 | PM | 34959916 | 📋 | Hesperidin Reduces Memory Impairment Associated with Adult Rat Hippocampal Neurogenesis Triggered by Valproic Acid |
| Hesperidin | Memory Performance | 1 | PM | 28659786 | 📋 | Flavonoid Hesperidin Induces Synapse Formation and Improves Memory Performance through the Astrocytic TGF-β1 |
| Hesperidin | Psychiatric Disorders | 1 | PM | 34653559 | 📋 | Prevention and reversal of ketamine-induced experimental psychosis in mice by the neuroactive flavonoid, hesperidin: the role of oxidative and cholinergic mechanisms |
| Hesperidin | Schizophrenia | 1 | PM | 34653559 | 📋 | Prevention and reversal of ketamine-induced experimental psychosis in mice by the neuroactive flavonoid, hesperidin: the role of oxidative and cholinergic mechanisms |
| Hesperidin | Stress | 1 | PM | 30928632 | 📋 | The antidepressant effects of hesperidin on chronic unpredictable mild stress-induced mice |
| Hesperidin | Subarachnoid Hemorrhage | 1 | PM | 30448580 | 📋 | Neuroprotective Effects of Hesperidin on Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Rats: Biochemical, Pathologic, and Histomorphometric Analysis |
| Hesperidin | Traumatic Brain Injury | 1 | PM | 30352242 | 📋 | Hesperidin attenuates depression-related symptoms in mice with mild traumatic brain injury |
