| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| EGCG | Aging Brain | 2 | PM | 34443485 | 📋 | Green Tea Suppresses Brain Aging |
| EGCG | Aging Brain | 1 | PM | 32788870 | 📋 | Epigallocatechin-3-gallate preconditioned Adipose-derived Stem Cells confer Neuroprotection in aging rat brain |
| EGCG | Alzheimer's Disease | 32 | PM | 38275516 | 📋 | Epigallocatechin-3-Gallate and Genistein for Decreasing Gut Dysbiosis, Inhibiting Inflammasomes, and Aiding Autophagy in Alzheimer's Disease |
| EGCG | Alzheimer's Disease | 31 | PM | 38095777 | 📋 | Epigallocatechin Gallate Modulates Microglia Phenotype to Suppress Pro-inflammatory Signalling Cues and Inhibit Phagocytosis |
| EGCG | Alzheimer's Disease | 30 | PM | 37507998 | 📋 | Alzheimer's Disease and Green Tea: Epigallocatechin-3-Gallate as a Modulator of Inflammation and Oxidative Stress |
| EGCG | Alzheimer's Disease | 24 | PM | 36591187 | 📋 | Structural Remodeling Mechanism of the Toxic Amyloid Fibrillary Mediated by Epigallocatechin-3-gallate |
| EGCG | Alzheimer's Disease | 23 | PM | 36078067 | 📋 | A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer's Disease |
| EGCG | Alzheimer's Disease | 22 | PM | 35721940 | 📋 | Inhibition Mechanisms of (-)-Epigallocatechin-3-gallate and Genistein on Amyloid-beta 42 Peptide of Alzheimer's Disease via Molecular Simulations |
| EGCG | Alzheimer's Disease | 21 | PM | 35327563 | 📋 | Epigallocatechin-3-Gallate (EGCG): New Therapeutic Perspectives for Neuroprotection, Aging, and Neuroinflammation for the Modern Age |
| EGCG | Alzheimer's Disease | 19 | PM | 34944489 | 📋 | (-)-Epigallocatechin-3-Gallate Diminishes Intra-and Extracellular Amyloid-Induced Cytotoxic Effects on Cholinergic-like Neurons from Familial Alzheimer's Disease PSEN1 E280A |
| EGCG | Alzheimer's Disease | 18 | PM | 34612422 | 📋 | Molecular mechanisms of resveratrol and EGCG in the inhibition of Aβ 42 aggregation and disruption of Aβ 42 protofibril: similarities and differences |
| EGCG | Alzheimer's Disease | 16 | PM | 34084282 | 📋 | Epigallocatechin-3-gallate modulates Tau Post-translational modifications and cytoskeletal network |
| EGCG | Alzheimer's Disease | 15 | PM | 34012254 | 📋 | Epigallocatechin-3-Gallate Provides Protection Against Alzheimer's Disease-Induced Learning and Memory Impairments in Rats |
| EGCG | Alzheimer's Disease | 20 | PM | 33353228 | 📋 | Nutraceutical Approaches of Autophagy and Neuroinflammation in Alzheimer's Disease: A Systematic Review |
| EGCG | Alzheimer's Disease | 13 | PM | 33278382 | 📋 | Green tea extract EGCG plays a dual role in Aβ 42 protofibril disruption and membrane protection: a molecular dynamic study |
| EGCG | Alzheimer's Disease | 12 | PM | 32981185 | 📋 | The Effects of Resveratrol, Caffeine, β-Carotene, and Epigallocatechin Gallate (EGCG) on Amyloid-β 25-35 Aggregation in Synthetic Brain Membranes |
| EGCG | Alzheimer's Disease | 17 | PM | 32942205 | 📋 | The pharmacological activity of epigallocatechin-3-gallate (EGCG) on Alzheimer's disease animal model: A systematic review |
| EGCG | Alzheimer's Disease | 11 | PM | 32751722 | 📋 | Insights into the Effect of Curcumin and (-)-Epigallocatechin-3-Gallate on the Aggregation of Aβ(1-40) Monomers by Means of Molecular Dynamics |
| EGCG | Alzheimer's Disease | 9 | PM | 32441920 | 📋 | Green Tea Extracts EGCG and EGC Display Distinct Mechanisms in Disrupting Aβ 42 Protofibril |
| EGCG | Alzheimer's Disease | 8 | PM | 32326457 | 📋 | Comparative Kinetics of Acetyl- And Butyryl-Cholinesterase Inhibition by Green Tea Catechins|Relevance to the Symptomatic Treatment of Alzheimer's Disease |
| EGCG | Alzheimer's Disease | 7 | PM | 32251872 | 📋 | miR-34a-5p and miR-125b-5p Attenuate Aβ-induced Neurotoxicity Through Targeting BACE1 |
| EGCG | Alzheimer's Disease | 5 | PM | 31838720 | 📋 | Epigallocatechin-3-Gallate (EGCG) Improves Cognitive Deficits Aggravated by an Obesogenic Diet Through Modulation of Unfolded Protein Response in APPswe/PS1dE9 Mice |
| EGCG | Alzheimer's Disease | 6 | PM | 31518035 | 📋 | Mitigative Effects of Epigallocatechin Gallate in Terms of Diminishing Apoptosis and Oxidative Stress Generated by the Combination of Lead and Amyloid Peptides in Human Neuronal Cells |
| EGCG | Alzheimer's Disease | 1 | PM | 30563837 | 📋 | Combined Treatment With the Phenolics (-)-epigallocatechin-3-gallate and Ferulic Acid Improves Cognition and Reduces Alzheimer-like Pathology in Mice |
| EGCG | Alzheimer's Disease | 3 | PM | 30150930 | 📋 | EGCG Nanoparticles Attenuate Aluminum Chloride Induced Neurobehavioral Deficits, Beta Amyloid and Tau Pathology in a Rat Model of Alzheimer's Disease |
| EGCG | Alzheimer's Disease | 25 | PM | 29209211 | 📋 | Diabetes Mellitus and Alzheimer's Disease: The Protection of Epigallocatechin-3-gallate in Streptozotocin Injection-Induced Models |
| EGCG | Alzheimer's Disease | 28 | PM | 28844000 | 📋 | Epigallocatechin gallate induces extracellular degradation of amyloid β-protein by increasing neprilysin secretion from astrocytes through activation of ERK and PI3K pathways |
| EGCG | Alzheimer's Disease | 33 | PM | 28520620 | 📋 | (-)-Epigallocatechin-3-gallate ameliorates memory impairment and rescues the abnormal synaptic protein levels in the frontal cortex and hippocampus in a mouse model of Alzheimer's disease |
| EGCG | Alzheimer's Disease | 4 | PM | 26207957 | 📋 | Epigallocatechin-3-gallate Enhances Clearance of Phosphorylated Tau in Primary Neurons |
| EGCG | Alzheimer's Disease | 2 | PM | 25882496 | 📋 | (-)-Epigallocatechin-3-gallate Attenuates Cognitive Deterioration in Alzheimer's Disease Model Mice by Upregulating Neprilysin Expression |
| EGCG | Alzheimer's Disease | 29 | PM | 24356899 | 📋 | (-)-Epigallocatechin-3-gallate ameliorates learning and memory deficits by adjusting the balance of TrkA/p75NTR signaling in APP/PS1 transgenic mice |
| EGCG | Alzheimer's Disease | 26 | PM | 23807728 | 📋 | Involvement of α7 nAChR signaling cascade in epigallocatechin gallate suppression of β-amyloid-induced apoptotic cortical neuronal insults |
| EGCG | Alzheimer's Disease | 27 | PM | 23660953 | 📋 | (-)-Epigallocatechin-3-gallate alleviates spatial memory impairment in APP/PS1 mice by restoring IRS-1 signaling defects in the hippocampus |
| EGCG | Alzheimer's Disease | 14 | PM | 19622237 | 📋 | Green tea polyphenol (-)-epigallocatechin-3-gallate enhances the inhibitory effect of huperzine A on acetylcholinesterase by increasing the affinity with serum albumin |
| EGCG | Alzheimer's Disease | 10 | PM | 18695518 | 📋 | Epigallocatechin-3-gallate and Curcumin Suppress Amyloid Beta-Induced Beta-Site APP Cleaving enzyme-1 Upregulation |
| EGCG | Brain Edema | 1 | PM | 36084697 | 📋 | (-)-Epicatechin gallate prevents inflammatory response in hypoxia-activated microglia and cerebral edema by inhibiting NF-κB signaling |
| EGCG | Brain Inflammation | 1 | PM | 31614951 | 📋 | Green Tea Polyphenol (-)-Epigallocatechin Gallate (EGCG) Attenuates Neuroinflammation in Palmitic Acid-Stimulated BV-2 Microglia and High-Fat Diet-Induced Obese Mice |
| EGCG | Brain Inflammation | 4 | PM | 26643169 | 📋 | Epigallocatechin Gallate Attenuates Amyloid β-Induced Inflammation and Neurotoxicity in EOC 13.31 Microglia |
| EGCG | Brain Injury | 1 | PM | 22692966 | 📋 | Green Tea epigallocatechin-3-gallate (EGCG) Promotes Neural Progenitor Cell Proliferation and Sonic Hedgehog Pathway Activation During Adult Hippocampal Neurogenesis |
| EGCG | Brain Injury | 2 | PM | 20013823 | 📋 | (-)-Epigallocatechin-3-gallate increases cell proliferation and neuroblasts in the subgranular zone of the dentate gyrus in adult mice |
| EGCG | Brain Tumor | 1 | PM | 11305413 | 📋 | Inhibitory Effect of Epigallocatechin-Gallate on Brain Tumor Cell Lines in Vitro |
| EGCG | Cerebral Hypoperfusion | 2 | PM | 36102206 | 📋 | HO-1 mediated by PI3K/Akt/Nrf2 signaling pathway is involved in (-)-epigallocatechin-3-gallate-rescueing impaired cognitive function induced by chronic cerebral hypoperfusion in rat model |
| EGCG | Cerebral Hypoperfusion | 1 | PM | 27080069 | 📋 | Neurorestorative Effects of epigallocatechin-3-Gallate on Cognitive Function in a Chronic Cerebral Hypoperfusion Rat Model |
| EGCG | Cerebral Ischemia | 6 | PM | 36782340 | 📋 | Epigallocatechin gallate restores the reduction of protein phosphatase 2 A subunit B caused by middle cerebral artery occlusion |
| EGCG | Cerebral Ischemia | 5 | PM | 35204278 | 📋 | Epigallocatechin Gallate Modulates Essential Elements, Zn/Cu Ratio, Hazardous Metal, Lipid Peroxidation, and Antioxidant Activity in the Brain Cortex during Cerebral Ischemia |
| EGCG | Cerebral Ischemia | 4 | PM | 34327632 | 📋 | Epigallocatechin Gallate Alleviates Down-Regulation of Thioredoxin in Ischemic Brain Damage and Glutamate-Exposed Neuron |
| EGCG | Cerebral Ischemia | 3 | PM | 32224555 | 📋 | Epigallocatechin Gallate (EGCG) Alleviates Neuronal Cell Damage Against Focal Cerebral Ischemia in Rats |
| EGCG | Cerebral Ischemia | 1 | PM | 27941526 | 📋 | Epigallocatechin Gallate Extends Therapeutic Window of Recombinant Tissue Plasminogen Activator Treatment for Brain Ischemic Stroke: A Randomized Double-Blind and Placebo-Controlled Trial |
| EGCG | Cerebral Ischemia | 2 | PM | 26851971 | 📋 | Epigallocatechin Gallate Extends the Therapeutic Window of Recombinant Tissue Plasminogen Activator Treatment in Ischemic Rats |
| EGCG | Cerebral Ischemia-Reperfusion | 2 | PM | 36147330 | 📋 | EGCG protects the mouse brain against cerebral ischemia/reperfusion injury by suppressing autophagy via the AKT/AMPK/mTOR phosphorylation pathway |
| EGCG | Cerebral Ischemia-Reperfusion | 1 | PM | 35232900 | 📋 | Effect of EGCG on inflammatory reaction in rats suffered cerebral ischemia/reperfusion injury |
| EGCG | Cognitive Disorders | 8 | PM | 36686657 | 📋 | Amelioration of cognitive impairment using epigallocatechin-3-gallate in ovariectomized mice fed a high-fat diet involves remodeling with Prevotella and Bifidobacteriales |
| EGCG | Cognitive Disorders | 7 | PM | 36394770 | 📋 | Epigallocatechin-3-gallate Enhances Cognitive and Memory Performance and Protects Against Brain Injury in Methionine-induced Hyperhomocysteinemia Through Interdependent Molecular Pathways |
| EGCG | Cognitive Disorders | 6 | PM | 36102206 | 📋 | HO-1 mediated by PI3K/Akt/Nrf2 signaling pathway is involved in (-)-epigallocatechin-3-gallate-rescueing impaired cognitive function induced by chronic cerebral hypoperfusion in rat model |
| EGCG | Cognitive Disorders | 5 | PM | 35552996 | 📋 | Epigallocatechin-3-Gallate Ameliorated Iron Accumulation and Apoptosis and Promoted Neuronal Regeneration and Memory/Cognitive Functions in the Hippocampus Induced by Exposure to a Chronic High-Altitude Hypoxia Environment |
| EGCG | Cognitive Disorders | 4 | PM | 35052505 | 📋 | Anti-Amnesic Effects of Epigallocatechin Gallate on Scopolamine-Induced Learning and Memory Dysfunction in Sprague-Dawley Rats |
| EGCG | Cognitive Disorders | 3 | PM | 34386880 | 📋 | Epigallocatechin-3-gallate improves chronic alcohol-induced cognitive dysfunction in rats by interfering with neuro-inflammatory, cell death and oxido-nitrosative cascade |
| EGCG | Cognitive Disorders | 2 | PM | 34012254 | 📋 | Epigallocatechin-3-Gallate Provides Protection Against Alzheimer's Disease-Induced Learning and Memory Impairments in Rats |
| EGCG | Cognitive Disorders | 1 | PM | 26196076 | 📋 | (-)Epigallocatechin-3-gallate Prevents the Reserpine-Induced Impairment of Short-Term Social Memory in Rats |
| EGCG | Cognitive Disorders | 9 | PM | 24356899 | 📋 | (-)-Epigallocatechin-3-gallate ameliorates learning and memory deficits by adjusting the balance of TrkA/p75NTR signaling in APP/PS1 transgenic mice |
| EGCG | Depression | 3 | PM | 38268911 | 📋 | (-)-Epigallocatechin gallate alleviates chronic unpredictable mild stress-induced depressive symptoms in mice by regulating the mTOR autophagy pathway and inhibiting NLRP3 inflammasome activation |
| EGCG | Depression | 2 | PM | 35939172 | 📋 | Effect of Epigallocatechin-3-gallate on Stress-Induced Depression in a Mouse Model: Role of Interleukin-1β and Brain-Derived Neurotrophic Factor |
| EGCG | Depression | 1 | PM | 32955535 | 📋 | Effects of EGCG on depression-related behavior and serotonin concentration in a rat model of chronic unpredictable mild stress |
| EGCG | Diabetic Encephalopathy | 1 | PM | 37449181 | 📋 | Influence of green tea on alcohol aggravated neurodegeneration of cortex, cerebellum and hippocampus of STZ-induced diabetic rats |
| EGCG | Glioblastoma | 2 | PM | 31026358 | 📋 | Epigallocatechin-3-gallate Induces Telomere Shortening and Clastogenic Damage in Glioblastoma Cells |
| EGCG | Glioblastoma | 3 | PM | 19894226 | 📋 | Flavonoids Activated Caspases for Apoptosis in Human Glioblastoma T98G and U87MG Cells but Not in Human Normal Astrocytes |
| EGCG | Glioblastoma | 1 | PM | 11305413 | 📋 | Inhibitory Effect of Epigallocatechin-Gallate on Brain Tumor Cell Lines in Vitro |
| EGCG | Glioma | 4 | PM | 37025487 | 📋 | A combination of metformin and epigallocatechin gallate potentiates glioma chemotherapy in vivo |
| EGCG | Glioma | 3 | PM | 35392560 | 📋 | Inhibitory Mechanism of Combined Hydroxychavicol With Epigallocatechin-3-Gallate Against Glioma Cancer Cell Lines: A Transcriptomic Analysis |
| EGCG | Glioma | 2 | PM | 25221872 | 📋 | Tocotrienol-rich Fraction, [6]-gingerol and Epigallocatechin Gallate Inhibit Proliferation and Induce Apoptosis of Glioma Cancer Cells |
| EGCG | Glioma | 5 | PM | 24338484 | 📋 | Epigallocatechin-3-gallate induces apoptosis, inhibits proliferation and decreases invasion of glioma cell |
| EGCG | Glioma | 1 | PM | 11305413 | 📋 | Inhibitory Effect of Epigallocatechin-Gallate on Brain Tumor Cell Lines in Vitro |
| EGCG | Hepatic Encephalopathy | 1 | PM | 36573265 | 📋 | Green Tea Catechin EGCG Ameliorates Thioacetamide-Induced Hepatic Encephalopathy in Rats via Modulation of the Microbiota-Gut-Liver Axis |
| EGCG | Intracerebral Hemorrhage | 2 | PM | 37633650 | 📋 | The protective effects of EGCG was associated with HO-1 active and microglia pyroptosis inhibition in experimental intracerebral hemorrhage |
| EGCG | Intracerebral Hemorrhage | 1 | PM | 33335777 | 📋 | EGCG treats ICH via up-regulating miR-137-3p and inhibiting Parthanatos |
| EGCG | Ischemic Stroke | 4 | PM | 38427657 | 📋 | Epigallocatechin gallate improves neuronal damage in animal model of ischemic stroke and glutamate-exposed neurons via modulation of hippocalcin expression |
| EGCG | Ischemic Stroke | 3 | PM | 33883340 | 📋 | Identification of regulated proteins by epigallocatechin gallate treatment in an ischemic cerebral cortex animal model: a proteomics approach |
| EGCG | Ischemic Stroke | 1 | PM | 27206430 | 📋 | Delayed Treatment With Green Tea Polyphenol EGCG Promotes Neurogenesis After Ischemic Stroke in Adult Mice |
| EGCG | Ischemic Stroke | 2 | PM | 27038929 | 📋 | (-)-Epigallocatechin Gallate Inhibits Asymmetric Dimethylarginine-Induced Injury in Human Brain Microvascular Endothelial Cells |
| EGCG | Memory Disorders | 4 | PM | 34820541 | 📋 | The beneficial effects of green tea on sleep deprivation-induced cognitive deficits in rats: the involvement of hippocampal antioxidant defense |
| EGCG | Memory Disorders | 3 | PM | 34012254 | 📋 | Epigallocatechin-3-Gallate Provides Protection Against Alzheimer's Disease-Induced Learning and Memory Impairments in Rats |
| EGCG | Memory Disorders | 1 | PM | 28739640 | 📋 | EGCG Ameliorates High-Fat- And High-Fructose-Induced Cognitive Defects by Regulating the IRS/AKT and ERK/CREB/BDNF Signaling Pathways in the CNS |
| EGCG | Memory Disorders | 2 | PM | 26126814 | 📋 | (-)Epigallocatechin-3-gallate Decreases the Stress-Induced Impairment of Learning and Memory in Rats |
| EGCG | Memory Disorders | 5 | PM | 23660953 | 📋 | (-)-Epigallocatechin-3-gallate alleviates spatial memory impairment in APP/PS1 mice by restoring IRS-1 signaling defects in the hippocampus |
| EGCG | Stroke | 1 | PM | 35532615 | 📋 | The Effect of Green Tea with EGCG Active Compound in Enhancing the Expression of M2 Microglia Marker (CD206) |
| EGCG | Stroke | 2 | PM | 24193141 | 📋 | Neuroprotection by (-)-epigallocatechin-3-gallate in a rat model of stroke is mediated through inhibition of endoplasmic reticulum stress |
| EGCG | Subarachnoid Hemorrhage | 1 | PM | 33564320 | 📋 | EGCG Promotes Neurite Outgrowth through the Integrin β 1/FAK/p38 Signaling Pathway after Subarachnoid Hemorrhage |
| EGCG | Subarachnoid Hemorrhage | 2 | PM | 29160895 | 📋 | Differential expression of microRNAs contributed to the health efficacy of EGCG in in vitro subarachnoid hemorrhage model |
| EGCG | Traumatic Brain Injury | 1 | PM | 32062732 | 📋 | (-)-Epigallocatechin-3-gallate provides neuroprotection via AMPK activation against traumatic brain injury in a mouse model |
