| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Berberine | Aging Brain | 1 | PM | 38727934 | 📋 | Berberine attenuates brain aging via stabilizing redox homeostasis and inflammation in an accelerated senescence model of Wistar rats |
| Berberine | Alzheimer's Disease | 42 | PM | 38678955 | 📋 | Berberine alleviates Alzheimer's disease by regulating the gut microenvironment, restoring the gut barrier and brain-gut axis balance |
| Berberine | Alzheimer's Disease | 41 | PM | 38293672 | 📋 | Effect of berberine on cognitive function and β-amyloid precursor protein in Alzheimer's disease models: a systematic review and meta-analysis |
| Berberine | Alzheimer's Disease | 40 | PM | 38259291 | 📋 | Neuroprotective effects and possible mechanisms of berberine in animal models of Alzheimer's disease: a systematic review and meta-analysis |
| Berberine | Alzheimer's Disease | 39 | PM | 37910530 | 📋 | Bioassays guided isolation of berberine from Berberis lycium and its neuroprotective role in aluminium chloride induced rat model of Alzheimer's disease combined with insilico molecular docking |
| Berberine | Alzheimer's Disease | 36 | PM | 37506403 | 📋 | Berberine ameliorates iron levels and ferroptosis in the brain of 3 × Tg-AD mice |
| Berberine | Alzheimer's Disease | 32 | PM | 37214397 | 📋 | Network pharmacology reveals that Berberine may function against Alzheimer's disease via the AKT signaling pathway |
| Berberine | Alzheimer's Disease | 31 | PM | 37073143 | 📋 | Cholinesterase Inhibitory and In Silico Toxicity Assessment of Thirty-Four Isoquinoline Alkaloids - Berberine as the Lead Compound |
| Berberine | Alzheimer's Disease | 30 | PM | 36982968 | 📋 | Berberine Rescues D-Ribose-Induced Alzheimer's Pathology via Promoting Mitophagy |
| Berberine | Alzheimer's Disease | 29 | PM | 36724611 | 📋 | Protective effects of berberine against β-amyloid-induced neurotoxicity in HT22 cells via the Nrf2/HO-1 pathway |
| Berberine | Alzheimer's Disease | 28 | PM | 36186093 | 📋 | Neuroprotective Effect of Root Extracts of Berberis Vulgaris (Barberry) on Oxidative Stress on SH-SY5Y Cells |
| Berberine | Alzheimer's Disease | 27 | PM | 35768254 | 📋 | Berberine Ameliorates Cognitive Disorder via GSK3β/PGC-1α Signaling in APP/PS1 Mice |
| Berberine | Alzheimer's Disease | 26 | PM | 35085532 | 📋 | Involvement of environmentally relevant toxic metal mixture in Alzheimer's disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening |
| Berberine | Alzheimer's Disease | 25 | PM | 34778460 | 📋 | SOCS1 Mediates Berberine-Induced Amelioration of Microglial Activated States in N9 Microglia Exposed to β Amyloid |
| Berberine | Alzheimer's Disease | 24 | PM | 34515019 | 📋 | Investigating Neuroprotective Potential of Berberine, Levetiracetam and Their Combination in The Management of Alzheimer's Disease Utilizing Drug Repurposing Strategy |
| Berberine | Alzheimer's Disease | 23 | PM | 34349640 | 📋 | Berberine Reduces Aβ 42 Deposition and Tau Hyperphosphorylation via Ameliorating Endoplasmic Reticulum Stress |
| Berberine | Alzheimer's Disease | 22 | PM | 34265361 | 📋 | Functional effects of berberine in modulating mitochondrial dysfunction and inflammatory response in the respective amyloidogenic cells and activated microglial cells - In vitro models simulating Alzheimer's disease pathology |
| Berberine | Alzheimer's Disease | 21 | PM | 34064687 | 📋 | Berberine Improves Cognitive Impairment by Simultaneously Impacting Cerebral Blood Flow and β-Amyloid Accumulation in an APP/tau/PS1 Mouse Model of Alzheimer's Disease |
| Berberine | Alzheimer's Disease | 20 | PM | 33983710 | 📋 | Berberine Improves Behavioral and Cognitive Deficits in a Mouse Model of Alzheimer's Disease via Regulation of β-Amyloid Production and Endoplasmic Reticulum Stress |
| Berberine | Alzheimer's Disease | 19 | PM | 33544523 | 📋 | Comparative effects of berberine and piperine on the neuroprotective potential of neostigmine |
| Berberine | Alzheimer's Disease | 18 | PM | 33361598 | 📋 | Ameliorating Ribosylation-Induced Amyloid-β Pathology by Berberine via Inhibiting mTOR/p70S6K Signaling |
| Berberine | Alzheimer's Disease | 17 | PM | 32832321 | 📋 | Berberine ameliorates rats model of combined Alzheimer's disease and type 2 diabetes mellitus via the suppression of endoplasmic reticulum stress |
| Berberine | Alzheimer's Disease | 16 | PM | 32779043 | 📋 | Berberine attenuates Aβ-induced neuronal damage through regulating miR-188/NOS1 in Alzheimer's disease |
| Berberine | Alzheimer's Disease | 15 | PM | 32389853 | 📋 | Network Pharmacology-Based Strategy to Investigate Pharmacological Mechanisms of Tinospora Sinensis for Treatment of Alzheimer's Disease |
| Berberine | Alzheimer's Disease | 4 | PM | 32272441 | 📋 | Antioxidant Berberine-Derivative Inhibits Multifaceted Amyloid Toxicity |
| Berberine | Alzheimer's Disease | 7 | PM | 32080784 | 📋 | Synergic Effects of Berberine and Curcumin on Improving Cognitive Function in an Alzheimer's Disease Mouse Model |
| Berberine | Alzheimer's Disease | 8 | PM | 31810131 | 📋 | Berberine Mitigates Cognitive Decline in an Alzheimer's Disease Mouse Model by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance |
| Berberine | Alzheimer's Disease | 13 | PM | 31429696 | 📋 | Berberine: A Plant-derived Alkaloid With Therapeutic Potential to Combat Alzheimer's Disease |
| Berberine | Alzheimer's Disease | 10 | PM | 31191803 | 📋 | Berberine Alleviates Amyloid β-Induced Mitochondrial Dysfunction and Synaptic Loss |
| Berberine | Alzheimer's Disease | 9 | PM | 31122236 | 📋 | Neuroprotective Effects of Berberine in Animal Models of Alzheimer's Disease: A Systematic Review of Pre-Clinical Studies |
| Berberine | Alzheimer's Disease | 2 | PM | 30873920 | 📋 | Berberine Alleviates Amyloid-beta Pathogenesis Via Activating LKB1/AMPK Signaling in the Brain of APP/PS1 Transgenic Mice |
| Berberine | Alzheimer's Disease | 12 | PM | 30542442 | 📋 | Berberine Alleviates Amyloid β 25-35-induced Inflammatory Response in Human Neuroblastoma Cells by Inhibiting Proinflammatory Factors |
| Berberine | Alzheimer's Disease | 14 | PM | 30272344 | 📋 | Berberine Promotes Nerve Regeneration Through IGFR‑mediated JNK‑AKT Signal Pathway |
| Berberine | Alzheimer's Disease | 3 | PM | 29962345 | 📋 | Berberine Alleviates Amyloid-Beta Pathology in the Brain of APP/PS1 Transgenic Mice via Inhibiting β/γ-Secretases Activity and Enhancing α-Secretases |
| Berberine | Alzheimer's Disease | 6 | PM | 29170048 | 📋 | Neuroprotective Effect of Berberine Against Environmental Heavy Metals-Induced Neurotoxicity and Alzheimer's-like Disease in Rats |
| Berberine | Alzheimer's Disease | 33 | PM | 29132092 | 📋 | Berberine attenuates cognitive impairment and ameliorates tau hyperphosphorylation by limiting the self-perpetuating pathogenic cycle between NF-κB signaling, oxidative stress and neuroinflammation |
| Berberine | Alzheimer's Disease | 11 | PM | 28822725 | 📋 | Berberine Modulates Amyloid-β Peptide Generation by Activating AMP-activated Protein Kinase |
| Berberine | Alzheimer's Disease | 38 | PM | 28223223 | 📋 | Berberine improves cognitive impairment by promoting autophagic clearance and inhibiting production of β-amyloid in APP/tau/PS1 mouse model of Alzheimer's disease |
| Berberine | Alzheimer's Disease | 5 | PM | 27746125 | 📋 | Berberine Protects Against Memory Impairment and Anxiogenic-Like Behavior in Rats Submitted to Sporadic Alzheimer's-like Dementia: Involvement of Acetylcholinesterase and Cell Death |
| Berberine | Alzheimer's Disease | 1 | PM | 25861937 | 📋 | The Therapeutic Potential of Berberine Against the Altered Intrinsic Properties of the CA1 Neurons Induced by Aβ Neurotoxicity |
| Berberine | Alzheimer's Disease | 37 | PM | 22459600 | 📋 | Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model |
| Berberine | Alzheimer's Disease | 34 | PM | 22152059 | 📋 | Decrease in the production of β-amyloid by berberine inhibition of the expression of β-secretase in HEK293 cells |
| Berberine | Alzheimer's Disease | 35 | PM | 21829148 | 📋 | Berberine: a potential multipotent natural product to combat Alzheimer's disease |
| Berberine | Brain Aneurysm | 1 | PM | 29899701 | 📋 | Berberine Attenuates Macrophages Infiltration in Intracranial Aneurysms Potentially Through FAK/Grp78/UPR Axis |
| Berberine | Brain Inflammation | 5 | PM | 31795609 | 📋 | Berberine Ameliorates Brain Inflammation in Poloxamer 407-Induced Hyperlipidemic Rats |
| Berberine | Brain Inflammation | 6 | PM | 28842306 | 📋 | Berberine Attenuates Depressive-Like Behaviors by Suppressing Neuro-Inflammation in Stressed Mice |
| Berberine | Brain Inflammation | 1 | PM | 28061403 | 📋 | Berberine Ameliorates Intrahippocampal Kainate-Induced Status Epilepticus and Consequent Epileptogenic Process in the Rat: Underlying Mechanisms |
| Berberine | Brain Inflammation | 2 | PM | 20976070 | 📋 | Berberine Attenuates Experimental Autoimmune Encephalomyelitis in C57 BL/6 Mice |
| Berberine | Brain Injury | 2 | PM | 29399112 | 📋 | Neuroprotective Effect of Berberine Against Learning and Memory Deficits in Diffuse Axonal Injury |
| Berberine | Cerebral Hypoperfusion | 2 | PM | 35697268 | 📋 | Berberine protects against chronic cerebral hypoperfusion-induced cognitive impairment and hippocampal damage via regulation of the ERK/Nrf2 pathway |
| Berberine | Cerebral Hypoperfusion | 1 | PM | 35142272 | 📋 | Berberine Ameliorates Cognitive Impairment by Regulating Microglial Polarization and Increasing Expression of Anti-inflammatory Factors following Permanent Bilateral Common Carotid Artery Occlusion in Rats |
| Berberine | Cerebral Ischemia | 6 | PM | 28722488 | 📋 | Berberine Promotes Ischemia-Induced Angiogenesis in Mice Heart via Upregulation of microRNA-29b |
| Berberine | Cerebral Ischemia | 4 | PM | 28495517 | 📋 | Berberine Confers Neuroprotection in Coping With Focal Cerebral Ischemia by Targeting Inflammatory Cytokines |
| Berberine | Cerebral Ischemia | 1 | PM | 27158406 | 📋 | Pharmacologic Preconditioning With Berberine Attenuating Ischemia-Induced Apoptosis and Promoting Autophagy in Neuron |
| Berberine | Cerebral Ischemia | 2 | PM | 24177287 | 📋 | Verapamil augments the neuroprotectant action of berberine in rat model of transient global cerebral ischemia |
| Berberine | Cerebral Ischemia | 3 | PM | 22052603 | 📋 | Effects of berberine on hippocampal neuronal damage and matrix metalloproteinase-9 activity following transient global cerebral ischemia |
| Berberine | Cerebral Ischemia-Reperfusion | 9 | PM | 37245860 | 📋 | Berberine modulates gut microbiota to attenuate cerebral ferroptosis induced by ischemia-reperfusion in mice |
| Berberine | Cerebral Ischemia-Reperfusion | 8 | PM | 34517069 | 📋 | Berberine exerts neuroprotective activities against cerebral ischemia/reperfusion injury through up-regulating PPAR-γ to suppress NF-κB-mediated pyroptosis |
| Berberine | Cerebral Ischemia-Reperfusion | 7 | PM | 33995012 | 📋 | Berberine Attenuates Cerebral Ischemia-Reperfusion Injury Induced Neuronal Apoptosis by Down-Regulating the CNPY2 Signaling Pathway |
| Berberine | Cerebral Ischemia-Reperfusion | 6 | PM | 33719277 | 📋 | [Protective effect and immune mechanism of berberine on cerebral ischemia/reperfusion injury in rats] |
| Berberine | Cerebral Ischemia-Reperfusion | 5 | PM | 33428132 | 📋 | Berberine Ameliorates Oxygen-glucose Deprivation/Reperfusion-induced Apoptosis by Inhibiting Endoplasmic Reticulum Stress and Autophagy in PC12 Cells |
| Berberine | Cerebral Ischemia-Reperfusion | 2 | PM | 30266998 | 📋 | Berberine Attenuates Ischemia-Reperfusion Injury Through Inhibiting HMGB1 Release and NF-κB Nuclear Translocation |
| Berberine | Cerebral Ischemia-Reperfusion | 4 | PM | 30266118 | 📋 | Effect of Berberine on Angiogenesis and HIF-1α / VEGF Signal Transduction Pathway in Rats With Cerebral Ischemia - Reperfusion Injury |
| Berberine | Cerebral Ischemia-Reperfusion | 1 | PM | 29357017 | 📋 | Berberine Ameliorates MCAO Induced Cerebral Ischemia/Reperfusion Injury via Activation of the BDNF-TrkB-PI3K/Akt Signaling Pathway |
| Berberine | Cerebral Ischemia-Reperfusion | 10 | PM | 23499694 | 📋 | Effect of berberine on cell cycle arrest and cell survival during cerebral ischemia and reperfusion and correlations with p53/cyclin D1 and PI3K/Akt |
| Berberine | Cerebral Ischemia-Reperfusion | 11 | PM | 22119079 | 📋 | PI3K p55γ promoter activity enhancement is involved in the anti-apoptotic effect of berberine against cerebral ischemia-reperfusion |
| Berberine | Cerebral Ischemia-Reperfusion | 3 | PM | 18838103 | 📋 | Neuroprotective Effects of Berberine on Stroke Models in Vitro and in Vivo |
| Berberine | Cognitive Disorders | 7 | PM | 37506403 | 📋 | Berberine ameliorates iron levels and ferroptosis in the brain of 3 × Tg-AD mice |
| Berberine | Cognitive Disorders | 6 | PM | 36594063 | 📋 | Berberine hydrochloride improves cognitive deficiency through hippocampal up-regulation of neurotrophins following inhalant self-administration of methamphetamine |
| Berberine | Cognitive Disorders | 4 | PM | 36561238 | 📋 | Neuroprotective Effects of Berberine Hydrochloride on Methamphetamine-induced Cognitive Dysfunction: Immunohistochemical and Behavioral Studies in Rats |
| Berberine | Cognitive Disorders | 5 | PM | 35768254 | 📋 | Berberine Ameliorates Cognitive Disorder via GSK3β/PGC-1α Signaling in APP/PS1 Mice |
| Berberine | Cognitive Disorders | 3 | PM | 35142272 | 📋 | Berberine Ameliorates Cognitive Impairment by Regulating Microglial Polarization and Increasing Expression of Anti-inflammatory Factors following Permanent Bilateral Common Carotid Artery Occlusion in Rats |
| Berberine | Cognitive Disorders | 2 | PM | 33460662 | 📋 | Berberine ameliorates doxorubicin-induced cognitive impairment (chemo brain) in rats |
| Berberine | Cognitive Disorders | 1 | PM | 31701723 | 📋 | [Effects of Berberine on Learning and Memory Ability in Vascular Cognitive Impairment Rats] |
| Berberine | Cognitive Disorders | 8 | PM | 28223223 | 📋 | Berberine improves cognitive impairment by promoting autophagic clearance and inhibiting production of β-amyloid in APP/tau/PS1 mouse model of Alzheimer's disease |
| Berberine | Depression | 19 | PM | 38318145 | 📋 | Research progress on antidepressant effects and mechanisms of berberine |
| Berberine | Depression | 18 | PM | 38296172 | 📋 | Jiao-tai-wan and its effective component-berberine improve diabetes and depressive disorder through the cAMP/PKA/CREB signaling pathway |
| Berberine | Depression | 17 | PM | 38113631 | 📋 | Berberine exerts antidepressant effects in vivo and in vitro through the PI3K/AKT/CREB/BDNF signaling pathway |
| Berberine | Depression | 16 | PM | 37595491 | 📋 | Berberine attenuates depression-like behavior by modulating the hippocampal NLRP3 ubiquitination signaling pathway through Trim65 |
| Berberine | Depression | 13 | PM | 36859349 | 📋 | Berberine ameliorates depression-like behaviors in mice via inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing neuroplasticity disruption |
| Berberine | Depression | 12 | PM | 36610597 | 📋 | Gut microbiota-SCFAs-brain axis associated with the antidepressant activity of berberine in CUMS rats |
| Berberine | Depression | 15 | PM | 36117760 | 📋 | Berberine exerts antidepressant-like effects via regulating miR-34a-synaptotagmin1/Bcl-2 axis |
| Berberine | Depression | 11 | PM | 36089660 | 📋 | Berberine ameliorates depression-like behavior in CUMS mice by activating TPH1 and inhibiting IDO1-associated with tryptophan metabolism |
| Berberine | Depression | 10 | PM | 35677435 | 📋 | Current Evidence and Future Directions of Berberine Intervention in Depression |
| Berberine | Depression | 9 | PM | 35221284 | 📋 | Label-free quantitative proteomic analysis of reserpine-induced depression in mice intervened by berberine |
| Berberine | Depression | 8 | PM | 35051489 | 📋 | Regulation of the kynurenine/serotonin pathway by berberine and the underlying effect in the hippocampus of the chronic unpredictable mild stress mice |
| Berberine | Depression | 7 | PM | 34049474 | 📋 | Berberine and Ginsenoside Rb1 Ameliorate Depression-Like Behavior in Diabetic Rats |
| Berberine | Depression | 6 | PM | 33654403 | 📋 | Berberine Suppresses Mice Depression Behaviors and Promotes Hippocampal Neurons Growth Through Regulating the miR-34b-5p/miR-470-5p/BDNF Axis |
| Berberine | Depression | 1 | PM | 32270794 | 📋 | Intranasal Delivery of Berberine via in Situ Thermoresponsive Hydrogels With Non-Invasive Therapy Exhibits Better Antidepressant-Like Effects |
| Berberine | Depression | 5 | PM | 28842306 | 📋 | Berberine Attenuates Depressive-Like Behaviors by Suppressing Neuro-Inflammation in Stressed Mice |
| Berberine | Depression | 2 | PM | 28465511 | 📋 | Berberine Produces Antidepressant-Like Effects in Ovariectomized Mice |
| Berberine | Depression | 3 | PM | 28339024 | 📋 | Effects of Berberine on a Rat Model of Chronic Stress and Depression via Gastrointestinal Tract Pathology and Gastrointestinal Flora Profile Assays |
| Berberine | Depression | 4 | PM | 26773864 | 📋 | Berberine Up-Regulates the BDNF Expression in Hippocampus and Attenuates Corticosterone-Induced Depressive-Like Behavior in Mice |
| Berberine | Depression | 14 | PM | 24246570 | 📋 | Inhibition of organic cation transporter 2 and 3 may be involved in the mechanism of the antidepressant-like action of berberine |
| Berberine | Diabetic Encephalopathy | 14 | PM | 38801506 | 📋 | Berberine improves cognitive impairment by alleviating brain atrophy and promoting white matter reorganization in diabetic db/db mice: a magnetic resonance imaging-based study |
| Berberine | Diabetic Encephalopathy | 13 | PM | 38230770 | 📋 | Berberine attenuates cognitive dysfunction and hippocampal apoptosis in rats with prediabetes |
| Berberine | Diabetic Encephalopathy | 9 | PM | 36029207 | 📋 | Berberine ameliorates lipopolysaccharide-induced cognitive impairment through Sirt1/Nrf2/NF-κB signaling pathway in C57BL/6J mice |
| Berberine | Diabetic Encephalopathy | 8 | PM | 35734409 | 📋 | Neuroprotective Effect and Possible Mechanisms of Berberine in Diabetes-Related Cognitive Impairment: A Systematic Review and Meta-Analysis of Animal Studies |
| Berberine | Diabetic Encephalopathy | 7 | PM | 34137676 | 📋 | Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action |
| Berberine | Diabetic Encephalopathy | 6 | PM | 33981233 | 📋 | Efficacy and Safety of Berberine Alone for Several Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Clinical Trials |
| Berberine | Diabetic Encephalopathy | 5 | PM | 33740285 | 📋 | Berberine ameliorates neuronal AD-like change via activating Pi3k/PGCε pathway |
| Berberine | Diabetic Encephalopathy | 4 | PM | 33725758 | 📋 | Effects of berberine on cholinesterases and monoamine oxidase activities, and antioxidant status in the brain of streptozotocin (STZ)-induced diabetic rats |
| Berberine | Diabetic Encephalopathy | 3 | PM | 33632015 | 📋 | Berberine elevates mitochondrial membrane potential and decreases reactive oxygen species by inhibiting the Rho/ROCK pathway in rats with diabetic encephalopathy |
| Berberine | Diabetic Encephalopathy | 2 | PM | 32005442 | 📋 | Berberine for Prevention of Dementia Associated With Diabetes and Its Comorbidities: A Systematic Review |
| Berberine | Diabetic Encephalopathy | 1 | PM | 31551793 | 📋 | Berberine Ameliorates Spatial Learning Memory Impairment and Modulates Cholinergic Anti-Inflammatory Pathway in Diabetic Rats |
| Berberine | Diabetic Encephalopathy | 11 | PM | 28782427 | 📋 | Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db Mice |
| Berberine | Diabetic Encephalopathy | 10 | PM | 23640014 | 📋 | Berberine chloride improved synaptic plasticity in STZ induced diabetic rats |
| Berberine | Diabetic Encephalopathy | 12 | PM | 21262264 | 📋 | Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes |
| Berberine | Encephalomyelitis | 1 | PM | 20976070 | 📋 | Berberine Attenuates Experimental Autoimmune Encephalomyelitis in C57 BL/6 Mice |
| Berberine | Encephalopathy | 1 | PM | 34867376 | 📋 | Blocking HMGB1/RAGE Signaling by Berberine Alleviates A1 Astrocyte and Attenuates Sepsis-Associated Encephalopathy |
| Berberine | Glioblastoma | 9 | PM | 35209812 | 📋 | Anticancer mechanisms of Berberine: a good choice for glioblastoma multiforme therapy |
| Berberine | Glioblastoma | 8 | PM | 33298057 | 📋 | Berberine reduces temozolomide resistance by inducing autophagy via the ERK1/2 signaling pathway in glioblastoma |
| Berberine | Glioblastoma | 7 | PM | 32410137 | 📋 | Berberine Induces Apoptosis in Glioblastoma Multiforme U87MG Cells via Oxidative Stress and Independent of AMPK Activity |
| Berberine | Glioblastoma | 4 | PM | 31841506 | 📋 | Combination Treatment of Berberine and Solid Lipid Curcumin Particles Increased Cell Death and Inhibited PI3K/Akt/mTOR Pathway of Human Cultured Glioblastoma Cells More Effectively Than Did Individual Treatments |
| Berberine | Glioblastoma | 2 | PM | 31070539 | 📋 | Berberine Inhibits Angiogenesis in Glioblastoma Xenografts by Targeting the VEGFR2/ERK Pathway |
| Berberine | Glioblastoma | 3 | PM | 27557493 | 📋 | Berberine Induces Autophagy in Glioblastoma by Targeting the AMPK/mTOR/ULK1-pathway |
| Berberine | Glioblastoma | 1 | PM | 25504754 | 📋 | Berberine Induces Senescence of Human Glioblastoma Cells by Downregulating the EGFR-MEK-ERK Signaling Pathway |
| Berberine | Glioblastoma | 6 | PM | 20930370 | 📋 | Berberine-induced Apoptosis in Human Glioblastoma T98G Cells Is Mediated by Endoplasmic Reticulum Stress Accompanying Reactive Oxygen Species and Mitochondrial Dysfunction |
| Berberine | Glioblastoma | 5 | PM | 18379040 | 📋 | Berberine Induces G1 Arrest and Apoptosis in Human Glioblastoma T98G Cells Through Mitochondrial/Caspases Pathway |
| Berberine | Glioma | 5 | PM | 36255058 | 📋 | Berberine Suppressed the Progression of Human Glioma Cells by Inhibiting the TGF-β1/SMAD2/3 Signaling Pathway |
| Berberine | Glioma | 4 | PM | 35944362 | 📋 | Berberine inhibits glioma cell migration and invasion by suppressing TGF-β1/COL11A1 pathway |
| Berberine | Glioma | 3 | PM | 34683083 | 📋 | Berberine Photo-Activation Potentiates Cytotoxicity in Human Astrocytoma Cells through Apoptosis Induction |
| Berberine | Glioma | 2 | PM | 33262612 | 📋 | Berberine Inhibits Cell Proliferation by Interfering with Wild-Type and Mutant P53 in Human Glioma Cells |
| Berberine | Glioma | 6 | PM | 32557203 | 📋 | Therapeutic Potential of Berberine in the Treatment of Glioma: Insights into Its Regulatory Mechanisms |
| Berberine | Glioma | 1 | PM | 31139563 | 📋 | Antitumor Effects of Berberine on Gliomas via Inactivation of Caspase-1-Mediated IL-1β and IL-18 Release |
| Berberine | Hepatic Encephalopathy | 1 | PM | 37371422 | 📋 | Effect of Berberine against Cognitive Deficits in Rat Model of Thioacetamide-Induced Liver Cirrhosis and Hepatic Encephalopathy (Behavioral, Biochemical, Molecular and Histological Evaluations) |
| Berberine | Intracerebral Hemorrhage | 3 | PM | 38639436 | 📋 | Atorvastatin-induced intracerebral hemorrhage is inhibited by berberine in zebrafish |
| Berberine | Intracerebral Hemorrhage | 2 | PM | 37036515 | 📋 | Berberine mitigates intracerebral hemorrhage-induced neuroinflammation in a gut microbiota-dependent manner in mice |
| Berberine | Intracerebral Hemorrhage | 1 | PM | 34942622 | 📋 | Berberine Protects against Neurological Impairments and Blood-Brain Barrier Injury in Mouse Model of Intracerebral Hemorrhage |
| Berberine | Ischemic Stroke | 5 | PM | 38201839 | 📋 | Berberine Mediates the Production of Butyrate to Ameliorate Cerebral Ischemia via the Gut Microbiota in Mice |
| Berberine | Ischemic Stroke | 4 | PM | 38180752 | 📋 | METTL3-dependent N6-methyladenosine modification is involved in berberine-mediated neuroprotection in ischemic stroke by enhancing the stability of NEAT1 in astrocytes |
| Berberine | Ischemic Stroke | 3 | PM | 35815278 | 📋 | Network Pharmacology and Bioinformatics Methods Reveal the Mechanism of Berberine in the Treatment of Ischaemic Stroke |
| Berberine | Ischemic Stroke | 2 | PM | 35093536 | 📋 | Novel mechanistic insight on the neuroprotective effect of berberine: The role of PPARδ for antioxidant action |
| Berberine | Ischemic Stroke | 1 | PM | 31020571 | 📋 | Berberine Facilitates Angiogenesis Against Ischemic Stroke Through Modulating Microglial Polarization via AMPK Signaling |
| Berberine | Memory Disorders | 8 | PM | 37649038 | 📋 | Berberine improves inhibitory avoidance memory impairment of Toxoplasma gondii-infected rat model of ketamine-induced schizophrenia |
| Berberine | Memory Disorders | 5 | PM | 33925781 | 📋 | Effect of Berberine Isolated from Barberry Species by Centrifugal Partition Chromatography on Memory and the Expression of Parvalbumin in the Mouse Hippocampus Proper |
| Berberine | Memory Disorders | 2 | PM | 31701723 | 📋 | [Effects of Berberine on Learning and Memory Ability in Vascular Cognitive Impairment Rats] |
| Berberine | Memory Disorders | 1 | PM | 31551793 | 📋 | Berberine Ameliorates Spatial Learning Memory Impairment and Modulates Cholinergic Anti-Inflammatory Pathway in Diabetic Rats |
| Berberine | Memory Disorders | 3 | PM | 29399112 | 📋 | Neuroprotective Effect of Berberine Against Learning and Memory Deficits in Diffuse Axonal Injury |
| Berberine | Memory Disorders | 7 | PM | 29186770 | 📋 | The Evaluation of Pro-Cognitive and Antiamnestic Properties of Berberine and Magnoflorine Isolated from Barberry Species by Centrifugal Partition Chromatography (CPC), in Relation to QSAR Modelling |
| Berberine | Memory Disorders | 4 | PM | 26159088 | 📋 | Protective Effect of Berberine, an Isoquinoline Alkaloid Ameliorates Ethanol-Induced Oxidative Stress and Memory Dysfunction in Rats |
| Berberine | Memory Disorders | 6 | PM | 24342459 | 📋 | Berberine rescues D-galactose-induced synaptic/memory impairment by regulating the levels of Arc |
| Berberine | Mild Cognitive Impairment | 2 | PM | 30066867 | 📋 | Cognitive Impairments Induced by Severe Acute Pancreatitis Are Attenuated by Berberine Treatment in Rats |
| Berberine | Postoperative Cognitive Dysfunction | 1 | PM | 27376853 | 📋 | Berberine Alleviates Postoperative Cognitive Dysfunction by Suppressing Neuroinflammation in Aged Mice |
| Berberine | Psychiatric Disorders | 2 | PM | 35538795 | 📋 | Berberine: is a Promising Agent for Mental Disorders Treatment? |
| Berberine | Psychiatric Disorders | 1 | PM | 32081663 | 📋 | Berberine Attenuated Olanzapine-Induced Metabolic Alterations in Mice: Targeting Transient Receptor Potential Vanilloid Type 1 and 3 Channels |
| Berberine | Schizophrenia | 5 | PM | 37069570 | 📋 | Berberine improves negative symptoms and cognitive function in patients with chronic schizophrenia via anti-inflammatory effect: a randomized clinical trial |
| Berberine | Schizophrenia | 4 | PM | 35037116 | 📋 | Improvement of adjunctive berberine treatment on negative symptoms in patients with schizophrenia |
| Berberine | Schizophrenia | 3 | PM | 34931749 | 📋 | Adjunctive Berberine Reduces Antipsychotic-Associated Weight Gain and Metabolic Syndrome in Patients with Schizophrenia: A Randomized Controlled Trial |
| Berberine | Schizophrenia | 2 | PM | 33812218 | 📋 | The effect of berberine adjunctive treatment on glycolipid metabolism in patients with schizophrenia: A randomized, double-blind, placebo-controlled clinical trial |
| Berberine | Schizophrenia | 1 | PM | 31103726 | 📋 | Ameliorating Effects of Berberine on MK-801-induced Cognitive and Motor Impairments in a Neonatal Rat Model of Schizophrenia |
| Berberine | Subarachnoid Hemorrhage | 1 | PM | 32754040 | 📋 | Berberine Ameliorates Subarachnoid Hemorrhage Injury via Induction of Sirtuin 1 and Inhibiting HMGB1/Nf-κB Pathway |
| Berberine | Traumatic Brain Injury | 1 | PM | 30027364 | 📋 | Berberine Protects Secondary Injury in Mice With Traumatic Brain Injury Through Anti-oxidative and Anti-inflammatory Modulation |
| Berberine | Traumatic Brain Injury | 2 | PM | 29512719 | 📋 | Neuroprotective Effect of Berberine Agonist Against Impairment of Learning and Memory Skills in Severe Traumatic Brain Injury via Sirt1/p38 MAPK Expression |
