| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Curcumin | Arthritis | 13 | PM | 33494792 | 📋 | A bioavailable form of curcumin, in combination with vitamin-D- and omega-3-enriched diet, modifies disease onset and outcomes in a murine model of collagen-induced arthritis |
| Curcumin | Arthritis | 12 | PM | 33478498 | 📋 | Anti-inflammatory effect of different curcumin preparations on adjuvant-induced arthritis in rats |
| Curcumin | Arthritis | 2 | PM | 32351596 | 📋 | Efficacy of Curcumin With Iontophoretic Application on Paw Edema and Hematological Responses in Collagen-Induced Arthritis Rat Models |
| Curcumin | Arthritis | 14 | PM | 30048884 | 📋 | Micellar solubilisation enhances the antiinflammatory activities of curcumin and boswellic acids in rats with adjuvant-induced arthritis |
| Curcumin | Arthritis | 4 | PM | 29306322 | 📋 | Curcumin Attenuates Collagen-Induced Inflammatory Response Through the "Gut-Brain Axis" |
| Curcumin | Arthritis | 15 | PM | 27178879 | 📋 | Amelioration of FCA induced arthritis on topical application of curcumin in combination with emu oil |
| Curcumin | Arthritis | 8 | PM | 25988362 | 📋 | Intrathecal Curcumin Attenuates Pain Hypersensitivity and Decreases Spinal Neuroinflammation in Rat Model of Monoarthritis |
| Curcumin | Arthritis | 10 | PM | 25836921 | 📋 | Oral Curcumin Has Anti-Arthritic Efficacy Through Somatostatin Generation via cAMP/PKA and Ca(2+)/CaMKII Signaling Pathways in the Small Intestine |
| Curcumin | Arthritis | 16 | PM | 25028100 | 📋 | Improvement of bioavailability and anti-inflammatory potential of curcumin in combination with emu oil |
| Curcumin | Arthritis | 3 | PM | 24138213 | 📋 | Curcumin Potentiates the Anti-Arthritic Effect of Prednisolone in Freund's Complete Adjuvant-Induced Arthritic Rats |
| Curcumin | Arthritis | 5 | PM | 20188213 | 📋 | Curcumin Attenuates Inflammatory Response in IL-1beta-induced Human Synovial Fibroblasts and Collagen-Induced Arthritis in Mouse Model |
| Curcumin | Arthritis | 7 | PM | 19763044 | 📋 | Oral Administration of Curcumin Suppresses Production of Matrix Metalloproteinase (MMP)-1 and MMP-3 to Ameliorate Collagen-Induced Arthritis: Inhibition of the PKCdelta/JNK/c-Jun Pathway |
| Curcumin | Arthritis | 9 | PM | 16807698 | 📋 | The Antioxidants Curcumin and Quercetin Inhibit Inflammatory Processes Associated With Arthritis |
| Curcumin | Arthritis | 11 | PM | 15541495 | 📋 | Complementary Inhibition of Synoviocyte, Smooth Muscle Cell or Mouse Lymphoma Cell Proliferation by a Vanadyl Curcumin Complex Compared to Curcumin Alone |
| Curcumin | Arthritis | 1 | PM | 9089639 | 📋 | Presence of an Acidic Glycoprotein in the Serum of Arthritic Rats: Modulation by Capsaicin and Curcumin |
| Curcumin | Arthritis | 6 | PM | 3521617 | 📋 | Effect of Curcumin on Platelet Aggregation and Vascular Prostacyclin Synthesis |
| Curcumin | Gout | 1 | PM | 11025157 | 📋 | Inhibition of xanthine oxidase by some Chinese medicinal plants used to treat gout |
| Curcumin | Osteoarthritis | 46 | PM | 38571919 | 📋 | Curcuma longa L. extract exhibits anti-inflammatory and cytoprotective functions in the articular cartilage of monoiodoacetate-injected rats |
| Curcumin | Osteoarthritis | 45 | PM | 38157375 | 📋 | Evaluating the potential of Vitamin D and curcumin to alleviate inflammation and mitigate the progression of osteoarthritis through their effects on human chondrocytes: A proof-of-concept investigation |
| Curcumin | Osteoarthritis | 44 | PM | 37938371 | 📋 | Analysis of the mechanism of curcumin against osteoarthritis using metabolomics and transcriptomics |
| Curcumin | Osteoarthritis | 43 | PM | 37771529 | 📋 | Curcumin reverses erastin-induced chondrocyte ferroptosis by upregulating Nrf2 |
| Curcumin | Osteoarthritis | 1 | PM | 37573656 | 📋 | Therapeutic effects of combining curcumin and swimming in osteoarthritis using a rat model |
| Curcumin | Osteoarthritis | 42 | PM | 36394597 | 📋 | Curcuma as an anti-inflammatory component in treating osteoarthritis |
| Curcumin | Osteoarthritis | 41 | PM | 36171802 | 📋 | Potential complementary and/or synergistic effects of curcumin and boswellic acids for management of osteoarthritis |
| Curcumin | Osteoarthritis | 40 | PM | 36034822 | 📋 | Curcuma longa and Boswellia serrata Extracts Modulate Different and Complementary Pathways on Human Chondrocytes In Vitro: Deciphering of a Transcriptomic Study |
| Curcumin | Osteoarthritis | 39 | PM | 35550528 | 📋 | Curcumin exerts chondroprotective effects against osteoarthritis by promoting AMPK/PINK1/Parkin-mediated mitophagy |
| Curcumin | Osteoarthritis | 38 | PM | 35458170 | 📋 | A Meta-Analysis of the Impact of Nutritional Supplementation on Osteoarthritis Symptoms |
| Curcumin | Osteoarthritis | 37 | PM | 35452417 | 📋 | Therapeutic Effects of Curcumin on Osteoarthritis and Its Protection of Chondrocytes Through the Wnt/Β-Catenin Signaling Pathway |
| Curcumin | Osteoarthritis | 36 | PM | 35399636 | 📋 | Quality of Evidence Supporting the Role of Curcuma Longa Extract/Curcumin for the Treatment of Osteoarthritis: An Overview of Systematic Reviews |
| Curcumin | Osteoarthritis | 35 | PM | 34649531 | 📋 | The benefit of combining curcumin, bromelain and harpagophytum to reduce inflammation in osteoarthritic synovial cells |
| Curcumin | Osteoarthritis | 34 | PM | 34474599 | 📋 | Intra-Articular Injections of Curcumin Monoglucuronide TBP1901 Suppresses Articular Cartilage Damage and Regulates Subchondral Bone Alteration in an Osteoarthritis Rat Model |
| Curcumin | Osteoarthritis | 33 | PM | 34350255 | 📋 | Curcumin exerts a protective effect on murine knee chondrocytes treated with IL-1β through blocking the NF-κB/HIF-2α signaling pathway |
| Curcumin | Osteoarthritis | 32 | PM | 34331696 | 📋 | A Systematic Review of the Clinical Use of Curcumin for the Treatment of Osteoarthritis |
| Curcumin | Osteoarthritis | 29 | PM | 34299264 | 📋 | Curcumin Attenuates Environment-Derived Osteoarthritis by Sox9/NF-kB Signaling Axis |
| Curcumin | Osteoarthritis | 28 | PM | 34257809 | 📋 | The Combination Treatment of Curcumin and Probucol Protects Chondrocytes from TNF- α Induced Inflammation by Enhancing Autophagy and Reducing Apoptosis via the PI3K-Akt-mTOR Pathway |
| Curcumin | Osteoarthritis | 27 | PM | 34103964 | 📋 | Curcumin-Alleviated Osteoarthritic Progression in Rats Fed a High-Fat Diet by Inhibiting Apoptosis and Activating Autophagy via Modulation of MicroRNA-34a |
| Curcumin | Osteoarthritis | 26 | PM | 34102742 | 📋 | [Research progress of curcumin in the treatment of osteoarthritis] |
| Curcumin | Osteoarthritis | 25 | PM | 34017975 | 📋 | The efficacy and safety of Curcuma longa Extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis |
| Curcumin | Osteoarthritis | 10 | PM | 33588606 | 📋 | Curcumin Supplementation Enhances Bone Marrow Mesenchymal Stem Cells to Promote the Anabolism of Articular Chondrocytes and Cartilage Repair |
| Curcumin | Osteoarthritis | 7 | PM | 33472415 | 📋 | Resveratrol and Curcumin Attenuate Ex Vivo Sugar-Induced Cartilage Glycation, Stiffening, Senescence, and Degeneration |
| Curcumin | Osteoarthritis | 6 | PM | 33377585 | 📋 | Curcumin ameliorates IL-1β-induced apoptosis by activating autophagy and inhibiting the NF-κB signaling pathway in rat primary articular chondrocytes |
| Curcumin | Osteoarthritis | 31 | PM | 33238379 | 📋 | Herbal Composition LI73014F2 Alleviates Articular Cartilage Damage and Inflammatory Response in Monosodium Iodoacetate-Induced Osteoarthritis in Rats |
| Curcumin | Osteoarthritis | 3 | PM | 33137380 | 📋 | Combination treatment with Lactobacillus acidophilus LA-1, vitamin B, and curcumin ameliorates the progression of osteoarthritis by inhibiting the pro-inflammatory mediators |
| Curcumin | Osteoarthritis | 24 | PM | 32776418 | 📋 | Curcumin reinforces MSC-derived exosomes in attenuating osteoarthritis via modulating the miR-124/NF-kB and miR-143/ROCK1/TLR9 signalling pathways |
| Curcumin | Osteoarthritis | 23 | PM | 32540725 | 📋 | Significant Immunomodulatory Properties of Curcumin in Patients With Osteoarthritis; A Successful Clinical Trial in Iran |
| Curcumin | Osteoarthritis | 22 | PM | 32523247 | 📋 | A Natural Supplement Formula Reduces Anti-Oxidative Stress and Enhances Osteo-Chondrogenic Differentiation Potential in Mesenchymal Stem Cells |
| Curcumin | Osteoarthritis | 30 | PM | 32349389 | 📋 | Anti-osteoarthritic Effects of an Herbal Composition LI73014F2 on Interleukin-1β-induced Primary Human Articular Chondrocytes |
| Curcumin | Osteoarthritis | 9 | PM | 31845532 | 📋 | Curcumin Has Immunomodulatory Effects on RANKL-stimulated Osteoclastogenesis in Vitro and Titanium Nanoparticle-Induced Bone Loss in Vivo |
| Curcumin | Osteoarthritis | 20 | PM | 30479972 | 📋 | Recently highlighted nutraceuticals for preventive management of osteoarthritis |
| Curcumin | Osteoarthritis | 14 | PM | 30466988 | 📋 | Curcumin Downregulates Expression of Opioid-Related Nociceptin Receptor Gene (OPRL1) in Isolated Neuroglia Cells |
| Curcumin | Osteoarthritis | 19 | PM | 29534559 | 📋 | Phytoproflex®: supplementary management of osteoarthrosis: a supplement registry |
| Curcumin | Osteoarthritis | 8 | PM | 29316908 | 📋 | Efficacy and Safety of Curcumin and Its Combination With Boswellic Acid in Osteoarthritis: A Comparative, Randomized, Double-Blind, Placebo-Controlled Study |
| Curcumin | Osteoarthritis | 12 | PM | 26311096 | 📋 | Role of Curcumin in Common Musculoskeletal Disorders: A Review of Current Laboratory, Translational, and Clinical Data |
| Curcumin | Osteoarthritis | 5 | PM | 25352926 | 📋 | A New Curcuma Extract (Flexofytol®) in Osteoarthritis: Results From a Belgian Real-Life Experience |
| Curcumin | Osteoarthritis | 21 | PM | 21345249 | 📋 | Molecular Targets of Natural Health Products in Arthritis |
| Curcumin | Osteoarthritis | 4 | PM | 21194249 | 📋 | Efficacy and Safety of Meriva®, a Curcumin-Phosphatidylcholine Complex, During Extended Administration in Osteoarthritis Patients |
| Curcumin | Osteoarthritis | 18 | PM | 20594343 | 📋 | Curcumin Mediated Suppression of Nuclear factor-κB Promotes Chondrogenic Differentiation of Mesenchymal Stem Cells in a High-Density Co-Culture Microenvironment |
| Curcumin | Osteoarthritis | 2 | PM | 19889203 | 📋 | Synergistic Chondroprotective Effects of Curcumin and Resveratrol in Human Articular Chondrocytes: Inhibition of IL-1beta-induced NF-kappaB-mediated Inflammation and Apoptosis |
| Curcumin | Osteoarthritis | 17 | PM | 19836480 | 📋 | Biological Actions of Curcumin on Articular Chondrocytes |
| Curcumin | Osteoarthritis | 13 | PM | 19723086 | 📋 | Interleukin-1beta-induced Extracellular Matrix Degradation and Glycosaminoglycan Release Is Inhibited by Curcumin in an Explant Model of Cartilage Inflammation |
| Curcumin | Osteoarthritis | 16 | PM | 17291458 | 📋 | Suppression of NF-kappaB Activation by Curcumin Leads to Inhibition of Expression of cyclo-oxygenase-2 and Matrix metalloproteinase-9 in Human Articular Chondrocytes: Implications for the Treatment of Osteoarthritis |
| Curcumin | Osteoarthritis | 15 | PM | 16320828 | 📋 | Curcumin Protects Human Chondrocytes From IL-l1beta-induced Inhibition of Collagen Type II and beta1-integrin Expression and Activation of caspase-3: An Immunomorphological Study |
| Curcumin | Osteoarthritis | 11 | PM | 15659840 | 📋 | Effects of Curcumin (Diferuloylmethane) on Nuclear Factor kappaB Signaling in interleukin-1beta-stimulated Chondrocytes |
| Curcumin | Osteoarthritis of the Knee | 21 | PM | 38707049 | 📋 | Efficacy and Safety of Two Chondroprotective Supplements in Patients With Knee Osteoarthritis: A Randomized, Single-Blind, Pilot Study |
| Curcumin | Osteoarthritis of the Knee | 20 | PM | 38589505 | 📋 | Curcumin regulates autophagy through SIRT3-SOD2-ROS signaling pathway to improve quadriceps femoris muscle atrophy in KOA rat model |
| Curcumin | Osteoarthritis of the Knee | 19 | PM | 38036015 | 📋 | Efficacy and safety of curcumin therapy for knee osteoarthritis: A Bayesian network meta-analysis |
| Curcumin | Osteoarthritis of the Knee | 18 | PM | 37879214 | 📋 | Combination of curcumin and catalase protects against chondrocyte injury and knee osteoarthritis progression by suppressing oxidative stress |
| Curcumin | Osteoarthritis of the Knee | 17 | PM | 35782767 | 📋 | Curcumin as an effective suppressor of miRNA expression in patients with knee osteoarthritis |
| Curcumin | Osteoarthritis of the Knee | 16 | PM | 35662715 | 📋 | Combined Administration of Curcumin and Chondroitin Sulfate Alleviates Cartilage Injury and Inflammation via NF-κB Pathway in Knee Osteoarthritis Rats |
| Curcumin | Osteoarthritis of the Knee | 15 | PM | 35107231 | 📋 | Analgesic effect of curcumin topical formulation in knee osteoarthritis patients: a clinical trial |
| Curcumin | Osteoarthritis of the Knee | 14 | PM | 35010916 | 📋 | An Investigation into the Effects of a Curcumin Extract (Curcugen ®) on Osteoarthritis Pain of the Knee: A Randomised, Double-Blind, Placebo-Controlled Study |
| Curcumin | Osteoarthritis of the Knee | 13 | PM | 34537344 | 📋 | The efficacy of high- and low-dose curcumin in knee osteoarthritis: A systematic review and meta-analysis |
| Curcumin | Osteoarthritis of the Knee | 12 | PM | 34035964 | 📋 | Prospective, Multicenter Evaluation of a Polyherbal Supplement alongside Standard-of-Care Treatment for Mild Knee Osteoarthritis |
| Curcumin | Osteoarthritis of the Knee | 9 | PM | 33032585 | 📋 | The effect of curcumin ointment on knee pain in older adults with osteoarthritis: a randomized placebo trial |
| Curcumin | Osteoarthritis of the Knee | 8 | PM | 32848491 | 📋 | The Efficacy and Safety of Highly-Bioavailable Curcumin for Treating Knee Osteoarthritis: A 6-Month Open-Labeled Prospective Study |
| Curcumin | Osteoarthritis of the Knee | 1 | PM | 32180294 | 📋 | Herbal Formulation "Turmeric Extract, Black Pepper, and Ginger" Versus Naproxen for Chronic Knee Osteoarthritis: A Randomized, Double-Blind, Controlled Clinical Trial |
| Curcumin | Osteoarthritis of the Knee | 2 | PM | 30449982 | 📋 | Current Status of Top 10 Nutraceuticals Used for Knee Osteoarthritis in India |
| Curcumin | Osteoarthritis of the Knee | 11 | PM | 29708818 | 📋 | A Placebo-Controlled Double-Blind Study Demonstrates the Clinical Efficacy of a Novel Herbal Formulation for Relieving Joint Discomfort in Human Subjects with Osteoarthritis of Knee |
| Curcumin | Osteoarthritis of the Knee | 10 | PM | 29622343 | 📋 | Efficacy of curcumin and Boswellia for knee osteoarthritis: Systematic review and meta-analysis |
| Curcumin | Osteoarthritis of the Knee | 3 | PM | 28470851 | 📋 | Effectiveness of Curcuminoids in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials |
| Curcumin | Osteoarthritis of the Knee | 6 | PM | 27482294 | 📋 | Curcumin and Tetrahydrocurcumin Both Prevent Osteoarthritis Symptoms and Decrease the Expressions of Pro-Inflammatory Cytokines in Estrogen-Deficient Rats |
| Curcumin | Osteoarthritis of the Knee | 4 | PM | 24853120 | 📋 | Curcuminoid Treatment for Knee Osteoarthritis: A Randomized Double-Blind Placebo-Controlled Trial |
| Curcumin | Osteoarthritis of the Knee | 5 | PM | 24672232 | 📋 | Efficacy and Safety of Curcuma Domestica Extracts Compared With Ibuprofen in Patients With Knee Osteoarthritis: A Multicenter Study |
| Curcumin | Osteoarthritis of the Knee | 7 | PM | 16249246 | 📋 | Curcumin Synergistically Potentiates the Growth-Inhibitory and Pro-Apoptotic Effects of Celecoxib in Osteoarthritis Synovial Adherent Cells |
| Curcumin | Psoriatic Arthritis | 1 | PM | 38625384 | 📋 | Patient-reported outcomes of curcumin supplementation in rheumatoid arthritis and psoriatic arthritis: a cross-sectional survey |
| Curcumin | Rheumatoid Arthritis | 22 | PM | 38699839 | 📋 | The efficacy of curcumin supplementation on serum total antioxidant capacity, malondialdehyde, and disease activity in women with rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial |
| Curcumin | Rheumatoid Arthritis | 21 | PM | 38625384 | 📋 | Patient-reported outcomes of curcumin supplementation in rheumatoid arthritis and psoriatic arthritis: a cross-sectional survey |
| Curcumin | Rheumatoid Arthritis | 20 | PM | 38487171 | 📋 | Immunomodulatory effects of curcumin on macrophage polarization in rheumatoid arthritis |
| Curcumin | Rheumatoid Arthritis | 19 | PM | 37325651 | 📋 | Effect of curcumin on rheumatoid arthritis: a systematic review and meta-analysis |
| Curcumin | Rheumatoid Arthritis | 18 | PM | 37031388 | 📋 | The Combined Effect of Curcumin and Crocin on the Reduction of Inflammatory Responses in Arthritic Rats |
| Curcumin | Rheumatoid Arthritis | 17 | PM | 36474395 | 📋 | Therapeutic Potential of Curcumin with and without Strengthening Exercises in Improving Rheumatoid Arthritis |
| Curcumin | Rheumatoid Arthritis | 16 | PM | 35609329 | 📋 | Curcumin alleviates rheumatoid arthritis progression through the phosphatidylinositol 3-kinase/protein kinase B pathway: an in vitro and in vivo study |
| Curcumin | Rheumatoid Arthritis | 15 | PM | 35473503 | 📋 | Curcumin relieved the rheumatoid arthritis progression via modulating the linc00052/miR-126-5p/PIAS2 axis |
| Curcumin | Rheumatoid Arthritis | 14 | PM | 35450396 | 📋 | The Impact of Curcumin on the Inflammatory Profile of SW982 Cells in a Rheumatoid Arthritis Model |
| Curcumin | Rheumatoid Arthritis | 13 | PM | 35178811 | 📋 | Effects of curcumin supplementation on metabolic parameters, inflammatory factors and obesity values in women with rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial |
| Curcumin | Rheumatoid Arthritis | 12 | PM | 34478838 | 📋 | Effects of curcumin supplementation on inflammatory biomarkers in patients with Rheumatoid Arthritis and Ulcerative colitis: A systematic review and meta-analysis |
| Curcumin | Rheumatoid Arthritis | 11 | PM | 34331695 | 📋 | The Clinical Use of Curcumin for the Treatment of Rheumatoid Arthritis: A Systematic Review of Clinical Trials |
| Curcumin | Rheumatoid Arthritis | 10 | PM | 33914984 | 📋 | Curcumin and rheumatoid arthritis: A systematic review of literature |
| Curcumin | Rheumatoid Arthritis | 9 | PM | 33404796 | 📋 | Immunomodulatory Effects of Curcumin in Rheumatoid Arthritis: Evidence from Molecular Mechanisms to Clinical Outcomes |
| Curcumin | Rheumatoid Arthritis | 8 | PM | 33377585 | 📋 | Curcumin ameliorates IL-1β-induced apoptosis by activating autophagy and inhibiting the NF-κB signaling pathway in rat primary articular chondrocytes |
| Curcumin | Rheumatoid Arthritis | 3 | PM | 25424293 | 📋 | Oral Administration of Curcumin (Curcuma Longa) Can Attenuate the Neutrophil Inflammatory Response in Zymosan-Induced Arthritis in Rats |
| Curcumin | Rheumatoid Arthritis | 7 | PM | 21345249 | 📋 | Molecular Targets of Natural Health Products in Arthritis |
| Curcumin | Rheumatoid Arthritis | 6 | PM | 20594343 | 📋 | Curcumin Mediated Suppression of Nuclear factor-κB Promotes Chondrogenic Differentiation of Mesenchymal Stem Cells in a High-Density Co-Culture Microenvironment |
| Curcumin | Rheumatoid Arthritis | 1 | PM | 19763044 | 📋 | Oral Administration of Curcumin Suppresses Production of Matrix Metalloproteinase (MMP)-1 and MMP-3 to Ameliorate Collagen-Induced Arthritis: Inhibition of the PKCdelta/JNK/c-Jun Pathway |
| Curcumin | Rheumatoid Arthritis | 5 | PM | 19371737 | 📋 | Decreased Activity of Neutrophils in the Presence of Diferuloylmethane (Curcumin) Involves Protein Kinase C Inhibition |
| Curcumin | Rheumatoid Arthritis | 2 | PM | 17671742 | 📋 | Curcumin Induces Apoptosis and Inhibits Prostaglandin E(2) Production in Synovial Fibroblasts of Patients With Rheumatoid Arthritis |
| Curcumin | Rheumatoid Arthritis | 4 | PM | 16807698 | 📋 | The Antioxidants Curcumin and Quercetin Inhibit Inflammatory Processes Associated With Arthritis |
