| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Saffron | Age-Related Diseases | 2 | PM | 38410190 | 📋 | NAMPT‑NAD+ is involved in the senescence‑delaying effects of saffron in aging mice |
| Saffron | Age-Related Diseases | 1 | PM | 35276955 | 📋 | Saffron ( Crocus sativus L.): A Source of Nutrients for Health and for the Treatment of Neuropsychiatric and Age-Related Diseases |
| Saffron | Age-Related Macular Degeneration | 4 | PM | 38485112 | 📋 | Saffron therapy for the ongoing treatment of age-related macular degeneration |
| Saffron | Age-Related Macular Degeneration | 3 | PM | 33180005 | 📋 | An Open-Label Pilot Study on Macumax Supplementation for Dry-Type Age-Related Macular Degeneration |
| Saffron | Age-Related Macular Degeneration | 2 | PM | 31997799 | 📋 | Beneficial Effects of Saffron ( Crocus sativus L.) in Ocular Pathologies, Particularly Neurodegenerative Retinal Diseases |
| Saffron | Age-Related Macular Degeneration | 1 | PM | 20688744 | 📋 | Influence of Saffron Supplementation on Retinal Flicker Sensitivity in Early Age-Related Macular Degeneration |
| Saffron | Alzheimer's Disease | 13 | PM | 33878882 | 📋 | Prospects of Saffron and its Derivatives in Alzheimer's Disease |
| Saffron | Alzheimer's Disease | 12 | PM | 33441068 | 📋 | Crocus sativus L. (Saffron) in Alzheimer's disease treatment: bioactive effects on cognitive impairment |
| Saffron | Alzheimer's Disease | 11 | PM | 33232931 | 📋 | Association between chronic stress and Alzheimer's disease: Therapeutic effects of Saffron |
| Saffron | Alzheimer's Disease | 2 | PM | 32534024 | 📋 | Crocin Attenuates the Granular Cells Damages on the Dentate Gyrus and Pyramidal Neurons in the CA3 Regions of the Hippocampus and Frontal Cortex in the Rat Model of Alzheimer's Disease |
| Saffron | Alzheimer's Disease | 1 | PM | 32445136 | 📋 | Effects of Saffron (Crocus Sativus L.) on Cognitive Function. A Systematic Review of RCTs |
| Saffron | Alzheimer's Disease | 15 | PM | 30971876 | 📋 | The Crocus sativus Compounds trans-Crocin 4 and trans-Crocetin Modulate the Amyloidogenic Pathway and Tau Misprocessing in Alzheimer Disease Neuronal Cell Culture Models |
| Saffron | Alzheimer's Disease | 10 | PM | 30414087 | 📋 | Nootropic and Anti-Alzheimer's Actions of Medicinal Plants: Molecular Insight Into Therapeutic Potential to Alleviate Alzheimer's Neuropathology |
| Saffron | Alzheimer's Disease | 14 | PM | 29564976 | 📋 | Antioxidant Properties of Crocus Sativus L. and Its Constituents and Relevance to Neurodegenerative Diseases; Focus on Alzheimer's and Parkinson's Disease |
| Saffron | Alzheimer's Disease | 6 | PM | 28471166 | 📋 | Crocus Sativus Extract Tightens the Blood-Brain Barrier, Reduces Amyloid β Load and Related Toxicity in 5XFAD Mice |
| Saffron | Alzheimer's Disease | 8 | PM | 28250905 | 📋 | Possible Role of Common Spices as a Preventive and Therapeutic Agent for Alzheimer's Disease |
| Saffron | Alzheimer's Disease | 7 | PM | 26124935 | 📋 | Inhibitory Effect of Crocin on Aggregation of 1N/4R Human Tau Protein in Vitro |
| Saffron | Alzheimer's Disease | 9 | PM | 25714974 | 📋 | Neuropharmacological Aspects of Crocus Sativus L.: A Review of Preclinical Studies and Ongoing Clinical Research |
| Saffron | Alzheimer's Disease | 3 | PM | 25163440 | 📋 | Comparing the Efficacy and Safety of Crocus Sativus L. With Memantine in Patients With Moderate to Severe Alzheimer's Disease: A Double-Blind Randomized Clinical Trial |
| Saffron | Alzheimer's Disease | 4 | PM | 20831681 | 📋 | Saffron in the Treatment of Patients With Mild to Moderate Alzheimer's Disease: A 16-week, Randomized and Placebo-Controlled Trial |
| Saffron | Alzheimer's Disease | 5 | PM | 19838862 | 📋 | A 22-week, Multicenter, Randomized, Double-Blind Controlled Trial of Crocus Sativus in the Treatment of Mild-To-Moderate Alzheimer's Disease |
| Saffron | Cellular Senescence | 1 | PM | 38410190 | 📋 | NAMPT‑NAD+ is involved in the senescence‑delaying effects of saffron in aging mice |
| Saffron | Genotoxicity | 2 | PM | 28298158 | 📋 | Intake of Saffron Reduces γ-radiation-induced Genotoxicity and Oxidative Stress in Mice |
| Saffron | Genotoxicity | 1 | PM | 14672873 | 📋 | Inhibitory Effects of Aqueous Crude Extract of Saffron (Crocus Sativus L.) on Chemical-Induced Genotoxicity in Mice |
| Saffron | Hypertension | 5 | PM | 34444896 | 📋 | The Effect of Saffron Supplementation on Blood Pressure in Adults: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials |
| Saffron | Hypertension | 4 | PM | 33496985 | 📋 | Saffron (Crocus sativus L.) in combination with resistance training reduced blood pressure in the elderly hypertensive men: a randomized controlled trial |
| Saffron | Hypertension | 1 | PM | 31338249 | 📋 | Beneficial Cardiovascular Effects of Hydroalcoholic Extract From Crocus Sativus in Hypertension Induced by Angiotensin II |
| Saffron | Hypertension | 3 | PM | 29952263 | 📋 | The Protective Role of Crocus Sativus L. (Saffron) Against Ischemia- Reperfusion Injury, Hyperlipidemia and Atherosclerosis: Nature Opposing Cardiovascular Diseases |
| Saffron | Hypertension | 2 | PM | 20013822 | 📋 | Hypotensive Effect of Aqueous Saffron Extract (Crocus Sativus L.) and Its Constituents, Safranal and Crocin, in Normotensive and Hypertensive Rats |
| Saffron | Memory Disorders | 1 | PM | 31915630 | 📋 | A Review of Potential Efficacy of Saffron ( Crocus sativus L.) in Cognitive Dysfunction and Seizures |
| Saffron | Osteoarthritis | 1 | PM | 37109424 | 📋 | Crocus sativus Extract as a Biological Agent for Disease-Modifying Therapy of Collagenase-Induced Mouse Model of Osteoarthritis |
| Saffron | Oxidative Stress | 14 | PM | 37896069 | 📋 | Evaluation of Crocin Content and In Vitro Antioxidant and Anti-Glycation Activity of Different Saffron Extracts |
| Saffron | Oxidative Stress | 13 | PM | 36817799 | 📋 | Effect of saffron supplementation on oxidative stress markers (MDA, TAC, TOS, GPx, SOD, and pro-oxidant/antioxidant balance): An updated systematic review and meta-analysis of randomized placebo-controlled trials |
| Saffron | Oxidative Stress | 12 | PM | 35331485 | 📋 | The potential role of saffron (Crocus Sativus L.) and its components in oxidative stress in diabetes mellitus: A systematic review |
| Saffron | Oxidative Stress | 11 | PM | 34646548 | 📋 | Effect of saffron supplementation on oxidative stress parameters: A systematic review and meta-analysis of randomized placebo-controlled trials |
| Saffron | Oxidative Stress | 10 | PM | 33615006 | 📋 | The role of Safranal and saffron stigma extracts in oxidative stress, diseases and photoaging: A systematic review |
| Saffron | Oxidative Stress | 9 | PM | 33542784 | 📋 | The Beneficial Effects of Saffron Extract on Potential Oxidative Stress in Cardiovascular Diseases |
| Saffron | Oxidative Stress | 8 | PM | 33356506 | 📋 | Saffron bioactives crocin, crocetin and safranal: effect on oxidative stress and mechanisms of action |
| Saffron | Oxidative Stress | 7 | PM | 32798261 | 📋 | The effect of saffron supplementation on some inflammatory and oxidative markers, leptin, adiponectin, and body composition in patients with nonalcoholic fatty liver disease: A double-blind randomized clinical trial |
| Saffron | Oxidative Stress | 2 | PM | 32470790 | 📋 | Multifaceted Targeting of Neurodegeneration With Bioactive Molecules of Saffron (Crocus Sativus): An Insilco Evidence-Based Hypothesis |
| Saffron | Oxidative Stress | 1 | PM | 32425787 | 📋 | The Hypoglycemic and Renal Protection Properties of Crocin via Oxidative Stress-Regulated NF-κB Signaling in Db/Db Mice |
| Saffron | Oxidative Stress | 5 | PM | 29524452 | 📋 | Protective Effects of Saffron and Its Active Components Against Oxidative Stress and Apoptosis in Endothelial Cells |
| Saffron | Oxidative Stress | 4 | PM | 26705857 | 📋 | Evidence of Neuroprotective Effects of Saffron and Crocin in a Drosophila Model of Parkinsonism |
| Saffron | Oxidative Stress | 3 | PM | 25671180 | 📋 | Protective Effects of Crocus Sativus L. Extract and Crocin Against Chronic-Stress Induced Oxidative Damage of Brain, Liver and Kidneys in Rats |
| Saffron | Oxidative Stress | 6 | PM | 25590719 | 📋 | Attenuation of Oxidative Stress, Inflammation and Apoptosis by Ethanolic and Aqueous Extracts of Crocus Sativus L. Stigma After Chronic Constriction Injury of Rats |
| Saffron | Parkinson's Disease | 3 | PM | 34224829 | 📋 | Saffron ameliorated motor symptoms, short life span and retinal degeneration in Parkinson's disease fly models |
| Saffron | Parkinson's Disease | 1 | PM | 30573341 | 📋 | Crocus Sativus Restores Dopaminergic and Noradrenergic Damages Induced by Lead in Meriones Shawi: A Possible Link With Parkinson's Disease |
| Saffron | Parkinson's Disease | 2 | PM | 29564976 | 📋 | Antioxidant Properties of Crocus Sativus L. and Its Constituents and Relevance to Neurodegenerative Diseases; Focus on Alzheimer's and Parkinson's Disease |
| Saffron | Perimenopausal Disorders | 1 | PM | 34463070 | 📋 | The Effects of a Saffron Extract (affron®) on Menopausal Symptoms in Women during Perimenopause: A Randomised, Double-Blind, Placebo-Controlled Study |
| Saffron | Postmenopausal Disorders | 3 | PM | 31598511 | 📋 | Effect of the Mixed Herbal Medicines Extract (Fennel, Chamomile, and Saffron) on Menopause Syndrome: a Randomized Controlled Clinical Trial |
| Saffron | Postmenopausal Disorders | 1 | PM | 29332222 | 📋 | Efficacy of Crocus Sativus (Saffron) in Treatment of Major Depressive Disorder Associated With Post-Menopausal Hot Flashes: A Double-Blind, Randomized, Placebo-Controlled Trial |
| Saffron | Postmenopausal Disorders | 2 | PM | 28546803 | 📋 | Effect of Tribulus terrestris, Ginger, Saffron, and Cinnamomum on Menopausal Symptoms: A Randomised, Placebo-Controlled Clinical Trial |
| Saffron | Skin Photo Damage | 2 | PM | 33973339 | 📋 | Optimization of the saffron compound essence formula and its effect on preventing skin photoaging |
| Saffron | Skin Photo Damage | 1 | PM | 33615006 | 📋 | The role of Safranal and saffron stigma extracts in oxidative stress, diseases and photoaging: A systematic review |
| Saffron | Sleep Disorders | 2 | PM | 34438361 | 📋 | An investigation into an evening intake of a saffron extract (affron®) on sleep quality, cortisol, and melatonin concentrations in adults with poor sleep: a randomised, double-blind, placebo-controlled, multi-dose study |
| Saffron | Sleep Disorders | 1 | PM | 22038919 | 📋 | Crocin Promotes Non-Rapid Eye Movement Sleep in Mice |
| Saffron | Sleep Quality | 4 | PM | 37484523 | 📋 | Saffron and Sleep Quality: A Systematic Review of Randomized Controlled Trials |
| Saffron | Sleep Quality | 3 | PM | 35325766 | 📋 | Effects of saffron supplementation on improving sleep quality: a meta-analysis of randomized controlled trials |
| Saffron | Sleep Quality | 2 | PM | 33960081 | 📋 | Saffron improves life and sleep quality, glycemic status, lipid profile and liver function in diabetic patients: A double-blind, placebo-controlled, randomized clinical trial |
| Saffron | Sleep Quality | 1 | PM | 33925432 | 📋 | Effects of Saffron Extract on Sleep Quality: A Randomized Double-Blind Controlled Clinical Trial |
