| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Pine Bark | AGE Products | 1 | PM | 23537316 | 📋 | Is pycnogenol a double-edged sword? Cataractogenic in vitro, but reduces cataract risk in diabetic rats |
| Pine Bark | Age-Related Cognitive Decline | 1 | PM | 31333448 | 📋 | Assessing the Efficacy and Mechanisms of Pycnogenol ® on Cognitive Aging From In Vitro Animal and Human Studies |
| Pine Bark | Age-Related Diseases | 1 | PM | 30215292 | 📋 | Pleiotropic Effects of French Maritime Pine Bark Extract to Promote Healthy Aging |
| Pine Bark | Aging | 1 | PM | 12127300 | 📋 | Kyolic and Pycnogenol Increase Human Growth Hormone Secretion in Genetically-Engineered Keratinocytes |
| Pine Bark | Aging | 2 | PM | 9817994 | 📋 | Pycnogenol Enhances Immune and Haemopoietic Functions in Senescence-Accelerated Mice |
| Pine Bark | Aging Skin | 3 | PM | 35150043 | 📋 | Efficacy of a topical serum containing l-ascorbic acid, neohesperidin, pycnogenol, tocopherol and hyaluronic acid in relation to skin aging signs |
| Pine Bark | Aging Skin | 1 | PM | 22956863 | 📋 | Oral Administration of French Maritime Pine Bark Extract (Flavangenol(®)) Improves Clinical Symptoms in Photoaged Facial Skin |
| Pine Bark | Aging Skin | 2 | PM | 15764035 | 📋 | Supplementation with Evelle improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women |
| Pine Bark | Alzheimer's Disease | 2 | PM | 31958081 | 📋 | Pine Bark Polyphenolic Extract Attenuates Amyloid-β and Tau Misfolding in a Model System of Alzheimer's Disease Neuropathology |
| Pine Bark | Alzheimer's Disease | 1 | PM | 30668321 | 📋 | French Maritime Pine Bark Treatment Decelerates Plaque Development and Improves Spatial Memory in Alzheimer's Disease Mice |
| Pine Bark | Chronic Disease | 2 | PM | 35583807 | 📋 | The role of Pycnogenol in the control of inflammation and oxidative stress in chronic diseases: Molecular aspects |
| Pine Bark | Chronic Disease | 1 | PM | 22513958 | 📋 | Pycnogenol® (extract of French maritime pine bark) for the treatment of chronic disorders |
| Pine Bark | Genotoxicity | 3 | PM | 33884173 | 📋 | Investigating the effects of bark extract and volatile oil of Pinus eldarica against cisplatin-induced genotoxicity on HUVECs cell line |
| Pine Bark | Genotoxicity | 2 | PM | 32454622 | 📋 | The Ameliorative Effects of Pycnogenol ® on Liver Ischemia-Reperfusion Injury in Rats |
| Pine Bark | Genotoxicity | 1 | PM | 32122842 | 📋 | Pine (Pinus sylvestris L.) bark proanthocyanidins affords prevention of peroxynitrite-induced l-tyrosine nitration, DNA damage and hydroxyl radical formation |
| Pine Bark | Hyperpigmentation | 3 | PM | 38592434 | 📋 | Pycnogenol® prevents skin hyperpigmentation following sclerotherapy |
| Pine Bark | Hyperpigmentation | 1 | PM | 33960120 | 📋 | In-vitro effect of pine bark extract on melanin synthesis, tyrosinase activity, production of endothelin-1 and PPAR in cultured melanocytes exposed to Ultraviolet, Infrared, and Visible light radiation |
| Pine Bark | Hyperpigmentation | 2 | PM | 26030901 | 📋 | UVB Stimulates the Expression of Endothelin B Receptor in Human Melanocytes via a Sequential Activation of the p38/MSK1/CREB/MITF Pathway Which Can Be Interrupted by a French Maritime Pine Bark Extract through a Direct Inactivation of MSK1 |
| Pine Bark | Hypertension | 8 | PM | 36280012 | 📋 | Effect of a polyphenol-rich dietary supplement containing Pinus Massoniana bark extract on blood pressure in healthy adults: a parallel, randomized placebo-controlled trial |
| Pine Bark | Hypertension | 4 | PM | 32325920 | 📋 | Antihypertensive Effects of Polyphenolic Extract From Korean Red Pine ( Pinus densiflora Sieb. Et Zucc.) Bark in Spontaneously Hypertensive Rats |
| Pine Bark | Hypertension | 6 | PM | 31637782 | 📋 | Effect of pycnogenol supplementation on blood pressure: A systematic review and meta-analysis of clinical trials |
| Pine Bark | Hypertension | 1 | PM | 30087862 | 📋 | Effect of Pycnogenol Supplementation on Blood Pressure: A Systematic Review and Meta-analysis |
| Pine Bark | Hypertension | 7 | PM | 22749577 | 📋 | Glucose and blood pressure lowering effects of Pycnogenol® are inefficient to prevent prolongation of QT interval in experimental diabetic cardiomyopathy |
| Pine Bark | Hypertension | 5 | PM | 20421515 | 📋 | Effects of melatonin and Pycnogenol on small artery structure and function in spontaneously hypertensive rats |
| Pine Bark | Hypertension | 2 | PM | 20097689 | 📋 | Kidney Flow and Function in Hypertension: Protective Effects of Pycnogenol in Hypertensive Participants--A Controlled Study |
| Pine Bark | Hypertension | 3 | PM | 17000888 | 📋 | Control of Edema in Hypertensive Subjects Treated With Calcium Antagonist (Nifedipine) or Angiotensin-Converting Enzyme Inhibitors With Pycnogenol |
| Pine Bark | Osteoarthritis | 3 | PM | 30561176 | 📋 | Pycnogenol®: Supplementary Management of Symptomatic Osteoarthritis With a Patch. An Observational Registry Study |
| Pine Bark | Osteoarthritis | 5 | PM | 28836883 | 📋 | Review on Sustained Relief of Osteoarthritis Symptoms With a Proprietary Extract From Pine Bark, Pycnogenol |
| Pine Bark | Osteoarthritis | 4 | PM | 27941690 | 📋 | Procyanidins Mitigate Osteoarthritis Pathogenesis By, at Least in Part, Suppressing Vascular Endothelial Growth Factor Signaling |
| Pine Bark | Osteoarthritis of the Knee | 5 | PM | 38381030 | 📋 | Periostial and cartilage morphology in knee osteoarthritis: beneficial effects of supplementation with Pycnogenol® + Centellicum® |
| Pine Bark | Osteoarthritis of the Knee | 3 | PM | 32444040 | 📋 | Mineral rich algae with pine bark improved pain, physical function and analgesic use in mild-knee joint osteoarthritis, compared to Glucosamine: A randomized controlled pilot trial |
| Pine Bark | Osteoarthritis of the Knee | 4 | PM | 29246219 | 📋 | Cellular pharmacodynamic effects of Pycnogenol® in patients with severe osteoarthritis: a randomized controlled pilot study |
| Pine Bark | Osteoarthritis of the Knee | 2 | PM | 19017467 | 📋 | Variations in C-reactive Protein, Plasma Free Radicals and Fibrinogen Values in Patients With Osteoarthritis Treated With Pycnogenol |
| Pine Bark | Osteoarthritis of the Knee | 1 | PM | 18570266 | 📋 | Effect of Pine Bark Extract (Pycnogenol) on Symptoms of Knee Osteoarthritis |
| Pine Bark | Osteopenia | 2 | PM | 33250314 | 📋 | Oligopin® Supplementation Mitigates Oxidative Stress in Postmenopausal Women with Osteopenia: A Randomized, Double-blind, Placebo-Controlled Trial |
| Pine Bark | Osteopenia | 1 | PM | 30907034 | 📋 | Effects of French Maritime Pine Bark Extract (Oligopin®) Supplementation on Bone Remodeling Markers in Postmenopausal Osteopenic Women: A Randomized Clinical Trial |
| Pine Bark | Oxidative Stress | 13 | PM | 36009279 | 📋 | Antioxidant Effects of a Polyphenol-Rich Dietary Supplement Incorporating Pinus massoniana Bark Extract in Healthy Older Adults: A Two-Arm, Parallel Group, Randomized Placebo-Controlled Trial |
| Pine Bark | Oxidative Stress | 12 | PM | 35583807 | 📋 | The role of Pycnogenol in the control of inflammation and oxidative stress in chronic diseases: Molecular aspects |
| Pine Bark | Oxidative Stress | 10 | PM | 33077109 | 📋 | Transcriptomic and biochemical effects of pycnogenol in ameliorating heat stress-related oxidative alterations in rats |
| Pine Bark | Oxidative Stress | 2 | PM | 31670494 | 📋 | Episodic Primary Migraine Headache: Prophylaxis With Pycnogenol® Precents Attacks and Controls Oxidative Stress |
| Pine Bark | Oxidative Stress | 4 | PM | 31099529 | 📋 | Pycnogenol® Prevents Oxidative Stress and Side Effects in Patients With Hypothyroidism During Levothyroxine Treatment |
| Pine Bark | Oxidative Stress | 3 | PM | 30887868 | 📋 | A Double-Blind, Cross-Over Study to Examine the Effects of Maritime Pine Extract on Exercise Performance and Postexercise Inflammation, Oxidative Stress, Muscle Soreness, and Damage |
| Pine Bark | Oxidative Stress | 5 | PM | 26635191 | 📋 | The COFU3 Study. Improvement in Cognitive Function, Attention, Mental Performance With Pycnogenol® in Healthy Subjects (55-70) With High Oxidative Stress |
| Pine Bark | Oxidative Stress | 7 | PM | 24919414 | 📋 | Modulating Effects of Pycnogenol® on Oxidative Stress and DNA Damage Induced by Sepsis in Rats |
| Pine Bark | Oxidative Stress | 6 | PM | 24675223 | 📋 | Pycnogenol® Improves Cognitive Function, Attention, Mental Performance and Specific Professional Skills in Healthy Professionals Aged 35-55 |
| Pine Bark | Oxidative Stress | 1 | PM | 24247188 | 📋 | Evaluation of the Effects of Supplementation With Pycnogenol® on Fitness in Normal Subjects With the Army Physical Fitness Test and in Performances of Athletes in the 100-minute Triathlon |
| Pine Bark | Oxidative Stress | 11 | PM | 24008606 | 📋 | A controlled study shows daily intake of 50 mg of French Pine Bark Extract (Pycnogenol®) lowers plasma reactive oxygen metabolites in healthy smokers |
| Pine Bark | Oxidative Stress | 8 | PM | 14990359 | 📋 | Antioxidant Activity and Inhibition of Matrix Metalloproteinases by Metabolites of Maritime Pine Bark Extract (Pycnogenol) |
| Pine Bark | Oxidative Stress | 9 | PM | 12557250 | 📋 | Pycnogenol Inhibits the Release of Histamine From Mast Cells |
| Pine Bark | Parkinson's Disease | 5 | PM | 36153882 | 📋 | Pycnogenol® supplementation alleviates symptoms of Parkinson's disease with mild cognitive impairment |
| Pine Bark | Parkinson's Disease | 4 | PM | 35024909 | 📋 | Pycnogenol ameliorates motor function and gene expressions of NF-ƙB and Nrf2 in a 6-hydroxydopamine-induced experimental model of Parkinson's disease in male NMRI mice |
| Pine Bark | Parkinson's Disease | 1 | PM | 31957998 | 📋 | Supplementary Management With Pycnogenol® in Parkinson's Disease to Prevent Cognitive Impairment |
| Pine Bark | Parkinson's Disease | 2 | PM | 26203556 | 📋 | Pycnogenol Protects Against Rotenone-Induced Neurotoxicity in PC12 Cells Through Regulating NF-κB-iNOS Signaling Pathway |
| Pine Bark | Parkinson's Disease | 3 | PM | 23391521 | 📋 | Protection of MPTP-induced neuroinflammation and neurodegeneration by Pycnogenol |
| Pine Bark | Perimenopausal Disorders | 1 | PM | 23447917 | 📋 | Effect of low-dose French maritime pine bark extract on climacteric syndrome in 170 perimenopausal women: a randomized, double-blind, placebo-controlled trial |
| Pine Bark | Postmenopausal Disorders | 1 | PM | 28116886 | 📋 | Normalization of cardiovascular risk factors in peri-menopausal women with Pycnogenol® |
| Pine Bark | Postmenopausal Osteoporosis | 1 | PM | 33769535 | 📋 | Pinus roxburghii alleviates bone porosity and loss in postmenopausal osteoporosis by regulating estrogen, calcium homeostasis and receptor activator of nuclear factor-κB, osteoprotegerin, cathepsin bone markers |
| Pine Bark | Postmenopausal Osteoporosis | 2 | PM | 26379883 | 📋 | Pycnogenol(®) treatment inhibits bone mineral density loss and trabecular deterioration in ovariectomized rats |
| Pine Bark | Skin Photo Damage | 2 | PM | 30316976 | 📋 | Diabetic skin and UV light: Protection by antioxidants |
| Pine Bark | Skin Photo Damage | 3 | PM | 26030901 | 📋 | UVB Stimulates the Expression of Endothelin B Receptor in Human Melanocytes via a Sequential Activation of the p38/MSK1/CREB/MITF Pathway Which Can Be Interrupted by a French Maritime Pine Bark Extract through a Direct Inactivation of MSK1 |
| Pine Bark | Skin Photo Damage | 1 | PM | 17803593 | 📋 | Anti-wrinkling effects of the mixture of vitamin C, vitamin E, pycnogenol and evening primrose oil, and molecular mechanisms on hairless mouse skin caused by chronic ultraviolet B irradiation |
