| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| N-Acetyl Cysteine | AGE Products | 1 | PM | 27315604 | 📋 | Advanced Glycation End Products Inhibit Testosterone Secretion by Rat Leydig Cells by Inducing Oxidative Stress and Endoplasmic Reticulum Stress |
| N-Acetyl Cysteine | Age-Related Cognitive Decline | 1 | PM | 37237908 | 📋 | GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Old Mice Improves Brain Glutathione Deficiency, Oxidative Stress, Glucose Uptake, Mitochondrial Dysfunction, Genomic Damage, Inflammation and Neurotrophic Factors to Reverse Age-Associated Cognitive Decline: Implications for Improving Brain Health in Aging |
| N-Acetyl Cysteine | Age-Related Diseases | 1 | PM | 35268089 | 📋 | GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage |
| N-Acetyl Cysteine | Age-Related Macular Degeneration | 2 | PM | 33726556 | 📋 | Protective effects of NAC and salubrinal on apoptosis of retinal pigment epithelial cells induced by all-trans retinoic acid |
| N-Acetyl Cysteine | Age-Related Macular Degeneration | 1 | PM | 32446621 | 📋 | Improving Retinal Mitochondrial Function as a Treatment for Age-Related Macular Degeneration |
| N-Acetyl Cysteine | Aging | 8 | PM | 34587244 | 📋 | GlyNAC Supplementation Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Aging Hallmarks, Metabolic Defects, Muscle Strength, Cognitive Decline, and Body Composition: Implications for Healthy Aging |
| N-Acetyl Cysteine | Aging | 7 | PM | 33783984 | 📋 | Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial |
| N-Acetyl Cysteine | Aging | 6 | PM | 33228213 | 📋 | Antioxidants N-Acetylcysteine and Vitamin C Improve T Cell Commitment to Memory and Long-Term Maintenance of Immunological Memory in Old Mice |
| N-Acetyl Cysteine | Aging | 5 | PM | 33191885 | 📋 | Legacy Effect of Antioxidant N-acetylcysteine in Cellular Senescence of Diet-induced Obesity Mice |
| N-Acetyl Cysteine | Aging | 1 | PM | 31115735 | 📋 | N-Acetylcysteine Extends Lifespan of Drosophila via Modulating ROS Scavenger Gene Expression |
| N-Acetyl Cysteine | Aging | 2 | PM | 20875196 | 📋 | Murine Models of Premature Ageing for the Study of Diet-Induced Immune Changes: Improvement of Leucocyte Functions in Two Strains of Old Prematurely Ageing Mice by Dietary Supplementation With Sulphur-Containing Antioxidants |
| N-Acetyl Cysteine | Aging | 3 | PM | 18325578 | 📋 | Nrf2 Activation by Sulforaphane Restores the Age-Related Decrease of T(H)1 Immunity: Role of Dendritic Cells |
| N-Acetyl Cysteine | Aging | 4 | PM | 12127300 | 📋 | Kyolic and Pycnogenol Increase Human Growth Hormone Secretion in Genetically-Engineered Keratinocytes |
| N-Acetyl Cysteine | Aging Skin | 1 | PM | 20595944 | 📋 | [Efficacy Study in Vitro: Assessment of the Properties of Resveratrol and Resveratrol + N-acetyl-cysteine on Proliferation and Inhibition of Collagen Activity] |
| N-Acetyl Cysteine | Alzheimer's Disease | 3 | PM | 36703196 | 📋 | Combined metabolic activators improve cognitive functions in Alzheimer's disease patients: a randomised, double-blinded, placebo-controlled phase-II trial |
| N-Acetyl Cysteine | Alzheimer's Disease | 2 | PM | 32390631 | 📋 | N-Acetyl Cysteine and Catechin-Derived Polyphenols: A Path Toward Multi-Target Compounds Against Alzheimer's Disease |
| N-Acetyl Cysteine | Alzheimer's Disease | 1 | PM | 30574085 | 📋 | N-Acetylcysteine Prevents the Spatial Memory Deficits and the Redox-Dependent RyR2 Decrease Displayed by an Alzheimer's Disease Rat Model |
| N-Acetyl Cysteine | Cellular Senescence | 7 | PM | 38718763 | 📋 | Ex vivo anti-senescence activity of N-acetylcysteine in visceral adipose tissue of obese volunteers |
| N-Acetyl Cysteine | Cellular Senescence | 6 | PM | 37794966 | 📋 | Effects of N-acetylcysteine on aging cell and obesity complications in obese adults: a randomized, double-blind clinical trial |
| N-Acetyl Cysteine | Cellular Senescence | 2 | PM | 34680063 | 📋 | Bisphenol A Induces Accelerated Cell Aging in Murine Endothelium |
| N-Acetyl Cysteine | Cellular Senescence | 1 | PM | 33191885 | 📋 | Legacy Effect of Antioxidant N-acetylcysteine in Cellular Senescence of Diet-induced Obesity Mice |
| N-Acetyl Cysteine | Cellular Senescence | 5 | PM | 32269708 | 📋 | Suppression Effect of N-acetylcysteine on Bone Loss in Ovariectomized Mice |
| N-Acetyl Cysteine | Cellular Senescence | 3 | PM | 31396339 | 📋 | N-acetylcysteine Prevents Orchiectomy-Induced Osteoporosis by Inhibiting Oxidative Stress and Osteocyte Senescence |
| N-Acetyl Cysteine | Cellular Senescence | 4 | PM | 30447351 | 📋 | N-acetylcysteine Ameliorates Cisplatin-Induced Renal Senescence and Renal Interstitial Fibrosis Through sirtuin1 Activation and p53 Deacetylation |
| N-Acetyl Cysteine | Genotoxicity | 3 | PM | 34733484 | 📋 | Ameliorative effects of hesperidin and N-acetylcysteine against formaldehyde-induced-hemato- and genotoxicity |
| N-Acetyl Cysteine | Genotoxicity | 2 | PM | 21049288 | 📋 | Ameliorating Effect of N-acetylcysteine and Curcumin on Pesticide-Induced Oxidative DNA Damage in Human Peripheral Blood Mononuclear Cells |
| N-Acetyl Cysteine | Genotoxicity | 1 | PM | 18028880 | 📋 | Protective Effect of N-acetylcysteine Against Radiation Induced DNA Damage and Hepatic Toxicity in Rats |
| N-Acetyl Cysteine | Immunosenescence | 1 | PM | 33228213 | 📋 | Antioxidants N-Acetylcysteine and Vitamin C Improve T Cell Commitment to Memory and Long-Term Maintenance of Immunological Memory in Old Mice |
| N-Acetyl Cysteine | Immunosenescence | 2 | PM | 20875196 | 📋 | Murine Models of Premature Ageing for the Study of Diet-Induced Immune Changes: Improvement of Leucocyte Functions in Two Strains of Old Prematurely Ageing Mice by Dietary Supplementation With Sulphur-Containing Antioxidants |
| N-Acetyl Cysteine | Immunosenescence | 3 | PM | 12366393 | 📋 | A Diet Supplemented With Thiolic Anti-Oxidants Improves Leucocyte Function in Two Strains of Prematurely Ageing Mice |
| N-Acetyl Cysteine | Longevity | 2 | PM | 35268089 | 📋 | GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage |
| N-Acetyl Cysteine | Longevity | 3 | PM | 34687363 | 📋 | A collective analysis of lifespan-extending compounds in diverse model organisms, and of species whose lifespan can be extended the most by the application of compounds |
| N-Acetyl Cysteine | Longevity | 1 | PM | 31115735 | 📋 | N-Acetylcysteine Extends Lifespan of Drosophila via Modulating ROS Scavenger Gene Expression |
| N-Acetyl Cysteine | Memory Disorders | 3 | PM | 36563904 | 📋 | Evaluation the cognition-improvement effects of N-acetyl cysteine in experimental temporal lobe epilepsy in rat |
| N-Acetyl Cysteine | Memory Disorders | 2 | PM | 36222315 | 📋 | Taurine and N-acetylcysteine treatments prevent memory impairment and metabolite profile alterations in the hippocampus of high-fat diet-fed female mice |
| N-Acetyl Cysteine | Memory Disorders | 1 | PM | 33498402 | 📋 | Subchronic N-acetylcysteine Treatment Decreases Brain Kynurenic Acid Levels and Improves Cognitive Performance in Mice |
| N-Acetyl Cysteine | Muscle Atrophy | 2 | PM | 37960231 | 📋 | Glycine and N-Acetylcysteine (GlyNAC) Combined with Body Weight Support Treadmill Training Improved Spinal Cord and Skeletal Muscle Structure and Function in Rats with Spinal Cord Injury |
| N-Acetyl Cysteine | Muscle Atrophy | 1 | PM | 29593571 | 📋 | Mechanistic Role of Reactive Oxygen Species and Therapeutic Potential of Antioxidants in Denervation- or Fasting-Induced Skeletal Muscle Atrophy |
| N-Acetyl Cysteine | Osteoarthritis | 2 | PM | 33717929 | 📋 | The protective role of glutathione in osteoarthritis |
| N-Acetyl Cysteine | Osteoarthritis | 1 | PM | 31822750 | 📋 | Oral Administration of N-acetyl Cysteine Prevents Osteoarthritis Development and Progression in a Rat Model |
| N-Acetyl Cysteine | Osteoporosis | 1 | PM | 32269708 | 📋 | Suppression Effect of N-acetylcysteine on Bone Loss in Ovariectomized Mice |
| N-Acetyl Cysteine | Osteoporosis | 2 | PM | 31396339 | 📋 | N-acetylcysteine Prevents Orchiectomy-Induced Osteoporosis by Inhibiting Oxidative Stress and Osteocyte Senescence |
| N-Acetyl Cysteine | Oxidative Stress | 8 | PM | 38472887 | 📋 | The Combined Antioxidant Effects of N-Acetylcysteine, Vitamin D3, and Glutathione from the Intestinal-Neuronal In Vitro Model |
| N-Acetyl Cysteine | Oxidative Stress | 21 | PM | 35975308 | 📋 | Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial |
| N-Acetyl Cysteine | Oxidative Stress | 20 | PM | 35593216 | 📋 | N-acetylcysteine improves diabetic associated erectile dysfunction in streptozotocin-induced diabetic mice by inhibiting oxidative stress |
| N-Acetyl Cysteine | Oxidative Stress | 19 | PM | 35154590 | 📋 | Effects of N-acetylcysteine on Noise Exposure-induced Oxidative Stress and Depressive- and Anxiety-like Behaviors in Adult Male Mice |
| N-Acetyl Cysteine | Oxidative Stress | 18 | PM | 33946939 | 📋 | Effectiveness of N-Acetylcysteine in the Treatment of Renal Deterioration Caused by Long-Term Exposure to Bisphenol A |
| N-Acetyl Cysteine | Oxidative Stress | 17 | PM | 33739173 | 📋 | Does Short-Term and Low-Dose N-Acetylcysteine Affect Oxidative Stress and Inflammation in The Liver Tissues of Diabetic Rats? |
| N-Acetyl Cysteine | Oxidative Stress | 16 | PM | 33632046 | 📋 | Trehalose and N-Acetyl Cysteine Alleviate Inflammatory Cytokine Production and Oxidative Stress in LPS-Stimulated Human Peripheral Blood Mononuclear Cells |
| N-Acetyl Cysteine | Oxidative Stress | 15 | PM | 33596158 | 📋 | l-Cysteine Stimulates the Effect of Vitamin D on Inhibition of Oxidative Stress, IL-8, and MCP-1 Secretion in High Glucose Treated Monocytes |
| N-Acetyl Cysteine | Oxidative Stress | 14 | PM | 33380301 | 📋 | The Multifaceted Therapeutic Role of N-Acetylcysteine (NAC) in Disorders Characterized by Oxidative Stress |
| N-Acetyl Cysteine | Oxidative Stress | 13 | PM | 33191885 | 📋 | Legacy Effect of Antioxidant N-acetylcysteine in Cellular Senescence of Diet-induced Obesity Mice |
| N-Acetyl Cysteine | Oxidative Stress | 12 | PM | 33062321 | 📋 | Effects of N-Acetylcysteine and N-Acetylcysteine Amide on Erythrocyte Deformability and Oxidative Stress in a Rat Model of Lower Extremity Ischemia-Reperfusion Injury |
| N-Acetyl Cysteine | Oxidative Stress | 11 | PM | 32958257 | 📋 | Effects of N-acetylcysteine on oxidative stress and inflammation reactions in a rat model of allergic rhinitis after PM 2.5 exposure |
| N-Acetyl Cysteine | Oxidative Stress | 10 | PM | 32728627 | 📋 | N-acetyl cysteine treatment preserves mitochondrial indices of functionality in the brain of hyperammonemic mice |
| N-Acetyl Cysteine | Oxidative Stress | 9 | PM | 32658336 | 📋 | Modulation of Bleomycin-induced oxidative stress and pulmonary fibrosis by N-acetylcysteine in Ratsvia AMPK/SIRT1/ NF-Kβ |
| N-Acetyl Cysteine | Oxidative Stress | 7 | PM | 32378169 | 📋 | Correlation Between Oxidative Stress and NF-κB Signaling Pathway in the Obesity-Asthma Mice |
| N-Acetyl Cysteine | Oxidative Stress | 2 | PM | 32215468 | 📋 | Reduction of Oxidative Stress Improves Insulin Signaling in Cardiac Tissue of Obese Mice |
| N-Acetyl Cysteine | Oxidative Stress | 4 | PM | 30407312 | 📋 | N-acetylcysteine Improves Oxidative Stress and Inflammatory Response in Patients With Community Acquired Pneumonia: A Randomized Controlled Trial |
| N-Acetyl Cysteine | Oxidative Stress | 5 | PM | 27793104 | 📋 | N-acetyl-cysteine Exhibits Potent Anti-Mycobacterial Activity in Addition to Its Known Anti-Oxidative Functions |
| N-Acetyl Cysteine | Oxidative Stress | 6 | PM | 26745386 | 📋 | Tetrachlorobenzoquinone Exhibits Neurotoxicity by Inducing Inflammatory Responses Through ROS-mediated IKK/IκB/NF-κB Signaling |
| N-Acetyl Cysteine | Oxidative Stress | 3 | PM | 25458464 | 📋 | The Effect of Short-Term, High-Dose Oral N-acetylcysteine Treatment on Oxidative Stress Markers in Cystic Fibrosis Patients With Chronic P. Aeruginosa Infection -- A Pilot Study |
| N-Acetyl Cysteine | Oxidative Stress | 1 | PM | 15630201 | 📋 | Oxidative Stress Is the Master Operator of Drug and Chemically-Induced Programmed and Unprogrammed Cell Death: Implications of Natural Antioxidants in Vivo |
| N-Acetyl Cysteine | Parkinson's Disease | 4 | PM | 37507913 | 📋 | Targeting the Cysteine Redox Proteome in Parkinson's Disease: The Role of Glutathione Precursors and Beyond |
| N-Acetyl Cysteine | Parkinson's Disease | 3 | PM | 37415931 | 📋 | Post-inflammatory administration of N-acetylcysteine reduces inflammation and alters receptor levels in a cellular model of Parkinson's disease |
| N-Acetyl Cysteine | Parkinson's Disease | 2 | PM | 37371987 | 📋 | N-Acetylcysteine Treatment May Compensate Motor Impairments through Dopaminergic Transmission Modulation in a Striatal 6-Hydroxydopamine Parkinson's Disease Rat Model |
| N-Acetyl Cysteine | Parkinson's Disease | 1 | PM | 31206613 | 📋 | N-Acetyl Cysteine Is Associated With Dopaminergic Improvement in Parkinson's Disease |
| N-Acetyl Cysteine | Postmenopausal Disorders | 1 | PM | 30951973 | 📋 | N-acetylcysteine and Alpha-Lipoic Acid Improve Antioxidant Defenses and Decrease Oxidative Stress, Inflammation and Serum Lipid Levels in Ovariectomized Rats via Estrogen-Independent Mechanisms |
| N-Acetyl Cysteine | Sarcopenia | 1 | PM | 31530262 | 📋 | N-Acetyl Cysteine Attenuates the Sarcopenia and Muscle Apoptosis Induced by Chronic Liver Disease |
| N-Acetyl Cysteine | Skin Photo Damage | 1 | PM | 12713590 | 📋 | Topical N-acetyl Cysteine and Genistein Prevent Ultraviolet-Light-Induced Signaling That Leads to Photoaging in Human Skin in Vivo |
