| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Luteolin | AGE Products | 1 | PM | 33058977 | 📋 | Protective actions of bioactive flavonoids chrysin and luteolin on the glyoxal induced formation of advanced glycation end products and aggregation of human serum albumin: In vitro and molecular docking analysis |
| Luteolin | AGE Products | 3 | PM | 29108086 | 📋 | Anti-degenerative effect of Apigenin, Luteolin and Quercetin on human keratinocyte and chondrocyte cultures: SAR evaluation |
| Luteolin | AGE Products | 2 | PM | 19489629 | 📋 | Low-density-lipoprotein (LDL)-bound flavonoids increase the resistance of LDL to oxidation and glycation under pathophysiological concentrations of glucose in vitro |
| Luteolin | Age-Related Hearing Loss | 1 | PM | 34187948 | 📋 | Luteolin inhibits H 2 O 2-induced cellular senescence via modulation of SIRT1 and p53 |
| Luteolin | Age-Related Macular Degeneration | 4 | PM | 37201365 | 📋 | Luteolin inhibits subretinal fibrosis and epithelial-mesenchymal transition in laser-induced mouse model via suppression of Smad2/3 and YAP signaling |
| Luteolin | Age-Related Macular Degeneration | 3 | PM | 35198094 | 📋 | Luteolin Alleviates Epithelial-Mesenchymal Transformation Induced by Oxidative Injury in ARPE-19 Cell via Nrf2 and AKT/GSK-3 β Pathway |
| Luteolin | Age-Related Macular Degeneration | 1 | PM | 33122970 | 📋 | Luteolin Attenuates IL-1 β-Induced THP-1 Adhesion to ARPE-19 Cells via Suppression of NF- κ B and MAPK Pathways |
| Luteolin | Age-Related Macular Degeneration | 2 | PM | 28113103 | 📋 | Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cells |
| Luteolin | Age-Related Macular Degeneration | 5 | PM | 26619957 | 📋 | Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation |
| Luteolin | Aging Skin | 1 | PM | 33368702 | 📋 | Luteolin as a modulator of skin aging and inflammation |
| Luteolin | Alzheimer's Disease | 20 | PM | 37943817 | 📋 | Synergistic inhibition of glioblastoma multiforme through an in-silico analysis of luteolin and ferulic acid derived from Angelica sinensis and Cannabis sativa: Advancements in computational therapeutics |
| Luteolin | Alzheimer's Disease | 19 | PM | 37597424 | 📋 | Protective effects of luteolin against amyloid beta-induced oxidative stress and mitochondrial impairments through peroxisome proliferator-activated receptor γ-dependent mechanism in Alzheimer's disease |
| Luteolin | Alzheimer's Disease | 18 | PM | 37563784 | 📋 | Role of corn silk for the treatment of Alzheimer's disease: A mechanism research based on network pharmacology combined with molecular docking and experimental validation |
| Luteolin | Alzheimer's Disease | 16 | PM | 36808033 | 📋 | Repurposing of phyto-ligand molecules from the honey bee products for Alzheimer's disease as novel inhibitors of BACE-1: small molecule bioinformatics strategies as amyloid-based therapy |
| Luteolin | Alzheimer's Disease | 15 | PM | 36710678 | 📋 | Luteolin and Exercise Combination Therapy Ameliorates Amyloid-β1-42 Oligomers-Induced Cognitive Impairment in Alzheimer's Disease Mice by Mediating Neuroinflammation and Autophagy |
| Luteolin | Alzheimer's Disease | 14 | PM | 35958986 | 📋 | Effect of Date Palm ( Phoenix dactylifera) Phytochemicals on Aβ 1-40 Amyloid Formation: An in-silico Analysis |
| Luteolin | Alzheimer's Disease | 13 | PM | 35250535 | 📋 | A Synergistic Combination of DHA, Luteolin, and Urolithin A Against Alzheimer's Disease |
| Luteolin | Alzheimer's Disease | 12 | PM | 34959189 | 📋 | Luteolin ameliorates depression-like behaviors by suppressing ER stress in a mouse model of Alzheimer's disease |
| Luteolin | Alzheimer's Disease | 11 | PM | 34502488 | 📋 | Deciphering the Potential Neuroprotective Effects of Luteolin against Aβ 1- 42-Induced Alzheimer's Disease |
| Luteolin | Alzheimer's Disease | 10 | PM | 33615581 | 📋 | Neuroinflammation in Alzheimer's disease and beneficial action of luteolin |
| Luteolin | Alzheimer's Disease | 9 | PM | 33347668 | 📋 | Protection against Alzheimer's disease by luteolin: Role of brain glucose regulation, anti-inflammatory activity, and the gut microbiota-liver-brain axis |
| Luteolin | Alzheimer's Disease | 8 | PM | 33335556 | 📋 | Luteolin Protects Pheochromocytoma (PC-12) Cells against A β 25-35-Induced Cell Apoptosis through the ER/ERK/MAPK Signalling Pathway |
| Luteolin | Alzheimer's Disease | 6 | PM | 30892166 | 📋 | Bioavailability and Pharmaco-therapeutic Potential of Luteolin in Overcoming Alzheimer's Disease |
| Luteolin | Alzheimer's Disease | 7 | PM | 30759846 | 📋 | Korean Thistle ( Cirsium japonicum var. maackii (Maxim.) Matsum.): A Potential Dietary Supplement against Diabetes and Alzheimer's Disease |
| Luteolin | Alzheimer's Disease | 3 | PM | 30527255 | 📋 | The combination of luteolin and l-theanine improved Alzheimer disease-like symptoms by potentiating hippocampal insulin signaling and decreasing neuroinflammation and norepinephrine degradation in amyloid-β-infused rats |
| Luteolin | Alzheimer's Disease | 5 | PM | 30420334 | 📋 | Therapeutic potential of luteolin in transgenic Drosophila model of Alzheimer's disease |
| Luteolin | Alzheimer's Disease | 17 | PM | 28528007 | 📋 | Luteolin as a potential preventive and therapeutic candidate for Alzheimer's disease |
| Luteolin | Alzheimer's Disease | 2 | PM | 25106636 | 📋 | Neuroprotection by association of palmitoylethanolamide with luteolin in experimental Alzheimer's disease models: the control of neuroinflammation |
| Luteolin | Alzheimer's Disease | 1 | PM | 18817573 | 📋 | Apigenin and Luteolin Modulate Microglial Activation via Inhibition of STAT1-induced CD40 Expression |
| Luteolin | Alzheimer's Disease | 4 | PM | 18410522 | 📋 | Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease beta-amyloid production |
| Luteolin | Cellular Senescence | 1 | PM | 34187948 | 📋 | Luteolin inhibits H 2 O 2-induced cellular senescence via modulation of SIRT1 and p53 |
| Luteolin | Chronic Disease | 1 | PM | 36768462 | 📋 | Immunopharmacological Activities of Luteolin in Chronic Diseases |
| Luteolin | Genotoxicity | 2 | PM | 34717250 | 📋 | The effect of Luteolin on DNA damage mediated by a copper catalyzed Fenton reaction |
| Luteolin | Genotoxicity | 3 | PM | 34272807 | 📋 | Luteolin mitigates potassium dichromate-induced nephrotoxicity, cardiotoxicity and genotoxicity through modulation of Kim-1/Nrf2 signaling pathways |
| Luteolin | Genotoxicity | 1 | PM | 28113103 | 📋 | Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cells |
| Luteolin | Hyperpigmentation | 1 | PM | 28753056 | 📋 | Gamma-Irradiated Luteolin Inhibits 3-Isobutyl-1-Methylxanthine-Induced Melanogenesis Through the Regulation of CREB/MITF, PI3K/Akt, and ERK Pathways in B16BL6 Melanoma Cells |
| Luteolin | Hypertension | 1 | PM | 36771206 | 📋 | Luteolin Attenuates Hypertension via Inhibiting NF-κB-Mediated Inflammation and PI3K/Akt Signaling Pathway in the Hypothalamic Paraventricular Nucleus |
| Luteolin | Hypertension | 2 | PM | 24080032 | 📋 | Combined antihypertensive effect of luteolin and buddleoside enriched extracts in spontaneously hypertensive rats |
| Luteolin | Memory Disorders | 4 | PM | 36379383 | 📋 | Dose-dependent manner of luteolin in the modulation of spatial memory with respect to the hippocampal level of HSP70 and HSP90 in sleep-deprived rats |
| Luteolin | Memory Disorders | 3 | PM | 30527255 | 📋 | The combination of luteolin and l-theanine improved Alzheimer disease-like symptoms by potentiating hippocampal insulin signaling and decreasing neuroinflammation and norepinephrine degradation in amyloid-β-infused rats |
| Luteolin | Memory Disorders | 5 | PM | 23651687 | 📋 | Effects of luteolin on spatial memory, cell proliferation, and neuroblast differentiation in the hippocampal dentate gyrus in a scopolamine-induced amnesia model |
| Luteolin | Memory Disorders | 1 | PM | 19857483 | 📋 | Luteolin promotes long-term potentiation and improves cognitive functions in chronic cerebral hypoperfused rats |
| Luteolin | Memory Disorders | 2 | PM | 19442706 | 📋 | The anti-amnesic effects of luteolin against amyloid beta(25-35) peptide-induced toxicity in mice involve the protection of neurovascular unit |
| Luteolin | Osteoarthritis | 2 | PM | 35154568 | 📋 | Luteolin Protects Chondrocytes from H 2 O 2-Induced Oxidative Injury and Attenuates Osteoarthritis Progression by Activating AMPK-Nrf2 Signaling |
| Luteolin | Osteoarthritis | 1 | PM | 31472053 | 📋 | Effect of luteolin on apoptosis, MAPK and JNK signaling pathways in guinea pig chondrocyte with osteoarthritis |
| Luteolin | Osteoporosis | 4 | PM | 35355555 | 📋 | Mechanism and Experimental Verification of Luteolin for the Treatment of Osteoporosis Based on Network Pharmacology |
| Luteolin | Osteoporosis | 3 | PM | 35164085 | 📋 | Anti-Osteoporosis Effect of Perilla frutescens Leaf Hexane Fraction through Regulating Osteoclast and Osteoblast Differentiation |
| Luteolin | Osteoporosis | 2 | PM | 33327910 | 📋 | Luteolin stimulates proliferation and inhibits late differentiation of primary rat calvarial osteoblast induced by high-dose Dexamethasone via Sema3A /NRP1/Pleixin A1 |
| Luteolin | Osteoporosis | 1 | PM | 20162352 | 📋 | Inhibitory effect of luteolin on osteoclast differentiation and function |
| Luteolin | Oxidative Stress | 14 | PM | 38757300 | 📋 | Protective effect of luteolin against oxidative stress‑mediated cell injury via enhancing antioxidant systems |
| Luteolin | Oxidative Stress | 13 | PM | 35228180 | 📋 | Urease inhibition and DPPH radical scavenging potential of phytoconstituent from Alstonia scholaris and molecular docking interactions of bioactive luteolin with target proteins |
| Luteolin | Oxidative Stress | 12 | PM | 33900851 | 📋 | Luteolin alleviates polycystic ovary syndrome in rats by resolving insulin resistance and oxidative stress |
| Luteolin | Oxidative Stress | 8 | PM | 32898663 | 📋 | Luteolin supplementation ameliorates cobalt-induced oxidative stress and inflammation by suppressing NF-кB/Kim-1 signaling in the heart and kidney of rats |
| Luteolin | Oxidative Stress | 2 | PM | 32485174 | 📋 | Neuroprotective Efficacy of Luteolin on a 900-MHz Electromagnetic Field-Induced Cerebellar Alteration in Adult Male Rat |
| Luteolin | Oxidative Stress | 10 | PM | 32439592 | 📋 | Luteolin alleviates ochratoxin A induced oxidative stress by regulating Nrf2 and HIF-1α pathways in NRK-52E rat kidney cells |
| Luteolin | Oxidative Stress | 1 | PM | 32402583 | 📋 | Protective Effects of Luteolin Against Oxidative Stress and Mitochondrial Dysfunction in Endothelial Cells |
| Luteolin | Oxidative Stress | 6 | PM | 32271832 | 📋 | Low dose of luteolin activates Nrf2 in the liver of mice at start of the active phase but not that of the inactive phase |
| Luteolin | Oxidative Stress | 9 | PM | 32208856 | 📋 | Neuroprotective role of luteolin against lead acetate-induced cortical damage in rats |
| Luteolin | Oxidative Stress | 7 | PM | 31896157 | 📋 | Luteolin Attenuates Diabetic Nephropathy through Suppressing Inflammatory Response and Oxidative Stress by Inhibiting STAT3 Pathway |
| Luteolin | Oxidative Stress | 4 | PM | 26327560 | 📋 | A Food-Derived Flavonoid Luteolin Protects against Angiotensin II-Induced Cardiac Remodeling |
| Luteolin | Oxidative Stress | 11 | PM | 25081655 | 📋 | Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review |
| Luteolin | Oxidative Stress | 3 | PM | 18558413 | 📋 | Inhibition of Superoxide Anion-Mediated Impairment of Endothelium by Treatment With Luteolin and Apigenin in Rat Mesenteric Artery |
| Luteolin | Oxidative Stress | 5 | PM | 16076083 | 📋 | Effects of verbascoside and luteolin on oxidative damage in brain of heroin treated mice |
| Luteolin | Parkinson's Disease | 4 | PM | 37632637 | 📋 | Luteolin Protects Against 6-Hydoroxydopamine-Induced Cell Death via an Upregulation of HRD1 and SEL1L |
| Luteolin | Parkinson's Disease | 3 | PM | 33671094 | 📋 | Suppressing Cdk5 Activity by Luteolin Inhibits MPP +-Induced Apoptotic of Neuroblastoma through Erk/Drp1 and Fak/Akt/GSK3β Pathways |
| Luteolin | Parkinson's Disease | 2 | PM | 33443305 | 📋 | Role of luteolin in overcoming Parkinson's disease |
| Luteolin | Parkinson's Disease | 1 | PM | 26295827 | 📋 | The Association of Palmitoylethanolamide with Luteolin Decreases Neuroinflammation and Stimulates Autophagy in Parkinson's Disease Model |
| Luteolin | Postmenopausal Disorders | 1 | PM | 31302373 | 📋 | Luteolin reduces adipose tissue macrophage inflammation and insulin resistance in postmenopausal obese mice |
| Luteolin | Postmenopausal Osteoporosis | 1 | PM | 38547625 | 📋 | Luteolin rescues postmenopausal osteoporosis elicited by OVX through alleviating osteoblast pyroptosis via activating PI3K-AKT signaling |
| Luteolin | Sarcopenia | 1 | PM | 36708177 | 📋 | Luteolin Protects Against Obese Sarcopenia in Mice with High-fat Diet-induced Obesity by Ameliorating Inflammation and Protein Degradation in Muscles |
| Luteolin | Skin Photo Damage | 4 | PM | 37609830 | 📋 | Luteolin photo-protects zebrafish from environmental stressor ultraviolet radiation (UVB) |
| Luteolin | Skin Photo Damage | 1 | PM | 27430964 | 📋 | Luteolin decreases the UVA‑induced autophagy of human skin fibroblasts by scavenging ROS |
| Luteolin | Skin Photo Damage | 3 | PM | 23839819 | 📋 | The photoprotective and antioxidative properties of luteolin are synergistically augmented by tocopherol and ubiquinone |
| Luteolin | Skin Photo Damage | 2 | PM | 23551430 | 📋 | Luteolin suppresses UVB-induced photoageing by targeting JNK1 and p90 RSK2 |
| Luteolin | Sleep Disorders | 1 | PM | 31646844 | 📋 | Sleep Promoting Effect of Luteolin in Mice via Adenosine A1 and A2A Receptors |
