| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Icariin | Age-Related Diseases | 1 | PM | 35165207 | 📋 | The neuroprotective effects of icariin on ageing, various neurological, neuropsychiatric disorders, and brain injury induced by radiation exposure |
| Icariin | Aging | 3 | PM | 38571677 | 📋 | Anti-aging effects of icariin and the underlying mechanisms: A mini-review |
| Icariin | Aging | 2 | PM | 33798737 | 📋 | Icariin enhances youth-like features by attenuating the declined gut microbiota in the aged mice |
| Icariin | Aging | 1 | PM | 33000191 | 📋 | Icariin modulates the sirtuin/NF‑κB pathway and exerts anti‑aging effects in human lung fibroblasts |
| Icariin | Aging Brain | 1 | PM | 33556283 | 📋 | Icariin improves brain function decline in aging rats by enhancing neuronal autophagy through the AMPK/mTOR/ULK1 pathway |
| Icariin | Alzheimer's Disease | 16 | PM | 38412923 | 📋 | Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in APP/PS1 mice via inhibition of ferroptosis-lipid peroxidation |
| Icariin | Alzheimer's Disease | 15 | PM | 38400523 | 📋 | Icariin ameliorates glycolytic dysfunction in Alzheimer's disease models by activating the Wnt/β-catenin signaling pathway |
| Icariin | Alzheimer's Disease | 14 | PM | 38276291 | 📋 | Study on the Pharmacological Mechanism of Icariin for the Treatment of Alzheimer's Disease Based on Network Pharmacology and Molecular Docking Techniques |
| Icariin | Alzheimer's Disease | 13 | PM | 37889523 | 📋 | Icariin improves cognitive impairment by inhibiting ferroptosis of nerve cells |
| Icariin | Alzheimer's Disease | 12 | PM | 37579923 | 📋 | Icariin improves learning and memory function in Aβ1-42-induced AD mice through regulation of the BDNF-TrκB signaling pathway |
| Icariin | Alzheimer's Disease | 11 | PM | 37229892 | 📋 | Molecular mechanisms and therapeutic potential of icariin in the treatment of Alzheimer's disease |
| Icariin | Alzheimer's Disease | 10 | PM | 37095548 | 📋 | Anti-Alzheimers molecular mechanism of icariin: insights from gut microbiota, metabolomics, and network pharmacology |
| Icariin | Alzheimer's Disease | 9 | PM | 36532735 | 📋 | HIF-1 signalling pathway was identified as a potential new pathway for Icariin's treatment against Alzheimer's disease based on preclinical evidence and bioinformatics |
| Icariin | Alzheimer's Disease | 7 | PM | 35802286 | 📋 | Icariin: A Potential Neuroprotective Agent in Alzheimer's Disease and Parkinson's Disease |
| Icariin | Alzheimer's Disease | 8 | PM | 35799540 | 📋 | Icariin ameliorates memory deficits through regulating brain insulin signaling and glucose transporters in 3×Tg-AD mice |
| Icariin | Alzheimer's Disease | 6 | PM | 35037164 | 📋 | Icariin Ameliorates Alzheimer's Disease Pathology by Alleviating Myelin Injury in 3 × Tg-AD Mice |
| Icariin | Alzheimer's Disease | 3 | PM | 34407393 | 📋 | Icariin ameliorate Alzheimer's disease by influencing SIRT1 and inhibiting Aβ cascade pathogenesis |
| Icariin | Alzheimer's Disease | 5 | PM | 33502043 | 📋 | Icaritin and icariin reduce p-Tau levels in a cell model of Alzheimer's disease by downregulating glycogen synthase kinase 3β |
| Icariin | Alzheimer's Disease | 1 | PM | 33061388 | 📋 | Effects of Co-Administration of Icariin and Panax notoginseng Saponins on Intestinal Microbiota and Hippocampal Protein Expression in a Mouse Model of Alzheimer's Disease |
| Icariin | Alzheimer's Disease | 4 | PM | 32727295 | 📋 | Icariin sustains the proliferation and differentiation of Aβ 25-35-treated hippocampal neural stem cells via the BDNF-TrkB-ERK/Akt signaling pathway |
| Icariin | Alzheimer's Disease | 2 | PM | 31612304 | 📋 | Icariin Ameliorates Amyloid Pathologies by Maintaining Homeostasis of Autophagic Systems in Aβ 1-42-Injected Rats |
| Icariin | Hypertension | 1 | PM | 33359002 | 📋 | Sex hormone-like Effects of Icariin on T-cells immune modulation in spontaneously hypertensive rats |
| Icariin | Longevity | 1 | PM | 38203522 | 📋 | Icariin Improves Stress Resistance and Extends Lifespan in Caenorhabditis elegans through hsf-1 and daf-2-Driven Hormesis |
| Icariin | Osteoarthritis | 7 | PM | 38636375 | 📋 | Icariin inhibits chondrocyte ferroptosis and alleviates osteoarthritis by enhancing the SLC7A11/GPX4 signaling |
| Icariin | Osteoarthritis | 6 | PM | 38570329 | 📋 | Icariin alleviates the apoptosis of chondrocytes in osteoarthritis through regulating SIRT-1-Nrf2-HO-1 signaling |
| Icariin | Osteoarthritis | 5 | PM | 37692948 | 📋 | Mechanism of icariin for the treatment of osteoarthritis based on network pharmacology and molecular docking method |
| Icariin | Osteoarthritis | 4 | PM | 36253872 | 📋 | Icariin alleviates osteoarthritis through PI3K/Akt/mTOR/ULK1 signaling pathway |
| Icariin | Osteoarthritis | 2 | PM | 34167449 | 📋 | Icariin alleviates osteoarthritis by regulating autophagy of chondrocytes by mediating PI3K/AKT/mTOR signaling |
| Icariin | Osteoarthritis | 3 | PM | 33365072 | 📋 | Icariin enhances cell survival in lipopolysaccharide-induced synoviocytes by suppressing ferroptosis via the Xc-/GPX4 axis |
| Icariin | Osteoarthritis | 1 | PM | 31511005 | 📋 | Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis |
| Icariin | Osteoarthritis of the Knee | 2 | PM | 35479319 | 📋 | Icariin: A Potential Molecule for Treatment of Knee Osteoarthritis |
| Icariin | Osteoarthritis of the Knee | 1 | PM | 34607107 | 📋 | Verification of pain-related neuromodulation mechanisms of icariin in knee osteoarthritis |
| Icariin | Osteoporosis | 15 | PM | 38471268 | 📋 | Icariin ameliorates osteoporosis in ovariectomized rats by targeting Cullin 3/Nrf2/OH pathway for osteoclast inhibition |
| Icariin | Osteoporosis | 14 | PM | 38415738 | 📋 | Icariin regulates RANKL-induced osteoclast differentiation via the ER α/ c-Src/RANK signaling |
| Icariin | Osteoporosis | 12 | PM | 38326818 | 📋 | Icariin promotes bone marrow mesenchymal stem cells osteogenic differentiation via the mTOR/autophagy pathway to improve ketogenic diet-associated osteoporosis |
| Icariin | Osteoporosis | 11 | PM | 38235994 | 📋 | Icariin ameliorates osteoporosis by activating autophagy in ovariectomized rats |
| Icariin | Osteoporosis | 10 | PM | 38092316 | 📋 | Icariin inhibits osteoblast ferroptosis via Nrf2/HO-1 signaling and enhances healing of osteoporotic fractures |
| Icariin | Osteoporosis | 9 | PM | 37058900 | 📋 | Osteoporosis remission via an anti-inflammaging effect by icariin activated autophagy |
| Icariin | Osteoporosis | 8 | PM | 35292240 | 📋 | Icariin triggers osteogenic differentiation of bone marrow stem cells by up-regulating miR-335-5p |
| Icariin | Osteoporosis | 1 | PM | 35182975 | 📋 | Icariin inhibits RANKL-induced osteoclastogenesis in RAW264.7 cells via inhibition of reactive oxygen species production by reducing the expression of NOX1 and NOX4 |
| Icariin | Osteoporosis | 2 | PM | 33249854 | 📋 | A Naringin- and Icariin-Contained Herbal Formula, Gushukang, Ameliorated Aged Osteoporosis of Aged Mice with High Calcium Intake |
| Icariin | Osteoporosis | 7 | PM | 33230092 | 📋 | Exploring the Mechanism of Icariin in Osteoporosis Based on a Network Pharmacology Strategy |
| Icariin | Osteoporosis | 5 | PM | 32508946 | 📋 | Icariin Alleviates Glucocorticoid-Induced Osteoporosis through EphB4/Ephrin-B2 Axis |
| Icariin | Osteoporosis | 6 | PM | 32380477 | 📋 | The shared KEGG pathways between icariin-targeted genes and osteoporosis |
| Icariin | Osteoporosis | 4 | PM | 31858585 | 📋 | Icariin reduces bone loss in a Rankl-induced transgenic medaka (Oryzias latipes) model for osteoporosis |
| Icariin | Osteoporosis | 3 | PM | 31661767 | 📋 | Icariin Promotes the Osteogenic Action of BMP2 by Activating the cAMP Signaling Pathway |
| Icariin | Osteoporosis | 13 | PM | 23261485 | 📋 | Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19) |
| Icariin | Parkinson's Disease | 3 | PM | 38176950 | 📋 | Icariin Inhibits Overexpression and Aggregation of α-Synuclein in A53T α-Synuclein Transgenic Mice by Regulating Parkin and PLK2 |
| Icariin | Parkinson's Disease | 2 | PM | 38160784 | 📋 | Icariin Attenuates Dopaminergic Neural Loss in Haloperidol-Induced Parkinsonism in Rats via GSK-3β and Tyrosine Hydroxylase Regulation Mechanism |
| Icariin | Parkinson's Disease | 1 | PM | 35802286 | 📋 | Icariin: A Potential Neuroprotective Agent in Alzheimer's Disease and Parkinson's Disease |
| Icariin | Perimenopausal Disorders | 1 | PM | 31618892 | 📋 | PI3K-AKT Signaling Activation and Icariin: The Potential Effects on the Perimenopausal Depression-Like Rat Model |
| Icariin | Postmenopausal Osteoporosis | 2 | PM | 35399950 | 📋 | Effects of Icariin on Modulating Gut Microbiota and Regulating Metabolite Alterations to Prevent Bone Loss in Ovariectomized Rat Model |
| Icariin | Postmenopausal Osteoporosis | 1 | PM | 33339654 | 📋 | Icariin ameliorates estrogen-deficiency induced bone loss by enhancing IGF-I signaling via its crosstalk with non-genomic ERα signaling |
| Icariin | Sarcopenia | 2 | PM | 36026561 | 📋 | A Phytomolecule Icariin Protects from Sarcopenia Partially by Suppressing Myosin Heavy Chain Degradation in Orchiectomized Rats |
| Icariin | Sarcopenia | 1 | PM | 34031457 | 📋 | Activation of IGF-1 pathway and suppression of atrophy related genes are involved in Epimedium extract (icariin) promoted C2C12 myotube hypertrophy |
