| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Gotu Kola | Age-Related Cognitive Decline | 3 | PM | 38770167 | 📋 | Amelioration of age-related cognitive decline and anxiety in mice by Centella asiatica extract varies by sex, dose and mode of administration |
| Gotu Kola | Age-Related Cognitive Decline | 2 | PM | 38336185 | 📋 | Centella asiatica improves memory and executive function in middle-aged rats by controlling oxidative stress and cholinergic transmission |
| Gotu Kola | Age-Related Cognitive Decline | 1 | PM | 38328129 | 📋 | Amelioration of age-related cognitive decline and anxiety in mice by Centella asiatica extract varies by sex, dose and mode of administration |
| Gotu Kola | Age-Related Diseases | 1 | PM | 35052625 | 📋 | Withania somnifera and Centella asiatica Extracts Ameliorate Behavioral Deficits in an In Vivo Drosophila melanogaster Model of Oxidative Stress |
| Gotu Kola | Age-Related Macular Degeneration | 2 | PM | 33923585 | 📋 | Preventive Effects against Retinal Degeneration by Centella asiatica Extract (CA-HE50) and Asiaticoside through Apoptosis Suppression by the Nrf2/HO-1 Signaling Pathway |
| Gotu Kola | Age-Related Macular Degeneration | 1 | PM | 32528628 | 📋 | Centella asiatica Extract Prevents Visual Impairment by Promoting the Production of Rhodopsin in the Retina |
| Gotu Kola | Aging | 2 | PM | 33425700 | 📋 | Anti-aging potential and phytochemicals of Centella asiatica, Nelumbo nucifera, and Hibiscus sabdariffa extracts |
| Gotu Kola | Aging | 1 | PM | 21629743 | 📋 | Centella asiatica Attenuates D-Galactose-Induced Cognitive Impairment, Oxidative and Mitochondrial Dysfunction in Mice |
| Gotu Kola | Aging Brain | 2 | PM | 34515324 | 📋 | Reversal of brain aging by targeting telomerase: A nutraceutical approach |
| Gotu Kola | Aging Brain | 1 | PM | 34267660 | 📋 | Mitoprotective Effects of Centella asiatica (L.) Urb.: Anti-Inflammatory and Neuroprotective Opportunities in Neurodegenerative Disease |
| Gotu Kola | Aging Skin | 2 | PM | 34188145 | 📋 | Insights into antioxidant activities and anti-skin-aging potential of callus extract from Centella asiatica (L.) |
| Gotu Kola | Aging Skin | 1 | PM | 33413787 | 📋 | Efficacy and Safety of Centella Asiatica ( L.) Urb. on Wrinkles: A Systematic Review of Published Data and Network Meta-Analysis |
| Gotu Kola | Alzheimer's Disease | 18 | PM | 37440991 | 📋 | Prediction of Translational Regulation by Network Interaction in Synaptic Plasticity Induced with Centella asiatica |
| Gotu Kola | Alzheimer's Disease | 17 | PM | 37334592 | 📋 | Centella asiatica (L.) Urban. Attenuates Cell Damage in Hydrogen Peroxide-Induced Oxidative Stress in Transgenic Murine Embryonic Stem Cell Line-Derived Neural-Like Cells: A Preliminary Study for Potential Treatment of Alzheimer's Disease |
| Gotu Kola | Alzheimer's Disease | 16 | PM | 36695831 | 📋 | Standardized Extract of Centella asiatica Prevents Fear Memory Deficit in 3xTg-AD Mice |
| Gotu Kola | Alzheimer's Disease | 10 | PM | 36589020 | 📋 | The Ameliorative Impact of Centella asiatica on the Working Memory Deficit in Streptozotocin-induced Rat Model of Alzheimer Disease |
| Gotu Kola | Alzheimer's Disease | 15 | PM | 34975484 | 📋 | Centella asiatica Alters Metabolic Pathways Associated With Alzheimer's Disease in the 5xFAD Mouse Model of ß-Amyloid Accumulation |
| Gotu Kola | Alzheimer's Disease | 14 | PM | 34924122 | 📋 | The protective effect of Centella asiatica and its constituent, araliadiol on neuronal cell damage and cognitive impairment |
| Gotu Kola | Alzheimer's Disease | 13 | PM | 34721056 | 📋 | Hypoxia-Induced Neuroinflammation in Alzheimer's Disease: Potential Neuroprotective Effects of Centella asiatica |
| Gotu Kola | Alzheimer's Disease | 5 | PM | 33935097 | 📋 | Prolonged Treatment with Centella asiatica Improves Memory, Reduces Amyloid-β Pathology, and Activates NRF2-Regulated Antioxidant Response Pathway in 5xFAD Mice |
| Gotu Kola | Alzheimer's Disease | 4 | PM | 33202902 | 📋 | Caffeoylquinic Acids in Centella asiatica Reverse Cognitive Deficits in Male 5XFAD Alzheimer's Disease Model Mice |
| Gotu Kola | Alzheimer's Disease | 3 | PM | 32721993 | 📋 | Combining In Silico and In Vitro Studies to Evaluate the Acetylcholinesterase Inhibitory Profile of Different Accessions and the Biomarker Triterpenes of Centella asiatica |
| Gotu Kola | Alzheimer's Disease | 1 | PM | 32387717 | 📋 | Evaluation of the Pre-Treatment Effect of Centella Asiatica Medicinal Plants on Long-Term Potentiation (LTP) in Rat Model of Alzheimer's Disease |
| Gotu Kola | Alzheimer's Disease | 6 | PM | 32079355 | 📋 | Inhibitory Effects of Raw-Extract Centella asiatica (RECA) on Acetylcholinesterase, Inflammations, and Oxidative Stress Activities via In Vitro and In Vivo |
| Gotu Kola | Alzheimer's Disease | 11 | PM | 31014012 | 📋 | Centella asiatica Protects d-Galactose/AlCl 3 Mediated Alzheimer's Disease-Like Rats via PP2A/GSK-3β Signaling Pathway in Their Hippocampus |
| Gotu Kola | Alzheimer's Disease | 12 | PM | 30935005 | 📋 | Protective Effects of Centella asiatica on Cognitive Deficits Induced by D-gal/AlCl₃ via Inhibition of Oxidative Stress and Attenuation of Acetylcholinesterase Level |
| Gotu Kola | Alzheimer's Disease | 8 | PM | 30599045 | 📋 | Medical Plants and Nutraceuticals for Amyloid-β Fibrillation Inhibition |
| Gotu Kola | Alzheimer's Disease | 9 | PM | 30551539 | 📋 | Protective effect of Centella asiatica against D-galactose and aluminium chloride induced rats: Behavioral and ultrastructural approaches |
| Gotu Kola | Alzheimer's Disease | 2 | PM | 30414087 | 📋 | Nootropic and Anti-Alzheimer's Actions of Medicinal Plants: Molecular Insight Into Therapeutic Potential to Alleviate Alzheimer's Neuropathology |
| Gotu Kola | Alzheimer's Disease | 7 | PM | 30253196 | 📋 | Centella asiatica attenuates hippocampal mitochondrial dysfunction and improves memory and executive function in β-amyloid overexpressing mice |
| Gotu Kola | Alzheimer's Disease | 19 | PM | 22506133 | 📋 | Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action |
| Gotu Kola | Cellular Senescence | 1 | PM | 30814868 | 📋 | Combined extract of Moringa oleifera and Centella asiatica modulates oxidative stress and senescence in hydrogen peroxide-induced human dermal fibroblasts |
| Gotu Kola | Hyperpigmentation | 1 | PM | 33938432 | 📋 | The Effectiveness of Galactomyces Ferment Filtrate, Dexpanthenol, and Centella Asiatica Combination Serum in the Treatment of Post-Acne Hyperpigmentation in Subjects with Skin of Color |
| Gotu Kola | Hypertension | 5 | PM | 34925007 | 📋 | Centella asiatica (L.) Urb. Prevents Hypertension and Protects the Heart in Chronic Nitric Oxide Deficiency Rat Model |
| Gotu Kola | Hypertension | 4 | PM | 34627325 | 📋 | A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Lei-gong-gen formula granule on a spontaneously hypertensive rat model |
| Gotu Kola | Hypertension | 1 | PM | 33849161 | 📋 | The effect of gotu kola (Centella asiatica L.) tea on blood pressure of hypertension |
| Gotu Kola | Hypertension | 2 | PM | 32695655 | 📋 | Vasculoprotective effects of Centella asiatica, Justicia gendarussa and Imperata cylindrica decoction via the NOXs-ROS-NF-κB pathway in spontaneously hypertensive rats |
| Gotu Kola | Memory Disorders | 2 | PM | 36589020 | 📋 | The Ameliorative Impact of Centella asiatica on the Working Memory Deficit in Streptozotocin-induced Rat Model of Alzheimer Disease |
| Gotu Kola | Memory Disorders | 1 | PM | 32403381 | 📋 | The Mixture of Gotu Kola, Cnidium Fruit, and Goji Berry Enhances Memory Functions by Inducing Nerve-Growth-Factor-Mediated Actions Both In Vitro and In Vivo |
| Gotu Kola | Memory Disorders | 3 | PM | 30105867 | 📋 | Hippocampal amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid GluA1 (AMPA GluA1) receptor subunit involves in learning and memory improvement following treatment with Centella asiatica extract in adolescent rats |
| Gotu Kola | Osteoarthritis | 2 | PM | 36345305 | 📋 | Madecassic Acid Ameliorates the Progression of Osteoarthritis: An in vitro and in vivo Study |
| Gotu Kola | Osteoarthritis | 4 | PM | 34705985 | 📋 | A standardized extract of Centella asiatica (ECa 233) prevents temporomandibular joint osteoarthritis by modulating the expression of local inflammatory mediators in mice |
| Gotu Kola | Osteoarthritis | 1 | PM | 32486519 | 📋 | Intra-Articular Route for the System of Molecules 14G1862 From Centella Asiatica: Pain Relieving and Protective Effects in a Rat Model of Osteoarthritis |
| Gotu Kola | Osteoarthritis of the Knee | 2 | PM | 38381030 | 📋 | Periostial and cartilage morphology in knee osteoarthritis: beneficial effects of supplementation with Pycnogenol® + Centellicum® |
| Gotu Kola | Osteoarthritis of the Knee | 1 | PM | 35733624 | 📋 | A Randomized Controlled Trial of Thai Medicinal Plant-4 Cream versus Diclofenac Gel in the Management of Symptomatic Osteoarthritis of the Knee |
| Gotu Kola | Oxidative Stress | 5 | PM | 37896010 | 📋 | Phytochemical Analysis and Antioxidant Activity of Centella Asiatica Extracts: An Experimental and Theoretical Investigation of Flavonoids |
| Gotu Kola | Oxidative Stress | 2 | PM | 34188145 | 📋 | Insights into antioxidant activities and anti-skin-aging potential of callus extract from Centella asiatica (L.) |
| Gotu Kola | Oxidative Stress | 4 | PM | 31817977 | 📋 | Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice |
| Gotu Kola | Oxidative Stress | 1 | PM | 30936009 | 📋 | Characterization of Moringa oleifera roots polysaccharide MRP-1 with anti-inflammatory effect |
| Gotu Kola | Oxidative Stress | 3 | PM | 30814868 | 📋 | Combined extract of Moringa oleifera and Centella asiatica modulates oxidative stress and senescence in hydrogen peroxide-induced human dermal fibroblasts |
| Gotu Kola | Parkinson's Disease | 1 | PM | 36150031 | 📋 | Oral administration of hydroalcoholic extract of Centella asiatica ameliorates neurotoxicity and neurobehavioral deficits in 3-nitropropionic acid-induced Huntington's like symptoms in adult zebrafish |
| Gotu Kola | Parkinson's Disease | 2 | PM | 28510600 | 📋 | Complete Comparison Display (CCD) evaluation of ethanol extracts of Centella asiatica and Withania somnifera shows that they can non-synergistically ameliorate biochemical and behavioural damages in MPTP induced Parkinson's model of mice |
| Gotu Kola | Skin Photo Damage | 1 | PM | 24278045 | 📋 | Centella asiatica in cosmetology |
| Gotu Kola | Skin Photo Damage | 2 | PM | 22948173 | 📋 | Titrated extract of Centella asiatica provides a UVB protective effect by altering microRNA expression profiles in human dermal fibroblasts |
| Gotu Kola | Telomere Dysfunction and Attrition | 3 | PM | 37921058 | 📋 | A novel nutraceutical formulation increases telomere length and activates telomerase activity in middle‑aged rats |
| Gotu Kola | Telomere Dysfunction and Attrition | 2 | PM | 34515324 | 📋 | Reversal of brain aging by targeting telomerase: A nutraceutical approach |
