| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Baicalein | AGE Products | 1 | PM | 38795756 | 📋 | Apigenin and baicalein ameliorate thoracic aortic structural deterioration and cognitive deficit via inhibiting AGEs/RAGE/NF-κB pathway in D-galactose-induced aging rats |
| Baicalein | Aging | 2 | PM | 38795756 | 📋 | Apigenin and baicalein ameliorate thoracic aortic structural deterioration and cognitive deficit via inhibiting AGEs/RAGE/NF-κB pathway in D-galactose-induced aging rats |
| Baicalein | Aging | 1 | PM | 35316094 | 📋 | Baicalein may act as a caloric restriction mimetic candidate to improve the anti-oxidant profile in a natural rodent model of aging |
| Baicalein | Aging Skin | 1 | PM | 37107277 | 📋 | The Cytoprotective Effects of Baicalein on H2O2-Induced ROS by Maintaining Mitochondrial Homeostasis and Cellular Tight Junction in HaCaT Keratinocytes |
| Baicalein | Alzheimer's Disease | 18 | PM | 38006681 | 📋 | Baicalein promotes the microglia M2 polarization and suppresses apoptosis by targeting HMOX1/PDE4D to alleviate Alzheimer's disease |
| Baicalein | Alzheimer's Disease | 17 | PM | 37098656 | 📋 | Baicalein ameliorates Alzheimer's disease via orchestration of CX3CR1/NF-κB pathway in a triple transgenic mouse model |
| Baicalein | Alzheimer's Disease | 16 | PM | 36978955 | 📋 | The Combination of Baicalein and Memantine Reduces Oxidative Stress and Protects against β-amyloid-Induced Alzheimer's Disease in Rat Model |
| Baicalein | Alzheimer's Disease | 15 | PM | 36909151 | 📋 | Effects of baicalein with memantine on aluminium chloride-induced neurotoxicity in Wistar rats |
| Baicalein | Alzheimer's Disease | 14 | PM | 36817510 | 📋 | Chronic treatment with baicalein alleviates behavioural disorders and improves cerebral blood flow via reverting metabolic abnormalities in a J20 transgenic mouse model of Alzheimer's disease |
| Baicalein | Alzheimer's Disease | 13 | PM | 35783137 | 📋 | Identification of miRNA-mRNA Pairs in the Alzheimer's Disease Expression Profile and Explore the Effect of miR-26a-5p/PTGS2 on Amyloid-β Induced Neurotoxicity in Alzheimer's Disease Cell Model |
| Baicalein | Alzheimer's Disease | 12 | PM | 35053900 | 📋 | Inhibitory Mechanism of Baicalein on Acetylcholinesterase: Inhibitory Interaction, Conformational Change, and Computational Simulation |
| Baicalein | Alzheimer's Disease | 11 | PM | 34966284 | 📋 | Baicalein Ameliorates Aβ-Induced Memory Deficits and Neuronal Atrophy via Inhibition of PDE2 and PDE4 |
| Baicalein | Alzheimer's Disease | 8 | PM | 34502362 | 📋 | Trans-Chalcone Plus Baicalein Synergistically Reduce Intracellular Amyloid Beta (Aβ 42) and Protect from Aβ 42 Induced Oxidative Damage in Yeast Models of Alzheimer's Disease |
| Baicalein | Alzheimer's Disease | 7 | PM | 33579328 | 📋 | Baicalein inhibits heparin-induced Tau aggregation by initializing non-toxic Tau oligomer formation |
| Baicalein | Alzheimer's Disease | 6 | PM | 33147823 | 📋 | Neuroprotective Effects of Baicalein, Wogonin, and Oroxylin A on Amyloid Beta-Induced Toxicity via NF-κB/MAPK Pathway Modulation |
| Baicalein | Alzheimer's Disease | 10 | PM | 31703329 | 📋 | Baicalein as a Potential Inhibitor against BACE1 and AChE: Mechanistic Comprehension through In Vitro and Computational Approaches |
| Baicalein | Alzheimer's Disease | 9 | PM | 31568753 | 📋 | Baicalein suppresses Repeat Tau fibrillization by sequestering oligomers |
| Baicalein | Alzheimer's Disease | 2 | PM | 29038007 | 📋 | Baicalin and Ginsenoside Rb1 Promote the Proliferation and Differentiation of Neural Stem Cells in Alzheimer's Disease Model Rats |
| Baicalein | Alzheimer's Disease | 5 | PM | 28106556 | 📋 | An Improved Drugs Screening System Reveals That Baicalein Ameliorates the Aβ/AMPA/NMDA-Induced Depolarization of Neurons |
| Baicalein | Alzheimer's Disease | 1 | PM | 28003750 | 📋 | Baicalein Improves Behavioral Dysfunction Induced by Alzheimer's Disease in Rats |
| Baicalein | Alzheimer's Disease | 3 | PM | 27233830 | 📋 | The Flavonoid Baicalein Rescues Synaptic Plasticity and Memory Deficits in a Mouse Model of Alzheimer's Disease |
| Baicalein | Alzheimer's Disease | 4 | PM | 24058373 | 📋 | Synergistic Action of Flavonoids, Baicalein, and Daidzein in Estrogenic and Neuroprotective Effects: A Development of Potential Health Products and Therapeutic Drugs Against Alzheimer's Disease |
| Baicalein | Cellular Senescence | 1 | PM | 34152720 | 📋 | Baicalein Delays H 2 O 2-Induced Astrocytic Senescence through Inhibition of Senescence-Associated Secretory Phenotype (SASP), Suppression of JAK2/STAT1/NF-κB Pathway, and Regulation of Leucine Metabolism |
| Baicalein | Genotoxicity | 1 | PM | 33667888 | 📋 | Protective effect of baicalein on DNA oxidative damage and its binding mechanism with DNA: An in vitro and molecular docking study |
| Baicalein | Hyperpigmentation | 1 | PM | 37434796 | 📋 | Baicalein Inhibits α-Melanocyte-stimulating Hormone-stimulated Melanogenesis via p38 Mitogen-activated Protein Kinase Pathway in B16F10 Mouse Melanoma Cells |
| Baicalein | Longevity | 1 | PM | 37463652 | 📋 | Baicalein mitigates oxidative stress and enhances lifespan through modulation of Wnt ligands and GATA factor: ELT-3 in Caenorhabditis elegans |
| Baicalein | Memory Disorders | 2 | PM | 37063260 | 📋 | Baicalein-corrected gut microbiota may underlie the amelioration of memory and cognitive deficits in APP/PS1 mice |
| Baicalein | Memory Disorders | 1 | PM | 34966284 | 📋 | Baicalein Ameliorates Aβ-Induced Memory Deficits and Neuronal Atrophy via Inhibition of PDE2 and PDE4 |
| Baicalein | Osteoarthritis | 5 | PM | 38525128 | 📋 | Baicalein inhibits IL-1β-induced extracellular matrix degradation with decreased MCP-1 expression in primary rat chondrocytes |
| Baicalein | Osteoarthritis | 4 | PM | 36657732 | 📋 | Baicalein limits osteoarthritis development by inhibiting chondrocyte ferroptosis |
| Baicalein | Osteoarthritis | 3 | PM | 35082670 | 📋 | Baicalein Alleviates Osteoarthritis Progression in Mice by Protecting Subchondral Bone and Suppressing Chondrocyte Apoptosis Based on Network Pharmacology |
| Baicalein | Osteoarthritis | 2 | PM | 33939310 | 📋 | Baicalein alleviates osteoarthritis by protecting subchondral bone, inhibiting angiogenesis and synovial proliferation |
| Baicalein | Osteoarthritis | 1 | PM | 33732318 | 📋 | Combination of baicalein and miR-106a-5p mimics significantly alleviates IL-1β-induced inflammatory injury in CHON-001 cells |
| Baicalein | Osteoarthritis of the Knee | 1 | PM | 32128354 | 📋 | Evaluation of the post-treatment anti-inflammatory capacity of osteoarthritic chondrocytes: An in vitro study using baicalein |
| Baicalein | Osteoporosis | 2 | PM | 35164085 | 📋 | Anti-Osteoporosis Effect of Perilla frutescens Leaf Hexane Fraction through Regulating Osteoclast and Osteoblast Differentiation |
| Baicalein | Osteoporosis | 1 | PM | 34198266 | 📋 | Baicalein ameliorates osteoporosis via AKT/FOXO1 signaling |
| Baicalein | Oxidative Stress | 4 | PM | 32547311 | 📋 | Baicalein Neutralizes Hypercholesterolemia-Induced Aggravation of Oxidative Injury in Rats |
| Baicalein | Oxidative Stress | 2 | PM | 27257012 | 📋 | Baicalein Protects Human Skin Cells Against Ultraviolet B-Induced Oxidative Stress |
| Baicalein | Oxidative Stress | 1 | PM | 26796879 | 📋 | Baicalein Protects C6 Glial Cells Against Hydrogen Peroxide-Induced Oxidative Stress and Apoptosis Through Regulation of the Nrf2 Signaling Pathway |
| Baicalein | Oxidative Stress | 3 | PM | 24716188 | 📋 | The Effects of Plantago Major on the Activation of the Neutrophil Respiratory Burst |
| Baicalein | Parkinson's Disease | 14 | PM | 38460310 | 📋 | Insights into dietary phytochemicals targeting Parkinson's disease key genes and pathways: A network pharmacology approach |
| Baicalein | Parkinson's Disease | 13 | PM | 36670874 | 📋 | Baicalein Attenuates Brain Iron Accumulation through Protecting Aconitase 1 from Oxidative Stress in Rotenone-Induced Parkinson's Disease in Rats |
| Baicalein | Parkinson's Disease | 12 | PM | 35981677 | 📋 | Baicalein exhibits differential effects and mechanisms towards disruption of α-synuclein fibrils with different polymorphs |
| Baicalein | Parkinson's Disease | 11 | PM | 35237220 | 📋 | Baicalein Induces Mitochondrial Autophagy to Prevent Parkinson's Disease in Rats via miR-30b and the SIRT1/AMPK/mTOR Pathway |
| Baicalein | Parkinson's Disease | 10 | PM | 34666128 | 📋 | Baicalein protects against MPP +/MPTP-induced neurotoxicity by ameliorating oxidative stress in SH-SY5Y cells and mouse model of Parkinson's disease |
| Baicalein | Parkinson's Disease | 9 | PM | 34457363 | 📋 | Baicalein Mediates Mitochondrial Autophagy via miR-30b and the NIX/BNIP3 Signaling Pathway in Parkinson's Disease |
| Baicalein | Parkinson's Disease | 8 | PM | 34087694 | 📋 | Baicalein alleviates depression-like behavior in rotenone- induced Parkinson's disease model in mice through activating the BDNF/TrkB/CREB pathway |
| Baicalein | Parkinson's Disease | 7 | PM | 33101006 | 📋 | Preclinical Evidence and Possible Mechanisms of Baicalein for Rats and Mice With Parkinson's Disease: A Systematic Review and Meta-Analysis |
| Baicalein | Parkinson's Disease | 6 | PM | 32761175 | 📋 | Baicalein Attenuates Neuroinflammation by Inhibiting NLRP3/caspase-1/GSDMD Pathway in MPTP Induced Mice Model of Parkinson's Disease |
| Baicalein | Parkinson's Disease | 2 | PM | 28623717 | 📋 | Baicalein Exerts Anti-Neuroinflammatory Effects to Protect Against Rotenone-Induced Brain Injury in Rats |
| Baicalein | Parkinson's Disease | 3 | PM | 27742410 | 📋 | Baicalein Attenuates α-Synuclein Aggregation, Inflammasome Activation and Autophagy in the MPP +-treated Nigrostriatal Dopaminergic System in Vivo |
| Baicalein | Parkinson's Disease | 1 | PM | 27425033 | 📋 | Baicalein Inhibits α-Synuclein Oligomer Formation and Prevents Progression of α-Synuclein Accumulation in a Rotenone Mouse Model of Parkinson's Disease |
| Baicalein | Parkinson's Disease | 5 | PM | 19327378 | 📋 | Baicalein Exerts Neuroprotective Effects in 6-hydroxydopamine-induced Experimental Parkinsonism in Vivo and in Vitro |
| Baicalein | Parkinson's Disease | 4 | PM | 15503194 | 📋 | Inhibition of Microglial Activation by the Herbal Flavonoid Baicalein Attenuates Inflammation-Mediated Degeneration of Dopaminergic Neurons |
| Baicalein | Postmenopausal Osteoporosis | 1 | PM | 26392752 | 📋 | Regulation of Bone Formation by Baicalein via the mTORC1 Pathway |
| Baicalein | Sarcopenia | 1 | PM | 28050282 | 📋 | Effect of the Lipoxygenase Inhibitor Baicalein on Muscles in Ovariectomized Rats |
| Baicalein | Skin Photo Damage | 1 | PM | 27257012 | 📋 | Baicalein Protects Human Skin Cells Against Ultraviolet B-Induced Oxidative Stress |
