| Substance | Condition | Seq | Src | PMID | Dtl | Title |
| Acetyl-L-Carnitine | Age-Related Cognitive Decline | 3 | PM | 36043711 | 📋 | Acetyl-L-carnitine can slow the progression from prefrailty to frailty in older subjects. A randomized interventional clinical trial |
| Acetyl-L-Carnitine | Age-Related Cognitive Decline | 1 | PM | 18846423 | 📋 | Mitochondrial Decay in the Brains of Old Rats: Ameliorating Effect of Alpha-Lipoic Acid and acetyl-L-carnitine |
| Acetyl-L-Carnitine | Age-Related Cognitive Decline | 2 | PM | 3229874 | 📋 | Mental Impairment in Aging: Selection of Patients, Methods of Evaluation and Therapeutic Possibilities of acetyl-L-carnitine |
| Acetyl-L-Carnitine | Age-Related Diseases | 1 | PM | 29656010 | 📋 | Age-related defects in short-term plasticity are reversed by acetyl-L-carnitine at the mouse calyx of Held |
| Acetyl-L-Carnitine | Age-Related Diseases | 3 | PM | 28980618 | 📋 | [The use of acetyl-L-carnitine in gerontological practice] |
| Acetyl-L-Carnitine | Age-Related Diseases | 2 | PM | 28534301 | 📋 | Effects of acetyl-L-carnitine in diabetic neuropathy and other geriatric disorders |
| Acetyl-L-Carnitine | Age-Related Diseases | 4 | PM | 20550520 | 📋 | Acetyl-L-carnitine protects yeast cells from apoptosis and aging and inhibits mitochondrial fission |
| Acetyl-L-Carnitine | Age-Related Macular Degeneration | 1 | PM | 15947501 | 📋 | Improvement of Visual Functions and Fundus Alterations in Early Age-Related Macular Degeneration Treated With a Combination of acetyl-L-carnitine, n-3 Fatty Acids, and Coenzyme Q10 |
| Acetyl-L-Carnitine | Aging | 3 | PM | 20370498 | 📋 | Acetyl-L-carnitine supplementation to old rats partially reverts the age-related mitochondrial decay of soleus muscle by activating peroxisome proliferator-activated receptor gamma coactivator-1alpha-dependent mitochondrial biogenesis |
| Acetyl-L-Carnitine | Aging | 1 | PM | 17658628 | 📋 | Acetyl L-carnitine (ALC) Treatment in Elderly Patients With Fatigue |
| Acetyl-L-Carnitine | Aging | 2 | PM | 11976222 | 📋 | Mitochondrial Decay in the Aging Rat Heart: Evidence for Improvement by Dietary Supplementation With acetyl-L-carnitine and/or Lipoic Acid |
| Acetyl-L-Carnitine | Aging Brain | 2 | PM | 28807823 | 📋 | Dietary supplementation with acetyl-l-carnitine counteracts age-related alterations of mitochondrial biogenesis, dynamics and antioxidant defenses in brain of old rats |
| Acetyl-L-Carnitine | Aging Brain | 3 | PM | 20590847 | 📋 | Acetyl-L-carnitine improves aged brain function |
| Acetyl-L-Carnitine | Aging Brain | 1 | PM | 11854529 | 📋 | Memory Loss in Old Rats Is Associated With Brain Mitochondrial Decay and RNA/DNA Oxidation: Partial Reversal by Feeding acetyl-L-carnitine and/or R-alpha -Lipoic Acid |
| Acetyl-L-Carnitine | Aging Heart | 2 | PM | 22322067 | 📋 | Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart |
| Acetyl-L-Carnitine | Aging Heart | 1 | PM | 11976222 | 📋 | Mitochondrial Decay in the Aging Rat Heart: Evidence for Improvement by Dietary Supplementation With acetyl-L-carnitine and/or Lipoic Acid |
| Acetyl-L-Carnitine | Aging Liver | 2 | PM | 22533417 | 📋 | Acetyl-L-carnitine activates the peroxisome proliferator-activated receptor-γ coactivators PGC-1α/PGC-1β-dependent signaling cascade of mitochondrial biogenesis and decreases the oxidized peroxiredoxins content in old rat liver |
| Acetyl-L-Carnitine | Aging Liver | 1 | PM | 21672642 | 📋 | Rat liver mitochondrial proteome: changes associated with aging and acetyl-L-carnitine treatment |
| Acetyl-L-Carnitine | Alzheimer's Disease | 6 | PM | 36988119 | 📋 | A comparative study of acetyl-l-carnitine and caloric restriction impact on hippocampal autophagy, apoptosis, neurogenesis, and astroglial function in AlCl3-induced Alzheimer's in rats |
| Acetyl-L-Carnitine | Alzheimer's Disease | 5 | PM | 34886786 | 📋 | Ameliorative effect of Acetyl L-carnitine in Alzheimer's Disease via Downregulating of Homocysteine Levels in Hyperhomocysteinemia Induced Cognitive Deficit in mouse model |
| Acetyl-L-Carnitine | Alzheimer's Disease | 4 | PM | 34164711 | 📋 | Mechanistic perspectives on differential mitochondrial-based neuroprotective effects of several carnitine forms in Alzheimer's disease in vitro model |
| Acetyl-L-Carnitine | Alzheimer's Disease | 10 | PM | 22027664 | 📋 | [Acetyl-L-carnitine (carnicetine) in the treatment of early stages of Alzheimer's disease and vascular dementia] |
| Acetyl-L-Carnitine | Alzheimer's Disease | 9 | PM | 21978079 | 📋 | Acetyl-L-carnitine attenuates homocysteine-induced Alzheimer-like histopathological and behavioral abnormalities |
| Acetyl-L-Carnitine | Alzheimer's Disease | 7 | PM | 21939756 | 📋 | Natural substances and Alzheimer's disease: from preclinical studies to evidence based medicine |
| Acetyl-L-Carnitine | Alzheimer's Disease | 8 | PM | 21689104 | 📋 | Acetyl-L-carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C |
| Acetyl-L-Carnitine | Alzheimer's Disease | 3 | PM | 21183322 | 📋 | Modulatory Effects of Vitamin E, acetyl-L-carnitine and α-Lipoic Acid on New Potential Biomarkers for Alzheimer's Disease in Rat Model |
| Acetyl-L-Carnitine | Alzheimer's Disease | 11 | PM | 20110616 | 📋 | Acetyl-L-carnitine attenuates okadaic acid induced tau hyperphosphorylation and spatial memory impairment in rats |
| Acetyl-L-Carnitine | Alzheimer's Disease | 2 | PM | 18846423 | 📋 | Mitochondrial Decay in the Brains of Old Rats: Ameliorating Effect of Alpha-Lipoic Acid and acetyl-L-carnitine |
| Acetyl-L-Carnitine | Alzheimer's Disease | 1 | PM | 1944900 | 📋 | Long-term acetyl-L-carnitine Treatment in Alzheimer's Disease |
| Acetyl-L-Carnitine | Frailty | 1 | PM | 36043711 | 📋 | Acetyl-L-carnitine can slow the progression from prefrailty to frailty in older subjects. A randomized interventional clinical trial |
| Acetyl-L-Carnitine | Genotoxicity | 1 | PM | 11854529 | 📋 | Memory Loss in Old Rats Is Associated With Brain Mitochondrial Decay and RNA/DNA Oxidation: Partial Reversal by Feeding acetyl-L-carnitine and/or R-alpha -Lipoic Acid |
| Acetyl-L-Carnitine | Hypertension | 3 | PM | 33368625 | 📋 | Role of carnitine in regulation of blood pressure (MAP/SBP) and gene expression of cardiac hypertrophy markers (α/β-MHC) during insulin-induced hypoglycaemia: Role of oxidative stress |
| Acetyl-L-Carnitine | Hypertension | 1 | PM | 19620516 | 📋 | Ameliorating Hypertension and Insulin Resistance in Subjects at Increased Cardiovascular Risk: Effects of acetyl-L-carnitine Therapy |
| Acetyl-L-Carnitine | Hypertension | 2 | PM | 17396066 | 📋 | Effect of Combined Treatment With alpha-Lipoic Acid and acetyl-L-carnitine on Vascular Function and Blood Pressure in Patients With Coronary Artery Disease |
| Acetyl-L-Carnitine | Memory Disorders | 1 | PM | 11854529 | 📋 | Memory Loss in Old Rats Is Associated With Brain Mitochondrial Decay and RNA/DNA Oxidation: Partial Reversal by Feeding acetyl-L-carnitine and/or R-alpha -Lipoic Acid |
| Acetyl-L-Carnitine | Mitochondrial Decay | 2 | PM | 21672642 | 📋 | Rat liver mitochondrial proteome: changes associated with aging and acetyl-L-carnitine treatment |
| Acetyl-L-Carnitine | Mitochondrial Decay | 3 | PM | 20370498 | 📋 | Acetyl-L-carnitine supplementation to old rats partially reverts the age-related mitochondrial decay of soleus muscle by activating peroxisome proliferator-activated receptor gamma coactivator-1alpha-dependent mitochondrial biogenesis |
| Acetyl-L-Carnitine | Mitochondrial Decay | 1 | PM | 11976222 | 📋 | Mitochondrial Decay in the Aging Rat Heart: Evidence for Improvement by Dietary Supplementation With acetyl-L-carnitine and/or Lipoic Acid |
| Acetyl-L-Carnitine | Oxidative Stress | 6 | PM | 34124692 | 📋 | Assessing the antioxidant and metabolic effect of an alpha-lipoic acid and acetyl-L-carnitine nutraceutical |
| Acetyl-L-Carnitine | Oxidative Stress | 2 | PM | 33710529 | 📋 | Acetyl-L-carnitine confers neuroprotection against lipopolysaccharide (LPS) -induced neuroinflammation by targeting TLR4/NFκB, autophagy, inflammation and oxidative stress |
| Acetyl-L-Carnitine | Oxidative Stress | 1 | PM | 33368625 | 📋 | Role of carnitine in regulation of blood pressure (MAP/SBP) and gene expression of cardiac hypertrophy markers (α/β-MHC) during insulin-induced hypoglycaemia: Role of oxidative stress |
| Acetyl-L-Carnitine | Oxidative Stress | 4 | PM | 31945029 | 📋 | Anti-Inflammatory and Antioxidant Effects of Acetyl-L-Carnitine on Atherosclerotic Rats |
| Acetyl-L-Carnitine | Oxidative Stress | 3 | PM | 31078678 | 📋 | Ketamine-induced attenuation of reactive oxygen species in zebrafish is prevented by acetyl l-carnitine in vivo |
| Acetyl-L-Carnitine | Oxidative Stress | 5 | PM | 26773361 | 📋 | Molecular and biochemical evidence on the protection of cardiomyocytes from phosphine-induced oxidative stress, mitochondrial dysfunction and apoptosis by acetyl-L-carnitine |
| Acetyl-L-Carnitine | Oxidative Stress | 7 | PM | 21618017 | 📋 | Acetyl-L-carnitine prevents carbon tetrachloride-induced oxidative stress in various tissues of Wistar rats |
| Acetyl-L-Carnitine | Parkinson's Disease | 1 | PM | 30890473 | 📋 | Neuroprotective effects of acetyl-l-carnitine (ALC) in a chronic MPTP-induced Parkinson's disease mouse model: Endothelial and microglial effects |
| Acetyl-L-Carnitine | Parkinson's Disease | 4 | PM | 28577987 | 📋 | ALCAR promote adult hippocampal neurogenesis by regulating cell-survival and cell death-related signals in rat model of Parkinson's disease like-phenotypes |
| Acetyl-L-Carnitine | Parkinson's Disease | 3 | PM | 28199883 | 📋 | Acetyl-l-carnitine protects dopaminergic nigrostriatal pathway in 6-hydroxydopamine-induced model of Parkinson's disease in the rat |
| Acetyl-L-Carnitine | Parkinson's Disease | 2 | PM | 27975173 | 📋 | Acetyl-L-Carnitine via Upegulating Dopamine D1 Receptor and Attenuating Microglial Activation Prevents Neuronal Loss and Improves Memory Functions in Parkinsonian Rats |
| Acetyl-L-Carnitine | Parkinson's Disease | 6 | PM | 26223802 | 📋 | ALCAR Exerts Neuroprotective and Pro-Neurogenic Effects by Inhibition of Glial Activation and Oxidative Stress via Activation of the Wnt/β-Catenin Signaling in Parkinsonian Rats |
| Acetyl-L-Carnitine | Parkinson's Disease | 5 | PM | 21958946 | 📋 | Acetyl-L-carnitine and α-lipoic acid affect rotenone-induced damage in nigral dopaminergic neurons of rat brain, implication for Parkinson's disease therapy |
| Acetyl-L-Carnitine | Parkinson's Disease | 7 | PM | 20414966 | 📋 | Combined R-alpha-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease |
