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When taken by mouth: Vitamin B6 is LIKELY SAFE for most people when used appropriately. Taking vitamin B6 in doses that do not exceed 100 mg per day is generally considered to be safe. Vitamin B6 is POSSIBLY SAFE when taken in doses less than 500 mg per day. In some people, vitamin B6 might cause nausea, vomiting, diarrhea, stomach pain, loss of appetite, headache, tingling, sleepiness, and other side effects. Vitamin B6 is POSSIBLY UNSAFE when taken by mouth in doses of 500 mg or more daily, long-term. High doses of vitamin B6, especially 1000 mg or more per day, might cause brain and nerve problems.
When given by IV: Vitamin B6 is LIKELY SAFE when given by IV under medical supervision for uses approved by the FDA.
When given as a shot: Vitamin B6 is LIKELY SAFE when given as a shot into the muscle under medical supervision in amounts approved by the FDA. Using large doses of vitamin B6 as a shot into the muscle is POSSIBLY UNSAFE. It might cause muscle problems.
Special Precautions & Warnings:
Pregnancy: Vitamin B6 is
LIKELY SAFE for pregnant women when taken under the supervision of their healthcare provider. It is sometimes used in pregnancy to control morning sickness. But high doses are
POSSIBLY UNSAFE. High doses can cause newborns to have seizures.
Breast-feeding: Vitamin B6 is
LIKELY SAFE for breast-feeding women when used in amounts not larger than 2 mg per day (the recommended dietary allowance). Avoid using higher amounts. Not enough is known about the safety of vitamin B6 at higher doses in breast-feeding women.
Procedures to widen narrowed arteries (angioplasty). Using vitamin B6 along with folic acid and vitamin B12 intravenously (by IV) or by mouth might worsen narrowed arteries. Vitamin B6 should not be used by people recovering from this procedure.
Weight loss surgery. Taking a vitamin B6 supplement is not needed for people that have had weight loss surgery. And taking too much vitamin B6 might increase the chance of side effects such as nausea, vomiting, and browning skin.
Diabetes. Using a combination of vitamin B6, folic acid, and vitamin B12 might increase the risk of cancer in people with diabetes and a recent stroke. Vitamin B6 should not be used by patients with diabetes that have had a recent stroke.
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