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When taken by mouth: Vitamin B12 is LIKELY SAFE for most people. Vitamin B12 is considered safe, even in large doses.
When applied to the skin: Vitamin B12 is LIKELY SAFE for most people when used appropriately.
When sprayed into the nose: Vitamin B12 is LIKELY SAFE for most people. Vitamin B12 is considered safe, even in large doses.
When given by IV: Vitamin B12 is LIKELY SAFE for most people. Vitamin B12 is considered safe, even in large doses.
When given as a shot: Vitamin B12 is LIKELY SAFE for most people. Vitamin B12 is considered safe, even in large doses.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Vitamin B12 is
LIKELY SAFE for pregnant or breast-feeding women when taken by mouth in the amounts recommended. The recommended amount for pregnant women is 2.6 mcg per day. Breast-feeding women should take no more than 2.8 mcg per day. Don't take larger amounts. The safety of larger amounts is unknown.
Post-surgical stent placement: Avoid using a combination of vitamin B12, folate, and vitamin B6 after receiving a coronary stent. This combination may increase the risk of blood vessel narrowing.
Allergy or sensitivity to cobalt or cobalamin: Do not use vitamin B12 if you have this condition.
Leber disease: Do not take vitamin B12 if you have this hereditary eye disease. It can seriously harm the optic nerve, which might lead to blindness.
Abnormal red blood cells (megaloblastic anemia): Megaloblastic anemia is sometimes corrected by treatment with vitamin B12. However, this can have very serious side effects. Don't attempt vitamin B12 therapy without close supervision by your healthcare provider.
High numbers of red blood cells (polycythemia vera): The treatment of vitamin B12 deficiency can unmask the symptoms of polycythemia vera.
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