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Pyridoxine is likely safe when taken in recommended amounts. However, prolonged supplementation with high doses (>1000 mg/day) can result in:
- • Nerve damage
- • Movement disorders
- • Skin lesions
High vitamin B6 doses may tell the body it has too much of this vitamin. In turn, enzymes that convert vitamin B6 to P-5-P are blocked, reducing P-5-P levels.
The conversion step is bypassed with P-5-P, but its long-term safety remains unknown.
Additionally, P-5-P may cause digestive side effects such as:
- • Vomiting
- • Diarrhea
- • Stomach cramps
Doctors had to withdraw P-5-P in some newborns with severe digestive issues. It also increased liver enzymes in newborns with no apparent symptoms.
Pyridoxine inhibited the pituitary gland and caused a slight drop in prolactin in 2 smaller clinical trials. In a study on mice cells, pyridoxal phosphate suppressed:
- • Prolactin
- • Growth hormone
- • ACTH
The safe upper limit for pyridoxine is 100 mg daily while there’s no established limit for P-5-P. Pregnant women should avoid P-5-P until we know more about its safety. *
