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When taken by mouth: The progesterone prescription products that have been approved by the Food and Drug Administration (FDA) are LIKELY SAFE for most people when used by mouth with the advice and care of a healthcare professional.
When applied to the skin: The progesterone prescription products that have been approved by the Food and Drug Administration (FDA) are LIKELY SAFE for most people when applied to the skin with the advice and care of a healthcare professional.
When given as a shot: The progesterone prescription products that have been approved by the Food and Drug Administration (FDA) are LIKELY SAFE for most people when injected into the muscle with the advice and care of a healthcare professional.
When applied into the vagina: The progesterone prescription products that have been approved by the Food and Drug Administration (FDA) are LIKELY SAFE for most people when applied into the vagina with the advice and care of a healthcare professional.
However, progesterone can cause many side effects including stomach upset, changes in appetite, weight gain, fluid retention and swelling (edema), fatigue, acne, drowsiness or insomnia, allergic skin rashes, hives, fever, headache, depression, breast discomfort or enlargement, premenstrual syndrome (PMS)-like symptoms, altered menstrual cycles, irregular bleeding, and other side effects.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Intravaginal progesterone gel is
LIKELY SAFE when used as part of infertility treatment or to prevent premature birth. However, progesterone is
LIKELY UNSAFE when used during pregnancy for any other purpose.
There isn't enough reliable information to know if progesterone is safe to use when breast-feeding. Stay on the safe side and avoid use.
Arterial disease: Don't use progesterone if you have arterial disease.
Breast cancer: Avoid use unless you are directed to do so by your healthcare provider.
Depression: Get your healthcare provider's advice first before using progesterone if you have major depression now or a history of major depression.
Liver disease: Progesterone might make liver disease worse. Don't use it.
Vaginal bleeding: If you have undiagnosed vaginal bleeding, don't use progesterone.
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