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Little is known about the safety of taking pregnenolone supplements. There is some concern that this prohormone can cause steroid-like side effects, such as irritability, overstimulation, trouble sleeping, anxiety, anger, acne, mood changes, headaches, irregular heartbeat and hair loss.
People with hormone-sensitive conditions should not use these supplements, especially conditions that may worsen because of exposure to estrogen. Pregnenolone is converted into estrogen and other sex hormones by the body, so people with endometriosis, uterine fibroids, breast cancer and uterine cancer should consult their health care providers before using this type of supplement.
There isn’t any research to support the safety of pregnenolone use for women who are pregnant or nursing, so it should be avoided to be on the safe side.
In addition, these supplements should not be taken with any kind of hormones, like birth control pills, estrogen pills or testosterone pills, because they may cause too much of a particular hormone in your body. *
The use of Pregnenolone has been considered safe and well tolerated for general consumption. However, some side effects have been reported and so the supplement should be used cautiously and should not be taken on a long term basis. Adverse effects of Pregnenolone are directly linked to the dosage taken. When taken at low doses, Pregnenolone can reduce stress and anxiety however, high doses of which can produce irritability and anxiety. Low doses of the drug can help with one's sleep however, high doses can result in the opposite effect such as insomnia and night sweats. In addition, Pregnenolone may also produce steroid-like side effects such as anger, irritability, overstimulation, negative mood changes, facial hair growth and even heart palpitations in some individuals. Since Pregnenolone converts into DHEA and then to testosterone, then to DHT, it can increase balding to those who are predisposed. It also has an effect on androgens, it can produce acne and oily skin. Moreover, when Pregnenolone is used in a long term basis, it can cause withdrawal symptoms for some. This includes anxiety, restlessness and nervousness. Some people also become fatigued and paranoid. In this case, it is recommended to slowly reduce the dose for 10 mg a day instead of abruptly stopping the supplement. *
