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Contraindications
Hypersensitivity to any of the components in pineapple. Cross-reaction with honeybee venom, olive tree pollen, celery, cypress pollen, bromelain, and papain have been reported.
Pregnancy/Lactation
Information regarding safety and efficacy in pregnancy and lactation is lacking. Data is lacking to support the historical use of pineapple to induce menstruation and abortion.
Interactions
Potentiation of amoxicillin and tetracycline because of increased volume of distribution by bromelain has been documented.
Side Effects
The juice from unripe pineapples can cause severe vomiting. Bromelain ingestion is associated with a low incidence of adverse reactions, including diarrhea, excess menstrual flow, nausea, skin rash, and vomiting. Swelling of the mouth and cheeks can result from eating large amounts of the fruit. *
