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When taken by mouth: Peony is POSSIBLY SAFE when used by mouth in appropriate amounts, short-term. Peony has been used safely for up to 6 months in adults. It can cause stomach upset in some people. There isn't enough reliable information to know if peony is safe or what the side effects might be when taken by mouth, long-term.
When applied to the skin: There isn't enough reliable information to know if peony is safe. It can cause rash in some people.
When given as an enema (rectally): Peony is POSSIBLY SAFE when administered by a healthcare professional twice daily for up to 7 days. There isn't enough reliable information to know if peony is safe or what the side effects might be when used for longer than 7 days.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Peony is
POSSIBLY UNSAFE when taken by mouth during pregnancy. Some developing research suggests that peony can cause uterine contractions. However, other research suggests a combination of peony and angelica might be safe. Until more is known, don't use peony if you are pregnant. Also avoid peony if you are breast-feeding. Not enough is known about the safety of using peony while breast-feeding.
Children: Peony is
POSSIBLY SAFE when taken by mouth in children for up to 12 months.
Bleeding disorders: Because peony might slow blood clotting, there is a concern that it might increase the risk of bleeding in people with bleeding disorders. Don't use it if you have a bleeding disorder.
Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Peony extract might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don't use peony.
Surgery: Peony might slow blood clotting, so there is a concern that it could increase the chance of bleeding during and after surgery. Stop using peony at least 2 weeks before a scheduled surgery.
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