Untitled Document
Papain supplements and ointments are generally safe for short-term use. High oral doses may cause side effects, including stomach upset and throat irritation. Dosages in excess of 1,500 milligrams (mg) per day are associated with an increased risk of esophageal perforation. Papain ointments and salves may cause mild pain and burning, especially on broken skin.
Little is known about the long-term safety of papain supplements. Due to the lack of safety research, papain should be avoided in children, pregnant women, and nursing mothers.
Perhaps the greater concern is the risk of allergy in people exposed to papain. The risk appears to be greatest in people with a known allergy to latex or kiwi. Symptoms can range from mild to severe and includes an itchy mouth, watery eyes, sneezing, nasal congestion, excessive sweating, and diarrhea.
On rare occasion, exposure to papain can lead to a potentially life-threatening, whole-body reaction known as anaphylaxis.
Call 911 or go to your nearest emergency room if you develop a rash, hives, shortness of breath, wheezing, rapid heart rate, or the swelling of the face, throat, or tongue after taking papain or using a papain ointment.
If left untreated, anaphylaxis can lead to asphyxiation, coma, cardiac or respiratory failure, or death.
Drug Interactions
Papain can slow blood clotting and should be avoided in people who take anticoagulants like Coumadin (warfarin) or antiplatelet drugs like Plavix (clopidogrel). Stop using papain at least two weeks before surgery to avoid excessive bleeding.
Papain can also lower your blood sugar and should be used with caution if you are on diabetes medications. Taking these together can lead to an excessive drop in blood sugar, known as hypoglycemia.
As a general rule, always advise your doctor about any dietary supplement you are taking to avoid interactions and unforeseen side effects. *
