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Nicotinamide riboside is likely safe with few — if any — side effects.
In human studies, taking 1,000–2,000 mg per day had no harmful effects.
However, most human studies are short in duration and have very few participants. For a more accurate idea of its safety, more robust human studies are needed.
Some people have reported mild to moderate side effects, such as nausea, fatigue, headaches, diarrhea, stomach discomfort and indigestion.
In animals, taking 300 mg per kg of body weight (136 mg per pound) daily for 90 days had no harmful effects. *
