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As a derivative of nattÅ, a food eaten for centuries in Japan, nattokinase is presumed to be safe, although there is little data as to its long-term effect. That doesn't mean that it is without concerns.
Because nattokinase can influence blood circulation and chemistry, it should be used with caution in certain groups, namely:
- People with bleeding disorders, such as hemophilia, in whom nattokinase may make symptoms worse
- People who take blood thinners, including arfarin, in whom nattokinase may promote bleeding and easy bruising
- People with low blood pressure, also known as hypotension, in whom nattokinase may cause lightheadedness, headaches, dizziness, and fainting
- People on antihypertensive drugs, like ACE inhibitors and calcium channel blockers, in whom nattokinase may intensify the drug's effect, triggering hypotension
Nattokinase should also be stopped no less than two weeks prior to a scheduled surgery to reduce the risk of excessive bleeding.
Due to the lack of research, nattokinase should be not be used in children or during pregnancy or breastfeeding. *
