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Mango leaf ethanolic extracts (62% mangiferin) at 18.4g/kg twice daily over two weeks does not appear to be associated with any overt or histological signs of toxicity while chronic supplementation of 100-900mg/kg of this extract (17.2-155.2 times the clinical effective dose of 5.8mg/kg) over three months in mice showed alterations in blood cells and lipids that were deemed to not be overly clinically relevant. *
