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When taken by mouth: MSM is POSSIBLY SAFE for most people when taken by mouth for up to 3 months. In some people, MSM might cause nausea, diarrhea, bloating, fatigue, headache, insomnia, itching, or worsening of allergy symptoms.
When applied to the skin: MSM is POSSIBLY SAFE for most people when applied to the skin in combination with other ingredients, such as silymarin or hyaluronic acid and tea tree oil, for up to 20 days.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if MSM is safe to use when pregnant or breast feeding. Stay on the safe side and avoid use.
Varicose veins and other circulatory problems (chronic venous insufficiency): Applying a lotion that contains MSM to the lower limbs can increase swelling and pain in people with varicose veins and other circulatory problems.
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MSM is considered safe and is generally well tolerated with minimal side effects.
Major regulatory agencies such as the FDA have given it the Generally Recognized As Safe (GRAS) designation.
Numerous toxicity studies have been done to assess the safety of MSM and doses up to 4,845.6 mg per day (4.8 grams) appear to be safe.
However, some people may experience mild reactions if they are sensitive to MSM, such as stomach issues like nausea, bloating and diarrhea. When applied to the skin, it may also cause mild skin or eye irritation.
Additionally, there is concern over mixing MSM with alcohol since other sulfur-containing medications can cause adverse reactions when mixed with alcoholic beverages.
However, no studies have explored this potentially problematic combination yet. *
