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Overall, ALA supplementation at moderate servings does not produce significant adverse effects. The most common reported side effects were skin reactions like itching, rashes or hives, with a small number of severe allergic reactions, and a few reported cases of nausea and stomach pain. Some people have experienced heartburn, but eating a small snack with supplementation has been shown to help. Some people report a sulfur smell in their urine, much like asparagus causes, when taking ALA.
Studies of older patients using supplements with servings ranging from 600 mg to 1,200 mg experienced nausea, acid reflux, and stomach discomfort. Persons with diabetes who are using supplemental insulin should monitor their blood glucose levels closely when taking ALA supplements as it influences insulin-mediated blood glucose utilization. Talk with a healthcare professional before taking supplemental ALA, especially if you are taking other medications or supplements. *
