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One of the main concerns that researchers face is the fact that methionine can be converted into homocysteine, which is an amino acid associated with heart disease. When a person has a high intake of methionine, it may lead to an increase of homocysteine.
One test has been performed over 6,000 times to evaluate the body’s response to methionine. During this test, a single large dose is given that is often around 45 mg/lb. Throughout the number of times this test has been performed, there were primarily only minor side effects reported including dizziness, sleepiness and changes in blood pressure.
Methionine is not toxic in healthy humans unless taken at extremely high doses. It should not be used in patients with acidosis and should be used with extreme caution in patients with severe liver disease. *
