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L-leucine is safe to supplement with. However, it is best to stick to the recommended dosage and not exceed 500 mg per kg of body weight per day. Above these levels, it can cause increases in the levels of ammonia in the body, which can have a range of adverse effects.
If you have ever been diagnosed with liver or kidney problems, then you should seek your doctor’s advice before taking this supplement.
Nausea
It is possible that excessive quantities of leucine can lead to nausea and, on occasion, vomiting. If you follow the dosage requirements, though, you should not experience this effect.
Indigestion
Very high doses of leucine can cause stomach aches and diarrhea. If you experience these symptoms, you should check that you have taken the correct dose of L-leucine. It may also be worth considering if any other supplements also contain L-leucine (BCAA, for instance). *
