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Histidine should not be taken if you are on blood pressure medications. Be sure to consult a doctor first. It is unclear if histidine is safe for pregnant or breastfeeding women. For that reason, it is best to avoid supplementation.
In some cases, taking histidine supplements over a long period of time can lead to low levels of zinc and copper, so it is advisable to take these supplements along with histidine. *
