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When taken by mouth: Hyaluronic acid is LIKELY SAFE when used appropriately. Rarely, it may cause allergic reactions.
When applied to the skin: Hyaluronic acid is LIKELY SAFE when used appropriately. Rarely, it may cause allergic reactions.
When given as a shot: Hyaluronic acid is LIKELY SAFE when used appropriately. Hyaluronic acid can cause redness and soreness when injected into the joint.
When applied into the eye: Hyaluronic acid is LIKELY SAFE when used appropriately. Hyaluronic acid can increase eye pressure when injected into the eye. But this usually resolves within 48 to 72 hours.
Special Precautions & Warnings:
Pregnancy: Hyaluronic acid is
POSSIBLY SAFE when given by injection when pregnant. However, there isn't enough reliable information to know if hyaluronic acid is safe to take by mouth or apply to the skin when pregnant. Stay on the safe side and avoid use.
Breast-feeding: Hyaluronic acid is
POSSIBLY SAFE when given by injection when breast feeding. But researchers do not know if it affects breast milk and what effect that might have on an infant. There isn't enough reliable information to know if hyaluronic acid is safe to take by mouth or apply to the skin when breastfeeding. Stay on the safe side and avoid use.
Hardening of skin and connective tissue (scleroderma): Applying hyaluronic acid to the skin might make skin ulcers worse in people who have a condition called scleroderma. If you have scleroderma, don't use hyaluronic acid on your skin.
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Hyaluronic acid is generally very safe to use, with few reported side effects. Since the body naturally produces it, allergic reactions are very rare. One study in 60 people with osteoarthritis who took 200 mg daily for one year reported no negative side effects.
However, its effects during pregnancy or breastfeeding have not been thoroughly studied, so these groups should be cautious and avoid supplementing with it.
There is also some evidence that cancer cells are sensitive to hyaluronic acid and taking supplements could make them grow faster. For this reason, it is generally advised that people with cancer or a history of cancer avoid supplementing with it.
Hyaluronic acid injections into the skin or joints have a higher risk of side effects. However, negative reactions are mostly associated with the injection procedure, rather than hyaluronic acid itself.
Hyaluronic acid is generally very safe when used as a supplement, but people who are pregnant or have cancer or a history of cancer may want to avoid taking it. *
