Untitled Document
In clinical trials, hesperidin and juices or fruits containing this flavonoid were generally safe and only occasionally caused mild digestive effects such as diarrhea, stomach pain, and upset digestion.
Similarly, its combination with diosmin (Daflon) caused no major side effects in clinical trials.
Hesperidin can slow blood clotting and increase blood flow, which may help prevent heart disease but also worsen bleeding disorders or increase the risk of bleeding in people undergoing surgical procedures.
Because it may lower blood pressure, people with diagnosed low blood pressure may want to avoid hesperidin to prevent their pressure from dropping to too low values. *
Hesperidin may trigger a number of side effects, including abdominal pain, diarrhea, contact dermatitis, and nausea.
Hesperidin supplements may not be safe for people taking certain medications (including anticoagulants, blood pressure drugs, and calcium channel blockers). Therefore, it's important to consult your physician if you're considering using hesperidin in combination with other medications.
Clinical research suggests that hesperidin may affect blood clotting and increase the risk of bleeding. People taking anticoagulant/antiplatelet medications and those with bleeding disorders shouldn't take hesperidin. In addition, it's safest to avoid hesperidin and foods, such as citrus, containing it within two weeks of surgery (before and after).
There was a reported case of thrombocytopenic purpura (a disorder that can lead to easy or excessive bleeding or bruising) associated with the use of two supplements containing mainly citrus bioflavonoids.
Keep in mind that self-treating a condition and avoiding or delaying standard care may have serious consequences. In addition, the safety of many supplements in pregnant women, nursing mothers, children, and those with medical conditions or who are taking medications has not been established. *
