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Certain sources list side effects like headache, itchy scalp, dizziness, or nausea that may occur when you take grape seed extract for a long period of time. But in human studies, grape seed extract powder is generally considered safe and well tolerated. A group of 29 healthy Japanese subjects received up to 2500 mg orally each day with no side effects and no one dropped out of the study.
Anyone allergic to grapes should not take grape seed extract. Because it might interact with iron absorption, it’s probably best to avoid grape seed extract if you have an iron deficiency.
Women who are pregnant or breastfeeding should avoid taking grape seed extract because of insufficient data for this population.
A word of caution to people on blood thinners or blood pressure medication: Grape seed extract could thin your blood, increase blood flow, and reduce your blood pressure.
As always, consult your doctor for medical advice and any drug interactions before adding new supplements to your daily regimen.
Another important precaution to note for grape seed extract is the number of conditions this supplement is said to reverse or treat, without scientific proof. Many articles state you can use GSE for the following conditions, but we were unable to find any supporting research to back up those claims:
- • Edema (swelling) caused by radiation for breast cancer
- • Weight loss
- • Insulin sensitivity *
