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Despite being stored in the body for long periods (which may lead to overload symptoms in some molecules), toxicity has not been noted in mouse models. When tested for its mutagenicity (ability to produce mutations in DNA), fucoxanthinol (the circulating metabolite of fucoxanthin) came back negative in all in vitro tests and oral dosages of 2,000 mg/kg bodyweight were unable to cause short-term adverse effects. *
Since there's currently a lack of studies testing fucoxanthin's effects in humans, little is known about the safety of long-term or regular use of fucoxanthin products and how it might interact with medications. One study reported increased total cholesterol levels in mice fed fucoxanthin.
Consuming large or regular amounts of seaweed may elevate your iodine levels. Excess iodine intake may result in iodine poisoning and interfere with the function of your thyroid gland. Seaweed may contain heavy metals (such as arsenic, cadmium, and lead) and other contaminants. *
